专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US08993619B2 Cyclic bridgehead ether DGAT1 inhibitors 有权
标题翻译：循环桥头醚DGAT1抑制剂
公开(公告)号：US08993619B2
公开(公告)日：2015-03-31
申请号：US13871586
申请日：2013-04-26
申请人： Sejal Patel , Justin Mao , Qian Liu , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
发明人： Sejal Patel , Justin Mao , Qian Liu , Rui Zheng , Tyler Harrison , Rohit Duvadie , Xin Chen , Frederic Zecri , Jay Larrow , Xuchun Zheng , Yizong Zhou , Jiong Ye , Yiping Ding , Yu Gai
IPC分类号： A01N43/08 , A61K31/34 , A01N43/16 , A61K31/35 , A61K31/505 , A01N43/40 , A61K31/44 , A01N43/82 , A61K31/41 , A01N43/76 , A61K31/42 , C07D401/00 , C07D403/00 , C07D405/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D285/12 , C07D285/14 , C07D513/00 , C07D271/10 , C07D271/12 , C07D498/00 , C07D263/00 , C07D263/34 , C07D493/08 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D413/12 , C07D417/12
CPC分类号： C07D493/08 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要： The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
摘要翻译：本发明涉及式（I）化合物：可用于治疗由酰基辅酶 - 二酰基甘油酰基转移酶1（DGAT1）介导的病症，例如，代谢紊乱。本发明还提供了治疗这些病症的方法，以及用于治疗的化合物和组合物等。

92. 发明授权

US08953838B2 Detecting ground geographic features in images based on invariant components 有权
标题翻译：基于不变元件检测图像中的地面地理特征
公开(公告)号：US08953838B2
公开(公告)日：2015-02-10
申请号：US12490538
申请日：2009-06-24
申请人： Xin Chen , Xiangheng Yang
发明人： Xin Chen , Xiangheng Yang
IPC分类号： G06K9/00
CPC分类号： G06K9/00791 , G06K9/00697 , G06K9/00704 , G06K9/00798
摘要： Systems, devices, features, and methods for detecting geographic features in images, such as, for example, to develop a navigation database are disclosed. For example, a method of detecting a path marking from collected images includes collecting a plurality of images of geographic areas along a path. An image of the plurality of images is selected. Components that represent an object on the path in the selected image are determined. In one embodiment, the determined components are independent or invariant to scale of the object. The determined components are compared to reference components in a data library. If the determined components substantially meet a matching threshold with the reference components, the object in the selected image is identified to be a path marking corresponding to the reference components in the data library.
摘要翻译：公开了用于检测图像中的地理特征的系统，设备，特征和方法，例如开发导航数据库。例如，从收集的图像中检测路径标记的方法包括沿着路径收集多个地理区域的图像。选择多个图像的图像。表示所选图像中路径上的对象的组件被确定。在一个实施例中，所确定的分量对象的尺度是独立的或不变的。将确定的组件与数据库中的参考组件进行比较。如果确定的分量基本上满足与参考分量的匹配阈值，则所选图像中的对象被识别为对应于数据库中的参考分量的路径标记。

93. 发明授权

US08859594B2 Polymorphs of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine, and preparation thereof and use thereof 有权
标题翻译： N-（6-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍的多晶型物及其制备及其用途
公开(公告)号：US08859594B2
公开(公告)日：2014-10-14
申请号：US13881706
申请日：2011-10-25
申请人： Hesheng Zhang , Xin Chen
发明人： Hesheng Zhang , Xin Chen
IPC分类号： C07D213/75 , C07D213/74 , A61K31/4409 , A61P35/00
CPC分类号： C07D213/75
摘要： Disclosed are a polymorphs I-VI of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine or of a solvate thereof, a preparation method thereof, and a use thereof as a biological active ingredient. The polymorphs are useful in treatment of cancers, and diseases or disorders caused by abnormal cell proliferation.
摘要翻译：公开了N-（6-（4-（4-氯苯氧基）己基）-N'-氰基-N“ - （4-吡啶基）胍或其溶剂合物的多晶型物I-VI及其制备方法及其用途作为生物活性成分。多晶型物可用于治疗由异常细胞增殖引起的癌症和疾病或病症。

94. 发明授权

US08791056B2 Alkylphosphorofluoridothioates having low wear volume and methods for synthesizing and using same 有权
标题翻译：具有低磨损体积的烷基磷氟代硫代磷酸酯及其合成和使用方法
公开(公告)号：US08791056B2
公开(公告)日：2014-07-29
申请号：US13168478
申请日：2011-06-24
申请人： Xin Chen , Pranesh B. Aswath , Ronald L. Elsenbaumer
发明人： Xin Chen , Pranesh B. Aswath , Ronald L. Elsenbaumer
IPC分类号： C07F9/20 , C10M137/10
CPC分类号： C07F9/20 , C10M137/105 , C10M2213/062 , C10M2223/04 , C10M2223/045 , C10M2223/047 , C10N2230/06 , C10N2230/08 , C10N2240/04 , C10N2270/00 , C10N2210/02
摘要： Alkylphosphorofluoridothioates containing alkyl groups of greater than four carbons which exhibit significantly lower wear volume compared to ZDDP, methods of making same with high yields, and methods of using same as lubricant additives.
摘要翻译：含有大于4个碳的烷基的烷基磷氟代硫酸酯与ZDDP相比显示出显着降低的磨损体积，以高产率制备其的方法，以及使用它们作为润滑剂添加剂的方法。

95. 发明授权

US08744782B2 System and method for simultaneously determining strain and temperature characteristics of an object 有权
标题翻译：同时确定物体的应变和温度特性的系统和方法
公开(公告)号：US08744782B2
公开(公告)日：2014-06-03
申请号：US12947066
申请日：2010-11-16
申请人： Xin Chen , Ming-Jun Li , Anping Liu , Daniel Aloysius Nolan
发明人： Xin Chen , Ming-Jun Li , Anping Liu , Daniel Aloysius Nolan
IPC分类号： G01L11/02 , G01L11/00 , G01K11/00 , G01K11/20
CPC分类号： G01L1/243 , G01K11/32 , G01K2011/322 , G01L1/242
摘要： A system for simultaneously determining strain and temperature characteristics of an object comprising: (i) at least one optical fiber having at least two Brillouin peaks; (ii) at least one connector securing the optical fiber to the object to be monitored; (iii) a laser positioned to provide laser light to said at least one optical fiber; (iv) a device measuring frequencies of said at least two Brillouin peaks, and determining frequency shifts of said at least two Brillouin peaks for said at least one optical fiber along the length of fiber; and (v) a system calculating strain and temperature characteristics along said fiber, based on the coefficients of strain and temperature as well as the measured Brillouin frequency shifts for said optical fiber along the length of said optical fiber.
摘要翻译：一种用于同时确定物体的应变和温度特性的系统，包括：（i）至少一个具有至少两个布里渊峰的光纤; （ii）至少一个将光纤固定到待监测对象的连接器; （iii）定位成向所述至少一个光纤提供激光的激光器; （iv）测量所述至少两个布里渊峰的频率的装置，以及确定沿所述光纤长度的所述至少一个光纤的所述至少两个布里渊峰的频移; 以及（v）基于应变和温度的系数以及所述光纤沿着所述光纤的长度测量的布里渊频移的系统来计算沿着所述光纤的应变和温度特性的系统。

96. 发明授权

US08557016B2 Reducing dross method of lead-free solder 有权
标题翻译：减少无铅焊料的浮渣法
公开(公告)号：US08557016B2
公开(公告)日：2013-10-15
申请号：US13125261
申请日：2009-06-11
申请人： Kun Du , Minghan Chen , Xin Chen , Liesong Cai
发明人： Kun Du , Minghan Chen , Xin Chen , Liesong Cai
IPC分类号： C22B25/08 , B23K31/02
CPC分类号： B23K35/262 , B23K35/22 , B23K35/24 , C22C1/03 , C22C13/00
摘要： A reducing dross method of lead-free solder includes the steps of: producing master alloy of reducing dross which comprises Sn and 0.1 to 0.8 wt % P; analyzing the percentage of P of the lead-free solder to be modified, in order to reach 0.008 to 0.015 wt % P in the lead-free solder, adding the master alloy into the lead-free solder with the percentage of P less than 0.008 wt % or no P; then sampling the lead-free solder at regular intervals to determine the percentage and the percentage loss of P, if the percentage of P being less than a given value from 0.008 to 0.015 wt %, adding the master alloy to keep the percentage of P as 0.008 to 0.015 wt %.
摘要翻译：无铅焊料的还原浮渣法包括以下步骤：制备包含Sn和0.1至0.8重量％P的还原浮渣的母合金; 分析待改性的无铅焊料的P的百分比，以便在无铅焊料中达到0.008〜0.015重量％的P，将母合金添加到P的百分比小于0.008的无铅焊料中重量％或无P; 然后定期对无铅焊料进行取样，以确定P的百分比和百分比损失，如果P的百分比小于给定值的0.008至0.015重量％，则加入母合金以保持P的百分比为 0.008〜0.015重量％。

97. 发明申请

US20130197040A1 POLYMORPHS OF DALFAMPRIDINE, PREPARATIONS AND USES THEREOF 审中-公开
标题翻译：达乐康的多聚体，制备及其用途
公开(公告)号：US20130197040A1
公开(公告)日：2013-08-01
申请号：US13878422
申请日：2011-10-08
申请人： Hesheng Zhang , Xin Chen
发明人： Hesheng Zhang , Xin Chen
IPC分类号： C07D213/73
CPC分类号： C07D213/73 , A61K31/44
摘要： Provided are polymorphs I to VIII of a dalfampridine or of its solvates, a preparation method therefore, and applications thereof as an active component of a medicine. Said polymorphs Ito VIII of the dalfampridine or of its solvents can be used to prepare formulations for improving the walking speed of patients of multiple sclerosis and for alleviating other symptoms of multiple sclerosis.
摘要翻译：提供了dalfampidine或其溶剂化物的多晶型物I至VIII，因此其制备方法及其作为药物的活性成分的应用。 dalfampridine或其溶剂的所述多晶型物Ito VIII可用于制备用于改善多发性硬化患者的行走速度并减轻多发性硬化症的其他症状的制剂。

98. 发明授权

US08399433B2 Amino pyrimidine anticancer compounds 有权
公开(公告)号：US08399433B2
公开(公告)日：2013-03-19
申请号：US12791047
申请日：2010-06-01
申请人： Rama Devi Appari , Xin Chen , Ramesh Chilukuri , Andrew P. Crew , Hanqing Dong , Caterina Ferraro , Kenneth Foreman , Ramesh C. Gupta , An-Hu Li , Dan Sherman , Kathryn M. Stolz , Brian Volk , Robert Zahler
发明人： Rama Devi Appari , Xin Chen , Ramesh Chilukuri , Andrew P. Crew , Hanqing Dong , Caterina Ferraro , Kenneth Foreman , Ramesh C. Gupta , An-Hu Li , Dan Sherman , Kathryn M. Stolz , Brian Volk , Robert Zahler
IPC分类号： A61K31/675 , C07D279/10 , C07D413/12 , C07F9/08
CPC分类号： C07F9/65583 , A61K31/497 , C07D401/12 , C07D403/12 , C07D403/14 , C07F9/6512 , C07F9/6544
摘要： Compounds of Formula 1, as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

99. 发明申请

US20120322769A1 METHODS OF REDUCING VIRULENCE IN BACTERIA 有权
标题翻译：减少细菌中毒性的方法
公开(公告)号：US20120322769A1
公开(公告)日：2012-12-20
申请号：US13579373
申请日：2011-02-16
申请人： Ching-Hong Yang , Xin Chen , Eric J. Toone
发明人： Ching-Hong Yang , Xin Chen , Eric J. Toone
IPC分类号： C12N1/36 , A61P31/04 , A01P1/00 , A01N37/10 , C07C57/30 , C07C57/38 , C07D333/24 , A61K31/381 , A01N43/10 , C07D209/18 , A61K31/405 , A01N43/38 , C07D213/55 , A61K31/435 , A01N43/40 , C07D233/64 , A61K31/4172 , A01N43/50 , C07C59/13 , C07C235/42 , A61K31/165 , A01N37/18 , C07F9/40 , A61K31/662 , A01N57/22 , A61K31/192
CPC分类号： C07C259/06 , A61K31/05 , A61K31/137 , A61K31/165 , A61K31/185 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/216 , A61K31/255 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/4172 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/662 , A61K31/683 , C07C211/29 , C07C215/54 , C07C233/65 , C07C235/34 , C07C237/20 , C07C243/32 , C07C259/08 , C07C309/24 , C07C309/68 , C07C2601/02 , C07D209/14 , C07D209/48 , C07D209/86 , C07D213/56 , C07D233/64 , C07D307/52 , C07D307/79 , C07D333/24 , C07D333/60 , C07D403/06 , C07D405/06 , C07F9/3826 , Y02A50/475 , Y02A50/481
摘要： A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.
摘要翻译：一种减少包含GacS / GacA型系统，HrpX / HrpY型系统，T3SS型系统和Rsm型系统中的至少一种的细菌中的毒力的方法，所述方法包括使细菌与有效量的本文所述的化合物。

100. 发明授权

US08309600B2 GPR120 receptor agonists and uses thereof 失效
公开(公告)号：US08309600B2
公开(公告)日：2012-11-13
申请号：US12641263
申请日：2009-12-17
申请人： Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
发明人： Dong Fang Shi , Jiangao Song , Jingyuan Ma , Aaron Novack , Phuongly Pham , Imad Fayek Nashashibi , Christopher J. Rabbat , Xin Chen
IPC分类号： A61K31/343 , C07D307/83
CPC分类号： C07D405/04 , C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/80 , C07D307/83 , C07D307/94 , C07D311/58 , C07D319/08 , C07D333/54 , C07D333/60 , C07D405/10 , C07D407/04 , C07D407/12
摘要： GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式