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91. 发明申请

US20050058665A1 Identification of virulence determinants activators in prokaryotic pathogens 审中-公开
标题翻译：鉴定原核病原体中毒力决定簇活化剂
公开(公告)号：US20050058665A1
公开(公告)日：2005-03-17
申请号：US10860727
申请日：2004-06-03
申请人： John Murphy , Li Sun
发明人： John Murphy , Li Sun
IPC分类号： C12N15/10 , C12N15/63 , C12Q1/68 , A61K39/05
CPC分类号： C12N15/1086 , C12N15/635 , C12Q1/6897
摘要： Disclosed is a method for identifying activators of a transition metal-dependent repressor of virulence gene expression in infectious prokaryotic pathogens. The method utilizes genetic circuitry that represents the response of a given prokaryote to nutritional stress and the expression of genes that contribute to the establishment of the infectious process. The exposure of recombinant cells or a cell-free system containing the genetic circuitry to a non-metal ion test substance that activates the repressor produces a detectable response. The method is applicable for any prokaryote employing metal ion-dependent repressors to regulate specific gene expression, specifically as it pertains to virulence determinant expression.
摘要翻译：公开了用于鉴定感染性原核病原体中毒性基因表达的过渡金属依赖性阻遏物的活化剂的方法。该方法利用代表给定原核生物对营养压力的反应的遗传回路和有助于建立感染过程的基因的表达。将包含遗传电路的重组细胞或无细胞系统暴露于激活阻遏物的非金属离子测试物质产生可检测的反应。该方法适用于任何使用金属离子依赖性阻遏物调节特异性基因表达的原核生物，特别是与毒力决定簇表达有关。

92. 发明申请

US20050039402A1 Modular fall protection system 审中-公开
标题翻译：模块化防坠落系统
公开(公告)号：US20050039402A1
公开(公告)日：2005-02-24
申请号：US10780338
申请日：2004-02-17
申请人： Richard Murphy , John Murphy
发明人： Richard Murphy , John Murphy
IPC分类号： E04G21/32 , E06B9/02 , E06B7/00
CPC分类号： E06B9/02 , E04G21/3204 , E06B2009/002
摘要： A wall opening fall protection support system is provided having a pair of brackets, each bracket of the pair having a substantially planar mounting portion, a support portion, a retaining portion including a locking element, and a standoff element, wherein the retaining portion is resiliently joined to the support portion. The system can further include a rail securable to each bracket by the retaining portion so as to be at least partially surrounded by the support portion, the retaining portion and the standoff element.
摘要翻译：提供了具有一对支架的壁开口下落保护支撑系统，该对的每个支架具有基本上平面的安装部分，支撑部分，包括锁定元件的保持部分和支撑元件，其中保持部分是弹性的连接到支撑部分。该系统还可以包括通过保持部分可固定到每个支架的导轨，以便至少部分地被支撑部分，保持部分和支架元件包围。

93. 发明申请

US20050031645A1 Vaccine compositions 审中-公开
标题翻译：疫苗组合物
公开(公告)号：US20050031645A1
公开(公告)日：2005-02-10
申请号：US10822953
申请日：2004-04-12
申请人： John Murphy , Edward O'Lear , Robert Harrison
发明人： John Murphy , Edward O'Lear , Robert Harrison
IPC分类号： C07K14/34 , C12N1/21 , A61K39/12 , A61K39/02
CPC分类号： C07K14/34
摘要： Disclosed are virulent or opportunistic prokaryotes in which metal ion-dependent gene regulation confers a growth or an infectious advantage. The prokaryote contains a DNA molecule containing a sequence encoding a dominant, metal ion-independent repressor protein or a partially metal-ion independent repressor protein. The prokaryotes are formulated into vaccine compositions and administered to a human or other animal to enhance protective immunity against infectious and diseases caused by prokaryotes in which metal ion-dependent gene regulation confers a growth or an infectious advantage.
摘要翻译：披露的是毒性或机会主义原核生物，其中金属离子依赖性基因调控赋予生长或感染优势。原核包含含有编码显性，金属离子非依赖性抑制蛋白或部分金属离子的阻遏蛋白的序列的DNA分子。将原核生物配制成疫苗组合物并施用于人或其他动物以增强针对由原核生物引起的感染性和疾病的保护性免疫，其中金属离子依赖性基因调节赋予生长或感染优势。

94. 发明授权

US06183337B2 Electronic toy and method of generating dual track sounds for the same 失效
标题翻译：电子玩具和产生双轨道声音的方法相同
公开(公告)号：US06183337B2
公开(公告)日：2001-02-06
申请号：US09335537
申请日：1999-06-18
申请人： Ralph Beckman , John Murphy , Kipp Bradford , Stephen Schwartz , Henry Sharpe, III
发明人： Ralph Beckman , John Murphy , Kipp Bradford , Stephen Schwartz , Henry Sharpe, III
IPC分类号： A63H328
CPC分类号： A63H3/28 , A63H2200/00
摘要： A toy figure has a movable mouth coupled to an actuator in the belly area. A speech generator stores sound elements for an entire song, verse, or nursery rhyme. The speech generator is provided with a first track of sequenced sound elements (singing version) that form a song when sequentially generated, and a related second track of a like number of sequenced sound elements (humming version). Sound elements from the first and second tracks are interchangeable at any given point during sequential output thereof A switch located in the mouth is connected to the speech generator to provide input as to the mouth position, i.e. open or closed. Squeezing the belly of the figure opens the mouth, changing the state of the switch and initiating an output sequence from the speech generator. When the mouth is open, the child is able to easily control the mouth position by varying the pressure on the belly actuator. The speech generator checks the state of the mouth switch at given intervals. If the speech generator senses that the mouth is closed, the speech generator switches tracks to begin output of the next corresponding “humming” segment of the song. The speech generator continues to check the state of the switch, and if the switch is then reopened, the toy begins to sing again at the same point within the sequenced output.
摘要翻译：玩具人物具有联接到腹部区域中的致动器的可移动的口。一个语音发生器存储整个歌曲，诗歌或童谣的声音元素。语音发生器设置有顺序生成时形成歌曲的排序声音元素（歌曲版本）的第一轨道和相似数量的排序声音元素（哼唱版本）的相关第二轨道。来自第一和第二轨道的声音元件在其顺序输出期间的任何给定点处是可互换的。位于口中的开关连接到语音发生器以提供关于嘴部位置（即打开或关闭）的输入。压缩图的腹部打开嘴巴，改变开关的状态并从语音发生器启动输出序列。当嘴部打开时，孩子能够通过改变腹部致动器上的压力来容易地控制嘴部位置。语音发生器以给定的间隔检查口开关的状态。如果语音发生器感测到该口闭合，则语音产生器切换轨道以开始下一个对应的“哼唱”段的输出。语音发生器继续检查开关的状态，如果开关重新打开，玩具将在顺序输出的同一点开始再次唱歌。

95. 发明授权

US5991807A System for controlling users access to a distributive network in accordance with constraints present in common access distributive network interface separate from a server 失效
标题翻译：用于根据存在于与服务器分离的公共接入分配网络接口中的约束来控制用户对分布式网络的访问的系统
公开(公告)号：US5991807A
公开(公告)日：1999-11-23
申请号：US669053
申请日：1996-06-24
申请人： Jonathan Schmidt , Lewis Donzis , Henry Donzis , John Murphy , Peter Baron , Herb Savage
发明人： Jonathan Schmidt , Lewis Donzis , Henry Donzis , John Murphy , Peter Baron , Herb Savage
IPC分类号： G06F13/00
CPC分类号： H04L12/2876 , H04L12/2858
摘要： A method of managing access to a distributive network provides both time and site access restraints for users or groups of users on a LAN or WAN adapted for accessing the network through a common network access interface system. The method utilizes the LAN server to develop and monitor the constraints, minimizing the utilization of the access interface system. The management parameters for each group or individual having access to the distributive network via the LAN or WAN is entered into the interface box by the administrator as a compact reference, a series of pointers to the larger database of users and groups stored in the existing LAN server directory services. The existing database of users and groups and their relationships exist already in the LAN servers as a normal consequence of LAN operation and a simple, graphical user interface in the preferred embodiment of the invention permits familiar selection of objects of that database and assignment of access constraints.
摘要翻译：管理对分配网络的访问的方法为适于通过公共网络访问接口系统访问网络的LAN或WAN上的用户或用户组提供时间和站点访问限制。该方法利用LAN服务器开发和监控约束，最大限度地减少访问接口系统的利用率。经由LAN或WAN访问分布式网络的每个组或个人的管理参数由管理员作为紧凑参考输入到接口盒中，一系列指向存储在现有LAN中的用户和组的较大数据库的指针服务器目录服务。用户和组的现有数据库及其关系已经作为LAN操作的正常结果已经存在于LAN服务器中，并且在本发明的优选实施例中的简单的图形用户界面允许对该数据库的对象的熟悉选择和访问约束的分配。

96. 外观设计

USD263344S Teller machine wall unit or the like 失效
公开(公告)号：USD263344S
公开(公告)日：1982-03-09
申请号：US93703
申请日：1979-11-13
申请人： Michael McCarthy , Paul Vieyra , Henry Feldman , John Murphy , Michael Kaminski
设计人： Michael McCarthy , Paul Vieyra , Henry Feldman , John Murphy , Michael Kaminski

97. 发明授权

US3990666A Wheel clamp 失效
标题翻译：轮夹
公开(公告)号：US3990666A
公开(公告)日：1976-11-09
申请号：US607548
申请日：1975-08-25
申请人： Leonard A. Morrison , Robert S. Hampton, Jr. , John Murphy , Leo C. Bogaerts
发明人： Leonard A. Morrison , Robert S. Hampton, Jr. , John Murphy , Leo C. Bogaerts
IPC分类号： G01B5/00 , G01B5/255 , G01B5/25 , G01B11/275 , G01C15/00
CPC分类号： G01B5/255 , G01B5/0025
摘要： A wheel clamp incorporates a pair of leg members each having a pair of spaced apart rim grippers, the leg members being simultaneously adjustable toward and away from a center mount assembly having a mounting surface supported for limited universal movement.
摘要翻译：轮夹包括一对腿部构件，每个腿部构件具有一对间隔开的边缘夹持器，腿部构件可以朝向和远离中心安装组件同时可调节，该中心安装组件具有被支撑用于有限的通用运动的安装表面。

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