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91. 发明申请

US20110112990A1 Efficient Production of Peptides 有权
标题翻译：肽的有效生产
公开(公告)号：US20110112990A1
公开(公告)日：2011-05-12
申请号：US12942450
申请日：2010-11-09
申请人： Michael H. B. Stowell , Jonathan Caruthers , Travis Nemkov , Brian Hiester , Leslie Boux , Mikhail Plam
发明人： Michael H. B. Stowell , Jonathan Caruthers , Travis Nemkov , Brian Hiester , Leslie Boux , Mikhail Plam
IPC分类号： C12P21/00 , C12N9/24 , C12N9/64 , C12N9/90 , C07K2/00 , C07K14/62 , C07K14/585 , C07K14/505 , C07K14/61 , C07K14/555 , C07K14/535 , C12N15/63 , C12N1/21 , C07K19/00 , C07K14/47 , G06Q90/00
CPC分类号： C12P21/06 , C07K1/04 , C07K1/12 , C07K14/005 , C07K14/4703 , C07K14/4711 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/585 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/755 , C07K2319/01 , C07K2319/20 , C07K2319/21 , C12N9/90 , C12N15/70 , C12N2740/16122 , C12Y503/03001 , G06Q99/00
摘要： The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than peptides produced according to prior art processes. The production process of the invention may lead to advantages in yield, purity, and/or price. Methods of marketing peptides are also disclosed.
摘要翻译：本发明涉及生产肽的方法，并且相应地生产肽。根据本发明产生的肽可以比根据现有技术方法生产的肽更有效地生产。本发明的生产方法可以产生产量，纯度和/或价格的优点。还公开了销售肽的方法。

92. 发明申请

US20110110947A1 VIRAL CHEMOKINE-ANTIGEN FUSION PROTEINS 失效
标题翻译：病毒抗原蛋白融合蛋白
公开(公告)号：US20110110947A1
公开(公告)日：2011-05-12
申请号：US13009572
申请日：2011-01-19
申请人： Larry W. Kwak , Arya Biragyn
发明人： Larry W. Kwak , Arya Biragyn
IPC分类号： A61K39/395 , C07K14/00 , C07H21/04 , C12N15/63 , C12N1/21 , A61K39/00 , A61K31/7088 , A61P35/00
CPC分类号： C07K14/521 , A61K39/39541 , A61K2039/505 , C07K14/005 , C07K14/4727 , C07K14/4748 , C07K14/523 , C07K16/00 , C07K16/2875 , C07K16/2896 , C07K2319/00 , C12N2710/16422 , C12N2740/16122 , Y10S514/885
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译：本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。特别地，本发明提供了融合蛋白，其包含与肿瘤抗原或病毒抗原融合的病毒趋化因子，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒的免疫应答感染。

93. 发明申请

US20110104199A1 MVA Expressing Modified HIV Envelope, GAG, and POL Genes 有权
标题翻译： MVA表达修饰的HIV信封，GAG和POL基因
公开(公告)号：US20110104199A1
公开(公告)日：2011-05-05
申请号：US12987791
申请日：2011-01-10
申请人： Bernard Moss , Linda Wyatt , Patricia Earl , Harriet L. Robinson
发明人： Bernard Moss , Linda Wyatt , Patricia Earl , Harriet L. Robinson
IPC分类号： A61K39/285 , C12N7/04 , A61P31/18 , A61P37/04
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/525 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N15/86 , C12N2710/24143 , C12N2710/24171 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2830/00 , C12N2830/15 , C12N2830/60
摘要： The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
摘要翻译：本发明提供了修饰的病毒安卡拉（MVA），一种表达人免疫缺陷病毒（HIV）env，gag和pol基因的痘苗病毒复制缺陷型菌株。

94. 发明申请

US20110091868A1 NOVEL ANTIGEN CONSTRUCTS USEFUL IN THE DETECTION AND DIFFERENTIATION OF ANTIBODIES TO HIV 失效
标题翻译：用于艾滋病毒抗体检测和鉴别的新型抗原结构
公开(公告)号：US20110091868A1
公开(公告)日：2011-04-21
申请号：US12973384
申请日：2010-12-20
申请人： John R. Hackett, JR. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
发明人： John R. Hackett, JR. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
IPC分类号： C12Q1/70 , C07K14/16 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , G01N2333/162
摘要： Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
摘要翻译：要求保护从HIV-1分离株HAM112获得的分离的HIV-1组O env多肽，以及（a）包含HIV-1组O型多肽和HIV-1组M env中的一种或多种的融合物的抗原构建体多肽和（b）另外的含有其他组O序列的抗原构建物，特别是分离株HAM112的gp41 IDR。还要求保护的是编码上述的多核苷酸序列，包含其的表达载体，由此转化的宿主细胞，以及利用本发明的抗原构建体的免疫测定方法和试剂盒。

95. 发明申请

US20110086028A1 PREVENTION OF HIV INFECTION 有权
标题翻译：预防艾滋病毒感染
公开(公告)号：US20110086028A1
公开(公告)日：2011-04-14
申请号：US12303985
申请日：2007-06-08
申请人： Drew Weissman , Stoddard Earl
发明人： Drew Weissman , Stoddard Earl
IPC分类号： A61K39/395 , A61K38/10 , C12N5/071 , C07K16/18 , C07K7/08 , G01N33/566 , A61P31/12 , A61P31/18
CPC分类号： C07K14/005 , A61K38/00 , A61K38/10 , A61K39/395 , C07K7/08 , C07K14/162 , C07K14/47 , C07K16/28 , C07K2299/00 , C12N2740/16111 , C12N2740/16122
摘要： This invention relates to methods compositions and devices for inhibiting infection of a subject's host cell by HIV. Specifically, the invention relates to methods and compositions capable of inhibiting the binding and subsequent infection by HIV of a host cell through the inhibition of the interaction between gp-340 expressed on the cell surface and V3 loop on the HIV envelope and devices comprising these compositions.
摘要翻译：本发明涉及用于通过HIV抑制受试者宿主细胞感染的方法组合物和装置。具体地，本发明涉及能够通过抑制细胞表面上表达的gp-340与HIV包膜上的V3环和包含这些组合物的装置之间的相互作用来抑制宿主细胞的结合和随后感染的方法和组合物。

96. 发明申请

US20110076248A1 IMMUNIZING COMPOSITIONS COMPRISING HIV-1 PROVIRAL CONSTRUCTS WITH AN INACTIVE P6 GAG TSG101 UEV BINDING DOMAIN CAPABLE OF PRODUCING BUDDING-DEFECTIVE VIRAL PARTICLES THAT REMAIN TETHERED TO THE CELL SURFACE. 失效
标题翻译：免疫组合物包含具有不活跃P6 GAG TSG101 UEV结合域的艾滋病毒1型构建体的组合物，其能够生产仍然存在于细胞表面的预防缺陷性病毒颗粒。
公开(公告)号：US20110076248A1
公开(公告)日：2011-03-31
申请号：US10327685
申请日：2002-12-20
申请人： Adrian Hobden , Kenton Zavitz , Scott Morham
发明人： Adrian Hobden , Kenton Zavitz , Scott Morham
IPC分类号： A61K39/21 , A61K38/20 , A61K38/21 , A61K39/395 , A61P31/18 , C12N15/63
CPC分类号： C07K14/005 , A61K38/162 , A61K48/00 , A61K2039/5156 , A61K2039/53 , A61K2039/55522 , A61K2039/57 , C07K2319/00 , C12N2740/16122 , C12N2740/16222
摘要： The present invention provides methods for preventing and treating HIV infection and AIDS by introducing cells displaying HIV late-domain phenotype into a patient, or by administering to a patient nucleic acids, polypeptides or small organic compounds to cause the formation of cells displaying HIV late-domain phenotype in the body of the patient.
摘要翻译：本发明提供了通过将显示HIV晚期域表型的细胞引入患者来预防和治疗HIV感染和AIDS的方法，或通过向患者施用核酸，多肽或小的有机化合物以引起显示艾滋病毒晚期 - 区域表型在患者体内。

97. 发明申请

US20110071082A1 LONG LASTING ANTI-ANGIOGENIC PEPTIDES 审中-公开
标题翻译：长寿命抗血栓肽
公开(公告)号：US20110071082A1
公开(公告)日：2011-03-24
申请号：US12759153
申请日：2010-04-13
申请人： Dominique P. Bridon , Michele Rasamoelisolo , Karen Thibaudeau , Xicai Huang , Richard Beliveau
发明人： Dominique P. Bridon , Michele Rasamoelisolo , Karen Thibaudeau , Xicai Huang , Richard Beliveau
IPC分类号： A61K38/38 , C07K19/00 , A61P35/00
CPC分类号： C07K14/005 , A61K38/00 , C07K14/605 , C12N2740/16122
摘要： Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly modified kringle 5 peptides are capable of forming a conjugate with a blood protein. Conjugates are prepared from anti-angiogenic peptides, particularly kringle 5 peptides, by combining the peptide with a reactive functional group with a blood protein. The conjugates may be formed in vivo or ex vivo. The conjugates are administered to patients to provide an anti-angiogenic effect.
摘要翻译：公开了修饰的抗血管生成肽。修饰的肽能够形成肽酶稳定的抗血管生成肽。修饰的抗血管生成肽，特别是修饰的三环5肽能够与血液蛋白形成缀合物。通过将肽与反应性官能团与血液蛋白结合，由抗血管生成肽，特别是kringle 5肽制备缀合物。缀合物可以在体内或离体形成。向患者施用共轭物以提供抗血管生成作用。

98. 发明申请

US20110065146A1 Expression of HIV polypeptides and production of virus-like particles 有权
标题翻译： HIV多肽的表达和病毒样颗粒的产生
公开(公告)号：US20110065146A1
公开(公告)日：2011-03-17
申请号：US12770905
申请日：2010-04-30
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12P21/00
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译：本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。

99. 发明授权

US07888003B2 Methods for the detection of HIV-1 antibodies employing polypeptides obtained from gag P6 protein 失效
标题翻译：使用从gag P6蛋白获得的多肽检测HIV-1抗体的方法
公开(公告)号：US07888003B2
公开(公告)日：2011-02-15
申请号：US11662370
申请日：2005-09-02
申请人： Hana Golding , Surender Khurana
发明人： Hana Golding , Surender Khurana
IPC分类号： C12Q1/70 , A61K39/21
CPC分类号： G01N33/6854 , C07K14/005 , C07K14/161 , C07K14/162 , C07K14/163 , C12N2740/16111 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： This invention relates to compositions and methods for the detection of HIV-1 antibodies employing polypeptides obtained from the Gag-p6 protein, the method comprising the steps of: (a) contacting a biological sample with a peptide having an epitope that is recognized by the anti-HIV-1 antibody where the contacting is under conditions sufficient to permit anti-HIV-1 present in the sample to bind to the epitope and form a peptide-anti-HIV-1 antibody complex; (b) contacting the formed peptide-anti-HIV-1 antibody complex with an anti-HIV-1 antibody binding molecule under conditions sufficient to permit the anti-HIV-1 antibody binding molecule to bind to anti-HIV-1 antibody of the formed peptide-anti-HIV-1 antibody complex and form an extended complex; said extended complex being immobilized on a solid support; and (c) removing unbound antibody from said extended complex; and (d) determining the presence or concentration of the anti-HIV-1 antibody in the biological sample by determining the presence or concentration of the formed extended complex.
摘要翻译：本发明涉及使用从Gag-p6蛋白获得的多肽检测HIV-1抗体的组合物和方法，所述方法包括以下步骤：（a）使生物样品与具有由所述抗HIV-1抗体，其中接触条件足以使样品中存在的抗HIV-1与表位结合并形成肽 - 抗HIV-1抗体复合物; （b）在足以允许抗HIV-1抗体结合分子结合抗HIV-1抗体结合分子的抗HIV-1抗体的条件下，使所形成的肽 - 抗HIV-1抗体复合物与抗HIV-1抗体结合分子接触形成肽 - 抗HIV-1抗体复合物并形成扩展复合物; 所述扩展的复合物被固定在固体支持物上; 和（c）从所述扩展复合物中除去未结合的抗体; 和（d）通过确定所形成的扩展复合物的存在或浓度来确定生物样品中抗HIV-1抗体的存在或浓度。

100. 发明申请

US20110014649A1 METHOD FOR PRODUCTION OF N36-BINDING PEPTIDE 审中-公开
标题翻译：生产N36-结合肽的方法
公开(公告)号：US20110014649A1
公开(公告)日：2011-01-20
申请号：US12296805
申请日：2007-07-26
申请人： Hiroko Tsutsumi , Hiroki Ishida , Hiromoto Hisada , Makiko Mizumoto , Yoji Hata , Nobutaka Fujii , Masao Matsuoka , Eiichi Kodama , Shinya Oishi
发明人： Hiroko Tsutsumi , Hiroki Ishida , Hiromoto Hisada , Makiko Mizumoto , Yoji Hata , Nobutaka Fujii , Masao Matsuoka , Eiichi Kodama , Shinya Oishi
IPC分类号： C12P21/06 , C12N9/26
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/15022 , C12N2740/16122
摘要： The present invention relates to the production of an N36-binding peptide at low cost and in a large quantity utilizing a microorganism. More specifically, the present invention relates to a method for producing an N36-binding peptide comprising introducing a recombinant vector into which a DNA molecule encoding an N36-binding peptide that binds to an N36 protein derived from a retrovirus that causes immunodeficiency in a mammal has been incorporated into E. coli as a host to produce a transformant.
摘要翻译：本发明涉及以低成本和大量利用微生物生产N36结合肽。更具体地说，本发明涉及一种N36-结合肽的制造方法，其特征在于，包括引入重组载体，其中编码与衍生自引起哺乳动物免疫缺陷的逆转录病毒的N36蛋白结合的N36结合肽的DNA分子作为宿主掺入大肠杆菌以产生转化体。

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