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91. 发明授权

US5984878A Multi-coating stainless steel guidewire 失效
标题翻译：多层不锈钢导丝
公开(公告)号：US5984878A
公开(公告)日：1999-11-16
申请号：US909623
申请日：1997-08-12
申请人： Erik T. Engelson
发明人： Erik T. Engelson
IPC分类号： A61M25/01 , A61L31/10 , A61M25/09 , A61B5/00
CPC分类号： A61L31/10 , A61M25/09 , A61M2025/09175
摘要： This is a surgical instrument. It is a guidewire made of a stainless steel alloy core which is coated with a non-hydrophilic lubricious polymer on the majority of its length located proximally and a hydrophilic polymer located at the majority of the remaining distal length of the guidewire. Preferably, the guidewire has a polymeric tie layer located between the metallic core of the guidewire assembly and the hydrophilic polymeric layer. The metallic core is one of a number of stainless steels so to preserve its torque transmitting capabilities. Desirably the outside diameter of the guidewire is constant from the distal end to the proximal end. The metallic core may be tapered at appropriate locations along the guidewire assembly.
摘要翻译：这是一种手术器械。它是由不锈钢合金芯制成的导丝，其在位于近端的大部分长度上涂覆有非亲水性润滑聚合物，并且位于导丝的剩余远端长度的大部分处的亲水性聚合物。优选地，导丝具有位于导丝组件的金属芯和亲水性聚合物层之间的聚合物连接层。金属芯是许多不锈钢之一，以保持其扭矩传递能力。理想地，导丝的外径从远端到近端是恒定的。金属芯可以沿着导丝组件的适当位置是锥形的。

92. 发明授权

US5976162A Soft-ended fibered micro vaso-occlusive devices 失效
标题翻译：软端纤维微血管闭塞装置
公开(公告)号：US5976162A
公开(公告)日：1999-11-02
申请号：US42416
申请日：1998-03-13
申请人： Hanh Doan , Kim Nguyen , Hong Doan , Son M. Gia , Liem Ho
发明人： Hanh Doan , Kim Nguyen , Hong Doan , Son M. Gia , Liem Ho
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61M25/00 , A61B17/04
CPC分类号： A61M25/008 , A61B17/12022 , A61B17/1215 , A61B17/12159 , A61B17/12181 , A61B90/39 , A61M2025/0081 , A61M25/0068
摘要： This is a micro-vaso-occlusive device intended generally for occlusion of small arteries located distally in the vasculature. The device is made up of a binder, often radio-opaque, which may be short in length by comparison to the length of the included thrombogenic fibers. The fibers form the other portion of the device. At least one end of the device includes a solid but comparatively soft end typically made of a molten mass of the fibers. The micro device may have multiple binder sections. The fibers may be straight, looped, or tufted.
摘要翻译：这是一种通常用于闭塞位于脉管系统远端的小动脉的微血管闭塞装置。该装置由通常不透射线的粘合剂组成，与所包含的血栓形成纤维的长度相比，其长度可能短。纤维形成装置的另一部分。该装置的至少一端包括通常由纤维的熔融物质制成的固体但相对较软的端部。微型装置可以具有多个粘合剂部分。纤维可以是直的，环状的或簇状的。

93. 发明授权

US5957948A Three dimensional in-filling vaso-occlusive coils 失效
标题翻译：三维填充血管闭塞线圈
公开(公告)号：US5957948A
公开(公告)日：1999-09-28
申请号：US845815
申请日：1997-04-29
申请人： Michael J. Mariant
发明人： Michael J. Mariant
IPC分类号： A61B17/00 , A61B17/12 , A61M29/00
CPC分类号： A61B17/12145 , A61B17/12022 , A61B17/1215
摘要： This is an implantable vaso-occlusive device. It is a complex, helically wound coil comprised of a primary helically wound coil which is then wound into a specific secondary shape. The final shape upon deployment is in the approximate shape of an anatomical cavity. upon deployment, the device first fills the periphery of the cavity and then continues to infill the center. The device is a self-forming shape made from a pre-formed linear helically wound. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the vaso-occlusive device into appropriately shaped forms and annealing them.
摘要翻译：这是一种植入式血管闭塞装置。它是一个复杂的，螺旋缠绕的线圈，其包括初级螺旋缠绕线圈，然后将其缠绕成特定的次级形状。部署后的最终形状为解剖腔的近似形状。在展开时，装置首先填充空腔的周边，然后继续填充中心。该装置是由预先形成的线性螺旋缠绕制成的自形成形状。纤维可以引入到装置上并固定到预成形的线性构件上。构成部件也可以用纤维编织物覆盖。该装置通常通过导管引入。该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。本发明还包括将血管闭塞装置卷绕成适当形状的形状并退火的方法。

94. 发明授权

US5935145A Vaso-occlusive device with attached polymeric materials 失效
标题翻译：具有附着聚合材料的血管闭塞装置
公开(公告)号：US5935145A
公开(公告)日：1999-08-10
申请号：US23564
申请日：1998-02-13
申请人： Francisco S. Villar , Nestor Aganon
发明人： Francisco S. Villar , Nestor Aganon
IPC分类号： A61B17/00 , A61B17/12 , A61M25/16 , A61M29/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12154 , A61B2017/00004
摘要： This is a device for occluding a space within the body, and particularly, it is useful as a vaso-occlusive device. In particular, it typically comprises a metallic core or core member, and two polymeric conjuncts, often polymeric members, of differing thrombogenicity. Typically, the core member will comprise a metallic helically-wound coil; the first polymeric member and second polymeric member will be fibrous materials woven into a braid. These devices may be placed at the desired site within a mammal to facilitate the formation of an occlusion. The inventive device has been found to promote the formation of scar tissue, healing tissue, or neocapillaries in vascular occlusions made by the device.
摘要翻译：这是用于阻塞体内的空间的装置，特别是作为血管闭塞装置是有用的。特别地，其通常包含金属芯或芯构件，以及具有不同血栓形成性的两个聚合物结合物，通常为聚合物构件。通常，芯构件将包括金属螺旋缠绕线圈; 第一聚合物构件和第二聚合物构件将是编织成编织物的纤维材料。这些装置可以放置在哺乳动物内的所需位置以便于形成闭塞。已经发现本发明的装置促进由该装置制成的血管闭塞中的瘢痕组织，愈合组织或新毛囊的形成。

95. 发明授权

US5925683A Liquid embolic agents 失效
公开(公告)号：US5925683A
公开(公告)日：1999-07-20
申请号：US734442
申请日：1996-10-17
申请人： Sangsoo Park
发明人： Sangsoo Park
IPC分类号： A61L31/00 , A61L24/06 , A61L31/04 , A61P43/00 , A61K47/00
CPC分类号： A61L24/06 , A61L31/048 , A61L2430/36
摘要： This relates to a composition of matter comprising partially hydrolyzed polyvinyl acetate solutions suitable for use as embolic agent precursors. In addition, a procedure for introducing the solutions into the human body to form precipitated embolic occlusion masses is shown. Finally, a procedure for treatment of hepatic tumors using portal vein embolism is described.

96. 发明授权

US5911731A Anatomically shaped vasoocclusive devices 失效
标题翻译：解剖形状的血管收缩装置
公开(公告)号：US5911731A
公开(公告)日：1999-06-15
申请号：US949066
申请日：1997-10-10
申请人： Pete Phong Pham , Hong Doan
发明人： Pete Phong Pham , Hong Doan
IPC分类号： A61B17/12 , A61F2/00 , A61F2/01 , A61L31/02 , A61L31/04 , A61L31/06 , B29C53/76 , B29C53/82 , B29C61/00 , B29C61/06
CPC分类号： B29C61/0608 , A61B17/12022 , A61B17/12145 , A61B17/1215 , A61L31/022 , A61L31/048 , A61L31/06 , B29C53/76 , B29C53/821 , B29C61/00 , A61F2/01 , A61F2002/30092 , A61F2210/0014 , B29K2029/00 , B29L2031/753 , B29L2031/7734
摘要： This is a vasoocclusive device which, as used, is in the approximate shape of an anatomical cavity. It may be deployed as a sphere, an ovoid, or other distorted spherical shape. The device is a self-forming shape made from a pre-formed vasoocclusion member. Prior to deployment, the vasoocclusive device is sufficiently straight that it is able to be pushed from a vascular catheter without excessive friction. The vasoocclusion member may be a small helical coil or braid variously comprising a suitable metal, or, in the case of a braid, such metal may be co-woven with various polymeric or natural fibers. Fibers may be introduced onto the device and affixed to the member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vasoocclusive device into appropriately shaped forms and annealing them to form various devices.
摘要翻译：这是一种血管收缩装置，如所用的那样，它们是解剖腔的近似形状。它可以部署为球体，卵球形或其他扭曲的球形。该装置是由预形成的血管闭塞构件制成的自形成形状。在部署之前，血管收缩装置是足够直的，使得能够在没有过度摩擦的情况下从血管导管推动。所述血管吸收构件可以是各种各样地包含合适金属的小螺旋线圈或编织物，或者在编织物的情况下，这种金属可以与各种聚合物或天然纤维共编织。纤维可以被引入到装置上并固定到构件上。构成部件也可以用纤维编织物覆盖。该装置通常通过导管引入。该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。本发明还包括将解剖形状的血管收缩装置卷绕成适当形状的形状并将其退火以形成各种装置的方法。

97. 发明授权

US5895391A Ball lock joint and introducer for vaso-occlusive member 失效
标题翻译：用于血管闭塞成员的球锁接头和引导器
公开(公告)号：US5895391A
公开(公告)日：1999-04-20
申请号：US714932
申请日：1996-09-27
申请人： Roger Farnholtz
发明人： Roger Farnholtz
IPC分类号： A61B17/00 , A61B17/12 , A61F2/82 , A61F11/00
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/1205
摘要： This is an assembly for controllably delivering vaso-occlusive devices to a selected site within the vasculature or other lumen of the human body by the use of a catheter. In particular, the device includes a holding member which is at least generally tubular and has an opening through the tubular wall. The vaso-occlusive device to be delivered has on one end a mating member which may be at least partially pressed into the opening in the wall of the holding member. The mating member attached to the vaso-occlusive member is held in the opening with an interference wire. The interference wire is axially movable within the holding member and has a diameter sufficient to hold the mating member within the wall opening. Upon proximal movement of the interference wire, the mating member becomes free to leave the holding member. The interference wire may be tapered or not. The vaso-occlusive member may be a helically wound coil or a braid or other appropriate form.
摘要翻译：这是一种用于通过使用导管将血管闭塞装置可控地输送到人体内的脉管系统或其他腔内的选定部位的组件。特别地，该装置包括保持构件，该保持构件至少大致为管状且具有通过管状壁的开口。待输送的血管闭塞装置在一端具有可以至少部分地压入保持构件的壁中的开口中的配合构件。连接到血管闭塞构件的配合构件用干涉线保持在开口中。干涉线在保持构件内可轴向移动，并且具有足以将配合构件保持在壁开口内的直径。在干涉丝的近端移动时，配合构件自由离开保持构件。干涉丝可以是锥形的或不是锥形的。血管闭塞性构件可以是螺旋缠绕的线圈或编织物或其它合适的形式。

98. 发明授权

US5891114A Soft-tip high performance braided catheter 失效
标题翻译：软尖高性能编织导管
公开(公告)号：US5891114A
公开(公告)日：1999-04-06
申请号：US941511
申请日：1997-09-30
申请人： Thomas Yung-Hui Chien , Lex P. Jansen , Henry Nita , Jeffrey A. Sarge
发明人： Thomas Yung-Hui Chien , Lex P. Jansen , Henry Nita , Jeffrey A. Sarge
IPC分类号： A61M25/00
CPC分类号： A61M25/0053 , A61M2025/0081 , A61M25/0054
摘要： This is a catheter assembly which may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of a stainless steel or super-elastic alloy ribbon, situated within the catheter body in such a way to create a catheter section having a thin wall, controlled stiffness, and high resistance to kinking. The distal-most section of the catheter is much more flexible than are other braided catheters of the genre due to choice of braid construction features of that distal-most section. The distal-most braid, and optionally, intermediate braid components are constructed to be more flexible than the more proximal sections due to deletion of ribbons from the braid structure, change of ribbon material, and change of pitch. The various sections include braids which may have a consistent pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections also due to the presence of stiff polymeric tubing or composited materials in the stiffer section.
摘要翻译：这是一种导管组件，其可以用于进入身体内的组织靶，通常是可通过血管系统接近的靶。本发明的中心是使用通常为不锈钢或超弹性合金带的编织金属加强件，其位于导管主体内，以便产生具有薄壁，受控刚度和高度的导管部分耐扭结。由于选择最远部分的编织结构特征，导管的最远端部分比其他类型的编织导管更加灵活。最远的编织物和任选的中间编织部件被构造成比近侧部分更柔软，这是由于从编织结构中删除丝带，带状材料的变化和间距的变化。各个部分包括可以具有一致间距的编织物或者可以沿着导管或导管部分的轴线的间距变化。编织带加强构件通常放置在柔性外管构件和内管构件之间以产生非常柔性但高度扭结的导管部分。导管组件的近端部分通常比较远的部分基本上更硬，这也是由于在刚性部分中存在刚性聚合物管或复合材料。

99. 发明授权

US5782811A Kink-resistant braided catheter with distal side holes 失效
标题翻译：具有远端侧孔的抗扭结编织导管
公开(公告)号：US5782811A
公开(公告)日：1998-07-21
申请号：US652701
申请日：1996-05-30
申请人： Gene Samson , Hanh Doan
发明人： Gene Samson , Hanh Doan
IPC分类号： A61L29/00 , A61M25/00 , A61M25/16
CPC分类号： A61M25/005 , A61M2025/0079 , A61M25/0053 , A61M25/007
摘要： This is a catheter section having a number of radially placed holes through the catheter section wall and a catheter assembly including that section. That catheter assembly may be used in accessing and treating a tissue target within the body, typically one which is accessible through the vascular system. Central to the catheter section is the presence of a braided metallic reinforcing member, typically of super-elastic alloy ribbon, situated in such a way to provide an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The orifices in the section are optimally placed in the interstices between the turns of the braid. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The catheter sections made according to this invention may be used alone or in conjunction with other catheter sections either made using the concepts shown herein or made in other ways. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections due to the presence of stiff polymeric tubing or metallic tubing or composited materials in the stiffer section.
摘要翻译：这是具有穿过导管部分壁的多个径向放置的孔的导管部分和包括该部分的导管组件。该导管组件可用于进入和治疗身体内的组织靶，通常是可通过血管系统接近的组织靶。导管部分的中心是存在通常为超弹性合金带的编织金属加强构件，其以这样的方式设置，以提供非常薄的壁，受控刚度，高抗扭结和体内从扭结中完全恢复情况该部分的孔口最佳地放置在编织物匝间的间隙中。编织物可以具有单个间距，或者可以沿着导管或导管部分的轴线变化。编织带加强构件通常放置在柔性外管构件和内管构件之间以产生非常柔性但高度扭结的导管部分。根据本发明制造的导管部分可以单独使用或与使用本文所示的概念或以其他方式制成的其它导管部分结合使用。由于在刚性部分中存在刚性聚合物管或金属管或合成材料，所以导管组件的近端部分通常比较远的部分更坚硬。

100. 发明授权

US5769796A Super-elastic composite guidewire 失效
标题翻译：超弹性复合导丝
公开(公告)号：US5769796A
公开(公告)日：1998-06-23
申请号：US789607
申请日：1997-01-22
申请人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee , Erik T. Engelson , Edward Snyder
发明人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee , Erik T. Engelson , Edward Snyder
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09175
摘要： This is a composite guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni--Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. Variations include multi-section guidewire assemblies having (at least) super-elastic distal portions and super-elastic braided reinforcements along the mid or distal sections. A variation of the inventive guidewire includes the coating of the wire with a tie layer and then with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen.
摘要翻译：这是用于导管的复合导丝，并用于进入患者体内的管腔系统中的目标部位。导丝芯或导丝部分可以是不锈钢或高弹性金属合金，优选Ni-Ti合金，也优选具有特定的物理参数。复合导丝组件对于接近外周或软组织靶是特别有用的。变型包括具有（至少）超弹性远端部分的多段导丝组件和沿着中部或远端部分的超弹性编织加强件。本发明的导丝的变体包括用连接层涂覆线材，然后使用一种或多种润滑聚合物来增强其在导管内和血管腔内部使用的适用性。

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