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91. 发明申请

US20070073403A1 ARTIFICIAL INTERVERTEBRAL DISC 有权
标题翻译：人造椎间盘
公开(公告)号：US20070073403A1
公开(公告)日：2007-03-29
申请号：US11534313
申请日：2006-09-22
申请人： Alan Lombardo , Mark Semler , Joseph Ferraro , Theodore Karwoski , Thomas Swanick , Brian Sunter
发明人： Alan Lombardo , Mark Semler , Joseph Ferraro , Theodore Karwoski , Thomas Swanick , Brian Sunter
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/025 , A61B2017/0256 , A61F2/30742 , A61F2/30767 , A61F2/4425 , A61F2/4611 , A61F2002/302 , A61F2002/30291 , A61F2002/30331 , A61F2002/30433 , A61F2002/30434 , A61F2002/30448 , A61F2002/30462 , A61F2002/30495 , A61F2002/30563 , A61F2002/30616 , A61F2002/30649 , A61F2002/30769 , A61F2002/30818 , A61F2002/30841 , A61F2002/30843 , A61F2002/30919 , A61F2002/3093 , A61F2002/30932 , A61F2002/3097 , A61F2002/443 , A61F2002/4495 , A61F2002/4627 , A61F2002/4628 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2230/0065 , A61F2230/0091 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00796 , Y10T29/49826
摘要： The present invention is directed to the field of prosthetic devices. More particularly, one embodiment of the present invention is directed to an artificial disc that can be used as a replacement for an intervertebral disc (e.g., a human intervertebral lumbar disc, a human intervertebral cervical disc and/or a human intervertebral thoracic disc).
摘要翻译：本发明涉及假体装置领域。更具体地，本发明的一个实施例涉及可用作椎间盘（例如人椎间盘腰椎，人椎间盘和/或人椎间胸椎间盘）的替代物的人造椎间盘。

92. 发明申请

US20050154416A1 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US20050154416A1
公开(公告)日：2005-07-14
申请号：US11068680
申请日：2005-02-28
申请人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/958 , A61L29/04 , B29C47/00 , B29C55/24 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

93. 发明授权

US06774155B2 Method for treating polymer materials and products produced therefrom 有权
标题翻译：用于处理由其制备的聚合物材料和产品的方法
公开(公告)号：US06774155B2
公开(公告)日：2004-08-10
申请号：US10196692
申请日：2002-07-16
申请人： Paul Martakos , Thomas M. Swanick , Theodore Karwoski
发明人： Paul Martakos , Thomas M. Swanick , Theodore Karwoski
IPC分类号： C08F248
CPC分类号： C08J7/123 , A61F2/06 , A61F2250/0023
摘要： The invention is directed to methods for fabricating devices from polymer precursors, along with devices so fabricated. The methods of the invention include the steps of plasma treating a polymer based resin, paste, preform billet, or extrudate, and employing the treated polymer in the fabricated device. According to one embodiment, the fabricated device can include implantable prosthetics such as heart valves, sutures, vascular access devices, vascular grafts, shunts, catheters, single layered membranes, double layered membranes, and the like. Devices fabricated according to one embodiment of the invention include regions having selected porosity, permeability and/or chemistry characteristics.
摘要翻译：本发明涉及从聚合物前体制造器件的方法以及如此制造的器件。本发明的方法包括以下步骤：等离子体处理聚合物基树脂，糊料，预成型坯坯或挤出物，并在制造的装置中使用经处理的聚合物。根据一个实施例，制造的装置可以包括可植入假肢，例如心脏瓣膜，缝线，血管通路装置，血管移植物，分流器，导管，单层膜，双层膜等。根据本发明的一个实施方案制造的装置包括具有选择的孔隙率，渗透性和/或化学特性的区域。

94. 发明授权

US06573311B1 Method for treating polymer materials and products produced therefrom 失效
公开(公告)号：US06573311B1
公开(公告)日：2003-06-03
申请号：US09400813
申请日：1999-09-22
申请人： Paul Martakos , Thomas M. Swanick , Theodore Karwoski
发明人： Paul Martakos , Thomas M. Swanick , Theodore Karwoski
IPC分类号： C08F248
CPC分类号： C08J7/123 , A61F2/06 , A61F2250/0023
摘要： The invention is directed to methods for fabricating devices from polymer precursors, along with devices so fabricated. The methods of the invention include the steps of plasma treating a polymer based resin, paste, preform billet, or extrudate, and employing the treated polymer in the fabricated device. According to one embodiment, the fabricated device can include implantable prosthetics such as heart valves, sutures, vascular access devices, vascular grafts, shunts, catheters, single layered membranes, double layered membranes, and the like. Devices fabricated according to one embodiment of the invention include regions having selected porosity, permeability and/or chemistry characteristics.

95. 发明申请

US20060078586A1 Barrier layer 有权
标题翻译：屏障层
公开(公告)号：US20060078586A1
公开(公告)日：2006-04-13
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
摘要翻译：阻挡层和相应的制备方法为可植入患者体内的医疗装置提供抗炎，非炎症和抗粘附功能。除了改善的愈合，非炎性和抗炎反应之外，阻挡层可以与医疗装置结构组合以提供抗粘附特性。阻挡层通常由天然存在的油或由天然存在的油的一部分形成的油组合物形成，其至少部分固化形成交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。

96. 发明申请

US20060067976A1 Formation of barrier layer 审中-公开
标题翻译：阻挡层的形成
公开(公告)号：US20060067976A1
公开(公告)日：2006-03-30
申请号：US11238532
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip Mcnamara , William Quigley , Mark Avella , Rick Chenel
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip Mcnamara , William Quigley , Mark Avella , Rick Chenel
IPC分类号： A61F2/00 , B05D3/00
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
摘要翻译：阻挡层和相应的制备方法为可植入患者的医疗装置提供抗炎和抗粘附功能。除了改善的愈合和抗炎反应之外，阻挡层可以与医疗装置结构组合以提供抗粘附特性。阻挡层通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。

97. 发明申请

US20050004664A1 Vascular graft 审中-公开
标题翻译：血管移植
公开(公告)号：US20050004664A1
公开(公告)日：2005-01-06
申请号：US10833930
申请日：2004-04-27
申请人： Paul Martakos , Joseph Ferraro , Theodore Karwoski , Ibrahim Dagher
发明人： Paul Martakos , Joseph Ferraro , Theodore Karwoski , Ibrahim Dagher
IPC分类号： A61F2/06 , A61L27/16
CPC分类号： A61F2/06 , A61F2002/065 , A61L27/16 , C08L27/18
摘要： Disclosed are vascular grafts including an expanded copolymer of tetrafluoroethylene (TFE) and perfluoropropylene vinyl ether (PPVE). In certain embodiments, the copolymer includes between about 0.01% and about 1.5% PPVE. Vascular grafts exhibit superior performance properties, e.g., radial strength, and suture strength, and manufacturing properties, e.g., sinter time. Methods of forming vascular grafts from the copolymer also are described.
摘要翻译：公开了包括四氟乙烯（TFE）和全氟丙烯乙烯基醚（PPVE）的发泡共聚物的血管移植物。在某些实施方案中，共聚物包括约0.01％至约1.5％的PPVE。血管移植物表现出优异的性能，例如径向强度和缝合强度，以及制造性质，例如烧结时间。还描述了从共聚物形成血管移植物的方法。

98. 发明申请

US20080113001A1 Tissue separating device with reinforced support for anchoring mechanisms 有权
标题翻译：组织分离装置，具有用于锚固机构的加强支撑
公开(公告)号：US20080113001A1
公开(公告)日：2008-05-15
申请号：US11980155
申请日：2007-10-30
申请人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
发明人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

99. 发明申请

US20070202149A1 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings 有权
标题翻译：用于生物可吸收药物载体涂层的疏水交联凝胶
公开(公告)号：US20070202149A1
公开(公告)日：2007-08-30
申请号：US11582135
申请日：2006-10-16
申请人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
发明人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
IPC分类号： A61F2/00 , A61F2/02
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

100. 发明申请

US20060067983A1 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US20060067983A1
公开(公告)日：2006-03-30
申请号：US11237264
申请日：2005-09-28
申请人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K31/355 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

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