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91. 发明申请

US20110119259A1 NETWORK BIOLOGY APPROACH FOR IDENTIFYING TARGETS FOR COMBINATION THERAPIES 审中-公开
标题翻译：识别组合治疗目标的网络生物学方法
公开(公告)号：US20110119259A1
公开(公告)日：2011-05-19
申请号：US12989083
申请日：2009-04-24
申请人： James J. Collins , Zheng Li , Ayla Ergun
发明人： James J. Collins , Zheng Li , Ayla Ergun
IPC分类号： G06F17/30
CPC分类号： G16B5/00
摘要： Described herein is a network biology approach useful for the identification of multiple therapeutic targets, which can be targeted simultaneously using an agent (or a plurality of agents) to modulate cellular phenotypes, or in combination with pharmaceutical compounds to improve drug sensitivity and/or reduce drug doses to maintain efficacy while minimizing side effects. The preferred approach disclosed herein relies on first identifying the mediators of a condition of interest, and second, selecting gene combinations that are in competing/parallel pathways as targets for combination therapy.
摘要翻译：本文描述了一种可用于鉴定多种治疗靶标的网络生物学方法，其可以使用试剂（或多种试剂）同时靶向调节细胞表型，或与药物化合物组合以改善药物敏感性和/或降低药物剂量以维持功效，同时尽量减少副作用。本文公开的优选方法依赖于首先鉴定感兴趣病症的介质，其次，选择以竞争/平行途径为基础的组合作为组合疗法的靶标。

92. 发明申请

US20110103434A1 GAIN CONTROL & FREQUENCY STABILITY IN DIGITALLY-CHANNELISED RF BI-DIRECTIONAL AMPLIFIERS 有权
标题翻译：数字通道RF双向放大器的增益控制和频率稳定性
公开(公告)号：US20110103434A1
公开(公告)日：2011-05-05
申请号：US12908910
申请日：2010-10-21
申请人： Lambertus Anthony M. Voskulen , Zheng Li , Mykola Kyrylenko , Michael Leigh Beard , Jack Zaprianov Grozev
发明人： Lambertus Anthony M. Voskulen , Zheng Li , Mykola Kyrylenko , Michael Leigh Beard , Jack Zaprianov Grozev
IPC分类号： H04L25/60 , H04B7/14
CPC分类号： H04B7/15542 , H03G3/3042 , H04B7/15535 , H04B2001/0416
摘要： Improved gain control for a digital signal processing (DSP) repeater, such as a bi-directional repeater, is disclosed. A repeater includes a back-end subsystem which comprises, for each channel in a set of wanted frequency channels that are amplified by the repeater, a coupler (314) arranged to provide a monitor signal corresponding with an output channel power level. A feedback loop (306) receives the monitoring signal, and incorporates a power control circuit (308) that compares the monitored output channel power level with a predetermined maximum output signal level (310). A corresponding control signal is generated, and provided to a variable attenuator (304) in order to maintain the individual output channel power level at or below the maximum output signal level (310). Advantageously, a DSP output level control function (404) is also provided, which maintains the output signal level of each digital channel below a maximum rated value for a digital-to-analogue converter (402). It is also advantageous to provide a front-end subsystem (420) including a variable gain attenuator (424) that is controlled by a signal (430) generated by a digital processing element (428) that monitors an output of an analogue-to-digital converter (426), in order to maintain an IF signal level at the analogue-to-digital converter input below a predetermined threshold value. An improved frequency stability control apparatus (600) and method (800) are also disclosed.
摘要翻译：公开了对诸如双向中继器的数字信号处理（DSP）中继器的改进的增益控制。中继器包括后端子系统，对于由中继器放大的一组有用频率信道中的每个信道，包括：耦合器（314），被配置为提供对应于输出信道功率电平的监视信号。反馈回路（306）接收监视信号，并且包括功率控制电路（308），其将所监视的输出通道功率电平与预定的最大输出信号电平进行比较（310）。产生对应的控制信号，并将其提供给可变衰减器（304），以便将各个输出通道功率电平维持在或等于最大输出信号电平（310）。有利地，还提供DSP输出电平控制功能（404），其将每个数字通道的输出信号电平维持在数模转换器（402）的最大额定值以下。提供包括可变增益衰减器（424）的前端子系统（420）也是有利的，该可变增益衰减器（424）由数字处理元件（428）生成的信号（430）控制，该数字处理元件（428）监视模拟 - 数字转换器（426），以便将模数转换器输入端的IF信号电平维持在预定阈值以下。还公开了一种改进的频率稳定性控制装置（600）和方法（800）。

93. 发明授权

US07868599B2 Method of optimum current blanking time implementation in current sense circuit 有权
标题翻译：电流检测电路实现最佳电流消隐时间的方法
公开(公告)号：US07868599B2
公开(公告)日：2011-01-11
申请号：US11986775
申请日：2007-11-26
申请人： Md Abidur Rahman , Huijuan Li , Brett E. Smith , Zheng Li
发明人： Md Abidur Rahman , Huijuan Li , Brett E. Smith , Zheng Li
IPC分类号： G05F1/00
CPC分类号： G01R19/0092 , H02M3/158 , H02M2001/0009
摘要： In a method and system for sensing current in a switching regulator (SWR) operating in a current mode, a power switch is coupled to receive the current from a switching element, the power switch being controlled by a gate signal. An inrush of the current causes an initial transient spike (ITS). A buffer having a buffer input and a buffer output is coupled to receive the gate signal and provide a buffered gate signal. The buffer output is disabled during the ITS. A sense switch (SW) is coupled to receive a portion of the current from the switching element, the SW being turned on by the buffered gate signal after the initial transient spike. A sense resistor (SR) is coupled to receive the portion of the current from the SW. An amplifier converts the portion of the current through the SR to a voltage signal for controlling the SWR.
摘要翻译：在用于感测以当前模式工作的开关调节器（SWR）中的电流的方法和系统中，电源开关被耦合以从开关元件接收电流，功率开关由门信号控制。电流的浪涌导致初始瞬态尖峰（ITS）。具有缓冲器输入和缓冲器输出的缓冲器被耦合以接收栅极信号并提供缓冲的栅极信号。缓冲区输出在ITS期间被禁用。感测开关（SW）被耦合以从开关元件接收电流的一部分，在初始瞬态尖峰之后，SW被缓冲的栅极信号导通。耦合感测电阻器（SR）以从SW接收电流的一部分。放大器将通过SR的电流的一部分转换成用于控制SWR的电压信号。

94. 发明申请

US20100136541A1 IDENTIFICATION AND VERIFICATION OF METHYLATION MARKER SEQUENCES 审中-公开
标题翻译：甲基标记序列的鉴定和验证
公开(公告)号：US20100136541A1
公开(公告)日：2010-06-03
申请号：US12489502
申请日：2009-06-23
申请人： Chris Beard , Chris Burgess , Allison Gannon , Jeanne Harvey , John F. Lechner , Zheng Li
发明人： Chris Beard , Chris Burgess , Allison Gannon , Jeanne Harvey , John F. Lechner , Zheng Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6827 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2523/125 , C12Q2565/501
摘要： The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also provides methods of using the selected CpG sites for purposes of diagnosis, prognosis, staging, assessing or monitoring the therapy of or recovery from a disease such as cancer.
摘要翻译：本发明涉及在具有疾病的细胞或组织中被下调的基因中鉴定的方法，所述基因在所述基因的CpG岛内具有CpG位点，其中所鉴定的CpG位点具有很大的诊断效用潜力。另一方面，本发明还提供了使用所选择的CpG位点用于诊断，预后，分期，评估或监测疾病如癌症的治疗或恢复的方法。

95. 发明申请

US20100076227A1 FLUIDIZED CATALYTIC PROCESS FOR PRODUCTION OF DIMETHYL ETHER FROM METHANOL 有权
标题翻译：用于从甲醇生产二甲醚的流化催化方法
公开(公告)号：US20100076227A1
公开(公告)日：2010-03-25
申请号：US12594006
申请日：2008-03-27
申请人： Zheng Li , Qiang Fu , Chaogang Xie , Minggang Li , Anguo Mao , Lisheng Li , Genquan Zhu , Fengmei Zhang , Yinbin Luo
发明人： Zheng Li , Qiang Fu , Chaogang Xie , Minggang Li , Anguo Mao , Lisheng Li , Genquan Zhu , Fengmei Zhang , Yinbin Luo
IPC分类号： C07C41/09
CPC分类号： B01J29/90 , B01J29/005 , B01J29/088 , B01J29/46 , B01J29/85 , B01J2229/42 , C07C41/09 , Y02P20/584 , Y02P20/588 , C07C43/043
摘要： The present invention provides a fluidized catalytic process for production of dimethyl ether from methanol, wherein said process is carried out in a reactor in which the catalyst is in a fluidized state. Said process comprises the following steps of (1) feeding the methanol feedstock via two or more locations selected from the bottom, lower part, middle part and upper part of the reactor, contacting with the catalyst for preparation of dimethyl ether by methanol dehydration, carrying out the reaction of preparing dimethyl ether by methanol dehydration to obtain the reaction stream, separating said reaction stream to obtain a coked catalyst and a crude product primarily containing the target product, i.e. dimethyl ether; (2) totally or partially feeding the coked catalyst obtained in step (1) into a regenerator in a continuous or batch manner for regeneration via coke-burning, the regenerated catalyst being directly recycled to step (1) after being totally or partially cooled.
摘要翻译：本发明提供了一种用于从甲醇生产二甲醚的流化催化方法，其中所述方法在催化剂处于流化状态的反应器中进行。所述方法包括以下步骤：（1）经由选自反应器的底部，底部，中部和上部的两个或多个位置进料甲醇原料，与甲醇脱水制备二甲醚的催化剂接触，携带通过甲醇脱水制备二甲醚以获得反应流的反应，分离所述反应流，得到主要含有目标产物（即二甲醚）的焦化催化剂和粗产物; （2）将在步骤（1）中获得的焦化催化剂全部或部分地以连续或间歇方式进料到再生器中，以通过焦炭燃烧再生，再生催化剂在全部或部分冷却后直接再循环到步骤（1）。

96. 发明申请

US20080286860A1 CANCER SPECIFIC PROMOTERS 有权
标题翻译：癌症特异性促进剂
公开(公告)号：US20080286860A1
公开(公告)日：2008-11-20
申请号：US11626655
申请日：2007-01-24
申请人： Mien-Chie Hung , Chi-Ping Day , Kun-Ming Rau , Xiaoming Xie , Zheng Li
发明人： Mien-Chie Hung , Chi-Ping Day , Kun-Ming Rau , Xiaoming Xie , Zheng Li
IPC分类号： C12N15/00
CPC分类号： C07K14/70582 , C07K14/82 , C12N9/93 , C12Q1/6886
摘要： The present invention regards cancer-specific control sequences that direct expression of a polynucleotide encoding a therapeutic gene product for treatment of the cancer. Specifically, the invention encompasses breast cancer-, prostate cancer-, and pancreatic cancer-specific control sequences. Two breast cancer-specific sequences utilize specific regions of topoisomerase IIα and transferrin receptor promoters, particularly in combination with an enhancer. The prostate cancer-specific and pancreatic cancer-specific control sequences utilize composites of tissue-specific control sequences, a two-step transcription amplification sequence, and a post-transcriptional control sequence. In more particular embodiments, these polynucleotides are administered in combination with liposomes.
摘要翻译：本发明涉及指导编码治疗性基因产物的多核苷酸的表达的癌症特异性控制序列，用于治疗癌症。具体地，本发明包括乳腺癌，前列腺癌和胰腺癌特异性控制序列。两个乳腺癌特异性序列利用拓扑异构酶IIal和转铁蛋白受体启动子的特异性区域，特别是与增强子组合。前列腺癌特异性和胰腺癌特异性控制序列利用组织特异性控制序列的复合物，两步转录扩增序列和转录后控制序列。在更具体的实施方案中，这些多核苷酸与脂质体组合施用。

97. 发明申请

US20060256834A1 METHOD AND APPARATUS FOR CONDUCTING PERFORMANCE TEST TO HEAT PIPE 审中-公开
标题翻译：用于对热管进行性能测试的方法和装置
公开(公告)号：US20060256834A1
公开(公告)日：2006-11-16
申请号：US11307588
申请日：2006-02-14
申请人： Chang-Shen Chang , Cheng-Hui Lin , Teng-Tsung Huang , Fei Han , Zheng Li
发明人： Chang-Shen Chang , Cheng-Hui Lin , Teng-Tsung Huang , Fei Han , Zheng Li
IPC分类号： G01N25/72
CPC分类号： F28D15/00 , F28F2200/005 , G01K1/026 , G01K13/00
摘要： Disclosed is a method for testing the performance of a heat pipe and an apparatus for conducting the performance test. The apparatus includes a heating device and a cooling device. Two ends of the heat pipe are thermally connected to the heating device and the cooling device, respectively. The heating device is applied to supply thermal energy to the heat pipe. When the quantity of thermal energy being transferred to the heat pipe reaches to a specified value, the temperatures at the two ends of the heat pipe are detected. If the temperature difference between the two ends is lower than a predetermined value, the heat pipe being tested is deemed as acceptable.
摘要翻译：公开了一种用于测试热管的性能的方法和用于进行性能测试的装置。该装置包括加热装置和冷却装置。热管的两端分别与加热装置和冷却装置热连接。加热装置用于向热管提供热能。当传递到热管的热能量达到规定值时，检测热管两端的温度。如果两端的温差低于预定值，则被测试的热管被认为是可以接受的。

98. 发明授权

US07056663B2 Prognostic methods for breast cancer 有权
公开(公告)号：US07056663B2
公开(公告)日：2006-06-06
申请号：US09816460
申请日：2001-03-23
申请人： Shanaz H. Dairkee , Zheng Li
发明人： Shanaz H. Dairkee , Zheng Li
IPC分类号： C12Q1/68
CPC分类号： G01N33/57415 , A61B10/0041 , C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , G01N2333/723 , G01N2500/10
摘要： Methods of determining the likelihood of the re-occurrence of tumors and of determining the aggressiveness of post-surgical treatment are provided which rely on analysis of a loss of heterogeneity at the particular chromosomal locus 3p24.3. Loss of expression or hypermethylation of the thyroid hormone receptor β1 gene is also predictive of an increased re-occurrence of tumors.

99. 发明授权

US06979237B2 Electrical connector having receptacle contacts 有权
标题翻译：具有插座触点的电连接器
公开(公告)号：US06979237B2
公开(公告)日：2005-12-27
申请号：US10428915
申请日：2003-05-02
申请人： XinHai Xiang , ZenCai Tao , Zheng Li
发明人： XinHai Xiang , ZenCai Tao , Zheng Li
IPC分类号： H01R13/11 , H01R13/115
CPC分类号： H01R13/111
摘要： An electrical connector (1) includes an insulative housing (10) defining a number of passageways (14), and a number of receptacle contacts (20) received in the passageways of the insulative housing. Each receptacle contact has a body portion (22), a pair of arms (30) extending from the body portion, a pair of mating portions (32) formed on free ends of the arms, and a tail portion (24) extending from the body portion. Each mating portion has an upper and a lower enlarged portions (322,321). The upper enlarged portion is vertically aligned with the lower enlarged portion.
摘要翻译：电连接器（1）包括限定多个通道（14）的绝缘壳体（10）和容纳在绝缘壳体的通道中的多个插座触头（20）。每个插座接触件具有主体部分（22），从主体部分延伸的一对臂（30），形成在臂的自由端上的一对配合部分（32）和从所述主体部分延伸的尾部（24）身体部位。每个配合部分具有上部和下部扩大部分（322,321）。上部放大部分与下部放大部分垂直对齐。

100. 发明申请

US20050256063A1 Crystal forms of azithromycin 失效
公开(公告)号：US20050256063A1
公开(公告)日：2005-11-17
申请号：US11123703
申请日：2005-05-06
申请人： Zheng Li , Andrew Trask
发明人： Zheng Li , Andrew Trask
IPC分类号： A61K9/16 , A61K9/28 , A61K31/7052 , A61P31/04 , A61P33/00 , C07H17/00 , C07H17/08
CPC分类号： C07H17/00 , A61K9/1688 , A61K9/2813 , A61K9/2826 , A61K9/2866 , A61K31/7052 , C07H17/08
摘要： The invention relates to novel crystal forms of azithromycin, an antibiotic useful in the treatment of infections.

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