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91. 发明授权

US07354924B2 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives 有权
标题翻译：取代的氮杂脱氧乙酸哌嗪衍生物的组成和抗病毒活性
公开(公告)号：US07354924B2
公开(公告)日：2008-04-08
申请号：US10969675
申请日：2004-10-20
申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda
IPC分类号： A61K31/496 , C07D487/02 , A61K31/497 , A61K31/501 , A61K31/506
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048
摘要： This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. Compound I is wherein: Q is selected from the group consisting of: m is 1 or 2; —W— is A is selected from the group consisting of C1-6alkoxy, aryl and heteroaryl; in which said aryl is phenyl or napthyl; said heteroaryl is selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, triazinyl, furanyl, thienyl, pyrrolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, quinolinyl, isoquinolinyl, benzofuranyl, benzothienyl, benzoimidazolyl and benzothiazolyl; and said aryl or heteroaryl is optionally substituted with one or two of the same or different members selected from the group consisting of amino, nitro, cyano, hydroxy, C1-6alkoxy, —C(O)NH2; and C1-6alkyl, —NHC(O)CH3, halogen and trifluoromethyl.
摘要翻译：本发明提供具有药物和生物影响性质的化合物I，其药物组合物和使用方法。特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。化合物I是其中：Q选自：m是1或2; -W-是A选自C 1-6烷氧基，芳基和杂芳基; 其中所述芳基是苯基或萘基; 吡啶基，吡嗪基，咪唑基，噻唑基，异噻唑基，恶唑基，异恶唑基，喹啉基，异喹啉基，苯并呋喃基，苯并噻吩基，苯并咪唑基和苯并噻唑基; 并且所述芳基或杂芳基任选被一个或两个相同或不同的选自氨基，硝基，氰基，羟基，C 1-6烷氧基，-C（O） NH 2; 和C 1-6烷基，-NHC（O）CH 3，卤素和三氟甲基。

92. 发明申请

US20070249579A1 DIKETO-PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS 有权
标题翻译：作为抗病毒剂的二酮 - 哌嗪和哌啶衍生物
公开(公告)号：US20070249579A1
公开(公告)日：2007-10-25
申请号：US11733283
申请日：2007-04-10
申请人： Tao Wang , John F. Kadow , Zhongxing Zhang , Zhiwei Yin , Nicholas A. Meanwell , Alicia Regueiro-Ren , Jacob Swidorski , Ying Han , David J. Carini
发明人： Tao Wang , John F. Kadow , Zhongxing Zhang , Zhiwei Yin , Nicholas A. Meanwell , Alicia Regueiro-Ren , Jacob Swidorski , Ying Han , David J. Carini
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , C07D471/02
CPC分类号： C07D471/04 , C07D403/12 , C07D417/14
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with diketo piperazine and piperadine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译：本公开提供了具有药物和生物影响性质的化合物，其药物组合物和使用方法。特别地，本公开涉及具有独特抗病毒活性的二酮哌嗪和哌嗪衍生物。更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。

93. 发明申请

US20070076936A1 Fast alignment of large-scale sequences using linear space techniques 审中-公开
标题翻译：使用线性空间技术快速对齐大规模序列
公开(公告)号：US20070076936A1
公开(公告)日：2007-04-05
申请号：US11240763
申请日：2005-09-30
申请人： Eric Li , Tao Wang , Yi Zhang
发明人： Eric Li , Tao Wang , Yi Zhang
IPC分类号： G06K9/00 , G06K9/62 , G06F19/00
CPC分类号： G16B30/00 , G06K9/6206
摘要： Large scale sequences and other types of patterns may be matched or aligned quickly using a linear space technique. In one embodiment, the invention includes, calculating a similarity matrix of a first sequence against a second sequence, determining a lowest cost path through the matrix, where cost is a function of sequence alignment, dividing the similarity matrix into a plurality of blocks, determining local start points on the lowest cost path, the local start points each corresponding to a block through which the lowest cost path passes, dividing sequence alignment computation for the lowest cost path into a plurality of independent problems based on the local start points, solving each independent problem independently, and concatenating the solutions to generate an alignment path of the first sequence against the second sequence.
摘要翻译：使用线性空间技术可以快速匹配或对齐大规模序列和其他类型的图案。在一个实施例中，本发明包括：计算第一序列与第二序列的相似度矩阵，确定通过矩阵的最低成本路径，其中成本是序列比对的函数，将相似性矩阵划分为多个块，确定最低成本路径上的本地起始点，每个对应于最低成本路径通过的块的本地起始点，基于本地起始点将最低成本路径的序列比对计算分解为多个独立问题，解决每个独立的问题，并且连接解决方案以产生第一序列与第二序列的对准路径。

94. 发明申请

US20060287531A1 Indole, azaindole and related heterocyclic pyrrolidine derivatives 审中-公开
公开(公告)号：US20060287531A1
公开(公告)日：2006-12-21
申请号：US11511123
申请日：2006-08-28
申请人： John Kadow , Qiufen Xue , Tao Wang , Zhongxing Zhang , Nicholas Meanwell
发明人： John Kadow , Qiufen Xue , Tao Wang , Zhongxing Zhang , Nicholas Meanwell
IPC分类号： C07D471/02 , C07D209/42
CPC分类号： C07D403/06 , C07D403/04 , C07D403/12 , C07D403/14 , C07D471/04
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

95. 发明申请

US20060247450A1 Exo- and diastereo- selective syntheses of himbacine analogs 有权
公开(公告)号：US20060247450A1
公开(公告)日：2006-11-02
申请号：US11331324
申请日：2006-01-12
申请人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
发明人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
IPC分类号： C07D307/02
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

96. 发明申请

US20060217422A1 Exo-selective synthesis of himbacine analogs 有权
标题翻译：非选择性合成替卡宾类似物
公开(公告)号：US20060217422A1
公开(公告)日：2006-09-28
申请号：US11330521
申请日：2006-01-12
申请人： Tiruvettipuram Thiruvengadam , Anantha Sudhakar , Ngiap Lim , Daw-long Kwok , George Wu , Tao Wang , Mingsheng Huang , Michael Green
发明人： Tiruvettipuram Thiruvengadam , Anantha Sudhakar , Ngiap Lim , Daw-long Kwok , George Wu , Tao Wang , Mingsheng Huang , Michael Green
IPC分类号： C07D405/02 , A61K31/4433
CPC分类号： C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
摘要翻译：本申请公开了一种用于合成烟肼类似物的新方法，以及由此制备的化合物。合成通过包括环状缩酮酰胺途径，手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。由此制备的化合物可用作凝血酶受体拮抗剂。本文公开的化学例如以下合成顺序：

97. 发明授权

US06486093B2 Vinyl acetate catalyst comprising metallic palladium and gold prepared with potassium aurate 有权
标题翻译：乙酸乙烯酯催化剂，包含金属钯和金，由金属钴制成
公开(公告)号：US06486093B2
公开(公告)日：2002-11-26
申请号：US09933214
申请日：2001-08-20
申请人： Tao Wang , Jerry A. Broussard
发明人： Tao Wang , Jerry A. Broussard
IPC分类号： B01J2358
CPC分类号： B01J23/52 , B01J35/008 , C07C67/055 , C07C69/01 , C07C69/15
摘要： A catalyst for the production of vinyl acetate by reaction of ethylene, oxygen and acetic acid comprising a porous support on the porous surfaces of which is deposited catalytically effective amounts of metallic palladium and gold, said catalyst having been prepared by steps comprising impregnating a porous support, the porous surfaces of which contain a catalytically effective amount of a prereduced metallic palladium, with a solution of potassium aurate, and reducing the potassium aurate to a catalytically effective amount of metallic gold. Alternate embodiments are also disclosed.
摘要翻译：一种用于通过乙烯，氧和乙酸的反应生产乙酸乙烯酯的催化剂，其包含多孔载体的多孔表面被沉积有催化有效量的金属钯和金，所述催化剂通过以下步骤制备，所述步骤包括浸渍多孔载体，其多孔表面含有催化有效量的预还原的金属钯，与钴酸钾的溶液一起，并将醇酸钾还原成催化有效量的金属金。还公开了替代实施例。

98. 发明授权

US06346501B1 Catalyst based on palladium, cadmium, alkali and lanthanoids and a method for producing vinyl acetate 失效
标题翻译：基于钯，镉，碱和镧系元素的催化剂及其生产乙酸乙烯酯的方法
公开(公告)号：US06346501B1
公开(公告)日：2002-02-12
申请号：US09581462
申请日：2000-07-20
申请人： Bernhard Herzog , Tao Wang , Ioan Nicolau
发明人： Bernhard Herzog , Tao Wang , Ioan Nicolau
IPC分类号： B01J2360
CPC分类号： B01J23/63 , B01J23/60 , C07C67/055 , C07C69/01 , C07C69/15
摘要： The invention relates to a catalyst which contains palladium and/or compounds thereof, cadmium compounds, alkali metal compounds and at least one lanthanoid metal. The invention also relates to the utilization of the catalyst in order to produce vinyl acetate from acetic acid, ethylene and oxygen or gases containing oxygen.
摘要翻译：本发明涉及含有钯和/或其化合物，镉化合物，碱金属化合物和至少一种镧系金属的催化剂。本发明还涉及使用催化剂以从乙酸，乙烯和氧气或含氧气体制备乙酸乙烯酯。

99. 发明授权

US06303537B1 Vinyl acetate catalyst comprising metallic palladium and gold and prepared utilizing sonication 失效
标题翻译：乙酸乙烯酯催化剂，包括金属钯和金，并使用超声处理制备
公开(公告)号：US06303537B1
公开(公告)日：2001-10-16
申请号：US09441603
申请日：1999-11-17
申请人： Tao Wang , Jerry A. Broussard , H. Robert Gerberich
发明人： Tao Wang , Jerry A. Broussard , H. Robert Gerberich
IPC分类号： B01J2358
CPC分类号： B01J37/343 , B01J23/44 , B01J23/52 , B01J23/58 , B01J37/0203 , B01J37/0205 , C07C67/055 , C07C69/01 , C07C69/15
摘要： A catalyst effective for the production of vinyl acetate by reaction of ethylene, oxygen and acetic acid, comprising a porous support on the porous surfaces of which is deposited catalytically effective amounts of metallic palladium and gold, and prepared by steps comprising impregnating the support with one or more aqueous solutions of water-soluble compounds of the metals, fixing the metals on the support as water-insoluble compounds in one or more fixing steps by reaction with an appropriate alkaline compound, and reducing the water-insoluble compounds of the catalytically active metals to their free metallic form in one or more reducing steps, at least one of the said reducing steps being carried out in an aqueous medium containing a reducing agent dissolved therein or through which a gaseous reducing agent is bubbled, and in which the support containing the fixed water-insoluble metal compounds is immersed, while sonicating, i.e., applying ultrasound waves to, such aqueous medium.
摘要翻译：通过乙烯，氧气和乙酸的反应生产乙酸乙烯酯有效的催化剂，包括多孔表面上的多孔载体沉积有催化有效量的金属钯和金，并通过以下步骤制备，包括用一种浸渍载体或更多的水溶性金属化合物的水溶液，通过与适当的碱性化合物反应在一个或多个固定步骤中将金属固定在载体上作为水不溶性化合物，并还原催化活性金属的水不溶性化合物在一个或多个还原步骤中以至少一种所述还原步骤在含有还原剂溶解在其中的还原剂的水性介质中进行，或通过该还原剂鼓泡气体还原剂，其中含有固定的不溶于水的金属化合物被浸没，同时超声处理，即对这种水性介质施加超声波。

100. 发明授权

US6017847A Vinyl acetate catalyst prepared with potassium aurate and comprising metallic palladium and gold on a carrier precoated with copper 失效
标题翻译：乙酸乙烯酯催化剂，其用钴酸钾制备，并在预涂有铜的载体上包含金属钯和金
公开(公告)号：US6017847A
公开(公告)日：2000-01-25
申请号：US88287
申请日：1998-06-02
申请人： Tao Wang
发明人： Tao Wang
IPC分类号： B01J23/52 , B01J23/58 , B01J23/89 , B01J37/03 , C07C67/055 , C07C69/15 , B01J23/72 , B01J23/42
CPC分类号： B01J23/8926 , B01J23/52 , C07C67/055
摘要： A catalyst for the production of vinyl acetate by reaction of ethylene, oxygen and acetic acid, comprising a porous support on the porous surfaces of which is deposited catalytically effective amounts of metallic copper, palladium and gold. The catalyst is prepared by steps comprising precoating the support with a water-insoluble form of copper, forming on the precoated support a water-insoluble palladium compound, reducing the palladium compound, and, if not previously reduced, the water-insoluble form of copper, to a catalytically effective amount of the free metal, impregnating the copper and palladium containing support with a solution of potassium aurate, and reducing the potassium aurate to a catalytically effective amount of metallic gold. The inventive process results in a catalyst wherein the Pd, Cu, and Au form a shell metal distribution on the catalyst support.
摘要翻译：用于通过乙烯，氧气和乙酸的反应生产乙酸乙烯酯的催化剂，其包含多孔表面上的多孔载体沉积有催化有效量的金属铜，钯和金。催化剂是通过以下步骤制备的，其步骤包括用水不溶性形式的铜预涂涂料，在预涂载的载体上形成水不溶性钯化合物，还原钯化合物，如果不是先前还原，则不溶于水的铜，催化有效量的游离金属，用钴酸钾溶液浸渍含有铜和钯的载体，并将钴酸钾还原成催化有效量的金属金。本发明的方法产生催化剂，其中Pd，Cu和Au在催化剂载体上形成壳金属分布。

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