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91. 发明申请

US20080096895A1 Heterocyclic Derivatives and Their Use as Stearoyl-Coa Desaturase Inhibitors 失效
标题翻译：杂环衍生物及其作为硬脂酰辅酶A去饱和酶抑制剂的用途
公开(公告)号：US20080096895A1
公开(公告)日：2008-04-24
申请号：US11575640
申请日：2005-09-20
申请人： Rajender Kamboj , Zaihui Zhang , Jian-Min Fu
发明人： Rajender Kamboj , Zaihui Zhang , Jian-Min Fu
IPC分类号： A61K31/496 , A61K31/497 , A61P1/16 , A61P3/04 , A61P3/10 , C07D401/14 , C07D403/14 , C12N9/99
CPC分类号： A61K31/496 , A61K31/501
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译：公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，G，J，K ，L，M，VR 2，R 3，R 4，R 5，R 5a R 6，R 6，R 6，R 7，R 7a，R 8，＆lt; 8a＆gt;和＆lt; 8a＆gt;在本文中定义。还公开了包含式（I）化合物的药物组合物。

92. 发明授权

US07030221B2 AMPA-binding human GluR3 receptors 失效
公开(公告)号：US07030221B2
公开(公告)日：2006-04-18
申请号：US10151003
申请日：2002-05-21
申请人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
发明人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , C07K14/70571
摘要： Described herein are isolated polynucleotides which code for a family of AMPA-type human CNS receptors. The receptors are characterized structurally and the construction and use of cell lines expressing these receptors are disclosed.

93. 发明授权

US06482609B1 Isolated human EDG-4 receptor and polynucletide encoding said receptor 失效
标题翻译：分离的人EDG-4受体和编码所述受体的多核苷酸
公开(公告)号：US06482609B1
公开(公告)日：2002-11-19
申请号：US09582200
申请日：2000-07-28
申请人： Donald G. Munroe , Rajender Kamboj , Diana Peters , Fatemch Kooshesh , Tejal B. Vyas , Ashwani K. Gupta
发明人： Donald G. Munroe , Rajender Kamboj , Diana Peters , Fatemch Kooshesh , Tejal B. Vyas , Ashwani K. Gupta
IPC分类号： C12N1512
CPC分类号： C07K14/705 , A61K38/00
摘要： A lysolipid receptor, a human EDG-4 receptor, a method of identifying lysolipid receptors involved in inflammatory response and the lysolipid receptors so identified, and a method of identifying ligands which interact with such lysolipid receptors.
摘要翻译：溶血素受体，人EDG-4受体，鉴定参与炎症反应的溶脂性受体的方法和如此鉴定的溶脂型受体，以及鉴定与这种脂质性受体相互作用的配体的方法。

94. 发明授权

US06406868B1 AMPA-binding human GluR1 receptors 失效
标题翻译： AMPA结合人GluR1受体
公开(公告)号：US06406868B1
公开(公告)日：2002-06-18
申请号：US08216326
申请日：1994-03-23
申请人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
发明人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
IPC分类号： G01N33567
CPC分类号： C07K14/70571 , C07K14/705
摘要： Described herein are isolated polynucleotides which code for an AMPA-type human CNS receptor, designated the human GluR1B receptor. The receptor is characterized structurally and the construction and use of cell lines expressing the receptor is disclosed.
摘要翻译：本文描述了编码AMPA型人CNS受体的分离的多核苷酸，其命名为人GluR1B受体。该受体的结构特征在于，公开了表达受体的细胞系的构建和用途。

95. 发明授权

US06391566B1 Ionotropic human glutamate receptor subunit NR3 失效
标题翻译：离子型人谷氨酸受体亚基NR3
公开(公告)号：US06391566B1
公开(公告)日：2002-05-21
申请号：US08264578
申请日：1994-06-23
申请人： Robert L. Foldes , Sally-Lin Adams , Rajender Kamboj
发明人： Robert L. Foldes , Sally-Lin Adams , Rajender Kamboj
IPC分类号： G01N33567
CPC分类号： C07K14/705 , C07K14/70571 , G01N33/567 , G01N33/68
摘要： Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. This neurotransmission has been found to be modulated by certain modulatory proteins. DNA coding for a family of such modulatory proteins has now been isolated and the modulatory proteins have been characterized. Herein described are recombinant cell lines which produce these modulatory proteins as heterologous membrane-bound products. Also described are related aspects of the invention, which are of commercial significance, including the use of cell lines which express the modulatory proteins either homomerically, or hotoromorically in a complex with an NMDA receptor, as a tool for discovery of compounds which affect the function of the modulatory proteins.
摘要翻译：兴奋性氨基酸（EAAs）如谷氨酸的神经传递通过膜结合表面受体介导。已经发现这种神经传递被某些调节蛋白调节。已经分离了编码这种调节蛋白家族的DNA，并且已经表征了调节蛋白质。本文描述了产生这些调节蛋白作为异源膜结合产物的重组细胞系。还描述了具有商业意义的本发明的相关方面，包括使用在与NMDA受体复合物中同源或热反式表达调节蛋白的细胞系作为影响功能的化合物的发现工具的调节蛋白。

96. 发明授权

US06333161B1 Kainate-binding, human CNS receptors of the EAA5 family 失效
标题翻译：胭脂红蛋白结合，EAA5家族的人CNS受体
公开(公告)号：US06333161B1
公开(公告)日：2001-12-25
申请号：US08178019
申请日：1994-01-06
申请人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
发明人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
IPC分类号： C12N1563
CPC分类号： C07K14/70571 , F02B2075/027
摘要： Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
摘要翻译：兴奋性氨基酸（EAAs）如谷氨酸的神经传递通过膜结合表面受体介导。已经分离了编码红藻氨酸结合型EAA受体的这些受体的一个家族的DNA，并且以受体蛋白为特征。本文描述了产生作为异源膜结合产物的EAA受体的重组细胞系。还描述了具有商业意义的本发明的相关方面。包括使用细胞系作为发现调节EAA受体刺激的化合物的工具。

97. 发明授权

US6040175A AMPA-binding human GluR2 receptors 失效
标题翻译： AMPA结合人GluR2受体
公开(公告)号：US6040175A
公开(公告)日：2000-03-21
申请号：US483327
申请日：1995-06-07
申请人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
发明人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
IPC分类号： C07K14/705 , C12N15/12 , C12N5/10
CPC分类号： C07K14/70571 , C07K14/705
摘要： Described herein are isolated polynucleotides which code for an AMPA-type human CNS glutamate receptor, designated the human GluR2B receptor. The receptor is characterized structurally and the construction and use of cell lines expressing these receptor is disclosed.
摘要翻译：本文描述了编码AMPA型人CNS谷氨酸受体的分离的多核苷酸，其命名为人GluR2B受体。该受体的结构特征在于，公开了表达这些受体的细胞系的构建和用途。

98. 发明授权

US5846823A Expression of human D4 dopamine receptors in stable cell lines 失效
标题翻译：人类D4多巴胺受体在稳定细胞系中的表达
公开(公告)号：US5846823A
公开(公告)日：1998-12-08
申请号：US623471
申请日：1996-03-28
申请人： Joshua Owolabi , Vikarna Rampersad , Rajender Kamboj
发明人： Joshua Owolabi , Vikarna Rampersad , Rajender Kamboj
IPC分类号： G01N33/566 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/12 , C12N5/16
CPC分类号： C07K14/70571
摘要： Cell lines that stably incorporate human D.sub.4 receptor-encoding DNA are provided which are particularly useful in procedures for screening compounds for potential anti-psychotic activity.
摘要翻译：提供了稳定并入人D4受体编码DNA的细胞系，其特别可用于筛选化合物以用于潜在的抗精神病活性的方法。

99. 发明授权

US5547855A Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, DNA encoding them, and expression of the DNA in transformed cells 失效
标题翻译：海参酸结合人CNS谷氨酸受体EAA3C和EAA3D，编码它们的DNA和转化细胞中DNA的表达
公开(公告)号：US5547855A
公开(公告)日：1996-08-20
申请号：US405392
申请日：1995-03-15
申请人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
发明人： Rajender Kamboj , Candace E. Elliott , Stephen L. Nutt
IPC分类号： C07K14/435 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/53 , G01N33/566 , C08L89/00
CPC分类号： C07K14/70571
摘要： Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Disclosed is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
摘要翻译：兴奋性氨基酸（EAAs）如谷氨酸的神经传递通过膜结合表面受体介导。编码一种红藻氨酸结合型EAA受体家族的DNA已经被分离出来，其特征在于受体蛋白质。本文描述了产生作为异源膜结合产物的EAA受体的重组细胞系。公开了将细胞系用作发现调节EAA受体刺激的化合物的工具。

100. 发明申请

US20060073497A1 Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof 失效
公开(公告)号：US20060073497A1
公开(公告)日：2006-04-06
申请号：US11197710
申请日：2005-08-04
申请人： Yigal Goldberg , Rajender Kamboj
发明人： Yigal Goldberg , Rajender Kamboj
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/79
CPC分类号： G01N33/5023 , A61K38/40 , A61K48/00 , C07K14/47 , C12Q1/6883 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5091 , G01N2500/10 , Y10T436/143333
摘要： Isolated fragments of the HFE2A protein able to bind and modulate HFE2A and other proteins, such as hepcidin, involved in the iron metabolism pathway are disclosed, such fragments being of molecular weight of approximately 7 kDa to 43 kDa. Also disclosed are corresponding isolated polynucleotides encoding the fragments of the HFE2A protein. The invention includes derivatives and analogs of the polypeptide fragments of HFE2A, along with compositions of these, that are functionally active, i.e. capable of interacting with the HFE2A, as well as methods of production of the HFE2A cleavage products, derivatives and analogs, e.g. by recombinant means. Methods for identifying modulators of HFE2A, comprising contacting a test compound with HFE2A and determining a change in HFE2A activity due to the compound, are provided. Also taught are methods of diagnosing an animal afflicted with or at risk of developing a disease of iron metabolism comprising determining a change in the level, amount or activity of a fragment of an HFE2A obtained in a sample from said animal relative to the level, amount or activity of a fragment of an HFE2A obtained in a control sample from an unaffected animal, wherein a change identifies said individual as being affect by or at risk of developing a disease of iron metabolism. Methods for treating and/or preventing a disorder in animals comprising administering to an animal afflicted therewith, or at risk of developing said disorder, a therapeutically effective amount of an HFE2A modulator are provided.

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