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91. 发明授权

US07512216B2 Joint fault detection 有权
标题翻译：联合故障检测
公开(公告)号：US07512216B2
公开(公告)日：2009-03-31
申请号：US10593307
申请日：2005-03-09
申请人： Ping Zhou , Andrew D Chattell
发明人： Ping Zhou , Andrew D Chattell
IPC分类号： H04M1/24 , H04M3/08 , H04M3/22
CPC分类号： H04M3/305 , H04M3/08
摘要： A method and apparatus for detecting a fault in a joint connecting sections of an electrical transmission line together are disclosed. Previously known methods for detecting joint faults require a visual inspection of the joint or testing the transmission line using sophisticated, expensive equipment. This manual testing is expensive and inefficient. In the proposed method, a fault in a joint (301) connecting sections of an electrical transmission line (107) together is detected by measuring the resistance to current flowing through the joint (301) in one and the other directions along said electrical transmission line (107) and detecting a fault in the joint (301) if the measured resistance differs substantially in said one and the other directions. The method has particular utility in relation to low power transmission lines such as telephone lines.
摘要翻译：公开了一种用于检测电传输线的接头连接部分中的故障的方法和装置。用于检测关节缺损的以前已知的方法需要使用复杂且昂贵的设备来目视检查关节或测试传输线。这种手动测试是昂贵且效率低下的。在所提出的方法中，通过沿沿着所述传输线的一个方向和另一个方向测量流过接头（301）的电流的电阻来检测电传输线（107）的连接部分（301）的接头（301）中的故障（107），并且如果所测量的电阻在所述一个和其它方向上显着不同，则检测接头（301）中的故障。该方法对于诸如电话线路的低功率传输线路具有特别的用途。

92. 发明申请

US20080306091A1 AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION 失效
标题翻译： AMINO-5-（5-MEMBERED）异星形霉素化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20080306091A1
公开(公告)日：2008-12-11
申请号：US12180795
申请日：2008-07-28
申请人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
发明人： Michael Sotirios Malamas , Ping Zhou , William Floyd Fobare , William Ronald Solvibile , Iwan Suwandi Gunawan , James Joseph Erdei , Yinfa Yan , Patrick Michael Andrae , Dominick Anthony Quagliato
IPC分类号： C07D403/10 , A61K31/506 , C07D401/10 , A61K31/4439 , A61K31/4152 , A61K31/4168 , A61K31/4178 , C07D233/96 , C07D231/10 , C07D413/10 , A61K31/5377
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法

93. 发明授权

US07452885B2 Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation 失效
标题翻译：氨基-5-（6元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US07452885B2
公开(公告)日：2008-11-18
申请号：US11478098
申请日：2006-06-29
申请人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
发明人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
IPC分类号： C07D403/04 , A61K31/4439
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

94. 发明申请

US20070191431A1 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation 审中-公开
标题翻译： 2-氨基-5-哌啶基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20070191431A1
公开(公告)日：2007-08-16
申请号：US11640751
申请日：2006-12-18
申请人： Ping Zhou , Ronald Bernotas , Yanfang Li , Pawel Nowak , Derek Cole , Eric Manas , Yi Fan , Yinfa Yan
发明人： Ping Zhou , Ronald Bernotas , Yanfang Li , Pawel Nowak , Derek Cole , Eric Manas , Yi Fan , Yinfa Yan
IPC分类号： A61K31/454 , C07D403/02 , C07D405/14
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14
摘要： The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula I The present invention also provides methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的2-氨基-5-哌啶基咪唑酮化合物本发明还提供了抑制β-分泌酶（BACE）和β-淀粉样蛋白沉积物和神经原纤维缠结的治疗的方法和组合物。

95. 发明申请

US20070004786A1 Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation 失效
标题翻译：氨基-5-（5元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20070004786A1
公开(公告)日：2007-01-04
申请号：US11478122
申请日：2006-06-29
申请人： Michael Malamas , Ping Zhou , William Fobare , William Solvibile , Iwan Gunawan , James Erdei , Yinfa Yan , Patrick Andrae , Dominick Quagliato
发明人： Michael Malamas , Ping Zhou , William Fobare , William Solvibile , Iwan Gunawan , James Erdei , Yinfa Yan , Patrick Andrae , Dominick Quagliato
IPC分类号： A61K31/427 , A61K31/422 , A61K31/4196 , C07D417/04 , C07D413/04 , C07D403/04
CPC分类号： C07D417/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法

96. 发明申请

US20070004730A1 Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation 失效
标题翻译：氨基-5-（6元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20070004730A1
公开(公告)日：2007-01-04
申请号：US11478098
申请日：2006-06-29
申请人： Ping Zhou , Michael Malamas , Yanfang Li , Albert Robichaud , Dominick Quagliato
发明人： Ping Zhou , Michael Malamas , Yanfang Li , Albert Robichaud , Dominick Quagliato
IPC分类号： A61K31/53 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法

97. 发明申请

US20060183790A1 Azolylacylguanidines as beta-secretase inhibitors 失效
公开(公告)号：US20060183790A1
公开(公告)日：2006-08-17
申请号：US11352820
申请日：2006-02-13
申请人： Derek Cole , Eric Manas , Lee Jennings , Frank Lovering , Joseph Stock , William Moore , John Ellingboe , Jeffrey Condon , Mohani Sukhdeo , Ping Zhou , JunJun Wu , Koi Morris
发明人： Derek Cole , Eric Manas , Lee Jennings , Frank Lovering , Joseph Stock , William Moore , John Ellingboe , Jeffrey Condon , Mohani Sukhdeo , Ping Zhou , JunJun Wu , Koi Morris
IPC分类号： A61K31/40 , C07D207/22
CPC分类号： C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D401/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

98. 发明申请

US20050255115A1 Anti human ovarian cancer-anti cd3 bispecific antibody 失效
标题翻译：抗人卵巢癌抗CD3双特异性抗体
公开(公告)号：US20050255115A1
公开(公告)日：2005-11-17
申请号：US10478345
申请日：2002-05-23
申请人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
发明人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , C07K19/00 , C12N15/13 , C12N15/62 , C12N15/63 , C12P21/08 , G01N33/574 , C12N5/06
CPC分类号： C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
摘要翻译：本发明提供了抗卵巢癌双特异性抗体。所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或其Fab片段，单CDR抗体或scFv。本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。

99. 发明申请

US20050202422A1 Novel nucleic acids and polypeptides 审中-公开
公开(公告)号：US20050202422A1
公开(公告)日：2005-09-15
申请号：US10291128
申请日：2002-11-08
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
IPC分类号： A61K38/00 , C07K14/81 , C12Q1/68 , A61K38/17 , C07H21/04 , C07K14/47 , C12N9/00
CPC分类号： C07K14/8107 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

100. 发明授权

US06932522B2 Method and apparatus for hermetically sealing photonic devices 失效
标题翻译：用于密封光子器件的方法和装置
公开(公告)号：US06932522B2
公开(公告)日：2005-08-23
申请号：US10444796
申请日：2003-05-22
申请人： Ping Zhou
发明人： Ping Zhou
IPC分类号： H01L23/28 , H01L31/02 , H01S5/022 , H01S5/183 , G02B6/36
CPC分类号： H01S5/02288 , H01S5/0222 , H01S5/183
摘要： A hermetically sealed photonic device submount includes a photonic device mounted on a substrate material and sealed in a flexible hermetic seal. In one configuration, the photonic device is configured to emit or to receive light through the substrate material. In this configuration, the photonic device is covered with an adhesive layer and a metal layer depositd onto the adhesive layer. In another configuration, the photonic device is configured to emit or to receive light in a direction substantially vertically upward from the substrate material. In this configuration, a cover is placed over the photonic device, then the cover is hermetically sealed to the substrate material with an adhesive layer and a metal layer depositd onto the adhesive layer. In both configurations, the photonic device submounts are hermetically sealed according to various aspects of the present invention on the substrate material without using a separate package. Accordingly, any number of hermetically sealed photonic device submounts can be mass produced on wafers using the present invention.
摘要翻译：密封的光子器件底座包括安装在基底材料上并密封在柔性密封件中的光子器件。在一种配置中，光子器件被配置为发射或接收穿过衬底材料的光。在该配置中，光子器件被粘合剂层覆盖，金属层沉积到粘合剂层上。在另一种配置中，光子器件被配置为发射或接收来自基底材料的基本垂直向上的方向的光。在该配置中，将盖放置在光子器件上方，然后将盖密封到基底材料上，粘合剂层和金属层沉积在粘合剂层上。在两种配置中，光子器件底座根据本发明的各个方面在衬底材料上气密密封，而不使用单独的封装。因此，可以使用本发明在晶片上大量生产任何数量的密封的光子器件底座。

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