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91. 发明授权

US07056466B2 Method of manufacture medical devices employing microwave energy 失效
公开(公告)号：US07056466B2
公开(公告)日：2006-06-06
申请号：US10212926
申请日：2002-08-06
申请人： Lixiao Wang , Jan Weber
发明人： Lixiao Wang , Jan Weber
IPC分类号： B29C35/08
CPC分类号： B29C49/78 , A61M25/1027 , A61M25/1029 , A61M25/1036 , B29C33/06 , B29C45/14655 , B29C47/0026 , B29C47/003 , B29C47/0071 , B29C47/86 , B29C47/862 , B29C47/8805 , B29C47/8835 , B29C47/90 , B29C47/903 , B29C47/907 , B29C47/908 , B29C49/0042 , B29C49/783 , B29C2035/0855 , B29C2049/0089 , B29K2105/258 , B29L2022/022 , B29L2031/7542 , H05B6/80
摘要： An apparatus and method for molding balloon catheters is disclosed. The balloon may be molded by providing a polymeric tube within a mold having an interior cavity in the shape of the desired balloon. Microwave energy, which may be generated by a gyrotron, may then be directed toward the mold, to heat the polymeric material without heating the mold. Once heated, pressurized fluid may be injected into the tube to blow the polymeric material against the interior cavity whereupon the material can cool to form the balloon or can be further heatset by additional microwave energy and be cooled to form the balloon. In accordance with one embodiment, microwave energy can also be used without a mold to form a medical device.

92. 发明申请

US20050228428A1 Balloon catheters and methods for manufacturing balloons for balloon catheters 审中-公开
标题翻译：球囊导管及球囊导管球囊的制造方法
公开(公告)号：US20050228428A1
公开(公告)日：2005-10-13
申请号：US10819469
申请日：2004-04-07
申请人： Afsar Ali , Daniel Horn , Jan Weber , Scott Schewe
发明人： Afsar Ali , Daniel Horn , Jan Weber , Scott Schewe
IPC分类号： A61F2/958 , A61M25/00 , B29C35/08 , B29C49/00 , B29C49/14 , B29C55/00 , A61M29/00 , B29C49/64
CPC分类号： A61M25/1027 , A61M2025/1063 , B29C49/00 , B29C2035/0838 , B29C2035/0855 , B29C2049/0089 , B29C2791/001 , B29C2791/009 , B29K2105/258 , B29L2031/7542
摘要： Catheters, balloons, and methods of manufacturing balloons for balloon catheters using lasers are disclosed. A catheter with a shaft sized for use with a 0.014 inch guide wire includes a polymeric balloon having a body portion with an inflated outer diameter of more than 6 millimeters. An inflatable balloon includes an inflated outer diameter to inner waist diameter ratio of 12.5 to 1. An inflatable polymeric balloon that has a body portion with two regions that have different molecular orientations is also provided. A method of processing an elongate polymeric material includes heating a portion of the polymeric material with a laser while longitudinally stretching the portion of the polymeric material. A method of manufacturing a balloon includes heating and longitudinally stretching a first and second portion of an elongate polymeric tube to form first and second end portion. The remaining body portion is radially expanded to form the balloon.
摘要翻译：公开了使用激光器的球囊导管制造气球的导管，球囊和方法。具有尺寸与0.014英寸导丝一起使用的轴的导管包括具有膨胀外径大于6毫米的主体部分的聚合物球囊。可充气气囊包括膨胀的外径至内腰直径比为12.5:1。还提供具有主体部分的充气聚合球囊，其具有不同分子取向的两个区域。处理细长聚合材料的方法包括在纵向拉伸聚合材料的一部分的同时用激光加热聚合材料的一部分。制造球囊的方法包括加热并纵向拉伸细长聚合物管的第一和第二部分以形成第一和第二端部。剩余的主体部分被径向扩张以形成气球。

93. 发明申请

US20050187603A1 Rotatable catheter assembly 有权
标题翻译：可旋转导管组件
公开(公告)号：US20050187603A1
公开(公告)日：2005-08-25
申请号：US10915209
申请日：2004-08-10
申请人： Tracee Eidenschink , Jan Weber
发明人： Tracee Eidenschink , Jan Weber
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/84
CPC分类号： A61F2/954 , A61F2/856 , A61F2/958 , A61F2210/008 , A61F2250/0003 , A61M25/10 , A61M25/1006 , A61M2025/0058 , A61M2025/1015 , A61M2025/1056
摘要： A catheter assembly comprises a catheter shaft, a balloon and a pair of collars engaged to the catheter shaft. Each collar has a body portion and at least one lip portion extending radially outward from the body portion. Each collar has a nonactivated state and an activated state, wherein in the nonactivated state the balloon is rotatable about the collars and each lip portion is constructed and arranged to abut a portion of the balloon to prevent the balloon from moving longitudinally relative thereto. In the activated state the body portion of each collar is sealingly engaged to at least a portion of the balloon.
摘要翻译：导管组件包括导管轴，气囊和接合到导管轴的一对凸缘。每个轴环具有主体部分和从主体部分径向向外延伸的至少一个唇部。每个衣领都具有非活动状态和活动状态，其中在非活动状态下，气囊可围绕套环旋转，并且每个唇部被构造和布置成邻接球囊的一部分以防止球囊相对于其纵向移动。在激活状态下，每个颈圈的主体部分密封地接合到球囊的至少一部分。

94. 发明申请

US20050129727A1 Localized drug delivery using drug-loaded nanocapsules 有权
标题翻译：使用载药纳米胶囊的局部药物递送
公开(公告)号：US20050129727A1
公开(公告)日：2005-06-16
申请号：US10768388
申请日：2004-01-30
申请人： Jan Weber , Samuel Robaina
发明人： Jan Weber , Samuel Robaina
IPC分类号： A61F2/00 , A61K20060101 , A61K9/50 , A61K38/17 , A61K49/18 , A61L27/54 , A61L29/16 , A61L31/16 , A61N1/00 , C12N9/99 , C12Q1/68
CPC分类号： B82Y5/00 , A61F2210/009 , A61K9/5094 , A61K47/6923 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/624 , Y10S977/81 , Y10S977/906
摘要： Nanocapsules are disclosed which comprise (a) a drug-containing core and (b) a polyelectrolyte multilayer encapsulating the drug-containing core. The nanocapsules include particles whose largest dimension typically ranges between 50 nm to 10000 nm. In some embodiments, the nanocapsules contain a single drug. In others, the nanocapsules contain multiple drugs, either within the same nanocapsules or within separate populations of nanocapsules. In some embodiments, the nanocapsules comprise surfaces that are functionalized, for example, with ligands that allow for attachment to bodily tissue. In some embodiments of the present invention, the nanocapsules are rendered magnetic or are rendered susceptible to magnetic fields. Also disclosed is a drug delivery method that comprises the steps of (a) providing nanocapsules such as those above; and (b) placing the nanocapsules at a desired location within the body of a subject using an implantable or insertable medical device.
摘要翻译：公开了纳米胶囊，其包含（a）含药物核心和（b）包封药物核心的聚电解质多层。纳米胶囊包括最大尺寸通常在50nm至10000nm之间的颗粒。在一些实施方案中，纳米胶囊含有单一药物。在其他方面，纳米胶囊含有多种药物，无论是在相同的纳米胶囊内还是在分开的纳米胶囊内。在一些实施方案中，纳米胶囊包含官能化的表面，例如具有允许附着于身体组织的配体。在本发明的一些实施方案中，纳米胶囊被磁化或变得易受磁场影响。还公开了药物递送方法，其包括以下步骤：（a）提供如上所述的纳米胶囊; 和（b）使用可植入或可插入的医疗装置将纳米胶囊放置在受试者体内的期望位置。

95. 发明授权

US06861088B2 Method for spray-coating a medical device having a tubular wall such as a stent 有权
标题翻译：用于喷涂具有管状壁（例如支架）的医疗装置的方法
公开(公告)号：US06861088B2
公开(公告)日：2005-03-01
申请号：US10809765
申请日：2004-03-24
申请人： Jan Weber , Gordon John Kocur
发明人： Jan Weber , Gordon John Kocur
IPC分类号： A61F2/06 , A61L27/34 , A61L29/08 , A61L31/10 , B05B5/08 , B05B5/12 , B05D1/04 , A16L27/00
CPC分类号： B05B5/087 , A61L27/34 , A61L29/085 , A61L31/10 , B05B5/12 , B05D1/045
摘要： A method for electrostatic spray-coating a medical device having a tubular wall, such as a stent, having an inner surface, an outer surface and openings therein. The tubular wall is grounded or electrically charged, and an electrically charged conductive core wire is located axially through the center of the stent. An electrical potential is applied to the conductive core wire to impart an electrical charge to the conductive core wire. The tubular wall is exposed to an electrically charged coating formulation, and the electrically charged coating formulation is deposited onto a portion of the tubular wall to form a coating. The electrical potentials of the conductive core wire and tubular wall can be repeatedly alternated.
摘要翻译：一种用于静电喷涂具有管状壁（例如支架）的医疗装置的方法，其具有内表面，外表面和开口。管状壁接地或带电，并且带电的导电芯线轴向位于支架的中心。向导电芯线施加电位以向导电芯线施加电荷。管状壁暴露于带电荷的涂层制剂中，并且带电的涂层制剂沉积在管状壁的一部分上以形成涂层。导电芯线和管状壁的电位可以重复交替。

96. 发明申请

US20050037050A1 Medical devices comprising drug-loaded capsules for localized drug delivery 有权
标题翻译：包括用于局部药物递送的药物负载胶囊的医疗装置
公开(公告)号：US20050037050A1
公开(公告)日：2005-02-17
申请号：US10638739
申请日：2003-08-11
申请人： Jan Weber
发明人： Jan Weber
IPC分类号： A61F2/00 , A61F2/04 , A61K9/16 , A61K9/50
CPC分类号： A61M25/10 , A61F2/04 , A61F2250/0068 , A61M25/1027 , A61M2025/0057 , A61M2025/0058 , A61M2025/105 , A61M2025/1088
摘要： A medical device comprising a plurality of capsules, and a method of administering therapeutic agent to a patient using the same. The capsules further comprise a therapeutic agent and a multilayer polyelectrolyte shell. The medical device is adapted to apply a pressure to the capsules that is greater than or equal to the critical pressure of at least a portion of the capsules, such that therapeutic agent is released from the capsules.
摘要翻译：一种包含多个胶囊的医疗装置，以及使用该胶囊向患者施用治疗剂的方法。胶囊还包含治疗剂和多层聚电解质外壳。医疗装置适于对胶囊施加大于或等于至少一部分胶囊的临界压力的压力，使得治疗剂从胶囊释放。

97. 发明授权

US06607598B2 Device for protecting medical devices during a coating process 失效
标题翻译：用于在涂覆过程中保护医疗装置的装置
公开(公告)号：US06607598B2
公开(公告)日：2003-08-19
申请号：US09804040
申请日：2001-03-13
申请人： Marlene Schwarz , Jan Weber , Henrik Hansen , Paul Lubinsky
发明人： Marlene Schwarz , Jan Weber , Henrik Hansen , Paul Lubinsky
IPC分类号： B05C1302
CPC分类号： B05B13/025 , A61L27/28 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/10 , A61L2300/252 , A61L2300/258 , A61L2300/606 , B05B13/02 , B05B13/0257 , B05D1/22 , C23C14/50 , C23C16/458
摘要： Methods and devices for protecting and/or coating medical devices are disclosed. In one embodiment, a method is disclosed that includes surrounding a medical device with a cage, the medical device having a surface. The method further includes attaching the medical device to the cage with at least one securement, suspending the medical device in an air stream, the air stream substantially devoid of suspending particles, and coating at least a portion of said surface of said suspended medical device with a first coating material.
摘要翻译：公开了用于保护和/或涂覆医疗器械的方法和装置。在一个实施例中，公开了一种包括用保持架围绕医疗装置的方法，该医疗装置具有表面。该方法还包括将医疗装置连接到具有至少一个固定件的保持器，将医疗装置悬挂在空气流中，空气流基本上没有悬浮颗粒，并且将所述悬挂的医疗装置的所述表面的至少一部分涂覆到第一涂料。

98. 发明授权

US5759172A Balloon catheter with lobed balloon and method for manufacturing such a catheter 失效
标题翻译：气囊导管带有裂片气囊和制造这种导管的方法
公开(公告)号：US5759172A
公开(公告)日：1998-06-02
申请号：US629720
申请日：1996-04-09
申请人： Jan Weber , Johannes Gerardus Maria Van Muiden
发明人： Jan Weber , Johannes Gerardus Maria Van Muiden
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/1029 , A61M25/1002 , A61M25/1038 , A61M2025/1072 , A61M25/0043 , A61M25/104
摘要： The invention relates to a catheter comprising a tube-like basic body with a proximal and a distal end and an expandable balloon member arranged close to the distal end to the basic body. The balloon member comprises a number of relatively stiff sections extending on a small diameter in a longitudinal direction of the basic body and relatively pliable sections extending inbetween, wherein the relatively pliable sections form lobes in an expanded state of the balloon member. The invention furthermore relates to a method for manufacturing a catheter according to the invention, wherein a piece of tube-like basic material is provided and, by blow molding, a balloon member is made in a mold, which is arranged to the bias material. The balloon member is manufactured in the mold cavity of a mold, the cross-section of which is lobated, by receiving a tube-like partial manufacture inside it and deforming it by blow molding into a shape corresponding to that of the shape of the mold cavity.
摘要翻译：本发明涉及一种导管，其包括具有近端和远端的管状基体，以及靠近基体的远端设置的可膨胀气囊构件。球囊构件包括在基体的纵向方向上以小直径延伸的多个相对刚性的部分和在其间延伸的相对柔韧的部分，其中相对柔韧的部分形成为球囊构件的展开状态的凸角。本发明还涉及一种根据本发明的制造导管的方法，其中提供了一块管状基材，并且通过吹塑成型，将气囊构件制成设置在偏置材料上的模具中。气囊构件通过在其内部容纳管状的部分制造而在模具的模腔中制造，其横截面为叶形，并通过吹塑成型为与模具形状相对应的形状腔。

99. 发明授权

US09463103B2 Medical devices comprising nanocomposites 有权
标题翻译：包含纳米复合材料的医疗器械
公开(公告)号：US09463103B2
公开(公告)日：2016-10-11
申请号：US13402141
申请日：2012-02-22
申请人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
发明人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens, Jr. , Jan Weber
IPC分类号： A61L29/00 , A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61L29/12 , A61L31/12
CPC分类号： A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61L29/126 , A61L31/125 , Y10S623/90 , Y10S977/905
摘要： The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
摘要翻译：本发明提供包含纳米复合材料的医疗装置。通过在其生产中利用纳米复合材料，本发明的医疗装置可以以各种有利的性质生产。还提供了制造本发明的医疗装置的方法。由于本发明的装置预期在使用中提供某些优点，还提供了包括治疗或诊断方法的医疗护理方法，其中本发明的装置与被治疗或被诊断的身体进行治疗接触。

100. 发明授权

US08876772B2 Variable stiffness shaft 有权
标题翻译：可变刚度轴
公开(公告)号：US08876772B2
公开(公告)日：2014-11-04
申请号：US11280120
申请日：2005-11-16
申请人： Jan Weber , Tracee E. J. Eidenschink
发明人： Jan Weber , Tracee E. J. Eidenschink
IPC分类号： A61M5/178 , A61L29/14 , A61L29/04 , A61B17/00 , A61M25/09 , A61M25/00
CPC分类号： A61M25/0054 , A61B2017/00398 , A61B2017/00871 , A61L29/041 , A61L29/14 , A61M25/0045 , A61M2025/0058 , A61M2025/0059 , A61M2025/006 , A61M2025/0063 , A61M2025/09133 , A61M2025/0915 , C08L39/04
摘要： Medical devices may include structure or provision that permit a physician or other health care professional to adjust particular parameters such as flexibility, stiffness and compressive strength of at least a portion of the medical device. In some instances, the medical device may be adjusted prior to inserting the medical device into a patient. In some cases, the medical device may be adjusted while in use within the patient.
摘要翻译：医疗设备可以包括允许医师或其他保健专业人员调整医疗设备的至少一部分的特定参数，例如柔性，刚度和抗压强度的结构或规定。在一些情况下，可以在将医疗装置插入病人之前调整医疗装置。在一些情况下，医疗装置可在患者使用期间进行调整。

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