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91. 发明授权

US08944102B1 Gas burst injection valve 有权
标题翻译：气体喷射阀
公开(公告)号：US08944102B1
公开(公告)日：2015-02-03
申请号：US13414210
申请日：2012-03-07
申请人： Daniel R. Wiederin , Nathan Saetveit
发明人： Daniel R. Wiederin , Nathan Saetveit
IPC分类号： F16K11/074 , G01N1/00 , G01N30/20
CPC分类号： F16K11/0743 , G01N2030/201 , G01N2030/202 , H01J49/0495 , H01J49/105 , Y10T137/86863
摘要： Valve assemblies are described that provide bursts of gas between fluids to furnish separation between the fluids. A valve assembly includes a first valve member having ports configured to connect to an external loop, an output, and a vent, and ports configured to receive a first fluid, a second fluid, and a pressurized gas. The valve assembly further includes a second valve member coupled adjacent the first valve member having channels configured to connect the external loop to the second fluid for charging the external loop with the second fluid, and to connect the external loop to the output for supplying the second fluid from the external loop to the output. The second valve member also has one or more channels for receiving a burst of the pressurized gas via a port of the first valve member and supplying the pressurized gas to the output and/or to the external loop.
摘要翻译：描述了在流体之间提供气体脉冲以提供流体之间的分离的阀组件。阀组件包括具有构造成连接到外部回路，输出端口和通气口的端口的第一阀构件以及被配置为接收第一流体，第二流体和加压气体的端口。所述阀组件还包括与所述第一阀构件相邻的第二阀构件，所述第二阀构件具有被配置为将所述外部回路连接到所述第二流体的通道，以使所述外部回路与所述第二流体充电，以及将所述外部回路连接到所述输出端，流体从外部回路输出。第二阀构件还具有一个或多个通道，用于经由第一阀构件的端口接收加压气体的爆裂并将加压气体供应到输出端和/或外部回路。

92. 发明申请

US20140338431A1 Methods for Injecting Samples in Liquid Chromatography, Particularly in High Performance Liquid Chromatography 审中-公开
标题翻译：在液相色谱中注射样品的方法，特别是在高效液相色谱中
公开(公告)号：US20140338431A1
公开(公告)日：2014-11-20
申请号：US14454563
申请日：2014-08-07
申请人： Dionex Softron GmbH
发明人： Hermann Hochgraeber
IPC分类号： G01N30/20 , G01N35/10 , G01N30/32
CPC分类号： G01N30/20 , G01N30/24 , G01N30/32 , G01N35/1097 , G01N2030/027 , G01N2030/201 , G01N2030/207
摘要： A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
摘要翻译：使用具有废物口，两个样品回路端口和两个高压端口的注射阀进行液相色谱法的样品注射方法。一个高压端口可以连接到泵，另一个高压端口可以连接到色谱柱。样品回路连接到一端的一个样品回路端口和另一端的样品输送装置的泵体积。样品回路的一部分可以分开，以便于在样品回路中接收样品流体。控制单元控制喷射阀和样品输送装置。样品注射器允许将样品装载到样品环中，然后在将样品注入色谱柱之前加压至操作压力。样品回路也可以与操作压力隔离，以便于循环的减压。

93. 发明授权

US08881582B2 Method and apparatus for sample injection in liquid chromatography 有权
标题翻译：液相色谱中样品注入的方法和装置
公开(公告)号：US08881582B2
公开(公告)日：2014-11-11
申请号：US13227078
申请日：2011-09-07
申请人： Theodore A. Dourdeville , Russell L. Keene , Theodore D. Ciolkosz , James E. Usowicz
发明人： Theodore A. Dourdeville , Russell L. Keene , Theodore D. Ciolkosz , James E. Usowicz
IPC分类号： G01N30/38 , G01N30/20
CPC分类号： F16K11/0853 , G01N30/20 , G01N2030/201 , G01N2030/202 , G01N2030/207 , Y10T137/0396 , Y10T137/86871
摘要： The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.
摘要翻译：本发明提供了用于基本上消除压力或流速的破坏性瞬变的方法和装置，其可能降低色谱柱的效率和使用寿命。通过消除与致动样品注射阀相关联的流动阻塞间隔，本发明能够通过色谱系统保持流动相液体的基本上恒定的流动。本发明还提供了一种方法，当将样品环引入色谱系统输送压力时，减少与样品环含量的加压相关的压力和流速瞬变。

94. 发明授权

US08621915B2 Apparatus and methods for multidimensional analysis 有权
标题翻译：多维分析的装置和方法
公开(公告)号：US08621915B2
公开(公告)日：2014-01-07
申请号：US12601035
申请日：2008-05-27
申请人： Hongji Liu
发明人： Hongji Liu
IPC分类号： G01N30/02
CPC分类号： G01N30/463 , G01N30/7233 , G01N2030/201
摘要： The invention provides improved methods and apparatus for multidimensional analysis, especially for multidimensional liquid chromatography. Methods and apparatus for the quantitative determination of one or more components comprised in a sample mixture are described. Methods and apparatus of the invention typically allow accurate quantitative determination of more components of the mixture than prior multidimensional methods. The invention is particularly useful for, but is not limited to the analysis of complex mixtures of peptides and proteins.
摘要翻译：本发明提供用于多维分析的改进的方法和装置，特别是用于多维液相色谱法。描述了用于定量测定样品混合物中包含的一种或多种组分的方法和装置。与先前的多维方法相比，本发明的方法和装置通常允许对混合物的更多组分进行准确的定量测定。本发明特别可用于但不限于肽和蛋白质的复杂混合物的分析。

95. 发明申请

US20130319088A1 LIQUID CHROMATOGRAPHY APPARATUS, LIQUID CHROMATOGRAPHY ANALYSIS METHOD, AND LIQUID CHROMATOGRAPHY ANALYSIS PROGRAM 审中-公开
标题翻译：液相色谱仪，液相色谱分析方法和液相色谱分析程序
公开(公告)号：US20130319088A1
公开(公告)日：2013-12-05
申请号：US13903291
申请日：2013-05-28
申请人： Seiji Satake , Tokuo Kasai
发明人： Seiji Satake , Tokuo Kasai
IPC分类号： G01N30/06
CPC分类号： G01N30/06 , B01D15/16 , B01D19/0042 , G01N30/26 , G01N2030/201 , G01N2030/202 , G01N2030/207 , G01N2030/8822
摘要： A liquid chromatography apparatus having: a column that adsorbs analysis components within a specimen; a plunger pump that feeds eluent A, that elutes the analysis components adsorbed at the column, in an amount greater than or equal to an amount needed for analysis of one specimen from a cylinder portion by a one-time pushing operation of a rod; a photometric unit that analyzes analysis components eluted by eluent A; an eluent loop that holds eluent B; a liquid feeding flow path that communicates the plunger pump and the column; and a first switching valve that switches the liquid feeding flow path to either of a first flow path, that causes eluent A to flow from the plunger pump to the column, and a second flow path, that causes eluent A to flow from the plunger pump through the first eluent holding loop to the column, is provided.
摘要翻译：一种液相色谱仪，具有：吸附试样内的分析成分的柱; 柱塞泵，其通过杆的一次推动操作，以大于或等于从圆筒部分分析一个样本所需的量来洗脱吸附在柱上的分析组分的洗脱液A; 分析由洗脱液A洗脱的分析成分的光度单位; 洗脱液循环，保持洗脱液B; 连通柱塞泵和柱的液体供给流路; 以及第一切换阀，其将液体供给流路切换到使得洗脱液A从柱塞泵流到塔的第一流路中的任一个，以及使得洗脱液A从柱塞泵流出的第二流路通过第一个洗脱液保持回到柱中。

96. 发明授权

US08544350B2 Sample injector 有权
标题翻译：样品注射器
公开(公告)号：US08544350B2
公开(公告)日：2013-10-01
申请号：US13041283
申请日：2011-03-04
申请人： Hiroshi Itafuji , Masayuki Kouketsu
发明人： Hiroshi Itafuji , Masayuki Kouketsu
IPC分类号： G01N35/10 , G01N30/20
CPC分类号： G01N30/20 , G01N35/1097 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： This invention provides a sample injector for injecting a fixed amount of a sample into a mobile phase medium and discharging the mobile phase medium with the sample. The sample injector includes a first member having a medium passage for supplying the mobile phase medium and a sample passage for supplying the sample and a second member having a discharge passage for discharging the mobile phase medium with the sample to an outside of the injector. The second member is provided in contact with the first member. The first member and the second member are configured to move to a sample charging position and a sample injection position. The sample charging position is for the sample chamber to connect with the sample passage. The sample injection position is for the sample chamber to connect with the medium passage and the discharge passage.
摘要翻译：本发明提供了一种样品注射器，用于将固定量的样品注入到流动相介质中并用样品排出流动相介质。样本注射器包括具有用于供应流动相介质的介质通道的第一构件和用于供给样品的样品通道和具有用于将具有样品的流动相介质排出到喷射器外部的排出通道的第二构件。第二构件设置成与第一构件接触。第一构件和第二构件被配置成移动到样品充电位置和样品注入位置。样品充电位置用于样品室与样品通道连接。样品注射位置用于样品室与介质通道和排出通道连接。

97. 发明授权

US08257586B2 Two-valve arrangement for liquid chromatography 有权
标题翻译：用于液相色谱的双阀排列
公开(公告)号：US08257586B2
公开(公告)日：2012-09-04
申请号：US12667673
申请日：2007-07-04
申请人： Bernhard Dehmer
发明人： Bernhard Dehmer
IPC分类号： B01D15/08
CPC分类号： G01N30/20 , G01N2030/201 , G01N2030/202 , Y10T137/8593
摘要： A valve arrangement is disclosed for providing a switchable fluid connection between a fluid delivery system for driving a mobile phase and a stationary phase adapted for separating compounds of a sample fluid comprised in the mobile phase. The valve arrangement comprises a first valve comprising a first port adapted to be coupled to the fluid delivery system, a second port, and a third port, wherein the first valve is adapted to switch, in a first switch transition, from a first state wherein the first port is coupled with the second port, over a second state wherein the first port, the second port and the third port are coupled altogether, to a third state wherein the first port is coupled with the third port, a second valve comprising a fifth port adapted to be coupled to the stationary phase, a sixth port, and a seventh port, wherein the second valve is adapted to switch, in a second switch transition from a fourth state wherein the fifth port is coupled with the sixth port, to a fifth state wherein the fifth port is coupled with the seventh port, a first fluid path connecting the second port and the sixth port, and a second fluid path connecting the third port and the seventh port, wherein the second fluid path comprises a sample introduction path adapted for introducing the sample fluid into the mobile phase.
摘要翻译：公开了一种阀装置，用于在用于驱动流动相的流体输送系统和适于分离包含在流动相中的样品流体的化合物的固定相之间提供可切换流体连接。阀装置包括第一阀，其包括适于联接到流体输送系统的第一端口，第二端口和第三端口，其中第一阀适于在第一开关转换中从第一状态切换到第一状态，所述第一端口与所述第二端口耦合，其中所述第一端口，所述第二端口和所述第三端口一起被耦合到第二状态，其中所述第一端口与所述第三端口联接，第二阀包括：第五端口，其适于联接到固定相，第六端口和第七端口，其中所述第二阀适于在第二开关转换中从所述第五端口与所述第六端口耦合的第四状态切换到第五状态，其中第五端口与第七端口连接，连接第二端口和第六端口的第一流体路径和连接第三端口和第七端口的第二流体路径，其中第二流体路径压缩机是用于将样品流体引入流动相中的样品引入路径。

98. 发明授权

US08236175B2 Liquid chromatograph system 有权
标题翻译：液相色谱系统
公开(公告)号：US08236175B2
公开(公告)日：2012-08-07
申请号：US13379603
申请日：2010-06-28
申请人： Yoshiki Maeda , Kenichi Yasunaga , Shinji Tanaka
发明人： Yoshiki Maeda , Kenichi Yasunaga , Shinji Tanaka
IPC分类号： B01D15/08
CPC分类号： F16K11/0743 , F16K39/045 , G01N30/20 , G01N30/36 , G01N2030/201 , G01N2030/202
摘要： A channel-switching valve into which a high-pressure liquid and a low-pressure liquid flow is provided. The channel-switching valve includes a stator and a rotor which has a surface in contact with one surface of the stator and rotates while sliding on the contact surface. The stator has a plurality of liquid flow ports open to the contact surface, and the rotor has a plurality of channel grooves for connecting the liquid flow ports. One of the channel grooves is a straight groove passing through the rotational center of the rotor, and the other channel grooves are line-symmetrically arranged with respect to the straight channel groove. Alternatively, among the channel grooves, the channel grooves into which the high-pressure liquid flows are configured to be located on both sides of the rotational center of the rotor. As a result, a local load acting on the rotor during a high-pressure liquid-feeding process is reduced, so that the contact surface is prevented from being scraped off by the edge of the opening of a port during the rotation of the rotor.
摘要翻译：一个通道切换阀，其中设有高压液体和低压液体流。通道切换阀包括定子和转子，其具有与定子的一个表面接触的表面，并且在接触表面上滑动时旋转。定子具有向接触表面开口的多个液体流动端口，并且转子具有用于连接液体流动端口的多个通道槽。通道槽中的一个是通过转子的旋转中心的直槽，而另一个通道槽相对于直槽形成线对称布置。或者，在沟槽中，高压液体流过的沟槽形成为位于转子的旋转中心的两侧。结果，降低了在高压液体供给过程中作用在转子上的局部负荷，使得在转子旋转期间防止接触表面被端口开口的边缘刮掉。

99. 发明授权

US08234939B2 Sample introduction method 有权
标题翻译：样品介绍方法
公开(公告)号：US08234939B2
公开(公告)日：2012-08-07
申请号：US12667677
申请日：2008-09-24
申请人： Yoshiaki Maeda , Shuzo Maruyama , Kenichi Yasunaga
发明人： Yoshiaki Maeda , Shuzo Maruyama , Kenichi Yasunaga
IPC分类号： B01L3/02
CPC分类号： G01N30/24 , G01N30/20 , G01N35/1097 , G01N2030/201 , G01N2030/202
摘要： A sample introduction method for reducing carry-over is provided. After a sample introduction device in a total volume injection method draws a proper amount of a sample solution from a sample container and further draws a solution with the same composition as a mobile phase solution with a needle 24, the needle 24 is inserted into an injection port 25. When flow paths are switched to communicate a liquid feeder, a sample loop 23, the needle 24, the injection port 25, and a separation/detection section, the solution with the same composition as the mobile phase solution is forced into a gap between the injection port 25 and the needle 24. Therefore, the samples squeezed out of a tip section of the needle 24 during the switching of the flow paths are prevented from being forced into the gap between the needle 24 and the injection port 25.
摘要翻译：提供了用于减少转移的样本引入方法。在总体积注射方法中的样品引入装置从样品容器中抽取合适量的样品溶液后，用针24进一步抽取具有与流动相溶液相同组成的溶液，将针24插入注射器端口25.当切换流路以连通液体进料器，样品回路23，针24，注射端口25和分离/检测部分时，具有与流动相溶液相同组成的溶液被迫进入注射口25和针24之间的间隙。因此，防止了在切换流道期间从针24的尖端部分挤出的样品被迫进入针24和注射端口25之间的间隙。

100. 发明申请

US20110185797A1 ANALYZING DEVICE AND METHOD FOR CONTROLLING SAME 有权
标题翻译：分析装置及其控制方法
公开(公告)号：US20110185797A1
公开(公告)日：2011-08-04
申请号：US13122059
申请日：2009-10-02
申请人： Toshikatsu Sakai , Akira Sezaki , Takeshi Takagi
发明人： Toshikatsu Sakai , Akira Sezaki , Takeshi Takagi
IPC分类号： G01N30/16 , G01N33/00
CPC分类号： G01N30/20 , G01N30/18 , G01N30/8658 , G01N30/8665 , G01N2030/042 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： An analyzing device includes a feeder connected to a container in which a sample is contained for sucking the sample from the container and feeding the sample, and a controller for performing control for feeding from the feeder to a measurer. In measuring the sample, the controller performs control so that results of a plurality of times of measurement are obtained with respect to the single container in which the sample is contained, without changing the container. This arrangement allows quick accuracy check.
摘要翻译：分析装置包括连接到容器的进料器，在该容器中容纳样品以从容器吸取样品并进料样品;以及控制器，用于进行从进料器进给到测量器的控制。在测量样品时，控制器执行控制，使得相对于容纳样品的单个容器获得多次测量的结果，而不改变容器。这种安排允许快速准确的检查。

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