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91. 发明申请

US20130045200A1 METHODS OF USING ANTI-PD-L1 ANTIBODIES AND THEIR USE TO TREAT INFECTION RESULTING FROM T-CELL DYSFUNCTION 审中-公开
标题翻译：使用抗PD-L1抗体的方法及其用于治疗由T细胞功能丧失的感染
公开(公告)号：US20130045200A1
公开(公告)日：2013-02-21
申请号：US13478421
申请日：2012-05-23
申请人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung
发明人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung
IPC分类号： A61K39/395 , A61P31/00 , A61P31/12 , A61P37/00
CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/489 , Y02A50/492 , A61K2300/00
摘要： The present application relates to methods of using anti-PD-L1 antibodies to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
摘要翻译：本申请涉及使用抗PD-L1抗体来增强T细胞功能以上调细胞介导的免疫应答和治疗T细胞功能障碍（包括感染（例如急性和慢性））和肿瘤免疫的方法。

92. 发明申请

US20120322989A1 CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES 失效
标题翻译：神经磷酸酯片段和神经营养因子 - 抗体复合物的晶体结构
公开(公告)号：US20120322989A1
公开(公告)日：2012-12-20
申请号：US13541411
申请日：2012-07-03
申请人： Brent A. APPLETON , Christian Wiesmann , Yan Wu
发明人： Brent A. APPLETON , Christian Wiesmann , Yan Wu
IPC分类号： C07K19/00
CPC分类号： C07K14/71 , C07K16/2863 , C07K2299/00 , C07K2317/55 , C07K2317/76
摘要： The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
摘要翻译：本发明提供单独的神经蛋白1（Nrp1）和神经毡蛋白2（Nrp2）片段与抗神经蛋白抗体复合物的晶体结构及其使用方法。本发明进一步提供抗Nrp抗体及其治疗应用的方法。

93. 发明申请

US20120294861A1 FGFR1 AGONISTS AND METHODS OF USE 有权
标题翻译： FGFR1激动剂及其使用方法
公开(公告)号：US20120294861A1
公开(公告)日：2012-11-22
申请号：US13472352
申请日：2012-05-15
申请人： Junichiro Sonoda , Yan Wu
发明人： Junichiro Sonoda , Yan Wu
IPC分类号： A61K39/395 , C12N15/13 , A61P3/00 , A61P3/04 , A61P1/16 , A61P3/06 , A61P9/12 , A61P3/10 , A61P5/50 , A61P9/00 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C12P21/02 , C07K16/28
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/75 , C07K2317/92
摘要： The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.
摘要翻译：本发明提供FGFR1激动剂，包括激动性抗FGFR1抗体及其使用方法。

94. 发明授权

US08274758B2 Composite writer shield for improving writer performance 有权
标题翻译：复合作家盾，提高作家的表现
公开(公告)号：US08274758B2
公开(公告)日：2012-09-25
申请号：US12157683
申请日：2008-06-12
申请人： Yan Wu , Kowang Liu
发明人： Yan Wu , Kowang Liu
IPC分类号： G11B5/147
CPC分类号： G11B5/3146 , G11B5/11 , G11B5/1278 , G11B5/3136
摘要： A PMR writer in a read/write head is disclosed wherein an upper shield covering the coil layer is comprised of a magnetic layer optimized for magnetic performance and a second layer used for tuning mechanical protrusion. The composite layer simultaneously provides high saturation magnetization and high permeability from the magnetic layer and low CTE from the second layer which tunes the relative spacing between the writer, reader, and the rest of the slider. In one embodiment, first and second write shields are formed on a write gap layer and have front portions at the ABS and back portions in a back gap region. The upper write shield connects on one side with the second write shield at the ABS and on a second side with the back gap region. This design can yield better reader and writer spacing for the same physical clearance which enables products with higher recording density.
摘要翻译：公开了一种读/写头中的PMR写入器，其中覆盖线圈层的上屏蔽包括针对磁性能优化的磁性层和用于调谐机械突起的第二层。复合层同时提供来自磁性层的高饱和磁化强度和高磁导率和来自第二层的低CTE，其调节写入器，读取器和滑块的其余部分之间的相对间隔。在一个实施例中，第一和第二写屏蔽形成在写间隙层上并且在ABS的前部和后间隙区中的后部形成。上写入屏蔽在一侧与ABS的第二写屏蔽连接，并且在第二侧与后间隙区域相连。该设计可以为相同的物理间隙产生更好的读取器和写入器间距，从而使具有更高记录密度的产品。

95. 发明申请

US20120156129A1 NOVEL ANTIBODIES 有权
公开(公告)号：US20120156129A1
公开(公告)日：2012-06-21
申请号：US13112839
申请日：2011-05-20
申请人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
IPC分类号： A61K39/395 , A61K51/10 , A61P35/00
CPC分类号： C07K16/2842 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising novel anti-α5β1 antibodies and methods of making and using them.

96. 发明授权

US08101365B2 Anti-EphB4 antibodies and methods using same 有权
标题翻译：抗EphB4抗体及其使用方法
公开(公告)号：US08101365B2
公开(公告)日：2012-01-24
申请号：US12160084
申请日：2007-01-04
申请人： Yan Wu , Minhong Yan
发明人： Yan Wu , Minhong Yan
IPC分类号： C12P21/08 , G01N33/53 , C07H21/04
CPC分类号： C07K16/2866 , A61K39/0011 , A61K2039/505 , C07K16/30 , C07K2317/33 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The invention provides anti-EphB4 antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译：本发明提供了抗EphB4抗体，组合物和使用这些抗体的方法。

97. 发明申请

US20110256146A1 NEUROPILIN ANTAGONISTS 有权
标题翻译：神经毒素拮抗剂
公开(公告)号：US20110256146A1
公开(公告)日：2011-10-20
申请号：US13173890
申请日：2011-06-30
申请人： Ryan J. Watts , Yan Wu
发明人： Ryan J. Watts , Yan Wu
IPC分类号： A61K39/395 , A61P35/04 , C07K16/22
CPC分类号： C07K16/2863 , A61K31/404 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/661 , A61K31/69 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K16/22 , C07K16/3023 , C07K2317/31 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译：公开了具有独特结构和功能特征的新型NRP1抗体及其变体。还提供了抗体在研究，诊断和治疗应用中的用途。

98. 发明授权

US07970064B2 Transmitter, method for generating a plurality of long preambles and communication device 有权
标题翻译：发射机，用于产生多个长前导码和通信设备的方法
公开(公告)号：US07970064B2
公开(公告)日：2011-06-28
申请号：US11573682
申请日：2005-08-13
申请人： Ho Wang Fung , Sumei Sun , Chin Keong Ho , Ying Chang Liang , Yan Wu , Zhongding Lei
发明人： Ho Wang Fung , Sumei Sun , Chin Keong Ho , Ying Chang Liang , Yan Wu , Zhongding Lei
IPC分类号： H04K1/10
CPC分类号： H04L27/2613 , H04L27/266 , H04L27/2675 , H04L2027/0028 , H04L2027/0048 , H04L2027/0095
摘要： A transmitter that has a determination unit for determining a plurality of symbols (301) such that each symbol (301) has a tail component (302) and the plurality is determined in such a way that the tail components (302) are substantially equal and a tone generation unit for arranging the plurality of symbols (301) to form a plurality of long preambles (300) such that the plurality of long preambles (300) are tone-interleaved.
摘要翻译：一种具有用于确定多个符号（301）的确定单元的发送器，使得每个符号（301）具有尾部分量（302），并且以使尾部分量（302）基本相等的方式确定多个，音调生成单元，用于将多个符号（301）排列成多个长前导码（300），使得多个长前导码（300）被进行音调交织。

99. 发明申请

US20110059013A1 ANTI-ROBO4 ANTIBODIES AND USES THEREFOR 审中-公开
公开(公告)号：US20110059013A1
公开(公告)日：2011-03-10
申请号：US12888316
申请日：2010-09-22
申请人： Alexander W. Koch , Scott Stawicki , Yan Wu , Richard Carano , Franklin V. Peale, JR. , Ryan J. Watts
发明人： Alexander W. Koch , Scott Stawicki , Yan Wu , Richard Carano , Franklin V. Peale, JR. , Ryan J. Watts
IPC分类号： A61K49/00 , A61K51/10
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/30 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The invention provides anti-Robo4 antibodies, and compositions comprising the antibodies and methods of using these antibodies, including diagnostic and therapeutic methods.

100. 发明授权

US07876670B2 Method for transmitting data, method for receiving data, transmitter, receiver, and computer program products 有权
标题翻译：发送数据的方法，接收数据的方法，发射机，接收机和计算机程序产品
公开(公告)号：US07876670B2
公开(公告)日：2011-01-25
申请号：US11815381
申请日：2006-02-02
申请人： Yuan Li , Sumei Sun , Yan Wu
发明人： Yuan Li , Sumei Sun , Yan Wu
IPC分类号： H04J11/00
CPC分类号： H04L1/0041 , H03M13/11 , H03M13/1148 , H03M13/255 , H03M13/356 , H04L1/0058 , H04L1/0071 , H04L5/0023 , H04L27/34 , H04L2001/0098
摘要： A method for transmitting data comprising a plurality of bits is described wherein the data is mapped to a plurality of modulation symbols, each modulation symbol comprising at least one more significant bit and at least one less significant bit, at least one parity bit is generated for the plurality of bits and the plurality of bits are mapped to more significant bits of the plurality of modulation symbols and the at least one parity bit is mapped to at least one less significant bit of the plurality of modulation symbols.
摘要翻译：描述了一种用于发送包括多个位的数据的方法，其中将数据映射到多个调制符号，每个调制符号包括至少一个更高有效位和至少一个较低有效位，至少一个奇偶校验位被产生用于多个位和多个位被映射到多个调制符号中的更高有效位，并且至少一个奇偶校验位被映射到多个调制符号中的至少一个较低有效位。

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