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91. 发明申请

US20140295458A1 METHOD OF REVERSIBLY STAINING A TARGET CELL 有权
标题翻译：反向污染目标细胞的方法
公开(公告)号：US20140295458A1
公开(公告)日：2014-10-02
申请号：US14234463
申请日：2012-07-17
申请人： Thomas Schmidt , Christian Stemberger , Dirk H. Busch , Lothar Germeroth
发明人： Thomas Schmidt , Christian Stemberger , Dirk H. Busch , Lothar Germeroth
IPC分类号： G01N33/566
CPC分类号： G01N33/56972 , A61K35/14 , A61K35/17 , C07K2319/00 , C07K2319/22 , C07K2319/74 , G01N1/30 , G01N33/557 , G01N33/566 , G01N2333/705 , G01N2458/00
摘要： The present invention relates to methods of reversibly staining a target cell. The invention also relates to methods of isolating a target cell or a target cell population that is defined by the presence of at least one common specific receptor molecule. The invention also provides kits that can be used to carry out the methods of the invention.
摘要翻译：本发明涉及对靶细胞进行可逆染色的方法。本发明还涉及分离由至少一种常见特异性受体分子的存在定义的靶细胞或靶细胞群的方法。本发明还提供可用于实施本发明方法的试剂盒。

92. 发明授权

US08778697B2 Method of measuring the affinity of biomolecules 失效
标题翻译：测量生物分子亲和力的方法
公开(公告)号：US08778697B2
公开(公告)日：2014-07-15
申请号：US12094073
申请日：2006-11-10
申请人： Trevor Clive Dale , Adrian John Harwood , Paola Borri
发明人： Trevor Clive Dale , Adrian John Harwood , Paola Borri
IPC分类号： G01N33/53
CPC分类号： G01N33/557 , B82Y15/00 , B82Y30/00 , C12N15/1055 , G01N33/5306 , G01N33/543 , G01N33/54373
摘要： The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the method comprising determining binding of adjacent first and second biomolecules to each other, varying at least one of the first and second tether lengths and determining binding of the first and second biomolecules. The invention also provides apparatus suitable for use in the method of the invention.
摘要翻译：本发明提供了测量第一和第二生物分子的亲和力的方法，其中第一生物分子被具有第一系链部分长度的第一系链部分束缚，并且第二生物分子被具有第二系链部分长度的第二系链部分束缚，所述方法包括确定相邻的第一和第二生物分子彼此的结合，改变第一和第二系链长度中的至少一个并确定第一和第二生物分子的结合。本发明还提供了适用于本发明方法的设备。

93. 发明授权

US08716008B2 Detection method and detection system 失效
标题翻译：检测方法和检测系统
公开(公告)号：US08716008B2
公开(公告)日：2014-05-06
申请号：US12906797
申请日：2010-10-18
申请人： Kazuyoshi Horii
发明人： Kazuyoshi Horii
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , G01N33/557
摘要： In a detection method for detecting the quantity of a target material, a labeled binding material in the amount corresponding to the quantity of the target material contained in a liquid specimen is bonded to the top of a sensor portion; and a signal based on light emitted from a label in an evanescent field or an enhanced optical field produced on a surface of the sensor portion when the sensor portion is irradiated with excitation light is detected. After the labeled binding material is bonded to the immobilization layer, the signal is detected while the fluid over the sensor portion is controlled to flow at a constant flow rate at which bonds between the labeled binding material and the immobilization layer are not broken and the above signal can be detected with a greater magnitude than when the liquid specimen exists over the sensor portion at rest.
摘要翻译：在用于检测目标材料的量的检测方法中，将与液体试样中包含的目标材料的量相对应的量的标记粘合材料粘合到传感器部分的顶部; 并且检测当传感器部分被激发光照射时基于在渐逝场中的标签发射的光或在传感器部分的表面上产生的增强的光场的信号。标记的粘结材料结合固定层后，检测信号，同时控制传感器部分上的流体以恒定的流速流动，在该流量下，标记的粘结材料和固定层之间的结合不被破坏，上述可以以比液体样本存在于传感器部分静止时更大的幅度来检测信号。

94. 发明申请

US20140100525A1 Sampling module device and method 有权
标题翻译：采样模块装置及方法
公开(公告)号：US20140100525A1
公开(公告)日：2014-04-10
申请号：US14095196
申请日：2013-12-03
申请人： Sanofi-Aventis Deutschland GmbH
发明人： Dominique M. Freeman
IPC分类号： A61M5/46 , A61M5/158
CPC分类号： A61M5/46 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15176 , A61B5/15178 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61B17/32093 , A61M5/158 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905 , G01N33/557 , G06F19/00
摘要： A medicament injection device includes a device body portion that includes a penetrating member channel. A penetrating member is provided with a sharpened distal tip and shaft portion that is slidably disposed within the penetrating channel to provide for a penetrating to travel in a linear axial movement. A pierceable membrane isolates a penetrating member in an associated penetrating member chamber. A medicament reservoir is in fluid communication with the penetrating member. The medicament reservoir is configured to house a medicament and is coupled to the penetrating member to allow for delivery of medicament to a tissue site.
摘要翻译：药物注射装置包括包括穿透构件通道的装置主体部分。穿透构件设置有锋利的远侧末端和轴部分，其可滑动地设置在穿透通道内以提供穿过线性轴向运动的行进。可刺穿的膜将穿透构件隔离在相关联的穿透构件室中。药剂容器与穿透构件流体连通。药物储存器被配置为容纳药物并且联接到穿透构件以允许药物递送到组织部位。

95. 发明授权

US08690796B2 Method and apparatus for penetrating tissue 有权
标题翻译：渗透组织的方法和装置
公开(公告)号：US08690796B2
公开(公告)日：2014-04-08
申请号：US11536720
申请日：2006-09-29
申请人： Dominique M. Freeman , Dirk Boecker , Don Alden
发明人： Dominique M. Freeman , Dirk Boecker , Don Alden
IPC分类号： A61B5/00
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15176 , A61B5/15178 , A61B5/15184 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.
摘要翻译：组织穿透系统具有壳体构件。多个穿透构件定位在壳体构件中。组织稳定构件联接到壳体。穿透构件传感器联接到多个穿透构件。穿透构件传感器被配置为提供关于穿透构件穿过皮肤表面的穿透深度的信息。

96. 发明授权

US08496601B2 Methods and apparatus for lancet actuation 有权
标题翻译：刺血针致动方法和装置
公开(公告)号：US08496601B2
公开(公告)日：2013-07-30
申请号：US11735817
申请日：2007-04-16
申请人： Barry Briggs , Dominique Freeman , Don Alden , Dirk Boecker
发明人： Barry Briggs , Dominique Freeman , Don Alden , Dirk Boecker
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150412 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150809 , A61B5/150824 , A61B5/150832 , A61B5/15087 , A61B5/150916 , A61B5/150954 , A61B5/151 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15174 , A61B5/15176 , A61B5/15184 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B17/32093 , B01L3/5027 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet and a processor coupled to the drive force generator capable of changing the direction and magnitude of force exerted on the lancet during the lancing cycle. The driver further includes a human interface on the housing providing at least one output for communicating with the patient.
摘要翻译：提供了一种刺血针驱动器，其中驾驶员在穿刺周期期间在柳叶刀上施加驱动力并且在组织部位上使用。驱动器包括用于使柳叶刀前进的驱动力发生器和与驱动力发生器耦合的处理器，其能够改变在穿刺周期期间施加在刺血针上的力的方向和大小。驱动器还包括在壳体上的人机接口，提供至少一个用于与患者通信的输出。

97. 发明申请

US20120330558A1 IDENTIFICATION OF BIOMARKERS 审中-公开
标题翻译：识别生物标志物
公开(公告)号：US20120330558A1
公开(公告)日：2012-12-27
申请号：US13504384
申请日：2010-10-26
申请人： Christian Baumgartner , Michael Netzer , Bernhard Pfeifer
发明人： Christian Baumgartner , Michael Netzer , Bernhard Pfeifer
IPC分类号： A61B5/00 , A61B5/02 , G01N33/493 , G06F19/00 , G01N33/49
CPC分类号： G01N33/557
摘要： The present invention relates to a method comprising the steps of obtaining a sample from the subject, measuring a plurality of biomolecules in the sample, identifying the measured biomolecules in the sample, characterized in that the method further comprises the steps of estimating a discriminatory ability of each measured biomolecule by using a paired test hypothesis, and integrating the estimated discriminatory abilities of the biomolecules into a kinetic analysis. More particularly, the present invention enables the use of such a method and a method for monitoring progress or treatment of a disease such as cardiovascular diseases. Such identification methods comprising the steps of obtaining a sample from the subject, measuring a plurality of biomolecules in the sample and identifying the measured biomolecules can particularly be used for monitoring progress or treatment of a disease.
摘要翻译：本发明涉及一种方法，包括以下步骤：从受试者获得样品，测量样品中的多个生物分子，鉴定样品中测量的生物分子，其特征在于该方法还包括以下步骤：估计样品的鉴别能力每个测量的生物分子通过使用配对测试假设，并将生物分子的估计的辨别能力整合到动力学分析中。更具体地，本发明能够使用这样的方法和方法来监测疾病如心血管疾病的进展或治疗。这种识别方法包括以下步骤：从受试者获得样品，测量样品中的多个生物分子并鉴定所测量的生物分子可特别用于监测疾病的进展或治疗。

98. 发明授权

US08337421B2 Tissue penetration device 有权
公开(公告)号：US08337421B2
公开(公告)日：2012-12-25
申请号：US12335813
申请日：2008-12-16
申请人： Dominique Freeman , Don Alden
发明人： Dominique Freeman , Don Alden
IPC分类号： A61B5/00
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150061 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15176 , A61B5/15178 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61B17/32093 , B01L3/5027 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet used for sampling blood. Electric field coils or solenoids may drive the lancet using electromagnetic force. Advancement and retraction of a lancet may be controlled by a feedback loop monitoring the position and velocity of the lancet embodiments of the lancet driver can be configured to follow a predetermined tissue lancing profile. Embodiments of the invention include a lancet and method for using a lancet to maintain the patency of the wound tract once the lancet has cut into the skin.

99. 发明授权

US08337419B2 Tissue penetration device 有权
公开(公告)号：US08337419B2
公开(公告)日：2012-12-25
申请号：US11244311
申请日：2005-10-04
申请人： Dominique M. Freeman , Dirk Boecker , Don Alden , Barry Dean Briggs , Jon Hewitt Leonard , Ray Freeman , George Gogue
发明人： Dominique M. Freeman , Dirk Boecker , Don Alden , Barry Dean Briggs , Jon Hewitt Leonard , Ray Freeman , George Gogue
IPC分类号： A61B5/00
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150061 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15176 , A61B5/15178 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61B17/32093 , B01L3/5027 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet used for sampling blood. Electric field coils or solenoids may drive the lancet using electromagnetic force. Advancement and retraction of a lancet may be controlled by a feedback loop monitoring the position and velocity of the lancet embodiments of the lancet driver can be configured to follow a predetermined tissue lancing profile. Embodiments of the invention include a lancet and method for using a lancet to maintain the patency of the wound tract once the lancet has cut into the skin.

100. 发明申请

US20120238473A1 Molecular sensor using temporal discrimination 审中-公开
标题翻译：分子传感器使用时间歧视
公开(公告)号：US20120238473A1
公开(公告)日：2012-09-20
申请号：US13420133
申请日：2012-03-14
申请人： Evelyne Gridelet , Hilco Suy , Filip Frederix
发明人： Evelyne Gridelet , Hilco Suy , Filip Frederix
IPC分类号： C40B40/00 , B82Y15/00
CPC分类号： G01N33/557 , G01N27/127 , G01N33/5438
摘要： A sensor device is disclosed, which depends on discrimination in time between groups of binding events of target particles to nano-electrodes. The target particles may be in the liquid phase or in suspension. The nano-electrodes form part of a sensor arrangement having a plurality of sensors. The sensor device is arranged such that different species of target particles arrive at the nano-electrodes at different times, using techniques such as chromatography or application of a field such as an electric, magnetic, or gravitational field. The particles may be labelled or unlabeled. The invention is particularly suited, but not limited, to sensing bioparticles.
摘要翻译：公开了一种传感器装置，其取决于目标颗粒与纳米电极的结合事件组之间的时间差异。目标颗粒可以是液相或悬浮液。纳米电极形成具有多个传感器的传感器装置的一部分。传感器装置布置成使得不同种类的目标颗粒在不同时间到达纳米电极，使用诸如色谱法或诸如电，磁场或重力场的场的应用的技术。颗粒可以被标记或未标记。本发明特别适用于但不限于感测生物颗粒。

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