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91. 发明授权

US07982375B2 Integrated actuator sensor structure 有权
标题翻译：集成执行器传感器结构
公开(公告)号：US07982375B2
公开(公告)日：2011-07-19
申请号：US12519099
申请日：2007-12-12
申请人： Xiaobo Tan , Ning Xi , Zheng Chen , Yantao Shen
发明人： Xiaobo Tan , Ning Xi , Zheng Chen , Yantao Shen
IPC分类号： H01L41/04
CPC分类号： H01L41/042 , H01L41/0825 , Y10S310/80
摘要： An integrated sensory actuator (10) which uses an electroactive polymer is provided. The sensory actuator is comprised of an actuating member (12) made of an ionic polymer-metal composite; a sensing member (14) made of a piezoelectric material; and an insulating member (16) interposed between the actuating member and the sensing member. The sensory actuator may further include a compensation circuit adapted to receive a sensed signal from the sensing member and an actuation signal from the actuating member and compensate the sensed signal for feedthrough coupling between the actuating member and the sensing member.
摘要翻译：提供使用电活性聚合物的综合感觉致动器（10）。感官致动器包括由离子聚合物 - 金属复合材料制成的致动构件（12）; 由压电材料制成的检测构件（14）; 以及介于所述致动构件和所述感测构件之间的绝缘构件（16）。感觉致动器还可以包括补偿电路，其适于从感测构件接收感测到的信号和来自致动构件的致动信号，并且补偿感测到的信号以用于致动构件和感测构件之间的馈通联接。

92. 发明授权

US07880000B2 Protein kinase modulators and method of use 有权
标题翻译：蛋白激酶调节剂及其使用方法
公开(公告)号：US07880000B2
公开(公告)日：2011-02-01
申请号：US11126000
申请日：2005-05-09
申请人： Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
发明人： Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
IPC分类号： C07D401/14 , C07D403/14 , A61K31/53 , A61K31/4427 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译：本发明涉及具有通式I的化合物，其中A，B，D，E，G，H1-5和R1-4在本文中定义，以及能够调节各种蛋白激酶受体酶的合成中间体，从而影响与这些激酶的活性相关的各种疾病状态和状况。例如，这些化合物能够调节激酶，从而影响血管生成过程并治疗血管生成相关疾病和其它包括癌症和炎症的复发性疾病。本发明还包括药物组合物，包括该化合物，以及治疗与蛋白激酶活性有关的疾病状态的方法。

93. 发明申请

US20100239576A1 AMINO ESTER DERIVATIVES, SAILTS THEREOF AND METHODS OF USE 有权
标题翻译：氨基酯衍生物及其使用方法和使用方法
公开(公告)号：US20100239576A1
公开(公告)日：2010-09-23
申请号：US12728153
申请日：2010-03-19
申请人： Ning Xi
发明人： Ning Xi
IPC分类号： A61K39/395 , C07D401/14 , A61K31/4709 , A61P35/00 , A61P9/10 , C07D401/12 , A61K31/704 , A61K31/708 , A61K31/661 , A61K31/573 , A61P35/04 , A61P37/06 , A61P35/02 , A61P1/04 , C12N5/02 , C12N9/12 , C12N9/99
CPC分类号： C07D215/20 , A61K31/4709 , A61K31/573 , A61K31/661 , A61K31/704 , A61K31/708 , A61K39/395 , A61K45/06 , C07D209/54 , C07D215/22 , C07D401/12 , C07D401/14 , C07D405/14 , C07K16/18 , A61K2300/00
摘要： The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译：本发明提供用于调节蛋白酪氨酸激酶活性以及调节细胞间和/或细胞内信号传导的氨基酯化合物，其盐和药物制剂。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。

94. 发明申请

US20100109595A1 INTEGRATED ACTUATOR SENSOR STRUCTURE 有权
标题翻译：集成执行器传感器结构
公开(公告)号：US20100109595A1
公开(公告)日：2010-05-06
申请号：US12519099
申请日：2007-12-12
申请人： Xiaobo Tan , Ning Xi , Zheng Chen , Yamtoa Shen
发明人： Xiaobo Tan , Ning Xi , Zheng Chen , Yamtoa Shen
IPC分类号： G05B1/06 , H01L41/04
CPC分类号： H01L41/042 , H01L41/0825 , Y10S310/80
摘要： An integrated sensory actuator (10) which uses an electroactive polymer is provided. The sensory actuator is comprised of an actuating member (12) made of an ionic polymer-metal composite; a sensing member (14) made of a piezoelectric material; and an insulating member (16) interposed between the actuating member and the sensing member. The sensory actuator may further include a compensation circuit adapted to receive a sensed signal from the sensing member and an actuation signal from the actuating member and compensate the sensed signal for feedthrough coupling between the actuating member and the sensing member.
摘要翻译：提供使用电活性聚合物的综合感觉致动器（10）。感官致动器包括由离子聚合物 - 金属复合材料制成的致动构件（12）; 由压电材料制成的检测构件（14）; 以及介于所述致动构件和所述感测构件之间的绝缘构件（16）。感觉致动器还可以包括补偿电路，其适于从感测构件接收感测到的信号和来自致动构件的致动信号，并且补偿感测到的信号以用于致动构件和感测构件之间的馈通联接。

95. 发明授权

US07582761B2 Vanilloid receptor ligands and their use in treatments 失效
标题翻译：香草素受体配体及其在治疗中的应用
公开(公告)号：US07582761B2
公开(公告)日：2009-09-01
申请号：US10688246
申请日：2003-10-16
申请人： Chenera Balan , Yunxin Bo , Celia Dominguez , Christopher H. Fotsch , Vijay K. Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Yi-xin Qian , Xianghong Wang , Ning Xi , Shimin Xu
发明人： Chenera Balan , Yunxin Bo , Celia Dominguez , Christopher H. Fotsch , Vijay K. Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Yi-xin Qian , Xianghong Wang , Ning Xi , Shimin Xu
IPC分类号： C07D401/04 , C07D401/06 , C07D403/04
CPC分类号： C07D401/04 , C07D235/30 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Therapeutic benzimidazoles having the general structure: and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有一般结构的治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱疾病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎症性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，糖尿病性神经病变疼痛，咳嗽，交感神经保持疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，胃肠疾病，胃溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

96. 发明授权

US07514564B2 Substituted amine derivatives and methods of use 失效
标题翻译：取代的胺衍生物和使用方法
公开(公告)号：US07514564B2
公开(公告)日：2009-04-07
申请号：US11417329
申请日：2006-05-02
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
IPC分类号： C07D211/94 , C07D211/98 , A61K31/44
CPC分类号： C07D401/14 , A61K31/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , Y02A50/401
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

97. 发明申请

US20090054405A1 PI3 kinase modulators and methods of use 有权
标题翻译： PI3激酶调节剂和使用方法
公开(公告)号：US20090054405A1
公开(公告)日：2009-02-26
申请号：US12221416
申请日：2008-08-01
申请人： Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
发明人： Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
IPC分类号： A61K31/55 , C07D401/14 , C07D401/10 , C07D413/14 , A61P35/00 , A61K31/435 , A61K31/5377 , A61K31/497
CPC分类号： C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04
摘要： The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括能够调节PI3激酶活性的新一类化合物，因此可用于治疗PI3激酶介导的疾病，包括黑素瘤，癌和其它癌症相关病症。所述化合物具有通式I，其中A1，A2，A3，A4，X，R1和R2各自在本文中定义。本发明还包括药物组合物，治疗PI3激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

98. 发明申请

US20080280917A1 Nitrogen-Containing heterocyclyl ketones and methods of use 有权
标题翻译：含氮杂环基酮及其使用方法
公开(公告)号：US20080280917A1
公开(公告)日：2008-11-13
申请号：US12070309
申请日：2008-02-15
申请人： Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/501 , C07D403/12 , A61K31/4709 , A61P25/00 , A61P35/00 , C07D471/00
CPC分类号： C07D237/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

99. 发明授权

US07439360B2 Vanilloid receptor ligands and their use in treatments 失效
标题翻译：香草素受体配体及其在治疗中的应用
公开(公告)号：US07439360B2
公开(公告)日：2008-10-21
申请号：US11251445
申请日：2005-10-14
申请人： Vijay Keshav Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Ning Xi
发明人： Vijay Keshav Gore , Vu Van Ma , Mark H. Norman , Vassil I. Ognyanov , Ning Xi
IPC分类号： A61K31/496 , C07D401/14
CPC分类号： C07D233/64 , C07D401/12
摘要： Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道，泌尿生殖道，胃肠道或血管区域内脏运动紊乱，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

100. 发明授权

US07176322B2 Calcium receptor modulating agents 有权
标题翻译：钙受体调节剂
公开(公告)号：US07176322B2
公开(公告)日：2007-02-13
申请号：US10444945
申请日：2003-05-22
申请人： Michael G. Kelly , Shimin Xu , Ning Xi , Robert Townsend , David Semin , Chiara Ghiron , Thomas Coulter
发明人： Michael G. Kelly , Shimin Xu , Ning Xi , Robert Townsend , David Semin , Chiara Ghiron , Thomas Coulter
IPC分类号： C07D209/82 , C07D209/14 , C07D209/04 , A61K31/403 , A61K31/404 , A61K31/4045
CPC分类号： C07D235/06 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/86 , C07D209/88 , C07D249/04 , C07D401/04 , C07D403/04 , C07D413/04 , C07D471/04 , C07D491/04
摘要： The compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：本发明的化合物由以下一般结构或其药学上可接受的盐以及含有它们的组合物表示，其中变量在本文中定义，及其用于减少或抑制PTH分泌的用途，包括减少或抑制PTH分泌的方法，以及用于治疗或预防与骨疾病相关的疾病如骨质疏松症或与过度分泌的PTH相关的疾病如甲状旁腺功能亢进的方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

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