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91. 发明申请

US20130204150A1 SYSTEM FOR ELECTROENCEPHALOGRAPHIC DETECTION OF AN INADEQUACY BETWEEN THE STATE OF A PATIENT PLACED UNDER VENTILATORY SUPPORT AND THE SETTING OF THE MACHINE USED FOR THIS SUPPORT, AND USE OF THIS DETECTION TO ADJUST THE SETTING 有权
标题翻译：用于电离层析检测在通气支持下放置的患者状态之间的不正常的系统以及用于该支持的机器的设置，以及使用该检测来调整设置
公开(公告)号：US20130204150A1
公开(公告)日：2013-08-08
申请号：US13808424
申请日：2011-07-06
申请人： Thomas Similowski , Mathieu Raux , Louise Tyvaert
发明人： Thomas Similowski , Mathieu Raux , Louise Tyvaert
IPC分类号： A61B5/04 , A61M16/00 , A61B5/08
CPC分类号： A61B5/04014 , A61B5/048 , A61B5/08 , A61B5/726 , A61M16/0051 , A61M16/0057 , A61M16/024 , A61M2205/502 , A61M2230/10 , G06K9/00536 , A61M2230/005
摘要： The invention relates to a system for electroencephalographic detection of an improper adjustment of a ventilator used on a mammal. The system includes an electroencephalograph, capable of measuring, as a function of time, an electroencephalographic signal representative of a breathing process; and an input for receiving a respiratory initiation signal, different from the electroencephalographic signal, capable of indicating a respiratory initiation time. The detection system further includes means for specifying a beta frequency band comprised between 15 and 30 Hz and with a width comprising between 5 and 10 Hz; means for processing the measured electroencephalographic signal, configured for processing the measured electroencephalographic signal as it is being acquired, in the sole specified beta frequency band; and means for identifying, for each breathing cycle, an improper adjustment of the ventilator from the electroencephalographic signals processed in the sole beta frequency band.
摘要翻译：本发明涉及一种用于脑电图检测用于哺乳动物的呼吸机的不正确调节的系统。该系统包括能够测量代表呼吸过程的脑电信号作为时间的函数的脑电图仪; 以及用于接收能够指示呼吸起始时间的与脑电信号不同的呼吸起始信号的输入。检测系统还包括用于指定包含在15和30Hz之间并且具有包括5和10Hz之间的宽度的β频带的装置; 用于处理测量的脑电信号的装置，被配置用于在唯一指定的β频带中处理被测量的脑电信号; 以及用于在每个呼吸周期中识别来自在唯一β频带中处理的脑电信号的呼吸机的不正确调节的装置。

92. 发明申请

US20130183706A1 Method for Culturing Adipocytes 审中-公开
标题翻译：培养脂肪细胞的方法
公开(公告)号：US20130183706A1
公开(公告)日：2013-07-18
申请号：US13699232
申请日：2011-05-23
申请人： Danièle Lacasa , Vanessa Pellegrinelli , Mayoura Keophiphath , Karine Clement
发明人： Danièle Lacasa , Vanessa Pellegrinelli , Mayoura Keophiphath , Karine Clement
IPC分类号： C12N5/071
CPC分类号： C12N5/0653 , C12N2501/39 , C12N2533/50 , G01N33/5044
摘要： The present invention relates to a method for culturing adipocytes, in which a homogeneous population of mature adipocytes isolated from adipose tissue is cultured on a three-dimensional culture substrate.
摘要翻译：本发明涉及培养脂肪细胞的方法，其中将从脂肪组织分离的成熟脂肪细胞的均匀群体培养在三维培养基质上。

93. 发明授权

US08487676B2 Device for generating clock signals for asymmetric comparison of phase errors 有权
标题翻译：用于产生不对称比较相位误差的时钟信号的装置
公开(公告)号：US08487676B2
公开(公告)日：2013-07-16
申请号：US13503738
申请日：2010-10-28
申请人： Eric Colinet , Dimitri Galayko , Anton Korniienko
发明人： Eric Colinet , Dimitri Galayko , Anton Korniienko
IPC分类号： H03L7/06
CPC分类号： H03L7/087 , H03L7/07 , H03L7/091 , H03L2207/50
摘要： A device for generating a clock signal, including a phase-locked loop including: a controlled oscillator to deliver a clock signal; plural phase comparators to compare a phase of the clock signal delivered by the controlled oscillator with plural clock signal phases applied at an input of the phase-locked loop; a mechanism for weighted summation of output signals of the plural phase comparators such that one or more of the weighting coefficients applied to one of the output signals has an absolute value that overrides the absolute values of the other weighting coefficients applied to the other output signals; and a mechanism filtering the weighted sum of the output signals of the plural phase comparators, to deliver at an output a control signal to the controlled oscillator.
摘要翻译：一种用于产生时钟信号的装置，包括锁相环，包括：控制振荡器，用于传送时钟信号; 多个相位比较器，用于将由受控振荡器发送的时钟信号的相位与施加在锁相环输入端的多个时钟信号相位进行比较; 用于对所述多个相位比较器的输出信号进行加权求和的机构，使得施加到所述输出信号之一的加权系数中的一个或多个具有覆盖施加到所述其它输出信号的其他加权系数的绝对值的绝对值; 以及滤除多个相位比较器的输出信号的加权和的机构，以将输出的控制信号传送到受控振荡器。

94. 发明申请

US20130160151A1 TRANSGENIC ANIMAL AS A MODEL FOR IDENTIFYING ADULT STEM CELLS, AND USES THEREOF 审中-公开
标题翻译：作为识别成熟干细胞的模型的转基因动物及其用途
公开(公告)号：US20130160151A1
公开(公告)日：2013-06-20
申请号：US13808343
申请日：2011-07-06
申请人： David Sassoon , Vanessa Besson , Giovanna Marazzi
发明人： David Sassoon , Vanessa Besson , Giovanna Marazzi
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , A01K67/0275 , A01K2217/07 , A01K2227/105 , A01K2267/0393 , A61K49/0008 , C12N15/8509
摘要： The present invention relates to the use of a transgenic non-human animal, such as a mouse, expressing a reporter gene detectable by a chromogenic, luminescent or fluorescent signal which identifies the cells that express Pw1, or of Pw1-expressing cells or tissues isolated therefrom, as a model for screening a candidate substance for its ability to stimulate adult stem cells, or for monitoring cell aging.
摘要翻译：本发明涉及表达报告基因的转基因非人动物如表达可通过显色，发光或荧光信号检测的报告基因的用途，其识别表达Pw1的细胞或分离的表达Pw1的细胞或组织作为用于筛选候选物质以刺激成体干细胞的能力或用于监测细胞衰老的模型。

95. 发明申请

US20130096660A1 IMPLANT HAVING THREE-DIMENSIONAL SHAPE FOR ELECTRICALLY STIMULATING A NERVE STRUCTURE 有权
标题翻译：具有三维形状的植入物用于电刺激神经结构
公开(公告)号：US20130096660A1
公开(公告)日：2013-04-18
申请号：US13695097
申请日：2011-04-29
申请人： Henri Lorach , Milan Djilas , Blaise Yvert , Philippe Bergonzo , Gaelle Lissorgues , Lionel Rousseau , Ryad Benjamin Benosman , Serge Picaud , Jose Sahel , Siohoi Ieng
发明人： Henri Lorach , Milan Djilas , Blaise Yvert , Philippe Bergonzo , Gaelle Lissorgues , Lionel Rousseau , Ryad Benjamin Benosman , Serge Picaud , Jose Sahel , Siohoi Ieng
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/025 , A61N1/05 , A61N1/37205
摘要： The invention relates to an implant which includes, in order to electrically stimulate a nerve structure, in particular the retina, an electrically insulating substrate (1), a array of recesses (2) formed in an upper surface of the substrate, stimulation electrodes (3) arranged at the bottom of the recesses, and an electrically conductive layer forming a ground plane (4) at the upper portion of the recesses. The sizes of the recesses and of the electrodes of the implant are such that the spatial selectivity of the stimulation current applied to the nerve structure is maximized
摘要翻译：本发明涉及一种植入物，其包括为了电刺激神经结构，特别是视网膜，电绝缘基底（1），形成在基底上表面的凹槽阵列（2），刺激电极 3）布置在凹部的底部，以及在凹部的上部形成接地平面（4）的导电层。植入物的凹部和电极的尺寸使得施加到神经结构的刺激电流的空间选择性最大化

96. 发明授权

US08420355B2 4S-iota-carrageenan sulfatase and use thereof to obtain alpha-carrageenan 失效
标题翻译： 4S-ι-角叉菜胶硫酸酯酶及其用途来获得α-角叉菜胶
公开(公告)号：US08420355B2
公开(公告)日：2013-04-16
申请号：US13265795
申请日：2010-04-22
申请人： Sabine Joncour Genicot , William Helbert
发明人： Sabine Joncour Genicot , William Helbert
IPC分类号： C12P19/04 , C12N9/16 , C12N15/00 , C12N5/02 , C12N5/04 , C12N1/20 , C12N1/00 , C12Q1/48 , C07K1/14
CPC分类号： C12N9/16 , C12P19/04
摘要： The present invention relates to 4S-iota-carrageenan sulfatase and to the use thereof for partially or totally converting the iota-carrageenan into iota-/alpha-carrageenan or alpha-carrageenan. The invention also relates to the method for extracting said enzyme from a Pseudoalteromonas bacteria population or from red marine algae. Finally, the present invention relates to the use of 4S-iota-carrageenan sulfatase to prepare a texturizing agent containing alpha-carrageenan.
摘要翻译：本发明涉及4S-ι-角叉菜胶硫酸酯酶及其用于部分或全部将ι-角叉菜胶转化为ι-阿卡非卡拉胶或α-角叉菜胶的用途。本发明还涉及从假黄色杆菌属细菌群体或红色海藻中提取所述酶的方法。最后，本发明涉及使用4S-i-角叉菜胶硫酸酯酶来制备含有α-角叉菜胶的组织化剂。

97. 发明申请

US20130065948A2 NUCLEIC ACID MOLECULES AND METHODS FOR EXCHANGING EXON(S) BY TRANSSPLICING 有权
标题翻译：核酸分子和通过转运进行转运的方法
公开(公告)号：US20130065948A2
公开(公告)日：2013-03-14
申请号：US13500612
申请日：2010-10-08
申请人： Luis GARCIA , Stephanie LORAIN
发明人： Luis GARCIA , Stephanie LORAIN
IPC分类号： C07H21/00 , A61K48/00 , A61K31/7088 , C12N15/63 , C12N5/10
CPC分类号： C07K14/4708 , A61K48/005 , C12N15/85 , C12N2840/445 , C12N2840/85
摘要： The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and to mediate a simple or double trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA).
摘要翻译：本发明提供了通过靶向剪接体介导的简单或双转录产生新型核酸分子的方法和组合物。本发明的组合物包括被设计为与靶前体信使RNA分子（靶前mRNA）相互作用并且介导简单或双重反式剪接反应的预转录分子（PTM），导致产生新的嵌合 RNA分子（嵌合RNA）。

98. 发明授权

US08383931B2 Derivatives or dipyrannylidene type as anode interface layer in electronic devices 有权
标题翻译：衍生物或二亚氨基亚型作为电子器件中的阳极界面层
公开(公告)号：US08383931B2
公开(公告)日：2013-02-26
申请号：US12577945
申请日：2009-10-13
申请人： Denis Fichou , Stéphane Berny , Ludovic Tortech
发明人： Denis Fichou , Stéphane Berny , Ludovic Tortech
IPC分类号： H01L31/00
CPC分类号： C07D335/02 , C07D309/34 , C07D407/04 , C07D409/04 , C23C14/12 , H01L51/0036 , H01L51/0065 , H01L51/0068 , H01L51/4253 , H01L51/4273 , H01L51/442 , H01L51/5088 , H01L2251/308 , Y02E10/549 , Y02P70/521 , Y10T428/25
摘要： The present invention relates to substrates coated with films comprising compounds of general formula (I) below: and also to the process for manufacturing them and to their use as anode interface layer in electronic devices. The present invention also relates to organic electroluminescent diodes (OLED), polymeric electroluminescent diodes (PLED), organic field-effect transistors (OFET) and organic solar cells (OSC) comprising a substrate according to the invention, to specific organic solar cells and to the process for manufacturing them.Compounds of formula (I) as such also form part of the invention.
摘要翻译：本发明涉及涂覆有包含以下通式（I）的化合物的膜的基材：以及其制备方法以及它们在电子器件中作为阳极界面层的用途。本发明还涉及有机电致发光二极管（OLED），聚合物电致发光二极管（PLED），有机场效应晶体管（OFET）和包含根据本发明的衬底的有机太阳能电池（OSC）到特定的有机太阳能电池，以及制造它们的过程。式（I）化合物也构成本发明的一部分。

99. 发明申请

US20120283572A1 DEVICE FOR MEASURING THE ACTIVITY OF THE SPINAL CORD OF A VERTEBRA 有权
标题翻译：用于测量VERTEBRA脊柱活动的装置
公开(公告)号：US20120283572A1
公开(公告)日：2012-11-08
申请号：US13509113
申请日：2010-11-10
申请人： Alexandre Goguin , Frederic Lesage , Serge Rossignol , Habib Benali
发明人： Alexandre Goguin , Frederic Lesage , Serge Rossignol , Habib Benali
IPC分类号： A61B5/107 , A61M5/168 , A61N1/36 , A61B6/00 , A61N5/06
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14551 , A61B5/1459 , A61B5/4504 , A61B5/4561 , A61B5/6846 , A61B8/0875 , A61B8/12
摘要： A measurement device for measuring activity of the spinal cord of a vertebrate, wherein the device includes at least one main probe (1) shaped to be fastened to a spinous process (2) of a vertebra (3) and to hold in position on opposite sides of the vertebra at least one emitter (6) for emitting a wave capable of interacting with the spinal cord (7) and at least one associated receiver (8) for receiving the wave that has interacted with the spinal cord and for generating a signal representative of the activity of the spinal cord.
摘要翻译：一种用于测量脊椎动物脊髓活动的测量装置，其中所述装置包括至少一个形成为被固定到椎骨（3）的棘突（2）的主探针（1）并且在相对的位置上保持就位至少一个用于发射能够与脊髓（7）相互作用的波的发射器（6）的至少一个发射器（6）和用于接收与脊髓相互作用并用于产生信号的至少一个相关联的接收器（8）代表脊髓活动。

100. 发明申请

US20120232894A1 DEVICE FOR RECONSTRUCTING SPEECH BY ULTRASONICALLY PROBING THE VOCAL APPARATUS 审中-公开
标题翻译：通过超声波探头来重构语音的设备
公开(公告)号：US20120232894A1
公开(公告)日：2012-09-13
申请号：US13496617
申请日：2010-09-15
申请人： Thomas Hueber , Bruce Denby , Gérard Dreyfus , Rémi Dubois , Perrie Roussel
发明人： Thomas Hueber , Bruce Denby , Gérard Dreyfus , Rémi Dubois , Perrie Roussel
IPC分类号： G10L15/28 , G01S15/06
CPC分类号： G10L15/24 , A61B5/4803 , A61B8/08 , G10L2021/105
摘要： The invention provides a portable device for recognizing and/or reconstructing speech by ultrasound probing of the vocal apparatus, the device including at least one ultrasound transducer (20) for generating an ultrasound wave and for receiving a wave reflected by the user's vocal apparatus, and analysis means for analyzing a signal generated by the ultrasound transducer, wherein the device includes locating means (21, 23) for determining the position of the ultrasound transducer relative to the skull of the user.
摘要翻译：本发明提供了一种用于通过声乐设备的超声波探测识别和/或重建语音的便携式设备，该设备包括用于产生超声波并用于接收用户声乐设备反射的波的至少一个超声换能器（20），以及用于分析由超声换能器产生的信号的分析装置，其中该装置包括用于确定超声换能器相对于使用者头骨的位置的定位装置（21,23）。

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