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91. 发明授权

US10841232B2 Apparatus and methods for removing a large- signal voltage offset from a biomedical signal 有权
公开(公告)号：US10841232B2
公开(公告)日：2020-11-17
申请号：US16718996
申请日：2019-12-18
申请人： BioSig Technologies, Inc.
发明人： Budimir S. Drakulic , Sina Fakhar , Thomas G. Foxall , Branislav Vlajinic
IPC分类号： A61B5/00 , H04L12/863 , H04L12/26 , A61B5/0402 , G16H40/63 , A61B5/0428 , H03F3/45 , H03K5/125 , A61B5/0215 , A61B5/0245 , A61B5/046 , A61B5/0464 , A61B18/14 , A61B18/00 , H02H9/04 , H03F3/68 , A61B5/024 , A61B5/0456 , A61B5/0472 , A61B5/053
CPC分类号： H04L47/50 , A61B5/0215 , A61B5/0245 , A61B5/0402 , A61B5/046 , A61B5/0428 , A61B5/0464 , A61B5/4836 , A61B5/7203 , A61B5/7217 , A61B5/7225 , A61B5/7246 , A61B5/742 , A61B5/7435 , A61B18/1492 , G16H40/63 , H03F3/45475 , H03K5/125 , H04L43/02 , A61B5/0006 , A61B5/02405 , A61B5/0456 , A61B5/0472 , A61B5/0538 , A61B2018/00351 , A61B2018/00577 , A61B2562/18 , A61B2562/223 , H01L2924/14335 , H02H9/04 , H02H9/045 , H03F3/45 , H03F3/68 , H03F2200/129 , H03F2200/171 , H03F2200/234 , H03F2200/375 , H03F2200/451 , H03F2203/45116 , H03F2203/45528 , H03F2203/45601 , H03H2017/0298 , H04B1/0014 , H04B1/0039
摘要： Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

92. 发明申请

US20180303539A1 OPTICAL TISSUE FEEDBACK DEVICE FOR AN ELECTROSURGICAL DEVICE 审中-公开
公开(公告)号：US20180303539A1
公开(公告)日：2018-10-25
申请号：US15570102
申请日：2016-04-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Waltherus Cornelis Jozef BIERHOFF , Bernardus Hendrikus Wilhelmus HENDRIKS , Franciscus Marinus Antonius Maria VAN GAAL , Torre Michelle BYDLON , Vishnu Vardhan PULLY , Christian REICH
IPC分类号： A61B18/14
CPC分类号： A61B18/148 , A61B5/0075 , A61B5/0084 , A61B5/6847 , A61B2017/00057 , A61B2017/00061 , A61B2017/00199 , A61B2018/0013 , A61B2018/00172 , A61B2018/00589 , A61B2018/00601 , A61B2018/00607 , A61B2018/00904 , A61B2018/0097 , A61B2018/00976 , A61B2018/1412 , A61B2505/05 , A61B2562/0238 , A61B2562/223 , A61B2562/228
摘要： A tissue sensing device for use with an electrosurgical knife is proposed which comprises a proximal end portion, a distal end portion and a grip portion there between. The proximal end portion is configured for attachment to a housing of the electrosurgical knife. The distal end portion is configured for movably supporting a blade of the knife. A distal end of an optical fiber is arranged at the distal end portion of the device and a proximal end of the optical fiber is connectable to an optical console, so that optical measurements can be performed at the distal end portion.

93. 发明授权

US09757057B2 Dry insertion and one-point in vivo calibration of an optical analyte sensor 有权
公开(公告)号：US09757057B2
公开(公告)日：2017-09-12
申请号：US14073661
申请日：2013-11-06
申请人： MEDTRONIC MINIMED, INC.
发明人： Stuart L. Gallant , William H. Markle , Manouchehr Goharlaee
IPC分类号： A61B5/1455 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/1495
CPC分类号： A61B5/14532 , A61B5/14539 , A61B5/1455 , A61B5/1459 , A61B5/14735 , A61B5/1495 , A61B2562/043 , A61B2562/223
摘要： Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration.

94. 发明申请

US20170143418A1 CATHETER WITH OMNI-DIRECTIONAL OPTICAL TIP HAVING ISOLATED OPTICAL PATHS 审中-公开
公开(公告)号：US20170143418A1
公开(公告)日：2017-05-25
申请号：US15418575
申请日：2017-01-27
申请人： BIOSENSE WEBSTER, INC.
发明人： James K. Lee
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/0075 , A61B5/0084 , A61B5/01 , A61B5/065 , A61B2017/00057 , A61B2017/00084 , A61B2018/00172 , A61B2018/00577 , A61B2018/00642 , A61B2018/00773 , A61B2018/00791 , A61B2018/00982 , A61B2034/2051 , A61B2090/397 , A61B2218/002 , A61B2562/12 , A61B2562/223 , A61M25/0147 , Y10T29/49002
摘要： A catheter enables real-time light measurements, for example, without limitation, diffuse reflectance, fluorescence, etc., from biological materials, such as tissue (including blood), while performing RF ablation. The catheter tip design isolates illumination and collection paths within the tip electrode such that light for illuminating the tissue of interest (e.g., cardiac tissue or blood) is isolated within the tip electrode from light that returns from the tissue to the catheter tip, and vice versa. Such a design advantageously avoids saturation of the optical detector, and ensures diffusion of the illumination light within the medium of interest. The catheter has a catheter body and a tip electrode with a shell wall and a hollow cavity. The shell wall has at least an illumination opening and a collection opening. The catheter further includes a first fiber optic cable in communication with the illumination opening, and a second fiber optic cable in communication with the hollow cavity, wherein light emitted from the first fiber optic cable exits the tip electrode to reach tissue through the illumination opening in defining a first path and returns to the tip electrode from the tissue into the hollow cavity through the collection opening in defining a second path, the first and second paths being optically isolated from each other within the tip electrode. The invention also includes a method of making an ablation electrode tip defining isolated optical paths with in the tip electrode for light exiting the tip electrode and light returning to the tip electrode.

95. 发明授权

US09380966B2 Tissue retractor oximeter 有权
标题翻译：组织牵开器血氧仪
公开(公告)号：US09380966B2
公开(公告)日：2016-07-05
申请号：US12126860
申请日：2008-05-24
申请人： Jimmy Jian-min Mao , Robert E. Lash
发明人： Jimmy Jian-min Mao , Robert E. Lash
IPC分类号： A61B5/145 , A61B5/1459 , A61B17/02 , A61B5/00
CPC分类号： A61B5/14552 , A61B5/0002 , A61B5/0022 , A61B5/0086 , A61B5/14542 , A61B5/1459 , A61B5/6846 , A61B5/742 , A61B17/02 , A61B2017/0262 , A61B2560/0214 , A61B2560/0266 , A61B2562/223 , A61B2562/225
摘要： A retractor has an oximeter sensor at its tip, which allows measuring of oxygen saturation of a tissue being retracted by the retractor. The tip includes one or more openings for at least one source and detector. A specific implementation is a spinal nerve root retractor with an oximeter sensor.
摘要翻译：牵开器在其尖端处具有血氧计传感器，其允许测量由牵开器缩回的组织的氧饱和度。尖端包括用于至少一个源和检测器的一个或多个开口。具体实现是具有血氧计传感器的脊神经根牵开器。

96. 发明申请

US20160120408A1 NON-CYLINDRICAL HYPOTUBES 审中-公开
标题翻译：非圆柱形汽油
公开(公告)号：US20160120408A1
公开(公告)日：2016-05-05
申请号：US14932298
申请日：2015-11-04
申请人： Corning Incorporated
发明人： Venkata Adiseshaiah Bhagavatula , Woraphat Dockchoorung , Klaus Hartkorn , Mark Alan McDermott , Stephen Quenton Smith
IPC分类号： A61B5/00 , A61B1/00
CPC分类号： A61B5/0066 , A61B5/0084 , A61B2560/0406 , A61B2562/223
摘要： A non-cylindrical hypotube is disclosed, such as for use in OCT and endoscopy. The hypotube is defined by a non-cylindrical, rotationally symmetric tube and has an interior, a proximal-end section with an outer diameter D1, a distal-end section with an outer diameter D3, and a middle section between the proximal-end and distal-end sections and having an outer diameter D2, wherein D2
摘要翻译：公开了非圆柱形海波管，例如用于OCT和内窥镜检查。海波管由非圆柱形，旋转对称的管限定，并且具有内部，具有外径D1的近端部分，具有外径D3的远端部分，以及近端和远端部分并且具有外径D2，其中D2

97. 发明申请

US20160073887A1 OPTOELECTRONIC DEVICE TO WRITE-IN AND READ-OUT ACTIVITY IN BRAIN CIRCUITS 审中-公开
标题翻译：光电设备在大脑电路中的写入和读出活动
公开(公告)号：US20160073887A1
公开(公告)日：2016-03-17
申请号：US14783741
申请日：2014-04-11
申请人： Brown University
发明人： Joonhee LEE , Arto V. NURMIKKO , Yoon-Kyu SONG
IPC分类号： A61B5/00 , A61B5/0476 , G02B6/132 , G02B6/122 , G02B6/42 , H01B11/22 , G02B6/44 , G02B6/43 , A61B5/04 , G02B6/136
CPC分类号： A61B5/0084 , A61B5/04001 , A61B5/0476 , A61B2503/40 , A61B2562/125 , A61B2562/222 , A61B2562/223 , A61N5/0622 , A61N2005/0652 , A61N2005/0662 , G02B6/122 , G02B6/132 , G02B6/136 , G02B6/4274 , G02B6/43 , G02B6/4416 , G02B2006/12195 , H01B11/22
摘要： Systems, apparatus and methods for a neural implant are provided. In one embodiment, a neural implant that can both optically stimulate neurons and record electrical signals from neurons is provided, including a wide band gap semiconductor opto electronic microarray, such optoelectronic microarray including a plurality of needles, each providing both optical transparency and electrical conductivity; a flexible optical conduit from the optoelectronic microarray to an optical signal source; a flexible electrical conduit from the optoelectronic microarray to an electrical signal sensor; integration of the optical and electrical conduits to a single monolithic optical cable; a circuit assembly coupled to the electrical signal source and the optical signal source; and a processor for providing control of at least one of the electrical signal sensor and the optical signal source. Further embodiments are described herein.
摘要翻译：提供了用于神经植入物的系统，装置和方法。在一个实施例中，提供了可以光学刺激神经元并从神经元记录电信号的神经植入物，其包括宽带隙半导体光电子微阵列，包括多个针的光电微阵列，每个针提供光学透明性和导电性; 从光电微阵列到光信号源的柔性光导管; 从光电微阵列到电信号传感器的柔性电导管; 将光和电导管集成到单个单片光缆; 耦合到电信号源和光信号源的电路组件; 以及用于提供至少一个电信号传感器和光信号源的控制的处理器。此处描述了另外的实施例。

98. 发明授权

US09194690B2 Power transmission and sensing device 有权
标题翻译：电力传输和传感装置
公开(公告)号：US09194690B2
公开(公告)日：2015-11-24
申请号：US14182499
申请日：2014-02-18
申请人： Corning Incorporated
发明人： Venkata Adiseshaiah Bhagavatula , Theresa Chang , Klaus Hartkorn , John Himmelreich
IPC分类号： G01B9/02 , A61B5/00 , G02B6/36
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0084 , A61B5/687 , A61B5/6873 , A61B5/6876 , A61B2562/12 , A61B2562/223 , G02B6/3624
摘要： A torque transmission assembly comprising: (i) an optical fiber coupled to an optical sensing component and capable of rotating and translating the optical sensing component and of transmitting light to and from the optical sensing component; and (b) an annular structure surrounding the optical fiber, the annular structure in conjunction with said optical fiber transmits torque from a rotating component to the optical sensing component, wherein the annular structure does not include a steel wire torque spring.
摘要翻译：一种扭矩传递组件，包括：（i）光纤，其耦合到光学感测部件，并且能够旋转和平移光学感测部件并将光传输到光学传感部件; 和（b）围绕光纤的环形结构，与所述光纤结合的环形结构将扭矩从旋转部件传递到光学传感部件，其中环形结构不包括钢丝扭矩弹簧。

99. 发明授权

US09149186B2 Configuration of cables for monitoring systems 有权
标题翻译：监控系统电缆配置
公开(公告)号：US09149186B2
公开(公告)日：2015-10-06
申请号：US13337034
申请日：2011-12-23
申请人： Joseph Grayzel , Jeffrey Grayzel
发明人： Joseph Grayzel , Jeffrey Grayzel
IPC分类号： A61B5/00 , A61B5/0428 , A61B5/0205 , A61B5/021
CPC分类号： A61B5/002 , A61B5/00 , A61B5/02055 , A61B5/021 , A61B5/0402 , A61B5/04286 , A61B5/0476 , A61B8/00 , A61B2562/221 , A61B2562/222 , A61B2562/223 , A61B2562/224 , A61B2562/225 , A61B2562/247
摘要： A physical configuration of cables connecting a monitoring apparatus to a human patient, where said patient and his immediate surroundings define a potentially infectious contaminated zone. The configuration provides for the monitor and main trunk cable to lie outside of the contamination zone, and one or more serial cables connect to the trunk cable and enter the contamination zone to provide contact with the patient. This physical configuration prevents contamination of the monitor and trunk cable, so they may be reused on successive patients, while lightweight and inexpensive serial cables contacting the patient and his contamination zone may be disposable. Examples of monitoring various physiological variables are provided to exemplify the universal concept of such physical configuration. Adaptation for wireless transmission is also described.
摘要翻译：将监测装置连接到人类患者的电缆的物理结构，其中所述患者及其直接周围环境限定潜在的感染性污染区域。该配置提供监视器和主干线电缆位于污染区域之外，并且一个或多个串行电缆连接到干线电缆并进入污染区域以提供与患者的接触。这种物理配置可以防止监视器和中继电缆的污染，因此它们可以在连续的病人身上重复使用，而与患者和他的污染区域接触的轻便和便宜的串联电缆可能是一次性的。提供了监测各种生理变量的示例以例示这种物理配置的通用概念。还描述了用于无线传输的适配。

100. 发明申请

US20150190080A1 NEEDLE-MOUNTED LINEAR-ARRAY OXYGEN SENSOR 审中-公开
标题翻译：针状线性阵列氧传感器
公开(公告)号：US20150190080A1
公开(公告)日：2015-07-09
申请号：US14589721
申请日：2015-01-05
申请人： Regents of the University of Minnesota
发明人： Shai Ashkenazi
IPC分类号： A61B5/1455 , A61B5/1459
CPC分类号： A61B5/14552 , A61B5/1459 , A61B2562/223
摘要： A low coherence light source is used to generate a time-varying and space-localized interference pattern to excite oxygen-sensitive dye embedded in a polymer matrix inside an elongated channel waveguide. The sensing mechanism may be based on triplet-state and phosphorescence quenching of the photosensitizer dye by oxygen molecules. Phosphorescence emission resulting from the time-varying, space-localized excitation light is collected. The intensity or frequency of an oscillating component of the phosphorescence signal is used to quantify the local value of pO2 at a plurality of active measurement points along the waveguide. An oxygen sensor including the waveguide may be formed along a long axis of a needle so that a depth-resolved profile of pO2 in tissue is obtained.
摘要翻译：低相干光源用于产生时变和空间局部化的干涉图案，以激发嵌入细长通道波导内的聚合物基质中的氧敏感染料。感测机理可以基于氧分子对光敏剂染料的三重态和磷光猝灭。收集时变，空间定位的激发光产生的磷光发射。磷光信号的振荡分量的强度或频率用于量化沿着波导的多个有源测量点处的pO2的局部值。可以沿着针的长轴形成包括波导的氧传感器，从而获得组织中pO 2的深度分辨分布。

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