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91. 发明授权

US06790648B2 DNA fragmentation factor involved in apoptosis 失效
标题翻译：涉及细胞凋亡的DNA片段因子
公开(公告)号：US06790648B2
公开(公告)日：2004-09-14
申请号：US09748451
申请日：2000-12-22
申请人： Xiaodong Wang , Xuesong Liu
发明人： Xiaodong Wang , Xuesong Liu
IPC分类号： C12N922
CPC分类号： G01N33/5011 , C07K14/4747
摘要： The invention provides methods and compositions relating to DNA Fragmentation Factor (DFF) polypeptides and related nucleic acids. More particularly, the present invention provides the sequence for the active subunit of DFF. The polypeptides may be produced recombinantly from host cells transformed from the disclosed DFF encoding nucleic acids or purified from human cells. The invention provides isolated DFF, hybridization probes and primers capable of specifically hybridization with the disclosed DFF genes, DFF-specific binding agents such as specific antibodies, and methods of making and using the subject compositions.
摘要翻译：本发明提供了与DNA片段化因子（DFF）多肽和相关核酸相关的方法和组合物。更具体地，本发明提供了DFF的活性亚基的序列。多肽可以从从所公开的DFF编码核酸转化的宿主细胞重组产生或从人细胞中纯化。本发明提供能够与所公开的DFF基因，DFF特异性结合剂如特异性抗体进行特异性杂交的分离的DFF，杂交探针和引物，以及制备和使用所述主题组合物的方法。

92. 发明授权

US06737849B2 Constant current source having a controlled temperature coefficient 有权
标题翻译：具有受控温度系数的恒流源
公开(公告)号：US06737849B2
公开(公告)日：2004-05-18
申请号：US10173628
申请日：2002-06-19
申请人： Aria Eshraghi , Xiaodong Wang
发明人： Aria Eshraghi , Xiaodong Wang
IPC分类号： G05F316
CPC分类号： G05F3/30 , Y10S323/907
摘要： A bandgap circuit for producing a constant current having a controllable temperature coefficient. A current mirror supplies first and second substantially identical currents to first and second bipolar transistors. A first resistor is connected across the emitters of the bipolar transistors. A second resistor connects one to the bipolar emitters to a common terminal where the current source currents are recombined and supplied to a common terminal of a power supply. The band gap voltage produced at the common base connections of the bipolar transistors have a voltage temperature coefficient which is controlled by the values of the resistors. A current source is coupled to receive the bandgap voltage and produces a current having a temperature coefficient corresponding to the voltage temperature coefficient of the bandgap voltage.
摘要翻译：一种用于产生具有可控温度系数的恒定电流的带隙电路。电流镜向第一和第二双极晶体管提供第一和第二基本相同的电流。第一电阻器连接在双极晶体管的发射极之间。第二个电阻将一个与双极发射极连接到公共端，其中电流源电流被重组并提供给电源的公共端。在双极晶体管的公共基极连接处产生的带隙电压具有由电阻器的值控制的电压温度系数。耦合电流源以接收带隙电压并产生具有对应于带隙电压的电压温度系数的温度系数的电流。

93. 发明授权

US06725025B1 Interference cancellation among wireless units using Gibbs sampling 有权
标题翻译：使用Gibbs采样的无线单元之间的干扰消除
公开(公告)号：US06725025B1
公开(公告)日：2004-04-20
申请号：US09665843
申请日：2000-09-20
申请人： Timothy M. Schmidl , Alan Gatherer , Xiaodong Wang , Rong Chen
发明人： Timothy M. Schmidl , Alan Gatherer , Xiaodong Wang , Rong Chen
IPC分类号： H04B106
CPC分类号： H04B1/71075 , H04L25/067
摘要： An improved interference cancellation technique is disclosed. Digital baseband circuitry (40) includes user and symbol detection circuitry (50) for performing a Gibbs sampler type of interference cancellation, either embodied in custom hardware (44) or in software. Random initial guesses for a signal sample (either a symbol or chip) are made for each user. Interference cancellation is performed on a user-by-user basis, using the then-current data decision values for the other, interfering users. A soft data decision is used to derive a probability distribution function for the actual data decision for the sample for the user. A randomly selected value is applied against the probability distribution function to generate the next data decision value for that user, and the process is repeated until convergence. Following convergence, a statistic is used to select a final data decision value for each user, from the set of intermediate data decision values stored in memory.
摘要翻译：公开了一种改进的干扰消除技术。数字基带电路（40）包括用于执行Gibbs采样器类型的干扰消除的用户和符号检测电路（50），或者体现在定制硬件（44）中或软件中。为每个用户制作信号样本（符号或芯片）的随机初始猜测。干扰消除是在逐个用户的基础上，使用当时的其他干扰用户的当前数据判定值进行的。软数据决策用于导出用于用户的样本的实际数据决定的概率分布函数。对概率分布函数应用随机选择的值以生成该用户的下一个数据判定值，并重复该过程直到收敛。收敛后，根据存储在存储器中的一组中间数据判定值，使用统计量为每个用户选择最终数据判定值。

94. 发明授权

US06608026B1 Apoptotic compounds 有权
标题翻译：凋亡化合物
公开(公告)号：US06608026B1
公开(公告)日：2003-08-19
申请号：US09645075
申请日：2000-08-23
申请人： Xiaodong Wang , Chunying Du
发明人： Xiaodong Wang , Chunying Du
IPC分类号： A01N3718
CPC分类号： A61K38/07 , A61K38/08 , C07K14/4747
摘要： The invention provides methods and compositions for enhancing apoptosis of pathogenic cells. The general method comprises the of contacting the cells with an effective amount of an AV peptoid, wherein the AV peptoid is a peptide comprising AX1, wherein X1 is V, I or L, or a peptide mimetic thereof, which interacts with an Inhibitor of Apoptosis protein (IAP) as measured by IAP binding, procaspase-3 activation or promotion of apoptosis, wherein apoptosis of the pathogenic cells is enhanced. The subject compositions encompass pharmaceutical compositions comprising a therapeutically effective amount of a subject AV peptoid in dosage form and a pharmaceutically acceptable carrier, wherein the AV peptoid is a peptide comprising AX1, wherein X1 is V, I or L, or a peptide mimetic thereof, which inhibits the activity of an Inhibitor of Apoptosis protein (IAP) as measured by IAP binding, procaspase-3 activation or promotion of apoptosis. The invention also provides assays for identifying agents which modulates the interaction of an AV peptoid with an IAP, active compounds identified in such screens and their use in the foregoing compositions and therapeutic methods.
摘要翻译：本发明提供了增强致病细胞凋亡的方法和组合物。一般方法包括使细胞与有效量的AV拟肽接触，其中AV拟肽是包含AX1的肽，其中X1是V，I或L或其肽模拟物，其与抑制剂的凋亡相互作用蛋白质（IAP），通过IAP结合测定，胱天蛋白酶原-3活化或促进凋亡，其中致病细胞的凋亡增强。主题组合物包含药物组合物，其包含治疗有效量的剂型AV药物和药学上可接受的载体，其中AV拟肽是包含AX1的肽，其中X1是V，I或L，或其模拟肽，其通过IAP结合，胱天蛋白酶原-3活化或促进凋亡测量来抑制凋亡抑制蛋白抑制剂（IAP）的活性。本发明还提供用于鉴定调节AV拟肽与IAP的相互作用的测定法，在该筛选中鉴定的活性化合物及其在前述组合物和治疗方法中的用途。

95. 发明授权

US06558900B2 Regulation of apoptosis and in vitro model for studies thereof 失效
标题翻译：细胞凋亡调控及体外模型研究
公开(公告)号：US06558900B2
公开(公告)日：2003-05-06
申请号：US08891525
申请日：1997-07-11
申请人： Xiaodong Wang , Xuesong Liu
发明人： Xiaodong Wang , Xuesong Liu
IPC分类号： C12Q168
CPC分类号： G01N33/5011 , G01N33/5008 , G01N2510/00
摘要： A cell-free system based on the cytosol of normally growing cells, which reproduces measurable aspects of the apoptotic program, is provided. The apoptotic program is initiated by addition of DATP in the specific exemplification of the HeLa 100,000×g supernatant. Fractionation of the cytosol yielded a 15 kDa protein, identified by absorption spectrum and protein sequence as cytochrome c, that is required for in vitro apoptosis. Elimination of cytochrome c from cytosol by immunodepletion or inclusion of sucrose to stabilize mitochondria during cytosol preparation, diminished the apoptotic activity. Addition of exogenous cytochrome c to cytochrome c-depleted extracts restored apoptotic activity. Cells undergoing apoptosis in vivo showed increased release of cytochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
摘要翻译：提供了基于正常生长细胞的细胞溶质的无细胞系统，其再现了可凋亡程序的可测量方面。通过在HeLa 100,000xg上清液的具体示例中加入DATP来启动凋亡程序。细胞质分离得到15kDa蛋白质，通过吸收光谱和蛋白质序列鉴定为细胞色素c，这是体外凋亡所必需的。通过免疫缺损或包含蔗糖在细胞质溶胶制备过程中消除细胞色素c从细胞质溶液中稳定线粒体，减少细胞凋亡活性。将外源细胞色素c加入到细胞色素c耗竭的提取物中恢复凋亡活性。体内细胞凋亡的细胞显示细胞色素c释放到其细胞溶质中，这表明线粒体可能通过释放细胞色素c而在细胞凋亡中起作用。

96. 发明授权

US06291643B1 Apaf-1 an activator of caspase-3 失效
标题翻译： Apaf-1是caspase-3的激活剂
公开(公告)号：US06291643B1
公开(公告)日：2001-09-18
申请号：US09092508
申请日：1998-06-05
申请人： Hua Zou , William J. Henzel , Xiaodong Wang
发明人： Hua Zou , William J. Henzel , Xiaodong Wang
IPC分类号： C07R1400
CPC分类号： C07K14/4747 , A01K2217/075 , A61K38/00 , C07K2319/00
摘要： Novel polypeptides, designated Apaf-1, which are capable of modulating apoptosis are provided. Compositions including Apaf-1 chimeras, nucleic acid encoding Apaf-1, and antibodies to Apaf-1 are also provided.
摘要翻译：提供了能够调节凋亡的新型多肽，称为Apaf-1。还提供了包括Apaf-1嵌合体，编码Apaf-1的核酸和Apaf-1抗体的组合物。

97. 发明授权

US6110691A Activators of caspases 有权
标题翻译：胱天蛋白酶的活化剂
公开(公告)号：US6110691A
公开(公告)日：2000-08-29
申请号：US479309
申请日：2000-01-06
申请人： Xiaodong Wang , Chunying Du
发明人： Xiaodong Wang , Chunying Du
IPC分类号： G01N33/50 , C07K14/47 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/53
CPC分类号： C07K14/4747
摘要： The invention provides methods and compositions relating to polypeptide activators of caspases such as polypeptide and polynucleotide sequences diagnostic of caspase activators. These sequences, and polypeptides and polynucleotides embodying these sequences, find a wide variety of diagnostic and therapeutic applications involving detecting and/or modulating expression and/or function of activators or caspases or genes or transcripts encoding such activators and generating genetic and immunogenic probes specific to activators of caspases.
摘要翻译：本发明提供了与胱天蛋白酶的多肽激活剂相关的方法和组合物，例如胱天蛋白酶激活剂诊断的多肽和多核苷酸序列。体现这些序列的这些序列，多肽和多核苷酸发现了广泛的诊断和治疗应用，涉及检测和/或调节激活剂或胱天蛋白酶或编码这种激活剂的基因或转录物的表达和/或功能，并产生特异性的遗传和免疫原性探针胱天蛋白酶的激活剂。

98. 发明申请

US20210111769A1 SYSTEMS, METHODS, AND MEDIA FOR RECOVERING DATA SYMBOLS IN MULTIPLE-INPUT, MULTIPLE-OUTPUT RECEIVERS 有权
公开(公告)号：US20210111769A1
公开(公告)日：2021-04-15
申请号：US17067281
申请日：2020-10-09
申请人： Xiaodong Wang
发明人： Xiaodong Wang
IPC分类号： H04B7/0417 , H04B7/0426 , H04B7/0456
摘要： Mechanisms for recovering data symbols in multiple-input, multiple-output (MIMO) receivers, the mechanisms comprising receiving, at Na antennas that each have an output: first signals corresponding to Np pilot symbols transmitted from each of K transmitters for a total of Np*K transmitted pilot symbols; and second signals corresponding to a plurality of transmitted data symbols transmitted from the K transmitters, wherein Np is less than Na, and wherein K is less than Na; receiving, at a hardware processor, first digital signals representing the Np*K transmitted pilot symbols; receiving, at the hardware processor, second digital signals representing the plurality of transmitted data symbols; and recovering the plurality of transmitted data symbols using the second digital signals and no more pilot symbols than the Np*K transmitted pilot symbols represented by the first digital signals using the hardware processor.

99. 发明授权

US09352224B2 Gathering path data from a massively multiplayer on-line role-playing game 有权
标题翻译：从大型多人在线角色扮演游戏收集路径数据
公开(公告)号：US09352224B2
公开(公告)日：2016-05-31
申请号：US13499746
申请日：2011-10-11
申请人： Xiaodong Wang , Jun Fang
发明人： Xiaodong Wang , Jun Fang
IPC分类号： A63F13/12 , A63F13/30 , G06N3/00
CPC分类号： A63F13/35 , A63F13/12 , A63F13/573 , A63F13/65 , A63F13/822 , A63F2300/535 , A63F2300/646 , A63F2300/69 , A63F2300/807 , G06N3/006
摘要： Technologies are generally disclosed for gathering path data from a massively multiplayer on-line role-playing game to determine a path through a mapping plane that may be a real-world or virtual-world representation.
摘要翻译：通常公开了用于从大型多人在线角色扮演游戏收集路径数据的技术，以确定通过可能是真实世界或虚拟世界表示的映射平面的路径。

100. 发明授权

US09324024B2 Pseudo message recognition based on ontology reasoning 有权
标题翻译：基于本体推理的伪消息识别
公开(公告)号：US09324024B2
公开(公告)日：2016-04-26
申请号：US13810815
申请日：2012-02-03
申请人： Xiaodong Wang , Jun Fang
发明人： Xiaodong Wang , Jun Fang
IPC分类号： G06F17/00 , G06N5/02 , G06N5/04
CPC分类号： G06N5/025 , G06N5/02 , G06N5/022 , G06N5/04 , H04L63/0407
摘要： In some examples, a method for recognizing a pseudo message is described. The method may include receiving a message intended for a recipient having an associated recipient Ontology. The method may also include semantically analyzing content of the message to determine whether the content is inconsistent with any rules in the recipient Ontology. The method may also include, upon a determination that the content is inconsistent with a rule in the recipient Ontology, authenticating the message as a pseudo message.
摘要翻译：在一些示例中，描述了用于识别伪消息的方法。该方法可以包括接收针对具有相关联的接收者本体的接收者的消息。该方法还可以包括语义上分析消息的内容以确定内容是否与接收者本体中的任何规则不一致。该方法还可以包括在确定内容与接受者本体中的规则不一致时将该消息认证为伪消息。

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