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91. 发明申请

US20170148620A1 ION TRANSPORT APPARATUS AND MASS SPECTROMETER USING THE SAME 有权
公开(公告)号：US20170148620A1
公开(公告)日：2017-05-25
申请号：US15310280
申请日：2014-05-14
申请人： SHIMADZU CORPORATION
发明人： Masaru NISHIGUCHI , Akiko IMAZU
IPC分类号： H01J49/06 , H01J49/42 , H01J49/24 , H01J49/22
CPC分类号： H01J49/063 , H01J49/061 , H01J49/22 , H01J49/24 , H01J49/422
摘要： An off-axis ion transport optical system (20) including a front-stage quadrupole ion guide (21), a rear-stage quadrupole ion guide (22), and an ion deflector (23) is disposed inside an intermediate vacuum chamber (2) in a stage next to an ionization chamber (1) maintained at an atmospheric pressure. Both of the quadrupole ion guides (21 and 22) have the same configuration as that of a conventional ion guide that transports ions while trapping the ions using a radio-frequency electric field. The ion deflector (23) includes a pair of parallel flat electrodes (231 and 232) and deflects ions using a direct-current electric field. By causing the deflected ions to reach the ion receiving range of the rear-stage quadrupole ion guide (22), it is possible to efficiency introduce ions while deflecting the ions. Meanwhile, the ions and neutral particles are separated from each other in the ion deflector (23). This provides an off-axis structure ion transport optical system that achieves a high ion transmission efficiency with a simple structure.

92. 发明申请

US20170140912A1 SYSTEMS AND METHODS FOR ANALYZING A SAMPLE FROM A SURFACE 审中-公开
公开(公告)号：US20170140912A1
公开(公告)日：2017-05-18
申请号：US15318846
申请日：2015-06-16
申请人： Purdue Research Foundation
发明人： Zheng Ouyang , Xiao Wang , Xiaoyu Zhou
IPC分类号： H01J49/04 , H01J49/00 , H01J49/24
CPC分类号： H01J49/04 , H01J49/0013 , H01J49/0468 , H01J49/24
摘要： The invention generally relates to systems and methods for analyzing a sample from a surface. In certain aspects, the invention provides systems that include a sample introduction member that has an inlet, an outlet, and an opening along a wall of the sample introduction member. The sample introduction member may be configured such that the opening couples with a surface that includes a sample in a manner in which molecules of the sample enter the sample introduction member via the opening and exit the sample introduction member via the outlet. A mass spectrometer is configured to receive the molecules of the sample.

93. 发明申请

US20170117128A1 IONIZATION SOURCE FOR ELECTROSPRAY IONIZATION MASS SPECTROMETRY AND MS ANALYSIS 有权
公开(公告)号：US20170117128A1
公开(公告)日：2017-04-27
申请号：US15331321
申请日：2016-10-21
申请人： ZHEJIANG HAOCHUANG BIOTECH CO., LTD.
发明人： Yixin Zhu , Tingting Lu
IPC分类号： H01J49/16 , H01J49/02 , H01J49/04 , H01J49/00 , H01J49/24
CPC分类号： H01J49/165 , H01J49/0031 , H01J49/022 , H01J49/0468 , H01J49/24
摘要： An ionization source for Electrospray Ionization (ESI) mass spectrometry includes a mass spectrometer having a source vacuum chamber having an inlet and an outlet. The outlet is disposed at an opening of the mass spectrometer. The ionization source further includes a hollow emission needle having an exit disposed at the inlet of the vacuum chamber. The hollow emission needle is configured to convey a first material toward the exit. An auxiliary line is disposed adjacent to the hollow emission needle to convey a second material toward the exit. A voltage supply apparatus is applied between the hollow emission needle and the mass spectrometer to establish a voltage between the hollow emission needle and the mass spectrometer and to induce particles to enter the mass spectrometer for analysis.

94. 发明申请

US20170103880A1 SYSTEMS FOR SEPARATING IONS AND NEUTRALS AND METHODS OF OPERATING THE SAME 审中-公开
公开(公告)号：US20170103880A1
公开(公告)日：2017-04-13
申请号：US15386684
申请日：2016-12-21
申请人： MORPHO DETECTION, LLC
发明人： Jack A. Syage
IPC分类号： H01J49/24 , H01J49/00 , H01J49/40
CPC分类号： H01J49/24 , H01J49/0022 , H01J49/0031 , H01J49/0495 , H01J49/162 , H01J49/40
摘要： A mass spectrometer system includes a sample injection device defining a sample injection aperture. The system also includes an ion trap defining an ion outlet aperture. The ion trap is coupled to the sample injection device. The system further includes a detector positioned downstream of the ion outlet aperture. The system also includes an ion source coupled to the ion trap. The ion source is configured to ionize a sample injected into the ion trap and generate a plurality of ionized molecules within the ion trap. The ion trap is configured to maintain the plurality of ionized molecules therein while a plurality of neutral molecules migrate out of the ion trap until a predetermined pressure is attained in the ion trap.

95. 发明申请

US20170084440A1 APPARATUS AND METHOD FOR THERMAL ASSISTED DESORPTION IONIZATION SYSTEMS 审中-公开
公开(公告)号：US20170084440A1
公开(公告)日：2017-03-23
申请号：US15368490
申请日：2016-12-02
申请人： IONSENSE INC.
发明人： Jordan Krechmer , Brian D. Musselman
IPC分类号： H01J49/04 , H01J49/24 , H01J49/00 , G01N27/62 , H01J27/26
CPC分类号： H01J49/049 , G01N27/622 , G01N27/626 , G01N27/64 , H01J27/26 , H01J49/004 , H01J49/04 , H01J49/0431 , H01J49/10 , H01J49/126 , H01J49/14 , H01J49/24 , Y10T436/24
摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

96. 发明申请

US20170025261A1 Mass Spectrometer Vacuum Interface Method and Apparatus 有权
标题翻译：质谱仪真空界面方法及仪器
公开(公告)号：US20170025261A1
公开(公告)日：2017-01-26
申请号：US15287385
申请日：2016-10-06
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich MAKAROV , Lothar ROTTMANN
IPC分类号： H01J49/06 , H01J49/10 , H01J49/24 , H01J49/04
CPC分类号： H01J49/06 , H01J49/0495 , H01J49/067 , H01J49/105 , H01J49/24
摘要： A mass spectrometer vacuum interface can include a skimmer apparatus having a skimmer aperture and an internal surface. A method of operating the mass spectrometer vacuum interface can include establishing an outwardly directed flow along the internal surface of the skimmer apparatus.
摘要翻译：质谱仪真空界面可以包括具有撇渣器孔和内表面的撇渣器。操作质谱仪真空界面的方法可以包括沿着分离器装置的内表面建立向外的流动。

97. 发明授权

US09514924B2 Droplet manipulation using gas-phase standing-wave ultrasound fields in MS sources 有权
公开(公告)号：US09514924B2
公开(公告)日：2016-12-06
申请号：US14719665
申请日：2015-05-22
申请人： Micromass UK Limited
发明人： Michael Raymond Morris , Steven Derek Pringle , Keith Richardson
IPC分类号： H01J49/26 , H01J49/16 , H01J49/00 , H01J49/02 , H01J49/04 , G01N27/62 , G01N29/22 , H01J49/24
CPC分类号： H01J49/165 , G01N27/622 , G01N29/22 , H01J49/0031 , H01J49/022 , H01J49/0454 , H01J49/24 , H01J49/26 , Y10T137/0391 , Y10T137/206
摘要： An ion source for a mass spectrometer is disclosed comprising an ionization device which emits a stream of droplets and one or more ultrasonic transmitters which create one or more acoustic standing waves. The acoustic standing waves may be used to further nebulize the stream of droplets and induce internal mixing of the droplets.

98. 发明申请

US20160351382A1 Coupling Intermediate Pressure Regions 审中-公开
标题翻译：耦合中压区域
公开(公告)号：US20160351382A1
公开(公告)日：2016-12-01
申请号：US15170133
申请日：2016-06-01
申请人： Micromass UK Limited
发明人： Kevin Giles
IPC分类号： H01J49/24 , G01N27/62
CPC分类号： H01J49/24 , G01N27/622
摘要： A method is disclosed for coupling a first chamber of a mass spectrometer or ion mobility spectrometer containing a first gas and a second chamber containing a second gas. The method comprises providing an intermediate region between the first and second chambers that is operated at a lower pressure to substantially prevent or reduce ingress of the first gas into the second chamber and/or of the second gas into the first chamber.
摘要翻译：公开了一种用于耦合含有第一气体的质谱仪或离子迁移谱仪的第一室和包含第二气体的第二室的方法。该方法包括提供在第一和第二室之间的中间区域，其在较低的压力下操作以基本上防止或减少第一气体进入第二室和/或将第二气体进入第一室。

99. 发明申请

US20160320342A1 Vacuum DMS with High Efficiency Ion Guides 有权
标题翻译：具有高效离子导管的真空DMS
公开(公告)号：US20160320342A1
公开(公告)日：2016-11-03
申请号：US15104954
申请日：2014-12-06
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Bradley B. Schneider , Hassan Javaheri , Thomas R. Covey
IPC分类号： G01N27/62 , H01J49/24 , H01J49/06 , H01J49/00
CPC分类号： G01N27/624 , H01J49/0031 , H01J49/063 , H01J49/066 , H01J49/24
摘要： Differential mobility spectrometry is performed under vacuum. Ions generated in a high pressure region are received from the inlet orifice of a vacuum chamber using a first ion guide located in the vacuum chamber. The first ion guide focuses the generated ions on a DMS device inlet end using a plurality of tapered electrodes. The DMS device is coaxial and adjacent to the first ion guide. The DMS device separates the focused ions using a plurality of electrodes. The inscribed diameter at the DMS device inlet end is larger than the inscribed diameter at the first ion guide exit end to maximize ion transfer. The separated ions are received from the DMS device using a second ion guide coaxial and adjacent to the DMS device. The second ion guide focuses the separated ions on an exit orifice of the vacuum chamber using a plurality of tapered electrodes.
摘要翻译：差示运动光谱法在真空下进行。在真空室中使用位于真空室中的第一离子导向器从真空室的入口孔接收在高压区域中产生的离子。第一离子导向器使用多个锥形电极将产生的离子聚焦在DMS器件入口端上。 DMS装置是同轴的并且与第一离子导向件相邻。 DMS装置使用多个电极分离聚焦的离子。 DMS设备入口端处的内接螺纹直径大于第一离子导出口端的内接直径，以最大化离子转移。使用第二离子导向器从DMS装置接收分离的离子，并且与DMS装置相邻。第二离子导向器使用多个锥形电极将分离的离子聚焦在真空室的出口上。

100. 发明授权

US09466474B2 Triple quadrupole mass spectrometer 有权
标题翻译：三重四极杆质谱仪
公开(公告)号：US09466474B2
公开(公告)日：2016-10-11
申请号：US14909764
申请日：2013-08-08
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda
IPC分类号： H01J49/26 , H01J49/42 , H01J49/06 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/005 , H01J49/06 , H01J49/24
摘要： The present triple quadrupole mass spectrometer determines the relationship between a parameter, such as the mass-to-charge ratio of a precursor ion or that of a product ion, and the optimal collision-gas pressure giving the highest signal intensity in an MRM measurement, derives an approximate equation expressing that relationship, and stores the information representing the equation in an optimum collision-gas pressure calculation information storage section. When a measurement is to be performed, an analysis operator enters the mass-to-charge ratio of a precursor ion or product ion of a target compound. Based on the approximate equation read from the storage section, an optimum collision-gas pressure calculator determines the optimum collision-gas pressure for the specified precursor ion or product ion, and sets this pressure as a measurement condition for the apparatus.
摘要翻译：本发明的三重四极杆质谱仪确定了前体离子或产物离子的质荷比等参数与在MRM测量中给出最高信号强度的最佳碰撞气体压力之间的关系，导出表示该关系的近似式，并将表示该方程的信息存储在最佳碰撞气体压力计算信息存储部中。当进行测量时，分析算子输入目标化合物的前体离子或产物离子的质荷比。基于从存储部分读取的近似方程，最佳碰撞气体压力计算器确定用于指定的前体离子或产物离子的最佳碰撞气体压力，并将该压力设定为该装置的测量条件。

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