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91. 发明申请

US20130178942A1 System and Method for Attaching Soft Tissue To An Implant 审中-公开
标题翻译：将软组织植入的系统和方法
公开(公告)号：US20130178942A1
公开(公告)日：2013-07-11
申请号：US13764259
申请日：2013-02-11
申请人： Thomas J. Webster , Venu Perla
发明人： Thomas J. Webster , Venu Perla
IPC分类号： A61F2/30
CPC分类号： A61F2/30771 , A61B17/08 , A61F2/30 , A61F2002/30011 , A61F2002/30062 , A61F2002/30064 , A61F2002/3084 , A61F2002/3092 , A61F2002/30929 , A61F2002/3093 , A61F2002/30968 , A61F2310/00023 , A61F2310/0097 , A61F2310/00982 , A61K9/0024 , A61K9/0092 , A61L27/04 , A61L27/32 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/56 , A61L31/022 , A61L31/16 , A61L2300/414 , A61L2300/604 , A61L2300/624 , A61L2400/12 , A61L2400/18 , A61L2430/02 , C25D5/34 , C25D11/02 , Y10T428/24355
摘要： One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.
摘要翻译：本发明的一个实施方案涉及用于增强软组织与金属假体装置的附着的组合物和方法。在一个实施方案中，提供了包括具有多孔金属区域的金属植入物的构造，其中所述多孔区域呈现纳米纹理表面。

92. 发明申请

US20130149387A1 BIODEGRADABLE TISSUE COMPOSITION WITH BIODEGRADABLE CROSS-LINKERS 有权
公开(公告)号：US20130149387A1
公开(公告)日：2013-06-13
申请号：US13763349
申请日：2013-02-08
申请人： Chandrashekhar P. Pathak , Sanjay M. Thigle
发明人： Chandrashekhar P. Pathak , Sanjay M. Thigle
IPC分类号： A61L27/36
CPC分类号： A61L27/16 , A61K35/12 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/3604 , A61L27/3608 , A61L27/3612 , A61L27/3625 , A61L27/3633 , A61L27/3641 , A61L27/3683 , A61L27/3687 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2300/406 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2400/18 , A61L2420/02 , A61L2420/08 , A61L2430/20 , A61L2430/34 , A61L2430/40
摘要： Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed.

93. 发明授权

US08445589B2 Lung volume reduction therapy using crosslinked non-natural polymers 有权
公开(公告)号：US08445589B2
公开(公告)日：2013-05-21
申请号：US13493409
申请日：2012-06-11
申请人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
IPC分类号： C08F8/00
CPC分类号： A61L24/06 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L2300/604 , A61L2400/06 , A61M25/10 , A61M2025/1052 , A61M2210/1039 , C08F116/06 , C08F2810/20 , C08J3/075 , C08J9/30 , C08J9/36 , C08J2205/022 , C08J2207/10 , C08J2329/04
摘要： One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.

94. 发明申请

US20130122067A1 Growth-inhibited hydroxyapatite, process for its preparation and use 有权
标题翻译：生长抑制羟基磷灰石，其制备和使用过程
公开(公告)号：US20130122067A1
公开(公告)日：2013-05-16
申请号：US13812497
申请日：2011-08-04
申请人： Sascha Heinemann , Christiane Heinemann , Hartmut Worch , Thomas Hanke , Wolfgang Pompe
发明人： Sascha Heinemann , Christiane Heinemann , Hartmut Worch , Thomas Hanke , Wolfgang Pompe
IPC分类号： A61F2/28
CPC分类号： A61L27/12 , A61F2/28 , A61L27/222 , A61L27/24 , A61L27/32 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/10 , A61L2300/412 , A61L2300/604 , A61L2300/63 , A61L2400/18 , A61L2420/00 , A61L2430/02 , C01B25/32
摘要： The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.
摘要翻译：本发明涉及用于改善骨愈合的生长抑制型羟基磷灰石。它与迄今为止使用的磷灰石的不同之处在于，它在生理溶液中释放钙离子和磷酸根离子，与传统的羟基磷灰石不同，它不结合。从而促进骨再生和骨骼生长。生长抑制羟基磷灰石含有预结构化胶原模板的附聚物，其上具有低于其临界核半径的微晶生长的羟基磷灰石晶体被外延形成。它通过以下步骤制备：a）在过饱和的含Ca和磷酸根离子的溶液中预结构化胶原模板的成矿，其中预结构的胶原模板能够扩散和/或迁移，使得HAP微晶在胶原模板上上游生长，与HAP微晶一起生长的胶原模板由于其扩散和/或迁移的能力而聚集，b）分离附聚物。

95. 发明申请

US20130073041A1 MEDICAL IMPLANTS WITH RESERVOIR (S), AND MATERIALS PREPARABLE FROM SAME 有权
标题翻译：具有储存器的医用植入物以及可从其制备的材料
公开(公告)号：US20130073041A1
公开(公告)日：2013-03-21
申请号：US13676625
申请日：2012-11-14
申请人： Warsaw Orthopedic, Inc.
发明人： Jeffrey L. Scifert , William F. McKay
IPC分类号： A61F2/02
CPC分类号： A61L27/24 , A61F2/02 , A61K9/0019 , A61K9/0024 , A61K9/1652 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/02 , A61L24/10 , A61L24/102 , A61L27/02 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45 , A61L2300/604 , A61L2400/06 , A61L2430/02 , A61L2430/38
摘要： Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients.
摘要翻译：描述了一种医学上有用的制品，其包括包含一种或多种可植入物质的三维体，其中所述主体限定用于接收生物相容性润湿液体量的一个或多个储存器。在某些实施方案中，身体在与生物相容性液体润湿时形成适形植入材料，例如油灰，糊状物或更易流动的润湿植入材料。还描述了制造这种医疗材料的方法，以及使用这种医疗材料来治疗患者的方法。

96. 发明授权

US08361139B2 Medical devices having metal coatings for controlled drug release 有权
标题翻译：具有用于受控药物释放的金属涂层的医疗装置
公开(公告)号：US08361139B2
公开(公告)日：2013-01-29
申请号：US12498829
申请日：2009-07-07
申请人： Aiden Flanagan , Barry O'Brien , Torsten Scheuermann
发明人： Aiden Flanagan , Barry O'Brien , Torsten Scheuermann
IPC分类号： A61F2/06 , A61F2/00
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/604 , A61L2300/624
摘要： Medical devices having a plurality of nanoparticles disposed over a surface of the medical device. The nanoparticles have a core comprising a therapeutic agent and a shell surrounding the core, wherein the shell comprises a metal. A barrier layer is disposed over the nanoparticles. The barrier layer is water-permeable and comprises a metal that may be different from the metal used in the nanoparticle shells. In certain embodiments, the metal in the barrier layer undergoes galvanic corrosion. Also disclosed are medical device having a reservoir containing a therapeutic agent, with nanoparticles and a barrier layer being disposed over the reservoir; and medical devices having multiple barrier layers and multiple reservoirs containing therapeutic agents.
摘要翻译：具有设置在医疗装置的表面上的多个纳米颗粒的医疗装置。纳米颗粒具有包含治疗剂的核心和围绕核心的壳体，其中壳体包含金属。阻挡层设置在纳米粒子上。阻挡层是透水性的并且包含可以与纳米颗粒壳中使用的金属不同的金属。在某些实施例中，阻挡层中的金属经历电偶腐蚀。还公开了具有包含治疗剂的储存器的医疗装置，其中纳米颗粒和阻挡层设置在储存器上方; 以及具有多个阻隔层的医疗装置和含有治疗剂的多个储存器。

97. 发明授权

US08303981B2 Fragmented polymeric compositions and methods for their use 有权
标题翻译：碎片聚合物组合物及其使用方法
公开(公告)号：US08303981B2
公开(公告)日：2012-11-06
申请号：US13174963
申请日：2011-07-01
申请人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
发明人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
IPC分类号： A61K9/14 , A61G13/00
CPC分类号： A61K38/4833 , A61K9/0002 , A61L2/081 , A61L2/087 , A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , A61L2400/04
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译：交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。

98. 发明申请

US20120275998A1 BIODEGRADABLE STENT COMPRISING AN ACID SCAVENGING AGENT 审中-公开
标题翻译：包含酸性助洗剂的可生物降解的手段
公开(公告)号：US20120275998A1
公开(公告)日：2012-11-01
申请号：US13512741
申请日：2010-12-02
申请人： Kadem Gayad Al-Lamee
发明人： Kadem Gayad Al-Lamee
IPC分类号： A61K31/519 , A61K47/30 , A61K49/18 , A61K31/522 , A61K51/00
CPC分类号： A61L31/16 , A61L31/06 , A61L31/148 , A61L2300/216 , A61L2300/604 , C08L67/04
摘要： A biodegradable stent comprising a biodegradable material having dissolved therein an acid scavenging agent. The biodegradable material may be PLLA or PLGA. The acid scavenging agent may be also a pharmaceutical agent, for example an antiproliferative agent, coronary vasodilator agent and/or a bronchodilator. Preferably the acid scavenging agent is dipyridamole and/or mopidamol. The invention also provides a method of preparing a biodegradable material for use in the stent of the invention comprising: (i) preparing a formulation of the biodegradable material and the acid scavenging agent; (ii) heating the formulation to melt the biodegradable material and the acid scavenging agent so as to dissolve the agent in the material; and (iii) collecting and cooling the formulation of step (ii).
摘要翻译：一种可生物降解的支架，其包括其中溶解有酸清除剂的可生物降解的材料。可生物降解材料可以是PLLA或PLGA。酸清除剂也可以是药剂，例如抗增生剂，冠状血管舒张剂和/或支气管扩张剂。优选地，除酸剂是双嘧达莫和/或莫匹达莫泊。本发明还提供了一种制备用于本发明支架的可生物降解材料的方法，包括：（i）制备可生物降解材料和除酸剂的制剂; （ii）加热制剂以熔化可生物降解材料和除酸剂，以将试剂溶解在材料中; 和（iii）收集和冷却步骤（ii）的制剂。

99. 发明申请

US20120245627A1 Lung Volume Reduction Therapy Using Crosslinked Non-Natural Polymers 有权
标题翻译：使用交联非天然聚合物的肺减容治疗
公开(公告)号：US20120245627A1
公开(公告)日：2012-09-27
申请号：US13493409
申请日：2012-06-11
申请人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
IPC分类号： A61L24/04 , A61B17/03
CPC分类号： A61L24/06 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L2300/604 , A61L2400/06 , A61M25/10 , A61M2025/1052 , A61M2210/1039 , C08F116/06 , C08F2810/20 , C08J3/075 , C08J9/30 , C08J9/36 , C08J2205/022 , C08J2207/10 , C08J2329/04
摘要： One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.
摘要翻译：本发明的一个方面涉及包含非天然聚合物的水凝胶，所述非天然聚合物包含多个侧链亲核基团和包含至少两个侧链亲电子基团的交联剂。本发明的另一方面涉及包含非天然聚合物的水凝胶，其包含多个侧链亲电基团和包含至少两个亲核基团的交联剂。本发明的另一方面涉及一种用于减少患者体内肺容量的方法，包括施用如本文所述的水凝胶组合物的步骤。此外，本发明的水凝胶可用于实现胸膜固定术，密封胸膜瘘，密封肺中的空气泄漏，实现止血，组织密封（例如血管，内脏）或其任何组合。在某些实施方案中，本文所述的组合物和方法旨在用于治疗患有肺气肿的患者。

100. 发明申请

US20120183629A1 LOW VISCOSITY LIQUID POLYMERIC DELIVERY SYSTEM 审中-公开
标题翻译：低粘度液体聚合物输送系统
公开(公告)号：US20120183629A1
公开(公告)日：2012-07-19
申请号：US13429890
申请日：2012-03-26
申请人： Richard L. Dunn
发明人： Richard L. Dunn
IPC分类号： A61K33/24 , A61K38/08 , A61K31/65 , A61K31/445 , A61K47/30 , A61K31/439
CPC分类号： A61L29/06 , A61K9/0024 , A61K31/445 , A61K31/485 , A61K31/65 , A61K33/24 , A61L27/18 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/14 , A61L29/148 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/43 , A61L2300/604 , A61L2400/06 , C08L67/04
摘要： Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a biodegradable liquid polymer implant are provided.
摘要翻译：提供了液体可生物降解聚合物和生物相容性溶剂的低粘度可生物降解聚合物溶液和使用该组合物形成可生物降解的液体聚合物植入物的方法。

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