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91. 发明申请

US20100009966A1 SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION 审中-公开
标题翻译：作为ABETA蛋白质生产的抑制剂的替代的LACTAMS
公开(公告)号：US20100009966A1
公开(公告)日：2010-01-14
申请号：US12560213
申请日：2009-09-15
申请人： Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
发明人： Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
IPC分类号： A61K31/55 , C07D243/24 , A61K31/5513 , C07D223/14 , A61P43/00
CPC分类号： C07D223/12 , C07D223/18 , C07D243/12 , C07D243/24 , C07D401/04
摘要： This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
摘要翻译：本发明涉及式（I）的新型内酰胺：具有药物和生物影响性质，其药物组合物和使用方法。这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

92. 发明申请

US20090247556A1 Azolopyrimidines as Inhibitors of Cannabinoid 1 Activity 失效
标题翻译：作为大麻素1活性抑制剂的偶氮嘧啶
公开(公告)号：US20090247556A1
公开(公告)日：2009-10-01
申请号：US12295555
申请日：2007-03-30
申请人： Xiaohui He , Kunyong Yang , Hong Liu , David Archer Ellis
发明人： Xiaohui He , Kunyong Yang , Hong Liu , David Archer Ellis
IPC分类号： A61K31/519 , C07D487/04 , A61K31/522 , A61P3/04 , C07D473/30
CPC分类号： C07D473/30 , C07D487/04
摘要： The invention provides compounds of formula (Ia), (Ic), (Ig) and (Ik), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
摘要翻译：本发明提供式（Ia），（Ic），（Ig）和（Ik）的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法）。

93. 发明申请

US20090190934A1 FIBER COMMUNICATION SYSTEM, FIBER AMPLIFIER, AND METHOD FOR FABRICATING FIBER AMPLIFIER 有权
标题翻译：光纤通信系统，光纤放大器以及制造光纤放大器的方法
公开(公告)号：US20090190934A1
公开(公告)日：2009-07-30
申请号：US12417947
申请日：2009-04-03
申请人： Wendou ZHANG , Dongming Li , Hong Liu
发明人： Wendou ZHANG , Dongming Li , Hong Liu
IPC分类号： H04B10/00 , H04B10/12
CPC分类号： H01S3/06754 , G02B6/12
摘要： The present invention discloses a fiber amplifier, a fabricating method thereof, and a fiber communication system. The fiber amplifier includes at least a pump laser, at least a gain medium and at least an integrated optical component. The integrated optical component includes multiple optical input/output ports, and the optical input/output ports are connected to the pump laser or gain medium directly or indirectly. The present invention may better address problems of unstable performance and difficulty in reducing the size of components in the prior art where fiber amplifiers are formed by a number of discrete components with many fiber fusion splices. In addition, the present invention may reduce the production complexity and costs of fiber amplifiers, and improve the productivity of fiber amplifiers.
摘要翻译：本发明公开了一种光纤放大器及其制造方法以及光纤通信系统。光纤放大器至少包括泵浦激光器，至少增益介质和至少一个集成的光学部件。集成光学部件包括多个光输入/输出端口，光输入/输出端口直接或间接连接到泵浦激光器或增益介质。本发明可以更好地解决现有技术中不稳定性能和难以减小组件尺寸的问题，其中光纤放大器由具有许多光纤熔接的许多分立组件形成。此外，本发明可以降低光纤放大器的生产复杂度和成本，并且提高光纤放大器的生产率。

94. 发明申请

US20090159455A1 BIO-ELECTROCHEMICALLY ASSISTED MICROBIAL REACTOR THAT GENERATES HYDROGEN GAS AND METHODS OF GENERATING HYDROGEN GAS 有权
标题翻译：产生氢气的生物电化学微生物反应器和产生氢气的方法
公开(公告)号：US20090159455A1
公开(公告)日：2009-06-25
申请号：US12360708
申请日：2009-01-27
申请人： Bruce Logan , Stephen Grot , Thomas E. Mallouk , Hong Liu
发明人： Bruce Logan , Stephen Grot , Thomas E. Mallouk , Hong Liu
IPC分类号： C25B1/02
CPC分类号： C25B9/00 , C02F3/005 , C02F2001/46133 , C02F2001/46161 , C02F2201/46115 , C25B1/02 , H01M8/16 , H01M8/186 , Y02E60/527 , Y02E60/528 , Y02W10/37
摘要： Systems and processes for producing hydrogen using bacteria are described. One detailed process for producing hydrogen uses a system for producing hydrogen as described herein, the system including a reactor. Anodophilic bacteria are disposed within the interior of the reactor and an organic material oxidizable by an oxidizing activity of the anodophilic bacteria is introduced and incubated under oxidizing reactions conditions such that electrons are produced and transferred to the anode. A power source is activated to increase a potential between the anode and the cathode, such that electrons and protons combine to produce hydrogen gas. In one system for producing hydrogen is provided which includes a reaction chamber having a wall defining an interior of the reactor and an exterior of the reaction chamber. An anode is provided which is at least partially contained within the interior of the reaction chamber and a cathode is also provided which is at least partially contained within the interior of the reaction chamber. The cathode is spaced apart at a distance in the range between 0.1-100 centimeters, inclusive, from the anode. A conductive conduit for electrons is provided which is in electrical communication with the anode and the cathode and a power source for enhancing an electrical potential between the anode and cathode is included which is in electrical communication at least with the cathode. A first channel defining a passage from the exterior of the reaction chamber to the interior of the reaction chamber is also included.
摘要翻译：描述了使用细菌产生氢的系统和方法。用于生产氢的一个详细的方法使用如本文所述的用于生产氢的系统，该系统包括反应器。将嗜盐细菌置于反应器的内部，并引入可通过阳极细菌的氧化活性氧化的有机物质，并在氧化反应条件下孵育，使得产生电子并转移至阳极。激活电源以增加阳极和阴极之间的电位，使得电子和质子组合以产生氢气。提供了一种用于生产氢的系统，其包括具有限定反应器内部的壁和反应室的外部的反应室。提供了至少部分地包含在反应室内部的阳极，还提供了至少部分地包含在反应室内部的阴极。阴极与阳极之间的距离在0.1-100厘米的范围内间隔开。提供用于电子的导电导管，其与阳极和阴极电连通，并且包括用于增强阳极和阴极之间的电位的电源，其至少与阴极电连通。还包括限定从反应室的外部到反应室内部的通道的第一通道。

95. 发明授权

US07551679B2 Symmetrical data signal processing 有权
标题翻译：对称数据信号处理
公开(公告)号：US07551679B2
公开(公告)日：2009-06-23
申请号：US11347747
申请日：2006-02-03
申请人： Hong Liu , Raul A. Casas , Haosong Fu
发明人： Hong Liu , Raul A. Casas , Haosong Fu
IPC分类号： H04K1/10
CPC分类号： H04L25/03171 , H04L25/0212 , H04L27/04 , H04L2025/03382 , H04L2025/03522
摘要： In a digital communications receiver configured to receive, via a communications channel, a received first signal representing a sequence of symbols, each symbol being encoded to be representative of data bits, a method of processing the received signal includes adjusting a magnitude, filtering, and applying cyclic prefix restoration, to the received signal to produce a second signal, converting the second signal from time domain to frequency domain to produce a frequency domain signal, and determining a first quantity of values representing a first portion of the symbols by evaluating a relationship of channel values representing characteristics of the communications channel and a second quantity of values representing a portion of the frequency domain signal, the first quantity being smaller than the second quantity.
摘要翻译：在被配置为经由通信信道接收表示符号序列的每个符号被编码为表示数据比特的数字通信接收机中，处理接收信号的方法包括调整幅度，滤波和对所接收的信号应用循环前缀恢复以产生第二信号，将所述第二信号从时域转换到频域以产生频域信号，以及通过评估所述符号的关系来确定表示所述符号的第一部分的第一数量的值表示所述通信信道的特性的信道值和表示所述频域信号的一部分的第二数量值，所述第一数量小于所述第二数量。

96. 发明授权

US07501408B2 Inhibitors of cathepsin S 失效
标题翻译：组织蛋白酶S抑制剂
公开(公告)号：US07501408B2
公开(公告)日：2009-03-10
申请号：US11932679
申请日：2007-10-31
申请人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC分类号： C07D417/12 , C07D295/10 , A61K31/541
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula (I): wherein Q is thiomorpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
摘要翻译：本发明提供了用于选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地，本发明提供具有式（I）的化合物：其中Q是硫代吗啉基; A，R5，R6，R7，R8，R9和Ar为取代基。

97. 发明授权

US07491453B2 Bio-electrochemically assisted microbial reactor that generates hydrogen gas and methods of generating hydrogen gas 有权
标题翻译：产生氢气的生物电化学辅助微生物反应器和产生氢气的方法
公开(公告)号：US07491453B2
公开(公告)日：2009-02-17
申请号：US11180454
申请日：2005-07-13
申请人： Bruce Logan , Stephen Grot , Thomas E. Mallouk , Hong Liu
发明人： Bruce Logan , Stephen Grot , Thomas E. Mallouk , Hong Liu
IPC分类号： H01M8/06 , H01M8/16
CPC分类号： C25B9/00 , C02F3/005 , C02F2001/46133 , C02F2001/46161 , C02F2201/46115 , C25B1/02 , H01M8/16 , H01M8/186 , Y02E60/527 , Y02E60/528 , Y02W10/37
摘要： Systems and processes for producing hydrogen using bacteria are described. One detailed process for producing hydrogen uses a system for producing hydrogen as described herein, the system including a reactor. Anodophilic bacteria are disposed within the interior of the reactor and an organic material oxidizable by an oxidizing activity of the anodophilic bacteria is introduced and incubated under oxidizing reactions conditions such that electrons are produced and transferred to the anode. A power source is activated to increase a potential between the anode and the cathode, such that electrons and protons combine to produce hydrogen gas. One system for producing hydrogen includes a reaction chamber having a wall defining an interior of the reactor and an exterior of the reaction chamber. An anode is provided which is at least partially contained within the interior of the reaction chamber and a cathode is also provided which is at least partially contained within the interior of the reaction chamber. The cathode is spaced apart at a distance in the range between 0.1-100 centimeters, inclusive, from the anode. A conductive conduit for electrons is provided which is in electrical communication with the anode and the cathode and a power source for enhancing an electrical potential between the anode and cathode is included which is in electrical communication at least with the cathode. A first channel defining a passage from the exterior of the reaction chamber to the interior of the reaction chamber is also included.
摘要翻译：描述了使用细菌产生氢的系统和方法。用于生产氢的一个详细的方法使用如本文所述的用于生产氢的系统，该系统包括反应器。将嗜盐细菌置于反应器的内部，并引入可通过阳极细菌的氧化活性氧化的有机物质，并在氧化反应条件下孵育，使得产生电子并转移至阳极。激活电源以增加阳极和阴极之间的电位，使得电子和质子组合以产生氢气。一种用于生产氢的系统包括具有限定反应器内部的壁和反应室的外部的反应室。提供了至少部分地包含在反应室内部的阳极，还提供了至少部分地包含在反应室内部的阴极。阴极与阳极之间的距离在0.1-100厘米的范围内间隔开。提供用于电子的导电导管，其与阳极和阴极电连通，并且包括用于增强阳极和阴极之间的电位的电源，其至少与阴极电连通。还包括限定从反应室的外部到反应室内部的通道的第一通道。

98. 发明申请

US20080261271A1 EXPRESSION OF HIV POLYPEPTIDES AND PRODUCTION OF VIRUS-LIKE PARTICLES 失效
标题翻译：表达艾滋病毒多肽和生产类病毒颗粒
公开(公告)号：US20080261271A1
公开(公告)日：2008-10-23
申请号：US12026619
申请日：2008-02-06
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12N15/49
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译：本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。还描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env-，tat-或Gag的蛋白质的应用中的表达盒的用途。本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。

99. 发明授权

US07423033B2 Hydroxyalkanoylaminolactams and related structures as inhibitors of aβ protein production 失效
标题翻译：羟基烷酰氨基内酰胺和相关结构作为abeta蛋白生产的抑制剂
公开(公告)号：US07423033B2
公开(公告)日：2008-09-09
申请号：US12024812
申请日：2008-02-01
申请人： Richard E. Olson , Hong Liu , Lorin Andrew Thompson
发明人： Richard E. Olson , Hong Liu , Lorin Andrew Thompson
IPC分类号： C07D243/24 , A61K31/395
CPC分类号： C07D223/18 , C07D223/10 , C07D223/12 , C07D223/16 , C07D243/08 , C07D243/14 , C07D243/24 , C07D243/26 , C07D401/04
摘要： This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
摘要翻译：本发明涉及具有式（I）的新型内酰胺：其药物组合物及其使用方法。这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

100. 发明申请

US20080108595A1 INHIBITORS OF CATHEPSIN S 失效
标题翻译： CATHEPSIN的抑制剂
公开(公告)号：US20080108595A1
公开(公告)日：2008-05-08
申请号：US11932679
申请日：2007-10-31
申请人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
IPC分类号： C07D413/00 , A61K31/535 , C07D265/30 , A61K31/5377 , A61K31/54 , C07D279/12 , C07D241/04 , A61K31/495 , A61K31/397 , C07D205/04
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译：本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。

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