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91. 发明申请

US20090087453A1 Virosome particles comprising antigens from influenza virus and hepatitis b virus 有权
标题翻译：包含来自流感病毒和乙型肝炎病毒的抗原的病毒颗粒
公开(公告)号：US20090087453A1
公开(公告)日：2009-04-02
申请号：US11666633
申请日：2005-10-20
申请人： Christian Moser , Giovanna Assero , Epifanio Fichera , Dario Ventura , Laurence Lempereur , Diana Felnerova
发明人： Christian Moser , Giovanna Assero , Epifanio Fichera , Dario Ventura , Laurence Lempereur , Diana Felnerova
IPC分类号： A61K39/145 , A61P31/12
CPC分类号： A61K39/292 , A61K39/12 , A61K39/145 , A61K39/29 , A61K2039/5252 , A61K2039/5258 , A61K2039/55572 , C12N2730/10134 , C12N2760/16134
摘要： The present invention provides a virosome comprising a virosomal membrane comprising at least one lipid and envelope proteins of an enveloped virus and of the virosome and attached to said envelope proteins. Furthermore, the invention provides a vaccine comprising the virosome of the invention and, a method for the production of a virosome of the invention. Moreover, the invention provides a use of a virosome of the invention for the preparation of a vaccine, e.g. for the prevention or alleviation of a disease related to an HBV infection, and a method for the vaccination of a subject.
摘要翻译：本发明提供了包含病毒颗粒膜的病毒颗粒，其包含包膜病毒和病毒体的至少一种脂质和包膜蛋白，并附着于所述包膜蛋白。此外，本发明提供了包含本发明的病毒颗粒的疫苗，以及用于制备本发明的病毒颗粒的方法。此外，本发明提供了本发明的病毒颗粒用于制备疫苗的用途，例如，用于预防或缓解与HBV感染相关的疾病，以及用于接种受试者的方法。

92. 发明申请

US20090074815A1 Immunomodulator Compounds as Vaccine Enhancers 审中-公开
标题翻译：免疫调节剂化合物作为疫苗增强剂
公开(公告)号：US20090074815A1
公开(公告)日：2009-03-19
申请号：US11912266
申请日：2006-04-21
申请人： Cynthia W. Tuthill , Alfred R. Rudolph
发明人： Cynthia W. Tuthill , Alfred R. Rudolph
IPC分类号： A61K39/145 , A61K39/00 , A61K39/29 , A61K39/12 , A61K39/275
CPC分类号： A61K39/39 , A61K39/04 , A61K39/12 , A61K39/292 , A61K2039/542 , A61K2039/55516 , A61K2039/57 , C12N2730/10134 , Y02A50/464 , Y02A50/466
摘要： A vaccination method utilizes a pharmaceutical combination for enhancing vaccine effectiveness. The method utilizes an immune response-triggering vaccine capable of stimulating production in an immunodefficicent animal of antibodies to a disease-causing agent foreign to the animal. As an adjuvant, a vaccine effectiveness-enhancing amount of an immunomodulator compound is administered, which enhances production and affinity of the antibodies in the animal, in response to the vaccine.
摘要翻译：疫苗接种方法利用药物组合来增强疫苗的有效性。该方法利用能够在免疫功能动物中刺激对动物异源的致病因子的抗体的免疫应答触发疫苗。作为辅助剂，施用疫苗有效性增强量的免疫调节剂化合物，其响应于疫苗增强抗体在动物中的产生和亲和力。

93. 发明申请

US20090074803A1 IMMUNOGEN PLATFORM 有权
公开(公告)号：US20090074803A1
公开(公告)日：2009-03-19
申请号：US12192776
申请日：2008-08-15
申请人： Matti Sallberg , Jonas Soderholm , Lars Felin
发明人： Matti Sallberg , Jonas Soderholm , Lars Felin
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K39/292 , A61K39/39 , A61K2039/53 , A61K2039/55511 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/575 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234
摘要： Aspects of the present invention relate to chimeric polypeptides including HCV NS3/4A sequences and T-cell epitopes. Embodiments include nucleic acids encoding the chimeric NS3/4A polypeptides, the encoded polypeptides, compositions containing said nucleic acids, compositions containing said chimeric polypeptides, as well as methods of making and using the aforementioned compositions including, but not limited to medicaments and vaccines.

94. 发明申请

US20090053299A1 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery 审中-公开
标题翻译：使用阳离子脂质体介导的核酸递送产生免疫反应的方法
公开(公告)号：US20090053299A1
公开(公告)日：2009-02-26
申请号：US12216715
申请日：2008-07-09
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A61K9/127 , A61K31/7088 , A61K39/395 , A61K38/40 , A61P31/12
CPC分类号： C12N15/88 , A61K9/1272 , A61K39/12 , A61K39/29 , A61K47/6911 , A61K47/6913 , A61K2039/53 , A61K2039/543 , A61K2039/55555 , C12N2730/10134 , C12N2740/16134 , C12N2760/16134 , C12N2770/20034 , C12N2770/24134 , C12N2810/80 , C12N2810/859
摘要： The present invention is in the fields of drug delivery, and specifically, cationic liposome-based vaccines. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of molecules to induce immune responses against viral antigens or to treat or prevent viral diseases. The specificity of the delivery system is derived from the targeting ligands.
摘要翻译：本发明涉及药物递送领域，特别是基于阳离子脂质体的疫苗。在实施方案中，本发明提供了制备用于递送分子以诱导针对病毒抗原的免疫应答或治疗或预防病毒性疾病的配体靶向（例如，抗体或抗体片段靶向的）脂质体的方法。递送系统的特异性来源于靶向配体。

95. 发明授权

US07488490B2 Method of inducing an antigen-specific immune response by administering a synergistic combination of adjuvants comprising unmethylated CpG-containing nucleic acids and a non-nucleic acid adjuvant 有权
标题翻译：通过施用包含非甲基化的含CpG的核酸和非核酸佐剂的佐剂的协同组合来诱导抗原特异性免疫应答的方法
公开(公告)号：US07488490B2
公开(公告)日：2009-02-10
申请号：US10023909
申请日：2001-12-18
申请人： Heather L. Davis , Joachim Schorr , Arthur M. Krieg
发明人： Heather L. Davis , Joachim Schorr , Arthur M. Krieg
IPC分类号： A61K45/00 , C07H21/02
CPC分类号： A61K39/39 , A61K39/12 , A61K39/292 , A61K2039/523 , A61K2039/53 , A61K2039/55505 , A61K2039/5555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , C12N2730/10134 , Y02A50/41
摘要： The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
摘要翻译：本发明一般涉及佐剂，特别涉及利用具有至少一个未甲基化CpG二核苷酸（CpG ODN）和非核酸佐剂的免疫刺激性寡核苷酸的协同组合的方法和产品。佐剂的这种组合可以与抗原或单独使用。本发明还涉及利用具有至少一种未甲基化CpG二核苷酸（CpG ODN）的免疫刺激性寡核苷酸诱导婴儿细胞免疫的方法和产品。

96. 发明申请

US20090028902A1 Modified Viral Particles with Immunogenic Properties and Reduced Lipid Content Useful for Treating and Preventing Infectious Diseases 审中-公开
标题翻译：用于治疗和预防传染病的具有免疫原性和降低脂质含量的改性病毒颗粒
公开(公告)号：US20090028902A1
公开(公告)日：2009-01-29
申请号：US12118451
申请日：2008-05-09
申请人： Bill E. Cham , Jo-Ann B. Maltais , Marc Bellotti
发明人： Bill E. Cham , Jo-Ann B. Maltais , Marc Bellotti
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/292 , A61K39/12 , A61K39/29 , A61K2039/5252 , A61K2039/55566 , A61K2039/57 , A61L2/0011 , A61L2/0088 , A61M1/3486 , C12N7/00 , C12N2730/10134 , C12N2730/10163 , C12N2740/15034 , C12N2740/15063 , C12N2770/20034 , C12N2770/24063 , C12N2770/24334 , C12N2770/24363
摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.
摘要翻译：本发明涉及一种减少感染性疾病，特别是感染性疾病的发生和严重性的方法，其中在生物流体例如血液中发现含有脂质的感染性病毒生物。本发明使用可用于从含脂质感染性病毒生物体提取脂质的溶剂，从而产生具有降低的感染性和增强的抗原性的改性病毒颗粒。本发明提供疫苗组合物，其包含具有降低的感染性和增强的抗原性的这些经修饰的病毒颗粒，任选与药学上可接受的载体或免疫刺激剂组合。将疫苗组合物施用于患者以提供针对含脂质感染性病毒生物体的保护。本发明的疫苗组合物包括由一种或多种病毒株和/或一种或多种病毒获得的经修饰的病毒颗粒的组合疫苗。

97. 发明申请

US20080279926A1 Vaccine Compositions Comprising a Saponin Adjuvant 审中-公开
标题翻译：包含皂苷佐剂的疫苗组合物
公开(公告)号：US20080279926A1
公开(公告)日：2008-11-13
申请号：US12096838
申请日：2006-12-12
申请人： Pierre Vandepapeliere
发明人： Pierre Vandepapeliere
IPC分类号： A61K9/127 , A61K39/00 , A61K39/25 , A61K39/09 , A61K39/015 , A61K39/145 , A61K39/12
CPC分类号： A61K39/39 , A61K39/00 , A61K39/015 , A61K39/092 , A61K39/102 , A61K39/1045 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , A61K2039/6037 , A61K2039/6068 , A61K2039/70 , C12N2710/10134 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2710/20071 , C12N2730/10134 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , C12N2760/16271 , C12N2760/20034 , Y02A50/412
摘要： An immunogenic composition in a dose volume suitable for human use comprising an antigen or antigenic preparation, in combination with an adjuvant which adjuvant comprises an immunologically active saponin fraction derived from the bark of Quillaja Saponaria Molina presented in the form of a liposome and a lipopolysaccharide wherein said saponin fraction and said lipopolysaccharide are both present in said human dose at a level of below 30 μg.
摘要翻译：适合于人类使用的剂量体积的免疫原性组合物包含抗原或抗原制剂，与佐剂组合，所述佐剂包含衍生自脂质体形式的Quillaja Saponaria Molina的皮肤的免疫学活性皂苷级分和脂多糖，其中所述皂苷部分和所述脂多糖均以所述人体剂量存在于30杯以下的水平。

98. 发明授权

US07408050B2 Modified CpG oligodeoxynucleotide with improved immunoregulatory function 失效
标题翻译：改良的CpG寡脱氧核苷酸具有改善的免疫调节功能
公开(公告)号：US07408050B2
公开(公告)日：2008-08-05
申请号：US10920181
申请日：2004-08-18
申请人： Soo Kie Kim , Seung Kyu Park , Su Jung Park , Hyun Chul Cho
发明人： Soo Kie Kim , Seung Kyu Park , Su Jung Park , Hyun Chul Cho
IPC分类号： C07H21/02 , A61K51/00 , A61K47/00 , A61K39/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/292 , A61K2039/55505 , A61K2039/55561 , C12N2730/10134
摘要： The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anti-cancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3′-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.
摘要翻译：本发明涉及通过将连续的脱氧胸腺嘧啶（dT）序列与具有免疫赋形功能的CpG ODN的3'末端偶联制备的修饰的CpG寡脱氧核苷酸（ODN），从而提高脾细胞，巨噬细胞和外周单核细胞的免疫活性，因此可以有效地用作预防和治疗乙型肝炎或抗癌剂的疫苗佐剂。由于在其3'末端具有dT连续序列的硫代磷酸酯CpG ODN显示高活性诱导Th-1免疫应答，并且不引起体内毒性并保证其安全性，因此可有效地用作疫苗佐剂。

99. 发明授权

US07407663B2 Modified immunodeficiency virus particles 失效
标题翻译：改良型免疫缺陷病毒颗粒
公开(公告)号：US07407663B2
公开(公告)日：2008-08-05
申请号：US10601656
申请日：2003-06-20
申请人： Bill E. Cham , Jo-Ann B. Maltais
发明人： Bill E. Cham , Jo-Ann B. Maltais
IPC分类号： A61K39/21
CPC分类号： C12N7/00 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5252 , A61K2039/55566 , A61K2039/57 , A61L2/0011 , A61L2/0088 , A61M1/3486 , C12N2730/10134 , C12N2730/10163 , C12N2770/24334 , C12N2770/24363
摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious organism, thereby reducing the infectivity of the infectious organism. The present invention uses optimal solvent systems such that the lipid envelope around the viral particle is dissolved while the viral particle remains intact, resulting in a modified viral particle. The present invention also provides an autologous vaccine composition, comprising a lipid-containing infectious organism, treated with solvents to reduce the lipid content of the infectious organism, combined with a pharmaceutically acceptable carrier. The vaccine composition is administered to an animal or a human to provide protection against the lipid-containing infectious organism. The present invention further provides a simple, inexpensive and easy to use kit for delipidating fluids and for delipidation of lipid-containing organisms in a fluid.
摘要翻译：本发明涉及一种降低感染性疾病，特别是生物流体如血液中含有脂质感染性生物的感染性疾病的发生和严重性的方法。本发明使用可用于从含脂质感染性生物体提取脂质的溶剂，从而降低感染性生物体的感染性。本发明使用最佳的溶剂体系，使病毒颗粒周围的脂质包膜溶解，同时病毒颗粒保持完整，导致改良的病毒颗粒。本发明还提供一种自体疫苗组合物，其包含用溶剂处理以降低感染性生物体的脂质含量并与药学上可接受的载体组合的含脂质感染性生物体。将疫苗组合物施用于动物或人体以提供针对含脂质感染生物的保护。本发明还提供了一种简单，便宜且易于使用的用于使流体脱脂和用于流体中含脂质生物体的脱脂作用的试剂盒。

100. 发明申请

US20080181909A1 Chimeric immunomodulatory compounds and methods of using the same 有权
标题翻译：嵌合免疫调节化合物及其使用方法
公开(公告)号：US20080181909A1
公开(公告)日：2008-07-31
申请号：US11891624
申请日：2007-08-10
申请人： Karen L. Fearon , Dino Dina , Stephen F. Tuck
发明人： Karen L. Fearon , Dino Dina , Stephen F. Tuck
IPC分类号： A61K39/00 , C07H21/00 , A61K31/7052 , C07K2/00
CPC分类号： A61K47/48023 , A61K39/12 , A61K39/292 , A61K47/54 , A61K47/549 , A61K2039/55561 , C07H15/18 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/332 , C12N2310/351 , C12N2310/3519 , C12N2310/52 , C12N2730/10134
摘要： The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
摘要翻译：本发明提供免疫调节化合物和使用免疫调节化合物免疫调节个体的方法。

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