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91. 发明申请

US20140093476A1 METHODS FOR TREATING PAIN 审中-公开
标题翻译：治疗疼痛的方法
公开(公告)号：US20140093476A1
公开(公告)日：2014-04-03
申请号：US14066581
申请日：2013-10-29
申请人： The Regents of the University of Colorado, a body corporate
发明人： LINDA MAY ROTHBLUM WATKINS , ERIN MILLIGAN
IPC分类号： A61K38/20
CPC分类号： A61K38/2066 , A61K38/1793 , A61K38/1841 , A61K38/20 , A61K38/2026 , A61K38/2086 , A61K38/34 , A61K48/00 , A61K48/005 , A61K48/0075 , A61K48/0083 , C07K2319/30 , C07K2319/32 , C07K2319/75 , C12N15/86 , C12N2710/10343 , C12N2750/14143
摘要： Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques. Alternatively, the agents can be delivered in protein compositions.
摘要翻译：描述了通过递送抗炎细胞因子，促炎细胞因子拮抗剂和用于减轻或预防促炎细胞因子作用的作用于神经系统的药物来治疗疼痛的方法。这些药物可以使用基因治疗技术递送。或者，所述试剂可以以蛋白质组合物递送。

92. 发明授权

US08658778B2 hTMC promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes 有权
标题翻译： hTMC启动子和载体用于癌症治疗基因的肿瘤选择性和高效表达
公开(公告)号：US08658778B2
公开(公告)日：2014-02-25
申请号：US11372246
申请日：2006-03-09
申请人： Lin X. Ji , Bingliang Fang , Jack A. Roth
发明人： Lin X. Ji , Bingliang Fang , Jack A. Roth
IPC分类号： C07H21/04
CPC分类号： A61K48/0058 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： Promoters that include a tissue-selective promoter sequence and a second promoter sequence operatively coupled to the tissue-selective promoter sequence, wherein the second promoter sequence includes a minimal viral promoter sequence, are disclosed. Nucleic acids and compositions that include these promoter sequences are also disclosed. Also disclosed are methods of improving the function of a tissue-selective promoter, involving operatively coupling a tissue-selective promoter sequence with a second promoter sequence that includes a minimal viral promoter sequence. Also disclosed are methods of delivering a gene into a cell, methods of treating a subject with a hyperproliferative disease, and methods of imaging a cell that involve use of the novel promoter sequences set forth herein.
摘要翻译：包括组织选择性启动子序列和可操作地偶联于组织选择性启动子序列的第二启动子序列的启动子，其中第二启动子序列包括最小病毒启动子序列。还公开了包含这些启动子序列的核酸和组合物。还公开了改善组织选择性启动子的功能的方法，其涉及将组织选择性启动子序列与包括最小病毒启动子序列的第二启动子序列可操作地偶联。还公开了将基因递送到细胞中的方法，用过度增殖性疾病治疗受试者的方法，以及涉及使用本文所述的新型启动子序列的细胞成像的方法。

93. 发明授权

US08642028B2 Recombinant adenoviruses encoding the specific iodine transporter (NIS) 有权
标题翻译：编码特异性碘转运蛋白（NIS）的重组腺病毒
公开(公告)号：US08642028B2
公开(公告)日：2014-02-04
申请号：US13540421
申请日：2012-07-02
申请人： Michel Perricaudet , Martin Schlumberger , Patrice Yeh , Anne Boland-Auge
发明人： Michel Perricaudet , Martin Schlumberger , Patrice Yeh , Anne Boland-Auge
IPC分类号： A61K35/76
CPC分类号： C12N15/86 , A61K38/177 , A61K48/00 , C12N2710/10343 , C12N2800/108
摘要： The present invention relates to the field of gene therapy and the treatment of tumors.
摘要翻译：本发明涉及基因治疗和肿瘤治疗领域。

94. 发明申请

US20140005257A1 METHODS OF GENE THERAPY FOR TREATING DISORDERS OF THE EAR BY ADMINISTERING A VECTOR ENCODING AN ATONAL-ASSOCIATED FACTOR 审中-公开
标题翻译：通过管理编码相关因子的矢量来治疗耳朵疾病的基因治疗方法
公开(公告)号：US20140005257A1
公开(公告)日：2014-01-02
申请号：US14024749
申请日：2013-09-12
申请人： GENVEC, INC.
发明人： Douglas E. Brough
IPC分类号： A61K38/17
CPC分类号： A61K38/17 , A61K38/00 , A61K48/005 , A61P27/00 , C07K14/4702 , C12N7/00 , C12N15/86 , C12N2501/60 , C12N2710/10343
摘要： The invention is directed to a method of changing the sensory perception of an animal. The method comprises administering an expression vector comprising a nucleic acid sequence encoding an atonal-associated factor, which is expressed to produce the atonal-associated factor resulting in generation of hair cells that allow perception of stimuli in the inner ear. Also provided is a method of generating a hair cell in differentiated sensory epithelia in vivo. The method comprises contacting differentiated sensory epithelial cells with an adenoviral vector (a) deficient in one or more replication-essential gene functions of the E1 region and E4 region, (b) comprising a spacer in the E4 region, and (c) comprising a nucleic acid sequence encoding an atonal-associated factor. The nucleic acid sequence is expressed to produce the atonal-associated factor such that a hair cell is generated. An adenoviral vector encoding an atonal-associated factor also is provided.
摘要翻译：本发明涉及一种改变动物的感觉知觉的方法。所述方法包括施用包含编码无关联因子的核酸序列的表达载体，所述核酸序列被表达以产生导致产生能够感知内耳中的刺激的毛细胞的无关性因子。还提供了一种在体内在分化感觉上皮细胞中产生毛细胞的方法。该方法包括使分化的感觉上皮细胞与E1区和E4区的一个或多个复制必需基因功能缺陷的腺病毒载体（a）接触，（b）在E4区中包含间隔基，和（c）包含编码无关联因子的核酸序列。表达核酸序列以产生无创因子，从而产生毛细胞。还提供了编码无关联因子的腺病毒载体。

95. 发明申请

US20130337008A1 ADENOVIRAL VECTOR-BASED DENGUE FEVER VACCINE 有权
标题翻译：腺病毒基因登革热疫苗
公开(公告)号：US20130337008A1
公开(公告)日：2013-12-19
申请号：US13993210
申请日：2011-12-20
申请人： Joseph T. Bruder , Duncan McVey , Douglas E. Brough
发明人： Joseph T. Bruder , Duncan McVey , Douglas E. Brough
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5256 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2770/24134 , C12N2810/6018 , Y02A50/386
摘要： The invention relates to a replication-deficient adenoviral vector comprising two or more nucleic acid sequences encoding Dengue virus antigens and a chimeric hexon protein. The chimeric hexon protein comprises a first portion and a second portion. The first portion comprises at least 10 contiguous amino acid residues from a first adenovirus serotype (e.g., serotype 5 adenovirus hexon protein), optionally with one amino acid substitution. The second portion comprises (a) at least one hypervariable region (HVR) of a hexon protein of an adenovirus of a second adenovirus serotype, or (b) at least one synthetic hypervariable region (HVR) that is not present in the hexon protein of the wild-type adenovirus of the first adenovirus serotype.
摘要翻译：本发明涉及包含编码登革热病毒抗原和嵌合六邻体蛋白质的两个或多个核酸序列的复制缺陷型腺病毒载体。嵌合六邻体蛋白质包含第一部分和第二部分。第一部分包含来自第一腺病毒血清型（例如血清型5腺病毒六邻体蛋白）的至少10个连续氨基酸残基，任选具有一个氨基酸取代。第二部分包含（a）第二种腺病毒血清型的腺病毒的六邻体蛋白质的至少一个高变区（HVR），或（b）至少一个不存在于第六腺体蛋白的六邻体蛋白质中的合成高变区（HVR）第一种腺病毒血清型的野生型腺病毒。

96. 发明申请

US20130315871A1 SUBFAMILY E SIMIAN ADENOVIRUSES A1302, A1320, A1331 AND A1337 AND USES THEREOF 有权
标题翻译：亚型艾美公司A1302，A1320，A1331和A1337及其用途
公开(公告)号：US20130315871A1
公开(公告)日：2013-11-28
申请号：US13896722
申请日：2013-05-17
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Soumitra Roy , James M. Wilson
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K35/761 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10342 , C12N2710/10343 , C12N2740/16234
摘要： Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒A1302（SAdV-A1302，SAdV-A1320，SAdV-A1331和/或SAdV-A1337序列和在调控序列控制下的异源基因），表达猿腺病毒SAdV-A1302，SAdV- 还公开了A1320，SAdV-A1331和/或SAdV-A1337基因。提供了使用载体和细胞系的方法。

97. 发明授权

US08591879B2 Recombinant adenovirus vector having a reduced side effect 失效
标题翻译：具有降低的副作用的重组腺病毒载体
公开(公告)号：US08591879B2
公开(公告)日：2013-11-26
申请号：US13152766
申请日：2011-06-03
申请人： Michio Nakai , Kazuo Komiya , Masashi Murata , Naoki Tohdoh , Izumu Saito
发明人： Michio Nakai , Kazuo Komiya , Masashi Murata , Naoki Tohdoh , Izumu Saito
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10361 , C12N2800/30
摘要： The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use in the production of the recombinant adenovirus vector, or a gene therapy method using the recombinant adenovirus vector.
摘要翻译：本发明提供了一种新的腺病毒载体，其通过抑制插入到腺病毒基因组中的外源启动子诱导腺病毒基因的表达来减轻其体内给药期间的炎症，以及生成载体的方法，细胞系用于重组腺病毒载体的生产，或使用重组腺病毒载体的基因治疗方法。

98. 发明申请

US20130309262A1 HSV-1 EPITOPES AND METHODS FOR USING SAME 有权
标题翻译： HSV-1抗生素及其使用方法
公开(公告)号：US20130309262A1
公开(公告)日：2013-11-21
申请号：US13892185
申请日：2013-05-10
申请人： University of Washington
发明人： DAVID M. KOELLE
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2035/124 , A61K2039/5156 , A61K2039/5158 , A61K2039/5256 , A61K2039/53 , C07K2319/00 , C12N2710/10343 , C12N2710/16034 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143
摘要： The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原和表位。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

99. 发明申请

US20130295053A1 Methods of Producing Adenovirus Vectors and Viral Preparations Generated Thereby 审中-公开
标题翻译：产生腺病毒载体和病毒制剂的方法
公开(公告)号：US20130295053A1
公开(公告)日：2013-11-07
申请号：US13826396
申请日：2013-03-14
申请人： Vascular Biogenics Ltd.
发明人： Livnat BANGIO , Naamit Sher , Eyal Breitbart
IPC分类号： C12N15/87 , C12N7/00
CPC分类号： C12N15/87 , C07K2319/00 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/008
摘要： The present invention, in some embodiments thereof, relates to methods of producing adenoviruses such as pro- and anti-angiogenic adenovirus vectors and preparations generated there by. Particularly, in some embodiments, the viral vectors comprise a heterologous pro- or anti-angiogenic gene under the transcriptional control of the murine pre-proendothelin promoter (e.g. PPE-1-3X), for targeted expression of in angiogenic endothelium.
摘要翻译：在一些实施方案中，本发明涉及产生腺病毒的方法，例如促血管生成腺病毒载体和抗血管生成腺病毒载体及其中产生的制剂。特别地，在一些实施方案中，病毒载体在鼠前期内皮素启动子（例如PPE-1-3X）的转录控制下包含用于靶向表达血管生成内皮的异源原或抗血管生成基因。

100. 发明授权

US08574590B2 Lipoparticles comprising proteins, methods of making, and using the same 有权
公开(公告)号：US08574590B2
公开(公告)日：2013-11-05
申请号：US10901399
申请日：2004-07-28
申请人： Benjamin J. Doranz , Sharon Willis , Eric Ross , Tiffani Anne Greene
发明人： Benjamin J. Doranz , Sharon Willis , Eric Ross , Tiffani Anne Greene
IPC分类号： A61K39/12 , A61K39/21
CPC分类号： G01N33/5432 , A61K39/12 , A61K39/245 , A61K39/39 , A61K47/6901 , A61K49/0002 , A61K2039/5258 , A61K2039/55533 , A61K2039/55555 , A61K2039/64 , C07K14/005 , C07K16/2812 , C07K16/2851 , C07K16/2866 , C07K16/32 , C12N2710/10343 , C12N2710/16422 , C12N2710/16434 , C12N2710/24143 , C12N2740/13022 , C12N2760/18522 , C12N2770/36122 , G01N33/569 , G01N33/586 , G01N33/6872 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

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