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91. 发明授权

US06711439B1 Evoked response variability as an indicator of autonomic tone and surrogate for patient condition 有权
标题翻译：诱发反应变异性作为患者状况的自主神经和代谢指标
公开(公告)号：US06711439B1
公开(公告)日：2004-03-23
申请号：US10077663
申请日：2002-02-14
申请人： Kerry Bradley , Euljoon Park , Laurence S. Sloman
发明人： Kerry Bradley , Euljoon Park , Laurence S. Sloman
IPC分类号： A61N1362
CPC分类号： A61N1/371 , A61B5/4035
摘要： Modern implantable cardiac stimulation devices include processing and data storage capabilities that may be exploited to track myocardial condition and autonomic tone. Implantable devices have a capability to measure and store electrogram information over a period of time in a relatively large capacity memory, with advances in technology allowing increases in memory size. The evoked response varies in amplitude and morphology with changes in autonomic tone, ventricular filling, paced rate, and other parameters. The implantable cardiac device can be configured to sense and accurately quantify the evoked response, derive parameters from the quantified evoked response, store the parameters over long time periods, and derive variability statistics from the parameters to assist in tracking the patient's condition over time, and guiding the patient's therapy.
摘要翻译：现代可植入心脏刺激装置包括可被利用来追踪心肌状况和自主神经紧张的处理和数据存储能力。可移植设备具有在相对大容量存储器中在一段时间内测量和存储电描记图信息的能力，技术的进步允许存储器大小增加。诱发反应的幅度和形态随着自主神经调节，心室充盈，起搏率和其他参数的变化而变化。可植入心脏装置可被配置为感测并准确量化诱发反应，从量化的诱发反应导出参数，在长时间段内存储参数，并从参数中导出可变性统计数据，以帮助随时间跟踪患者的状况，以及指导患者的治疗。

92. 发明授权

US08301246B2 System and method for improving CRT response and identifying potential non-responders to CRT therapy 有权
标题翻译：用于改善CRT反应并鉴定CRT治疗的潜在无反应者的系统和方法
公开(公告)号：US08301246B2
公开(公告)日：2012-10-30
申请号：US11759756
申请日：2007-06-07
申请人： Euljoon Park , Xiaoyi Min
发明人： Euljoon Park , Xiaoyi Min
IPC分类号： A61N1/368
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/3627 , A61N1/3684
摘要： A method is disclosed that includes selecting an electrode configuration from a plurality of electrode configurations associated with electrodes of an implantable lead, sensing activity of the right ventricle and the left ventricle, determining an interval between sensed activity of the right ventricle and sensed activity of the left ventricle and determining whether the selected electrode configuration is suitable based at least in part on the interval. In one embodiment, an implantable device performs such a method to improve patient response to the CRT therapy, for example, by selecting a different electrode configuration if the current configuration is not suitable. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：公开了一种方法，其包括从与可植入引线的电极相关联的多个电极配置中选择电极配置，感测右心室和左心室的活动，确定感测到的右心室的活动与感测的右心室的活动之间的间隔并且至少部分地基于间隔来确定所选择的电极配置是否合适。在一个实施例中，可植入装置执行这种方法以改善患者对CRT治疗的反应，例如，如果当前配置不合适，则通过选择不同的电极配置。还公开了其它示例性方法，装置，系统等。

93. 发明授权

US08241221B2 Systems and methods for use with an implantable medical device for detecting stroke based on electrocardiac signals 有权
标题翻译：用于基于心电信号检测卒中的可植入医疗装置的系统和方法
公开(公告)号：US08241221B2
公开(公告)日：2012-08-14
申请号：US12366526
申请日：2009-02-05
申请人： Euljoon Park
发明人： Euljoon Park
IPC分类号： A61B5/0205
CPC分类号： A61B5/0472 , A61B5/0006 , A61B5/0031
摘要： Techniques are provided for detecting stroke within a patient using an implantable medical device in conjunction with an external confirmation system. In one example, a preliminary detection of stroke is performed by a subcutaneous monitor based on an analysis of features of an electrocardiogram (ECG) sensed within the patient. Exemplary ECG features indicative of possible stroke include the onset of prominent U-waves, the onset of notched T-waves, and changes in ST segment duration or QT duration or dynamic trends in these parameters. The monitor transmits a signal indicative of possible stroke to a bedside monitor or other external system, which generates a stroke questionnaire for use in confirming the stroke. Family members or other caregivers input answers to the questionnaire into the external system, which confirms or disconfirms the stroke. Emergency personnel can be automatically notified. Implantable systems that detect stroke based on intracardiac electrogram (IEGM) signals are also described herein.
摘要翻译：提供技术用于使用可植入医疗装置结合外部确认系统检测病人内的卒中。在一个示例中，基于对在患者体内感测的心电图（ECG）的特征的分析，通过皮下监测器进行中风的初步检测。指示可能的中风的示例性ECG特征包括突出U波的开始，开槽的T波，以及ST段持续时间或QT持续时间的变化或这些参数中的动态趋势。监视器将指示可能的行程的信号发送到床边监视器或其他外部系统，其产生用于确认行程的笔画问卷。家庭成员或其他护理人员将调查表的答案输入到外部系统中，这确认或不确定中风。应急人员可以自动通知。本文还描述了基于心内电描记图（IEGM）信号检测中风的植入式系统。

94. 发明授权

US07946995B1 Analyzing circadian variations of a hemodynamic parameter to determine an adverse cardiac condition 有权
标题翻译：分析血液动力学参数的昼夜变化以确定不良心脏病
公开(公告)号：US07946995B1
公开(公告)日：2011-05-24
申请号：US11558284
申请日：2006-11-09
申请人： Steve Koh , Euljoon Park , Dorin Panescu
发明人： Steve Koh , Euljoon Park , Dorin Panescu
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/0205 , A61B5/029 , A61B5/0538 , A61B5/1118 , A61B5/4809 , A61B5/686
摘要： A system and method of determining the status of an adverse cardiac condition of a medical patient based on circadian variation of one or more hemodynamic parameters are provided. In some embodiments, the system and method calculate a first average value of a series of first values during a first time period, a second average value of a series of second values during a second time period, and a difference between the first average value and the second average value. The method provides an indication of an adverse cardiac condition when the difference is less than a predetermined threshold.
摘要翻译：提供了一种基于一个或多个血液动力学参数的昼夜变化来确定医疗患者的不良心脏状态的状态的系统和方法。在一些实施例中，系统和方法在第一时间周期期间计算一系列第一值的第一平均值，在第二时间段期间计算一系列第二值的第二平均值，以及第一平均值与第二个平均值。当差小于预定阈值时，该方法提供不良心脏状况的指示。

95. 发明申请

US20100179610A1 METHODS AND DEVICES FOR MONITORING MYOCARDIAL MECHANICAL STABILITY 有权
标题翻译：用于监测心肌机械稳定性的方法和装置
公开(公告)号：US20100179610A1
公开(公告)日：2010-07-15
申请号：US12576488
申请日：2009-10-09
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/7264 , A61B7/023 , A61B2562/0219 , A61N1/3622 , A61N1/36521 , A61N1/37258 , A61N1/3962
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，用于基于指示患者心脏对于多个连续节拍的机械功能的信号来监测心肌机械稳定性。某些实施例使用时域技术，而其他实施例使用频域技术来监测心肌机械稳定性。在某些实施例中，使用重复每N次跳动的图案化起搏序列来对患者的心脏进行起搏。在其他实施例中，患者的心脏不需要起搏。本摘要不是对本发明的完整描述或限制本发明的范围。

96. 发明授权

US07689280B1 Automatic system for determining bi-ventricular pacing responders 失效
标题翻译：用于确定双心室起搏应答者的自动系统
公开(公告)号：US07689280B1
公开(公告)日：2010-03-30
申请号：US11290938
申请日：2005-11-29
申请人： Mark W. Kroll , Euljoon Park
发明人： Mark W. Kroll , Euljoon Park
IPC分类号： A61N1/08
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36521 , A61N1/3684 , A61N1/37258
摘要： A method of predicting a patient's response to multi-chamber pacing by implanting at least three sensing electrodes, measuring across at least two different impedance vectors of the heart via the three electrodes to obtain at least two impedance signals, and evaluating the at least two impedance signals for indications of contractile dysynchrony. Contractile dysynchrony indicates that the patient is likely to have a positive response to multi-chamber pacing. Also an implantable cardiac stimulation device with an implantable housing, a stimulation pulse generator positioned within the housing, at least two implantable leads, and a controller communicating with the pulse generator to induce the generator to deliver therapeutic stimulation to a patient's heart. The leads are arranged to measure a physiological parameter along at least two different spatial orientations. The controller evaluates relative timing of the physiological parameters along the different orientations for indications of contractile synchrony of the patient's heart.
摘要翻译：一种通过植入至少三个感测电极来预测患者对多室起搏的反应的方法，通过三个电极测量心脏的至少两个不同阻抗向量，以获得至少两个阻抗信号，并评估至少两个阻抗用于收缩异常现象的信号。收缩异常表示患者可能对多室起搏有积极的反应。还有一种具有可植入壳体的可植入心脏刺激装置，位于壳体内的刺激脉冲发生器，至少两个可植入引线，以及与脉冲发生器通信以使发生器向患者心脏输送治疗刺激的控制器。引线布置成沿着至少两个不同的空间取向测量生理参数。控制器评估沿着不同方向的生理参数的相对时间，用于指示患者心脏的收缩同步。

97. 发明授权

US07333856B1 Method and system to graphically display programming parameters for multi-chamber devices 有权
标题翻译：用于图形显示多室设备的编程参数的方法和系统
公开(公告)号：US07333856B1
公开(公告)日：2008-02-19
申请号：US10847709
申请日：2004-05-17
申请人： Siew Bee Er , Qiuju Huang , Euljoon Park , Paul A. Levine
发明人： Siew Bee Er , Qiuju Huang , Euljoon Park , Paul A. Levine
IPC分类号： A61N1/362
CPC分类号： A61N1/37247
摘要： A method and system for programming an implantable therapeutic stimulation device sensing from and delivering therapeutic stimulations to multiple sites within a patient under a plurality of programmable parameters. The method includes automatically determining which parameters need to be programmed, graphically indicating specific parameters that need to be programmed in a spatial correspondence to the affected sites in the patient and/or displaying a waveform corresponding to expected physiological activity with the programming, and providing control inputs to program the specific parameters. The method can also include automatically evaluating the programmed parameters, and if errors exist in the programming, indicating the errors and awaiting corrective input, else programming the implantable device. The method can also include automatically determining a number of sensing and stimulation electrodes connected to the device.
摘要翻译：一种用于编程可植入治疗刺激装置的方法和系统，其在多个可编程参数下感测并向患者内的多个部位递送治疗刺激。该方法包括自动确定哪些参数需要被编程，以图形方式指示需要编程的具体参数与病人的受影响部位的空间对应，和/或显示与编程有关的预期生理活动的波形，以及提供控制输入来编程具体参数。该方法还可以包括自动评估编程参数，并且如果编程中存在错误，指示错误并等待校正输入，则编程可植入设备。该方法还可以包括自动确定连接到该装置的感测和刺激电极的数量。

98. 发明授权

US07171271B2 System and method for evaluating heart failure using an implantable medical device based on heart rate during patient activity 有权
标题翻译：使用基于患者活动期间的心率的可植入医疗装置评估心力衰竭的系统和方法
公开(公告)号：US07171271B2
公开(公告)日：2007-01-30
申请号：US10844078
申请日：2004-05-11
申请人： Steve Koh , Euljoon Park
发明人： Steve Koh , Euljoon Park
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61B5/0006 , A61B5/0031 , A61B5/0245 , A61B5/0422 , A61B5/0816 , A61B5/1118 , A61B5/145 , A61B5/222 , A61B5/7275 , A61B2562/0219 , A61N1/3627
摘要： Techniques are provided for detecting and tracking heart failure based on heart rate, rest rate and activity levels. Briefly, histograms are generated based on rest-rate adjusted heart rate values and corresponding activity level values. Heart failure is then detected and tracked based on an analysis of the histogram. In one example, so long as the activity level of the patient exceeds some minimum threshold, the ratio of adjusted heart rate to activity level is periodically calculated and resulting values are stored in a histogram. Each day, the histogram is compared against a previous histogram to detect any overall trend. For example, the centroid of the histogram can be calculated each day with any changes in the centroid values used to track progression of heart failure.
摘要翻译：提供了基于心率，静息率和活动水平检测和跟踪心力衰竭的技术。简而言之，基于休息率调整心率值和相应的活动水平值产生直方图。然后基于直方图的分析检测和跟踪心力衰竭。在一个示例中，只要患者的活动水平超过某个最小阈值，则定期计算调整心率与活动水平的比例，并将结果值存储在直方图中。每天，将直方图与先前的直方图进行比较，以检测任何总体趋势。例如，直方图的质心可以每天计算用于跟踪心力衰竭进展的质心值的任何变化。

99. 发明申请

US20060276848A1 Evoked response and impedance measures for monitoring heart failure and respiration 有权
标题翻译：用于监测心力衰竭和呼吸的诱发反应和阻抗措施
公开(公告)号：US20060276848A1
公开(公告)日：2006-12-07
申请号：US11149058
申请日：2005-06-06
申请人： Xiaoyi Min , Euljoon Park , Malin Ohlander
发明人： Xiaoyi Min , Euljoon Park , Malin Ohlander
IPC分类号： A61N1/365
CPC分类号： A61B5/0535 , A61B5/0402 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61N1/3601 , A61N1/365 , A61N1/36521 , A61N1/371
摘要： An exemplary method includes acquiring impedance values over one or more respiratory cycles, determining an impedance span based on the impedance values and, based at least in part on the impedance span, determining cardiac condition or respiratory condition. Another exemplary method includes acquiring IEGMs over one or more respiratory cycles, determining evoked response measure values based on the IEGMs, determining an evoked response span based on the evoked response measure values and, based at least in part on the evoked response span, determining cardiac condition or respiratory condition. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括：通过一个或多个呼吸周期获取阻抗值，基于阻抗值确定阻抗跨度，并且至少部分地基于阻抗跨度，确定心脏状况或呼吸状况。另一示例性方法包括通过一个或多个呼吸周期获取IEGM，基于IEGM确定诱发的应答测量值，基于诱发的响应测量值确定诱发的应答跨度，并且至少部分地基于诱发的响应跨度，确定心脏病情或呼吸状况。还公开了其它示例性方法，装置，系统等。

100. 发明授权

US07139609B1 System and method for monitoring cardiac function via cardiac sounds using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置通过心脏声音监测心脏功能的系统和方法
公开(公告)号：US07139609B1
公开(公告)日：2006-11-21
申请号：US10346809
申请日：2003-01-17
申请人： Xiaoyi Min , Paul A. Levine , Euljoon Park
发明人： Xiaoyi Min , Paul A. Levine , Euljoon Park
IPC分类号： A61B5/02 , A61N1/365
CPC分类号： A61N1/36585 , A61B5/02 , A61B5/04004 , A61B5/0402 , A61B5/7239 , A61B7/04 , A61N1/3627
摘要： Techniques are provided for performing internal measurement of heart sounds to estimate patient cardiac function in terms of stroke volume, cardiac output, or a maximum rate of change of aortic pressure with time (max dP/dt). Control parameters of the medical device are then automatically adjusted so as to optimize overall cardiac function or to provide for ventricular resynchronization therapy. In one example, heart sound signals are derived from acceleration signals received from an accelerometer. The heart sound signals are analyzed to identify S1 and S2 heart sounds as well as ejection period and isovolumic interval (ISOV). Proxies for max dP/dt, stroke volume and cardiac output are then derived from the S1 and S2 heart sounds, the ejection period and the ISOV. Alternative techniques, not requiring detection of ISOV, are employed for use if the patient has heart value regurgitation.
摘要翻译：提供技术用于进行心脏声音的内部测量，以根据中风量，心输出量或主动脉压随时间的最大变化率（最大dP / dt）来估计患者心脏功能。然后自动调节医疗装置的控制参数，以便优化整体心脏功能或提供心室再同步治疗。在一个示例中，从加速度计接收的加速度信号导出心音信号。分析心音信号以识别S1和S2心音，以及射血期和等容间隔（ISOV）。然后从S1和S2心脏声音，射血期和ISOV导出最大dP / dt，搏出量和心输出量的代理。如果患者有心脏反流，则采用不需要检测ISOV的替代技术。

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