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91. 发明申请

US20060134752A1 Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 审中-公开
公开(公告)号：US20060134752A1
公开(公告)日：2006-06-22
申请号：US11347870
申请日：2006-02-06
申请人： Ruth Gimeno , Zhidan Wu , Rosana Kapeller-Libermann , Brian Hubbard
发明人： Ruth Gimeno , Zhidan Wu , Rosana Kapeller-Libermann , Brian Hubbard
IPC分类号： C12P21/06 , C12N9/10 , C07H21/04
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.

92. 发明授权

US07001753B2 59079 and 12599, protein kinase family members and uses therefor 失效
公开(公告)号：US07001753B2
公开(公告)日：2006-02-21
申请号：US10077130
申请日：2002-02-15
申请人： Rosana Kapeller-Libermann , Susan L. Acton
发明人： Rosana Kapeller-Libermann , Susan L. Acton
IPC分类号： C12N9/20 , C12N15/00 , C12N1/20 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 59079 and 12599 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 59079 or 12599 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 59079 or 12599 gene has been introduced or disrupted. The invention still further provides isolated 59079 and 12599 proteins, fusion proteins, antigenic peptides and anti-59079 and anti-12599 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

93. 发明申请

US20060014244A1 Novel nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and ATPase-like molecules and uses therefor 审中-公开
公开(公告)号：US20060014244A1
公开(公告)日：2006-01-19
申请号：US11040595
申请日：2005-01-21
申请人： Miyoung Chun , Maria Glucksmann , Rosana Kapeller-Libermann , Rachel Meyers
发明人： Miyoung Chun , Maria Glucksmann , Rosana Kapeller-Libermann , Rachel Meyers
IPC分类号： C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1229 , C07K14/47 , C12N9/1288 , C12N9/14 , G01N33/574 , G01N33/6896
摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

94. 发明授权

US06962811B2 14715, a human fringe family member nucleic acids and uses therefor 失效
标题翻译： 14715，人类边缘家族成员核酸及其用途
公开(公告)号：US06962811B2
公开(公告)日：2005-11-08
申请号：US10141604
申请日：2002-05-08
申请人： Rosana Kapeller-Libermann , Karen L. Anderson
发明人： Rosana Kapeller-Libermann , Karen L. Anderson
IPC分类号： C07K14/47 , C12N9/10 , C12N5/10 , C12N15/12
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids molecules, designated 14715 nucleic acid molecules, which encode novel fringe family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14715 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14715 gene has been introduced or disrupted. The invention still further provides isolated 14715 proteins, fusion proteins, antigenic peptides and anti-14715 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的边缘家族成员的分离的核酸分子，命名为14715个核酸分子。本发明还提供了反义核酸分子，含有14715个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已导入或破坏了14715基因的非人转基因动物。本发明还进一步提供分离的14715蛋白，融合蛋白，抗原肽和抗-14515抗体。还提供了利用本发明组合物的诊断和治疗方法。

95. 发明授权

US06864078B2 14790, novel protein kinase molecule and uses therefor 失效
标题翻译： 14790，新型蛋白激酶分子及其用途
公开(公告)号：US06864078B2
公开(公告)日：2005-03-08
申请号：US09515806
申请日：2000-02-29
申请人： William James Cook , Rosana Kapeller-Libermann , Helga Rubsamen-Waigmann , Frank Spaltmann
发明人： William James Cook , Rosana Kapeller-Libermann , Helga Rubsamen-Waigmann , Frank Spaltmann
IPC分类号： A61K38/00 , A61K48/00 , C12N9/12 , C12N15/54 , C12N5/00 , C12N15/00 , C12P21/06 , C12Q1/48
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C12Y207/01037
摘要： The invention provides an isolated nucleic acid molecule, designated as a kinase nucleic acid molecule, which encodes a novel protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing kinase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. The invention still further provides isolated 14790 proteins, fusion proteins, antigenic peptides and anti-kinase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了编码新型蛋白激酶的分离的核酸分子，命名为激酶核酸分子。本发明还提供反义核酸分子，含有激酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已经引入或破坏了激酶基因的非人类转基因动物。本发明还进一步提供分离的14790蛋白，融合蛋白，抗原肽和抗激酶抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。

96. 发明授权

US06864064B2 18891, a novel human lipase 失效
标题翻译： 18891，一种新型人类脂肪酶
公开(公告)号：US06864064B2
公开(公告)日：2005-03-08
申请号：US10847165
申请日：2004-05-17
申请人： Rosana Kapeller-Libermann
发明人： Rosana Kapeller-Libermann
IPC分类号： A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , C12N9/20 , C12N15/55 , C12Q1/44 , C12Q1/48 , C07K1/00 , C12N5/00 , C12N15/00
CPC分类号： C12Q1/44 , A01K2217/05 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N9/20
摘要： The present invention relates to a newly identified human lipase belonging to the family of mammalian lipases. The invention also relates to polynucleotides encoding the lipase. The invention further relates to methods using the lipase polypeptides and polynucleotides as a target for diagnosis and treatment in lipase-mediated or -related disorders. The invention further relates to drug-screening methods using the lipase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the lipase polypeptides and polynucleotides. The invention further relates to procedures for producing the lipase polypeptides and polynucleotides.
摘要翻译：本发明涉及属于哺乳动物脂肪酶家族的新鉴定的人类脂肪酶。本发明还涉及编码脂肪酶的多核苷酸。本发明还涉及使用脂肪酶多肽和多核苷酸作为在脂肪酶介导或相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用脂肪酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于脂肪酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生脂肪酶多肽和多核苷酸的方法。

97. 发明授权

US06558936B1 Human lipase proteins, nucleic acids encoding them, and uses of both of these 失效
标题翻译：人类脂肪酶蛋白，编码它们的核酸，以及这两者的用途
公开(公告)号：US06558936B1
公开(公告)日：2003-05-06
申请号：US09411132
申请日：1999-10-01
申请人： Mehran Khodadoust , Rosana Kapeller-Libermann
发明人： Mehran Khodadoust , Rosana Kapeller-Libermann
IPC分类号： C12N920
CPC分类号： C12N9/20 , A61K38/00 , A61K48/00 , C12Q1/6883
摘要： The invention provides isolated nucleic acids encoding human lipase proteins and fragments, derivatives, and variants thereof. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders associated, for example, with aberrant lipid metabolism or aberrant pancreatic activity. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides, and antibodies. Diagnostic, prognostic, screening, and therapeutic methods involving use of compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes relating to mono-, di-, and triglyceride metabolism and pancreatic function.
摘要翻译：本发明提供编码人脂肪酶蛋白质的分离的核酸及其片段，衍生物和变体。这些核酸和蛋白质可用于诊断，预防和治疗与例如异常脂质代谢或异常胰腺活动相关的许多人和其它动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了涉及使用本发明组合物的诊断，预后，筛选和治疗方法。本发明的核酸和多肽可用作调节与甘油三酯，甘油三酯和甘油三酯代谢相关的各种细胞过程和胰腺功能的调节剂。

98. 发明授权

US06337187B1 18891, a novel human lipase 失效
公开(公告)号：US06337187B1
公开(公告)日：2002-01-08
申请号：US09434613
申请日：1999-11-05
申请人： Rosana Kapeller-Libermann
发明人： Rosana Kapeller-Libermann
IPC分类号： C12Q168
CPC分类号： C12Q1/44 , A01K2217/05 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N9/20
摘要： The present invention relates to a newly identified human lipase belonging to the family of mammalian lipases. The invention also relates to polynucleotides encoding the lipase. The invention further relates to methods using the lipase polypeptides and polynucleotides as a target for diagnosis and treatment in lipase-mediated or -related disorders. The invention further relates to drug-screening methods using the lipase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the lipase polypeptides and polynucleotides. The invention further relates to procedures for producing the lipase polypeptides and polynucleotides.

99. 发明授权

US06329171B1 23484, A novel human ubiquitin protease 失效
标题翻译： 23484，一种新型人类泛素蛋白酶
公开(公告)号：US06329171B1
公开(公告)日：2001-12-11
申请号：US09408865
申请日：1999-09-30
申请人： Rosana Kapeller-Libermann
发明人： Rosana Kapeller-Libermann
IPC分类号： C12N1512
CPC分类号： C12N9/6472 , C07K2319/00
摘要： The present invention relates to a newly identified human ubiquitin protease belonging to the family of mammalian deubiquitinating enzymes. The invention also relates to polynucleotides encoding the ubiquitin protease. The invention further relates to methods using the ubiquitin protease polypeptides and polynucleotides as a target for diagnosis and treatment in ubiquitin-mediated or -related disorders. The invention further relates to drug-screening methods using the ubiquitin protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ubiquitin protease polypeptides and polynucleotides. The invention further relates to procedures for producing the ubiquitin protease polypeptides and polynucleotides.
摘要翻译：本发明涉及属于哺乳动物脱蛋白酶家族的新鉴定的人泛素蛋白酶。本发明还涉及编码泛素蛋白酶的多核苷酸。本发明还涉及使用泛素蛋白酶多肽和多核苷酸作为在泛素介导的或相关疾病中进行诊断和治疗的靶标的方法。本发明还涉及使用泛素蛋白酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于泛素蛋白酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及生产泛素蛋白酶多肽和多核苷酸的方法。

100. 发明授权

US6146876A 22025, a novel human cyclic nucleotide phosphodiesterase 失效
标题翻译： 22025，一种新的人类环状核苷酸磷酸二酯酶
公开(公告)号：US6146876A
公开(公告)日：2000-11-14
申请号：US330970
申请日：1999-06-11
申请人： Keith E. Robision , Rosana Kapeller-Libermann , David White
发明人： Keith E. Robision , Rosana Kapeller-Libermann , David White
IPC分类号： G01N33/53 , A61K38/00 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P15/08 , A61P19/00 , A61P19/10 , A61P25/24 , A61P25/28 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07K16/40 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12Q1/68 , G01N33/566 , C12N1/20 , C07H21/04 , C12N15/00
CPC分类号： C12Y301/04017 , C12N9/16 , A61K38/00
摘要： The present invention relates to a newly identified human cyclic nucleotide phosphodiesterase belonging to the superfamily of mammalian phosphodiesterases. The invention also relates to polynucleotides encoding the phosphodiesterase. The invention further relates to methods using the phosphodiesterase polypeptides and polynucleotides as a target for diagnosis and treatment in phosphodiesterase-mediated or -related disorders. The invention further relates to drug-screening methods using the phosphodiesterase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the phosphodiesterase polypeptides and polynucleotides. The invention further relates to procedures for producing the phosphodiesterase polypeptides and polynucleotides.
摘要翻译：本发明涉及属于哺乳动物磷酸二酯酶超家族的新鉴定的人环核苷酸磷酸二酯酶。本发明还涉及编码磷酸二酯酶的多核苷酸。本发明还涉及使用磷酸二酯酶多肽和多核苷酸作为磷酸二酯酶介导的或相关病症中的诊断和治疗的靶标的方法。本发明还涉及使用磷酸二酯酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于磷酸二酯酶多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生磷酸二酯酶多肽和多核苷酸的方法。

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