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91. 发明申请

US20110245820A1 APPARATUS FOR ENHANCING BRIGHTNESS OF A WAVELENGTH CONVERTING ELEMENT 有权
标题翻译：用于增强波长转换元件亮度的装置
公开(公告)号：US20110245820A1
公开(公告)日：2011-10-06
申请号：US12751127
申请日：2010-03-31
申请人： Michael James Papac , Christopher Horvath
发明人： Michael James Papac , Christopher Horvath
IPC分类号： A61B1/07
CPC分类号： A61B3/0008 , A61B1/0653 , A61B1/0669 , F21K9/64 , G02B6/0003 , G02B6/0006 , G02F1/353 , H01L33/505 , H01L33/507
摘要： Disclosed is an exemplary illumination device for enhancing the brightness of wavelength converting element. The illumination device includes a wavelength converting element operable for receiving light from a light source at a first wavelength range and converting the light to a second wavelength range. The wavelength converting element includes a first face, a second face opposite the first face, and a side edge extending between the first and second faces. A reflective optical element is arranged adjacent the side edge of the wave converting element. The reflective optical element is configured to reflect light in at least the first wavelength range toward the wavelength converting element.
摘要翻译：公开了一种用于增强波长转换元件的亮度的示例性照明装置。照明装置包括波长转换元件，其可操作用于从第一波长范围的光源接收光并将光转换成第二波长范围。波长转换元件包括第一面，与第一面相对的第二面，以及在第一和第二面之间延伸的侧边缘。反射型光学元件布置成与波转换元件的侧边相邻。反射光学元件被配置为将至少第一波长范围内的光反射到波长转换元件。

92. 发明申请

US20110149592A1 LIGHT COLLECTOR FOR A WHITE LIGHT LED ILLUMINATOR 审中-公开
标题翻译：用于白光LED照明器的集光器
公开(公告)号：US20110149592A1
公开(公告)日：2011-06-23
申请号：US12961946
申请日：2010-12-07
申请人： Alexander N. Artsyukhovich , Mikhail Boukhny , Ronald T. Smith , Christopher Horvath
发明人： Alexander N. Artsyukhovich , Mikhail Boukhny , Ronald T. Smith , Christopher Horvath
IPC分类号： H01L33/00
CPC分类号： G02B19/0028 , G02B19/0061 , H01L33/58
摘要： A white light source includes a light-emitting diode (LED) configured to emit white light in an angular distribution. The white light source further includes a light guide and a light collector configured to collect light across the angular distribution. The light collected by the light collector contributes to a total luminous flux of the white light coupled into the light guide.
摘要翻译：白光源包括被配置为以角度分布发射白光的发光二极管（LED）。白光源还包括导光体和被配置为收集角度分布上的光的集光器。由光收集器收集的光有助于耦合到光导中的白光的总光通量。

93. 发明申请

US20110037948A1 White light emitting diode (LED) illuminator for ophthalmic endoillumination 有权
标题翻译：白光发光二极管（LED）照明器用于眼内光照射
公开(公告)号：US20110037948A1
公开(公告)日：2011-02-17
申请号：US12845216
申请日：2010-07-28
申请人： Christopher Horvath , Michael J. Papac , Ronald T. Smith , Michael J. Yadlowsky
发明人： Christopher Horvath , Michael J. Papac , Ronald T. Smith , Michael J. Yadlowsky
IPC分类号： A61B3/10
CPC分类号： A61B3/0008 , A61B1/0653 , A61B1/0684
摘要： An ophthalmic endoilluminator is provided. The ophthalmic endoilluminator includes one or more white light emitting diodes (LEDs), an additional light source, a first optical assembly, an optical coupling element, and an optical fiber optically coupled to the optical coupling element. The white LED is capped with a phosphor layer. The additional light source illuminates at least a portion of an exterior surface of the phosphor layer within an absorption band of phosphor material of the phosphor layer in order to excite the phosphor layer and produce additional white light. The first optical assembly receives and substantially collimates the white light. The optical coupling element receives the substantially collimated white light from the first optical assembly and directs the light to an optical fiber. The optical fiber is then used to conduct the white light into an eye.
摘要翻译：提供了一种眼科内照射器。眼科内窥镜包括一个或多个白光发光二极管（LED），附加光源，第一光学组件，光耦合元件以及与光耦合元件光耦合的光纤。白色LED用磷光体层盖住。附加光源在荧光体层的荧光体材料的吸收带内照亮荧光体层的外表面的至少一部分，以激发荧光体层并产生额外的白光。第一光学组件接收并基本准直白光。光耦合元件接收来自第一光学组件的基本准直的白光，并将光引导到光纤。然后使用光纤将白光导入眼睛。

94. 发明授权

US07781941B2 Footswitch operable to control a surgical system 有权
标题翻译：脚踏开关可操作以控制外科系统
公开(公告)号：US07781941B2
公开(公告)日：2010-08-24
申请号：US11389808
申请日：2006-03-27
申请人： Christopher Horvath , Mark Buczek , T. Scott Rowe
发明人： Christopher Horvath , Mark Buczek , T. Scott Rowe
IPC分类号： H01L41/113 , G05G1/30
CPC分类号： G05G1/38 , A61B17/00 , A61B34/20 , A61B2017/00119 , A61B2017/00194 , A61B2017/00199 , A61B2017/00221 , A61B2017/00973 , A61C1/0023 , H01H21/26 , H01H2239/076 , H01H2300/014 , H01H2300/03 , Y02B70/3241 , Y04S20/227 , Y10T74/2054 , Y10T74/20888 , Y10T307/747
摘要： The present invention provides a surgical footswitch that includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator. The pedal mounts upon the base and pivots. The encoder assembly couples to the pedal. As the pedal pivots, the encoder assembly translates the mechanical signal of the pedal into a control signal based on the pedals position and/or orientation. The wireless interface couples the encoder assembly to receive the control signal. The wireless interface also couples the surgical footswitch to a surgical console operable to control and direct surgical equipment. The wireless interface passes the control signal from the encoder to the surgical console, which then directs the surgical equipment based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in the surgical theater. The internal power generator translates footswitch movement into stored energy to eliminate potential failures of the footswitch during a procedure and overcome the need to replace batteries within the footswitch.
摘要翻译：本发明提供了一种手术脚踏开关，其包括底座，踏板，编码器组件，无线接口和内部发电机。踏板安装在底座上并枢转。编码器组件耦合到踏板。当踏板枢转时，编码器组件基于踏板位置和/或方向将踏板的机械信号转换为控制信号。无线接口耦合编码器组件以接收控制信号。无线接口还将手术脚踏开关连接到可操作以控制和引导手术设备的外科手术台。无线接口将控制信号从编码器传递到外科控制台，然后控制信号根据控制信号引导外科设备。这种无线接口消除了电线或绳索的缠结，这可能是外科手术室的危险。内部发电机将脚踏开关转换为储存的能量，以消除脚踏开关在程序期间的潜在故障，并克服了更换脚踏开关内的电池的需要。

95. 发明申请

US20080004609A1 APPARATUS AND METHOD FOR AUTO-TITRATING A LASER 有权
标题翻译：用于自动投射激光的装置和方法
公开(公告)号：US20080004609A1
公开(公告)日：2008-01-03
申请号：US11768576
申请日：2007-06-26
申请人： Christopher Horvath
发明人： Christopher Horvath
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61F9/00821 , A61F9/00823 , A61F2009/00863 , A61F2009/00868
摘要： An apparatus and method for auto-titrating a surgical laser are disclosed. One embodiment of the method comprises: providing an algorithm, wherein the algorithm is operable to configure the laser based on one or more user inputs; providing a first user input operable to cause the algorithm to execute and fire the laser in a defined pattern; providing a second user input, in response to an observed condition, operable to cause the laser to stop firing and to cause the algorithm to determine one or more laser parameter values and configure the laser based on the one or more laser parameter values, wherein a final laser power value when the laser stops firing is an input to the algorithm and wherein the algorithm determines the one or more laser parameters based on the final laser power value. The method can further comprise placing the laser in a “ready” (surgical) mode, either automatically by the auto-titration algorithm or via another user input. Once in a ready mode, a user, such as a surgeon, can perform a surgical procedure with the automatically configured laser. The user inputs can be provided by activating a control switch, such as the footswitch typically used by ophthalmic surgeons to control the operation of an ophthalmic surgical laser.
摘要翻译：公开了一种用于自动滴定手术激光的装置和方法。该方法的一个实施例包括：提供一种算法，其中该算法可操作以基于一个或多个用户输入来配置激光; 提供第一用户输入，其可操作以使所述算法以限定的模式执行和激发所述激光; 提供响应于观察条件的第二用户输入，其可操作以使激光停止点火，并使算法确定一个或多个激光参数值，并且基于一个或多个激光参数值配置激光，其中a 当激光停止点火时的最终激光功率值是算法的输入，并且其中该算法基于最终的激光功率值确定一个或多个激光参数。该方法还可以包括通过自动滴定算法或通过另一用户输入自动地将激光置于“准备”（外科）模式。一旦处于就绪模式，用户（例如外科医生）可以用自动配置的激光器执行外科手术。用户输入可以通过激活控制开关来提供，例如通常由眼科医生使用的脚踏开关来控制眼科手术激光器的操作。

96. 发明授权

US07189224B2 System and method for improved material processing using a laser beam 有权
标题翻译：使用激光束改善材料处理的系统和方法
公开(公告)号：US07189224B2
公开(公告)日：2007-03-13
申请号：US11083793
申请日：2005-03-18
申请人： Ronald M. Kurtz , Tibor Juhasz , Peter Goldstein , Imre Hegedus , Christopher Horvath , Gordon Scott Scholler , Alan W. Berg
发明人： Ronald M. Kurtz , Tibor Juhasz , Peter Goldstein , Imre Hegedus , Christopher Horvath , Gordon Scott Scholler , Alan W. Berg
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00827 , A61F9/00836 , A61F2009/00872 , A61F2009/00897
摘要： A method and system for improved material processing using a laser beam. The method and system includes directing a laser beam above, at or below the surface of the material in one or more preferred patterns and with preferred laser pulse characteristics specific to the material to reduce or mitigate the accumulation or effects of gas, debris, fluid, or other by-products of photodisruption either at the location where additional laser pulses are being placed or in other sensitive locations in the material.
摘要翻译：一种使用激光束改进材料处理的方法和系统。该方法和系统包括以一种或多种优选图案将激光束引导到材料表面上方或下方，并且具有对材料特有的优选激光脉冲特性，以减少或减轻气体，碎片，流体，或者在其他激光脉冲被放置的位置处或在材料中的其它敏感位置的光致破坏的其他副产物。

97. 发明申请

US20050214299A1 Method of inhibiting stenosis and restenosis 审中-公开
标题翻译：抑制狭窄和再狭窄的方法
公开(公告)号：US20050214299A1
公开(公告)日：2005-09-29
申请号：US10662061
申请日：2003-09-12
申请人： Christopher Horvath , Patricia Rao
发明人： Christopher Horvath , Patricia Rao
IPC分类号： A61K45/06 , A61K39/395 , A61M29/02 , A61M31/00 , A61P9/10 , A61P9/14 , C07K16/28 , C07K16/36
CPC分类号： C07K16/2866 , A61K2039/505 , A61M25/104 , C07K16/2845 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD18 or CCR2.
摘要翻译：本发明涉及一种抑制受试者狭窄或再狭窄的方法。在一个实施方案中，向有需要的受试者施用抑制嗜中性粒细胞和单核细胞向血管损伤部位的募集和/或粘附的药剂。在另一个实施方案中，将抑制嗜中性粒细胞募集和/或粘附到血管损伤部位的第一药剂和抑制单核细胞募集和/或粘附到血管损伤部位的第二药剂施用于需要的受试者其中。在具体实施方案中，所述试剂是结合CD18或CCR2的抗体或其抗原结合片段。

98. 发明授权

US06727349B1 Recombinant anti-CCR2 antibodies and methods of use therefor 有权
标题翻译：重组抗CCR2抗体及其用途的方法
公开(公告)号：US06727349B1
公开(公告)日：2004-04-27
申请号：US09497625
申请日：2000-02-03
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： C07K1600
CPC分类号： C07K14/7158 , A61K2039/505 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译：本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。

99. 发明授权

US06696550B2 Humanized anti-CCR2 antibodies and methods of use therefor 有权
标题翻译：人源化抗CCR2抗体及其使用方法
公开(公告)号：US06696550B2
公开(公告)日：2004-02-24
申请号：US09840459
申请日：2001-04-23
申请人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
发明人： Gregory J. LaRosa , Christopher Horvath , Walter Newman , S. Tarran Jones , Siobhan H. O'Brien , Theresa O'Keefe
IPC分类号： C07K1600
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
摘要翻译：本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。

100. 发明授权

US6081543A Stretcher-compressor assembly having a single grating 失效
标题翻译：具有单个光栅的担架压缩机组件
公开(公告)号：US6081543A
公开(公告)日：2000-06-27
申请号：US79334
申请日：1998-05-14
申请人： Xinbing Liu , Alan Braun , Christopher Horvath
发明人： Xinbing Liu , Alan Braun , Christopher Horvath
IPC分类号： H01S3/00 , H01S3/08
CPC分类号： H01S3/0057
摘要： The invention provides a compact, combined stretcher-compressor assembly which utilizes a single grating element. The single grating element is preferably a holographic transmission grating element. The grating element has first and second surfaces which are opposed major surfaces with a thickness between the surfaces. The grating pattern is patterned in or on the grating element. The grating element is arranged in the assembly to receive a beam for stretching laser pulses in a stretcher beam path, and in the same arrangement, to receive a beam for compressing laser beam pulses in a compressor beam path. The stretcher and compressor beam paths pass through the single grating element. Respective reflecting means are arranged to provide a desired number of passes through the grating element by the stretcher beam path, and through the grating element by the compressor beam path.
摘要翻译：本发明提供了一种使用单个光栅元件的紧凑的组合的拉伸 - 压缩机组件。单个光栅元件优选为全息透射光栅元件。光栅元件具有第一和第二表面，它们是相对的主表面之间的厚度。光栅图案被图案化在光栅元件中或栅格元件上。光栅元件被布置在组件中以接收用于在担架光束路径中拉伸激光脉冲的光束，并且在相同的布置中，接收用于压缩压缩机光束路径中的激光束脉冲的光束。担架和压缩机光束路径通过单个光栅元件。各个反射装置被布置成通过担架射束路径提供期望数量的通过光栅元件的通过，并且通过压缩机光束路径通过光栅元件。

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