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91. 发明申请

US20130158621A1 ECTOPIC-TRIGGERED PARA-HIS STIMULATION 审中-公开
公开(公告)号：US20130158621A1
公开(公告)日：2013-06-20
申请号：US13716810
申请日：2012-12-17
申请人： Jiang Ding , Allan C. Shuros , Dan Li , Yinghong Yu , Stephen J. Hahn
发明人： Jiang Ding , Allan C. Shuros , Dan Li , Yinghong Yu , Stephen J. Hahn
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02152 , A61B5/0464 , A61B5/0468 , A61N1/365 , A61N1/37 , A61N1/371
摘要： Ectopic cardiac activity can be detected, such as in the absence of a diagnosed tachyarrhythmia episode. In response to the detected ectopic activity, electrostimulation can be provided to a para-Hisian region, such as to activate natural cardiac contraction mechanisms or to interrupt re-entrant cardiac activity. Subsequent ectopic cardiac activity can be detected, and subsequent electrostimulation can be provided to the para-Hisian region, such as according to one or more adjustable electrostimulation parameters.
摘要翻译：可以检测异位心脏活动，例如在没有诊断的快速性心律失常发作时。响应于检测到的异位活动，可以向对等神经区域提供电刺激，例如激活自然心脏收缩机制或中断再入心脏活动。可以检测随后的异位心脏活动，并且可以根据一个或多个可调节的电刺激参数来向对 - Hisian区域提供随后的电刺激。

92. 发明授权

US08280512B2 Identifying heart failure patients suitable for resynchronization therapy using QRS complex width from an intracardiac electrogram 有权
标题翻译：确定适合于使用QRS复合宽度的心脏电图进行再同步治疗的心力衰竭患者
公开(公告)号：US08280512B2
公开(公告)日：2012-10-02
申请号：US12221650
申请日：2008-08-05
申请人： Jiang Ding , Yinghong Yu , Julio C. Spinelli
发明人： Jiang Ding , Yinghong Yu , Julio C. Spinelli
IPC分类号： A61N1/37
CPC分类号： A61B5/053 , A61B5/0452 , A61B5/0456 , A61B5/0472 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/36592 , A61N1/3682
摘要： Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.
摘要翻译：公开了用于确定患者是心脏再同步治疗的应答者的方法和系统。通过从植入患者心脏的一个或多个电极测量的信号来确定内在性心室去极化的开始和结束。计算内在心室去极化的开始和结束之间的间隔，并将其与阈值进行比较。阈值可以凭经验确定。然后可以例如通过基于患者是否对心脏再同步治疗作出积极响应来设定起搏心房延迟来配置诸如起搏器的心脏刺激装置的起搏参数。

93. 发明授权

US08271084B2 Determination of stimulation delay between ventricular sites 有权
标题翻译：确定心室部位之间的刺激延迟
公开(公告)号：US08271084B2
公开(公告)日：2012-09-18
申请号：US12259055
申请日：2008-10-27
申请人： Yinghong Yu , Jiang Ding
发明人： Yinghong Yu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An earlier intrinsic activation and a later intrinsic activation of a right ventricle and a left ventricle are determined. This information is used for computing a biventricular pacing interval as a function of an interval from a pacing energy delivered to a ventricle corresponding to the later intrinsic activation and a depolarization sensed in a ventricle having earlier intrinsic activation, the depolarization evoked in response to the pacing energy.
摘要翻译：确定右心室和左心室的早期内在激活和后期固有激活。该信息用于计算作为从输送到心室的起搏能量对应于后来的内部激活的间隔的函数的计算双心室起搏间隔，以及在具有较早内在激活的心室中感测到的去极化，响应于起搏引起的去极化能源。

94. 发明授权

US08170652B2 Method and apparatus for predicting acute response to cardiac resynchronization therapy 有权
标题翻译：用于预测心脏再同步治疗急性反应的方法和装置
公开(公告)号：US08170652B2
公开(公告)日：2012-05-01
申请号：US11962708
申请日：2007-12-21
申请人： Yinghong Yu , Jiang Ding , Julio Spinelli , Angelo Auricchio
发明人： Yinghong Yu , Jiang Ding , Julio Spinelli , Angelo Auricchio
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A method and apparatus for predicting acute response to cardiac resynchronization therapy is disclosed. The method can comprise measuring a first interval during an intrinsic systolic cycle and measuring a second interval during a stimulated systolic cycle. The acute response can be predicted by comparing the percent change in duration between the first interval and the second interval against a pre-determined threshold value. The first and second time intervals can be measured using, for example, a surface ECG or, alternatively, an intracardiac electrogram. In one embodiment, the first interval can be the duration of an intrinsic QRS complex measured during a non-stimulated systolic cycle. Similarly, the second interval can be the duration of a stimulated QRS complex measured during a stimulated systolic cycle.
摘要翻译：公开了用于预测心脏再同步治疗的急性反应的方法和装置。该方法可以包括在本征收缩周期期间测量第一间隔并且在刺激的收缩期期间测量第二间隔。可以通过将第一间隔和第二间隔之间的持续时间的百分比变化与预定阈值进行比较来预测急性反应。第一和第二时间间隔可以使用例如表面ECG或者心内电描记图来测量。在一个实施例中，第一间隔可以是在非刺激的收缩期期间测量的固有QRS复合物的持续时间。类似地，第二间隔可以是在刺激的收缩期期间测量的受激QRS复合物的持续时间。

95. 发明申请

US20110092836A1 METHOD AND APPARATUS FOR DETERMINING THE CORONARY SINUS VEIN BRANCH ACCESSED BY A CORONARY SINUS LEAD 有权
标题翻译：用于确定冠状动脉导管接收的冠状动脉支架的方法和装置
公开(公告)号：US20110092836A1
公开(公告)日：2011-04-21
申请号：US12976397
申请日：2010-12-22
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
IPC分类号： A61B5/0408
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

96. 发明申请

US20110054557A1 DYNAMIC DEVICE THERAPY CONTROL FOR TREATING POST MYOCARDIAL INFARCTION PATIENTS 有权
标题翻译：用于治疗心肌梗死患者的动态装置治疗控制
公开(公告)号：US20110054557A1
公开(公告)日：2011-03-03
申请号：US12942471
申请日：2010-11-09
申请人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
发明人： Yinghong Yu , Jiang Ding , Joseph M. Pastore
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.
摘要翻译：心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行后重建控制。

97. 发明授权

US07856270B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US07856270B2
公开(公告)日：2010-12-21
申请号：US11049181
申请日：2005-02-02
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

98. 发明授权

US07580745B2 Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy 有权
标题翻译：心率变异性控制起搏治疗最大跟踪率的方法和装置
公开(公告)号：US07580745B2
公开(公告)日：2009-08-25
申请号：US11037723
申请日：2005-01-18
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/36592 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。

99. 发明申请

US20090198299A1 METHOD AND APPARATUS FOR OPTIMIZING VENTRICULAR SYNCHRONY DURING DDD RESYNCHRONIZATION THERAPY USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS 有权
标题翻译：使用可调节ATRIO-VENTRICULAR延迟在DDD再生治疗中优化心脏同步的方法和装置
公开(公告)号：US20090198299A1
公开(公告)日：2009-08-06
申请号：US12424136
申请日：2009-04-15
申请人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/36564 , A61N1/368 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟心室起搏脉冲的最佳时机。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

100. 发明申请

US20090163971A1 THERAPY CALCULATION AND THERAPY DELIVERY MODES 审中-公开
标题翻译：治疗计算和治疗方式
公开(公告)号：US20090163971A1
公开(公告)日：2009-06-25
申请号：US12336036
申请日：2008-12-16
申请人： Yinghong Yu , Jiang Ding
发明人： Yinghong Yu , Jiang Ding
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/3682
摘要： A therapy can be provided using a therapy control parameter calculated using physiological data received at a first time. The therapy can be inhibited at a second time and the therapy control parameter can be recalculated using physiological data received at or near the second time while the therapy is inhibited, and the therapy can be provided using the recomputed therapy control parameter.
摘要翻译：可以使用使用在第一次接收的生理数据计算的治疗控制参数来提供治疗。可以第二次抑制治疗，并且可以在治疗被抑制时使用在第二次或接近第二次时接收的生理数据来重新计算治疗控制参数，并且可以使用重新计算的治疗控制参数来提供治疗。

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