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91. 发明授权

US07393318B2 Methods and compositions for interaction trap assays 有权
标题翻译：相互作用阱测定法的方法和组成
公开(公告)号：US07393318B2
公开(公告)日：2008-07-01
申请号：US10801994
申请日：2004-03-16
申请人： J. Keith Joung , Jeffrey Miller , Carl O. Pabo
发明人： J. Keith Joung , Jeffrey Miller , Carl O. Pabo
IPC分类号： C40B40/08 , C40B40/06 , C40B40/10 , C07H21/04
CPC分类号： G01N33/502 , C12N15/1055 , C12Q1/6897 , G01N33/50 , G01N33/5008 , C12Q2565/201
摘要： The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antagonize a protein-protein, protein-DNA, or protein-RNA interaction. In certain embodiments, the interaction trap system of the invention is useful for screening libraries with greater than 107 members. In other embodiments, the interaction trap system of the invention is used in conjunction with flow cytometry. The invention further provides a means for simultaneously screening a target protein or nucleic acid sequence for the ability to interact with two or more test proteins or nucleic acids.
摘要翻译：本发明提供了用于检测蛋白质 - 蛋白质，蛋白质-DNA或蛋白质 - RNA相互作用的相互作用阱测定法的方法和组合物。本发明的方法和组合物还可用于鉴定可能激动或拮抗蛋白质 - 蛋白质，蛋白质-DNA或蛋白质 - RNA相互作用的试剂。在某些实施方案中，本发明的相互作用捕获系统可用于筛选具有大于10个成员的文库。在其它实施方案中，本发明的相互作用阱系统结合流式细胞术使用。本发明还提供了用于同时筛选靶蛋白或核酸序列以获得与两种或多种测试蛋白或核酸相互作用的能力的方法。

92. 发明授权

US07361635B2 Simultaneous modulation of multiple genes 有权
公开(公告)号：US07361635B2
公开(公告)日：2008-04-22
申请号：US10651761
申请日：2003-08-29
申请人： Jeffrey Miller , Guofu Li , Carl Pabo , Trevor Collingwood
发明人： Jeffrey Miller , Guofu Li , Carl Pabo , Trevor Collingwood
IPC分类号： A61K38/00 , C12P21/06 , C07K14/00 , C07H21/04 , G01N33/53
CPC分类号： C07K14/4702
摘要： Disclosed herein are compositions and methods that regulate expression of two or more endogenous genes.

93. 发明申请

US20080026647A1 Detachable coupling for a remote inspection device 有权
标题翻译：用于远程检测装置的可拆卸联轴器
公开(公告)号：US20080026647A1
公开(公告)日：2008-01-31
申请号：US11895516
申请日：2007-08-24
申请人： Al Boehnlein , Paul Eckhoff , Brandon Watt , Tye Newman , Jeffrey Miller
发明人： Al Boehnlein , Paul Eckhoff , Brandon Watt , Tye Newman , Jeffrey Miller
IPC分类号： H01R4/60
CPC分类号： H01R13/5205 , G02B23/2476 , H01R13/523
摘要： A remote inspection device is provided for inspecting visually obscured locations. The device is generally comprised of a imager housing and a display housing disposed on opposite ends of a modular, flexible cable. An imaging device and one or more light sources are embedded in the end of the cylindrical imager housing. A display housing is coupled to the other end of the flexible cable and configured to be grasped by a user of the device. A display device supported by the display housing receives a video signal from the imaging device and converts the video signal to a video image. The flexible cable can be removably attached to other components with a detachable coupling. The detachable coupling is adapted to facilitate movement of the coupling through confined spaces and inhibit relative axial rotation. Components of the coupling can have tapered mating surfaces to inhibit longitudinal movement within the coupling.
摘要翻译：提供了一个远程检查装置，用于检查视觉模糊的位置。该装置通常包括设置在模块化的柔性电缆的相对端上的成像器外壳和显示器外壳。成像装置和一个或多个光源嵌入在圆柱形成像器壳体的端部中。显示器壳体耦合到柔性电缆的另一端并且被配置为由设备的用户掌握。由显示器壳体支持的显示装置从成像装置接收视频信号并将视频信号转换为视频图像。柔性电缆可拆卸地连接到其他部件上。可拆卸联轴器适于促使联轴器通过密闭空间运动并阻止相对轴向旋转。联轴器的部件可以具有锥形配合表面，以阻止联接器内的纵向运动。

94. 发明授权

US07297491B2 Methods and compositions for interaction trap assays 有权
标题翻译：相互作用阱测定法的方法和组成
公开(公告)号：US07297491B2
公开(公告)日：2007-11-20
申请号：US10915233
申请日：2004-08-10
申请人： J. Keith Joung , Jeffrey Miller , Carl O. Pabo
发明人： J. Keith Joung , Jeffrey Miller , Carl O. Pabo
IPC分类号： C12Q1/68
CPC分类号： C12N15/1055 , C12Q1/6897 , G01N33/50 , G01N33/5008 , G01N33/502 , C12Q2565/201
摘要： The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the invention may also be used to identify agents which may agonize or antagonize a protein-protein, protein-DNA, or protein-RNA interactions. In certain embodiments, the interaction trap system of the invention is useful for screening libraries with greater than 107 members. In other embodiments, the interaction trap system of the invention is used in conjunction with flow cytometry. The invention further provides a means for simultaneously screening a target protein or nucleic acid sequence for the ability to interact with two or more test proteins or nucleic acids.
摘要翻译：本发明提供了用于检测蛋白质 - 蛋白质，蛋白质-DNA或蛋白质 - RNA相互作用的相互作用阱测定法的方法和组合物。本发明的方法和组合物还可用于鉴定可能激动或拮抗蛋白质 - 蛋白质，蛋白质-DNA或蛋白质 - RNA相互作用的试剂。在某些实施方案中，本发明的相互作用捕获系统可用于筛选具有大于10个成员的文库。在其它实施方案中，本发明的相互作用阱系统结合流式细胞术使用。本发明还提供了用于同时筛选靶蛋白或核酸序列以获得与两种或多种测试蛋白或核酸相互作用的能力的方法。

95. 发明申请

US20070034853A1 Structures for reducing operating voltage in a semiconductor device 失效
标题翻译：用于降低半导体器件中的工作电压的结构
公开(公告)号：US20070034853A1
公开(公告)日：2007-02-15
申请号：US11203917
申请日：2005-08-15
申请人： Virginia Robbins , Steven Lester , Jeffrey Miller , David Bour
发明人： Virginia Robbins , Steven Lester , Jeffrey Miller , David Bour
IPC分类号： H01L29/06 , H01L31/00
CPC分类号： H01S5/305
摘要： A light-emitting device comprises an active region configured to generate light in response to injected charge, and an n-type material layer and a p-type material layer, wherein at least one of the n-type material layer and the p-type material layer is doped with at least two dopants, at least one of the dopants having an ionization energy higher than the ionization energy level of the other dopant.
摘要翻译：发光装置包括响应于注入的电荷而被配置为产生光的有源区，以及n型材料层和p型材料层，其中n型材料层和p型材料层中的至少一种材料层掺杂有至少两种掺杂剂，所述掺杂剂中的至少一种具有高于另一种掺杂剂的电离能级的电离能。

96. 发明申请

US20060270565A1 Subterranean fluids having improved environmental characteristics and methods of using these fluids in subterranean formations 失效
标题翻译：具有改善的环境特性的地下流体和在地下地层中使用这些流体的方法
公开(公告)号：US20060270565A1
公开(公告)日：2006-11-30
申请号：US11500112
申请日：2006-08-07
申请人： Lance Brothers , Jeffrey Miller
发明人： Lance Brothers , Jeffrey Miller
IPC分类号： C09K8/42
CPC分类号： C09K8/467 , C04B28/02 , C04B28/12 , C04B2103/0072 , C04B2103/0074 , C04B2111/00146 , C09K8/424 , Y02W30/92 , C04B24/10 , C04B2103/40 , C04B7/02 , C04B14/108 , C04B18/08 , C04B24/34
摘要： Subterranean fluids are provided that have improved environmental characteristics, and more particularly, subterranean fluids are provided that include a hydraulic cement in an invert emulsion. Methods of using such fluids in subterranean operations also are provided. An example of a method is a method of using a fluid in a subterranean formation. An example of a composition is a fluid comprising a hydraulic cement and an invert emulsion of an oleaginous fluid, a nonoleaginous fluid, and an emulsifying surfactant, wherein the emulsifying surfactant: has an LC50 or EC50 that is greater than about 10 milligrams/liter with respect to Skeletonema costatum, Acartia tonsa, Scopthalmus maximus (juvenile), or Corophium volutator; and demonstrates a biodegradability of: greater than about 70% biodegradation in 28 days when tested according to method OECD 301A or 301E; or greater than about 60% biodegradation in 28 days when tested according to method OECD 301B, 301C, 301F, or 306.
摘要翻译：提供具有改善的环境特性的地下流体，更具体地说，提供了包括反相乳液中的水硬性水泥的地下流体。还提供了在地下操作中使用这种流体的方法。方法的一个实例是在地层中使用流体的方法。组合物的实例是包含水硬性水泥和油性流体，非油性流体和乳化表面活性剂的反相乳液的流体，其中所述乳化表面活性剂具有LC 50或EC 大于约10毫克/升，相对于骷髅毛癣菌，Ac a a，，，，，us（or or or;;;;;;;;;;;;;;;; 并证实了生物降解性：当根据方法OECD 301A或301E测试时，在28天内大于约70％的生物降解; 或在根据方法OECD 301B，301C，301F或306进行测试时，在28天内大于约60％的生物降解。

97. 发明申请

US20060236244A1 Command links 审中-公开
标题翻译：命令链接
公开(公告)号：US20060236244A1
公开(公告)日：2006-10-19
申请号：US11106723
申请日：2005-04-15
申请人： Mark Coburn , Harold Gomez , Jan Miksovsky , Jeffrey Miller , Vincent Pasceri , Charles Stabb , Randall Winjum
发明人： Mark Coburn , Harold Gomez , Jan Miksovsky , Jeffrey Miller , Vincent Pasceri , Charles Stabb , Randall Winjum
IPC分类号： G06F17/00
CPC分类号： G06F3/0481
摘要： A command link input control has a main title portion describing a user input option corresponding to selection of that command link. Upon selection of the command link, a dialog containing that command link is completed without requiring a user to select additional input controls. The command link may optionally contain a subtitle portion for providing supplementary text further explaining or otherwise elaborating upon the option corresponding to the command link. The command link may also contain a glyph. Upon hovering a cursor over a command link or otherwise indicating potential selectability of the command link, the entire link is highlighted by, e.g., altering the background color of the display region containing the main title, subtitle and/or glyph.
摘要翻译：命令链接输入控件具有描述与该命令链接的选择相对应的用户输入选项的主标题部分。在选择命令链接之后，包含该命令链接的对话框完成，而不需要用户选择其他输入控件。命令链接可以可选地包含用于提供补充文本的字幕部分，进一步解释或以其他方式阐述与命令链接相对应的选项。命令链接也可以包含字形。当将光标悬停在命令链接上或以其它方式指示命令链接的可选择性时，整个链接通过例如改变包含主标题，字幕和/或字形的显示区域的背景颜色来突出显示。

98. 发明授权

US07114281B2 Fishing rod holder 失效
公开(公告)号：US07114281B2
公开(公告)日：2006-10-03
申请号：US10246326
申请日：2002-09-18
申请人： Jeffrey Miller
发明人： Jeffrey Miller
IPC分类号： A01K97/10
CPC分类号： A01K97/10
摘要： A fishing rod holding apparatus that can be mounted alone or in series to a vessel such as a boat, wherein the assembly includes a mounting base, a channel for receiving and attaching one or more fishing rod holding assemblies. Each rod-holding assembly comprises a fishing rod holding tube and a spring biased pivoting assembly. The pivoting assembly allows the angle of the fishing rod holder to be adjusted manually by depressing a button while simultaneously repositioning the rod holder. Once the desired angle is achieved, the assembly locks in position by simply releasing the button.

99. 发明申请

US20060207914A1 Packaging system for a component including a compressive and shock-absorbent packing insert 审中-公开
标题翻译：用于包括压缩和吸震性包装插入件的部件的包装系统
公开(公告)号：US20060207914A1
公开(公告)日：2006-09-21
申请号：US11080766
申请日：2005-03-15
申请人： Paul Cance , William Green , Jeffrey Johnson , Jeffrey Miller
发明人： Paul Cance , William Green , Jeffrey Johnson , Jeffrey Miller
IPC分类号： B65D81/02 , B65D85/30
CPC分类号： B65D5/509 , B65D81/1075
摘要： A packaging system for a component is disclosed. The packaging system includes a compressible and shock-absorbent packing insert, wherein the packing insert includes deformable “cushion elements” that accommodate components of varying sizes and shapes in a protective manner.
摘要翻译：公开了一种用于组件的包装系统。该包装系统包括一个可压缩且具有吸震性的包装插入件，其中包装插入件包括可变形的“缓冲元件”，以保护方式容纳不同尺寸和形状的部件。

100. 发明申请

US20060166840A1 Drilling fluids containing biodegradable organophilic clay 有权
标题翻译：含有可生物降解的有机粘土的钻井液
公开(公告)号：US20060166840A1
公开(公告)日：2006-07-27
申请号：US11042560
申请日：2005-01-25
申请人： Jeffrey Miller
发明人： Jeffrey Miller
IPC分类号： C09K8/18
CPC分类号： C09K8/36 , C09K8/145
摘要： Drilling fluids are provided that comprise an organophilic clay treated with a quaternary ammonium surfactant having an amide linkage. The quaternary ammonium surfactant may comprise a compound generally represented by the following formula: where M− is an anion such as a chloride, methyl sulfate, bromide, acetate, or iodide ion; R1 is an alkyl group such as a saturated hydrocarbon with 10 or more carbons; R2, R3, and R4 are the same or different alkyl groups such as a methyl, ethyl, or benzyl group, and x is greater than or equal to 1. The organophilic clay treated in this manner is substantially biodegradable. In embodiments, the drilling fluids comprise the foregoing organophilic clay, an oil-based fluid and a weighting agent. In still embodiments, the drilling fluids comprise the foregoing organophilic clay, an invert emulsion, an emulsifier, and a weighting agent.
摘要翻译：提供钻井液，其包含用具有酰胺键的季铵表面活性剂处理的亲有机物质粘土。季铵表面活性剂可以包含通常由下式表示的化合物：其中M是阴离子，例如氯化物，甲基硫酸盐，溴化物，乙酸盐或碘离子; R 1是具有10个或更多个碳的饱和烃的烷基; R 2，R 3和R 4是相同或不同的烷基，例如甲基，乙基或苄基，x 大于或等于1.以这种方式处理的有机粘土基本上是可生物降解的。在实施方案中，钻井流体包括前述亲有机粘土，油基流体和加重剂。在仍然的实施方案中，钻井流体包括前述亲有机粘土，反相乳液，乳化剂和加重剂。

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