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91. 发明申请

US20080166378A1 DEATH RECEPTOR SENSITIZING COMPOUNDS AND METHODS OF USE THEREFOR 有权
标题翻译：死亡受体敏化化合物及其使用方法
公开(公告)号：US20080166378A1
公开(公告)日：2008-07-10
申请号：US11622229
申请日：2007-01-11
申请人： Aaron D. Schimmer , John C. Reed
发明人： Aaron D. Schimmer , John C. Reed
IPC分类号： A61K39/00 , G01N33/574 , A61K31/498 , A61K31/167 , A61K31/495 , A61P35/00 , A61K31/341 , A61K31/4184 , C12N5/06
CPC分类号： A61K31/167 , A61K31/341 , A61K31/4184 , A61K31/495 , A61K31/498 , G01N33/5011
摘要： Methods of identifying death receptor sensitizing compounds and methods of using death receptor sensitizing compounds are provided.
摘要翻译：提供了识别死亡受体敏化化合物的方法和使用死亡受体敏化化合物的方法。

92. 发明授权

US07393666B2 Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis 失效
标题翻译：乙型肝炎X相互作用蛋白（HBXIP）在凋亡调控中的应用
公开(公告)号：US07393666B2
公开(公告)日：2008-07-01
申请号：US11440177
申请日：2006-05-24
申请人： Ingo Tamm , John C. Reed
发明人： Ingo Tamm , John C. Reed
IPC分类号： C12P19/34
CPC分类号： A61K38/1709 , C07K16/18 , C07K16/30 , C07K2317/73 , G01N2333/70503 , G01N2333/96466
摘要： Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of enhancing apoptosis of neoplastic cells comprises inhibiting interaction of hepatitis B X-interacting protein (HBXIP) with Survivin.
摘要翻译：描述了通过影响乙型肝炎X相互作用蛋白（HBXIP）与存活蛋白相互作用来调节细胞凋亡的新方法。更具体地说，这些增强肿瘤细胞凋亡的新方法包括抑制乙型肝炎X相互作用蛋白（HBXIP）与存活蛋白的相互作用。

93. 发明授权

US07314927B2 Regulation of bcl-2 gene expression 有权
标题翻译：调节bcl-2基因表达
公开(公告)号：US07314927B2
公开(公告)日：2008-01-01
申请号：US10961458
申请日：2004-10-07
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： C07H21/04 , A61K31/70
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.
摘要翻译：本发明提供了新的抗交联低聚物及其用于控制表达bcl-2基因的癌细胞生长的方法。

94. 发明授权

US07304603B2 Radar apparatus and processing method for detecting human carried explosive devices 有权
标题翻译：用于检测人体携带的爆炸装置的雷达装置和处理方法
公开(公告)号：US07304603B2
公开(公告)日：2007-12-04
申请号：US11356997
申请日：2006-02-17
申请人： John C. Reed , John D. Gorman
发明人： John C. Reed , John D. Gorman
IPC分类号： G01S13/02 , G01S13/56
CPC分类号： G01S13/04 , G01S7/024 , G01S7/411 , G01S13/34 , G01S13/887
摘要： A linear FM pulse radar with Doppler processing of co-polarized and cross-polarized radar return signals isolates the target echo signal content associated with a moving pedestrian to provide high quality target echo data for standoff HCE detection based on polarimetric signature analysis. Baseband co-polarized and cross-polarized radar return signals are repeatedly and coherently integrated across numerous successive radar return pulses to create co-polarized and cross-polarized range vs. velocity (Doppler) data maps. The co-polarized data map is used to identify a moving pedestrian, and co-polarized and cross-polarized data subsets corresponding to the identified pedestrian are extracted and subjected to polarization signature analysis to determine if the pedestrian is bearing explosive devices. Low pass filtering of the of the baseband co-polarized and cross-polarized radar return signals prior to integration provides range aliasing to reject signal content associated with objects beyond the unambiguous range of the radar apparatus.
摘要翻译：具有共极化和交叉极化雷达返回信号的多普勒处理的线性FM脉冲雷达隔离与移动行人相关联的目标回波信号内容，以提供基于偏振签名分析的高质量目标回波数据进行离散HCE检测。基带共极化和交叉极化雷达返回信号在多个连续的雷达返回脉冲之间被重复和相干地整合，以产生共极化和交叉极化的范围与速度（多普勒）数据图。共同极化数据图用于识别移动的行人，并且提取对应于所识别的行人的共极化和交叉极化数据子集，并进行极化特征分析以确定行人是否承载爆炸装置。在集成之前，基带共极化和交叉偏振雷达返回信号的低通滤波提供范围混叠，以排除与超出雷达装置的明确范围的物体相关联的信号内容。

95. 发明授权

US06696558B2 Bag proteins and nucleic acid molecules encoding them 失效
标题翻译：袋蛋白和编码它们的核酸分子
公开(公告)号：US06696558B2
公开(公告)日：2004-02-24
申请号：US09394142
申请日：1999-09-09
申请人： John C. Reed , Shinichi Takayama
发明人： John C. Reed , Shinichi Takayama
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S. pombe (BAG-1A, BAG-1B) and the nucleic acid molecules that encode them.
摘要翻译：本发明提供了来自人的BAG-1相关蛋白家族（BAG-1L，BAG-1，BAG-2，BAG-3，BAG-4和BAG-5），无脊椎动物线虫（BAG-1， BAG-2）和裂殖酵母S.pombe（BAG-1A，BAG-1B）和编码它们的核酸分子。

96. 发明授权

US06514761B1 Methods of using BCL-2 for the therapeutic treatment and prevention of diseases 失效
公开(公告)号：US06514761B1
公开(公告)日：2003-02-04
申请号：US09188066
申请日：1998-11-06
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： C12N1587
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/01 , A01K2267/025 , A01K2267/03 , A01K2267/0318 , A61K35/39 , A61K38/00 , C07K14/82 , C07K16/00 , C12N15/8509 , C12N2840/20 , C12N2840/203
摘要： The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the disease or pathological condition. Diseases or pathological conditions can include, for example, neurodegenerative diseases, cancer and viral infections. Also provided is a method of prolonging the in vivo survival of transplanted cells for the treatment of a disease or pathological condition. The method includes increasing the activity of Bcl-2 in a population of cells and transplanting the population of cells having increased Bcl-2 activity into a subject. Diseases or pathological conditions can include, for example, neurodegenerative diseases, cancer and viral infections. A method to enhance the sensitivity of malignant cells to therapy is provided that includes decreasing the activity of Bcl-2 in the malignant cells. Methods to identify compounds that alter apoptotic cell death and to enhance monoclonal antibody production are also provided by the invention disclosed herein.

97. 发明授权

US5837838A Bax inhibitor proteins 失效
公开(公告)号：US5837838A
公开(公告)日：1998-11-17
申请号：US818514
申请日：1997-03-14
申请人： John C. Reed , Qunli Xu
发明人： John C. Reed , Qunli Xu
IPC分类号： C07K14/47 , C07H21/04
CPC分类号： C07K14/4747
摘要： The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid molecules complementary thereto (SEQ ID NO: 2 and SEQ ID NO: 5, respectively), portions of such nucleic acid molecules, vectors containing the nucleic acid molecules, and host cells containing the vectors. The invention also provides methods of using such nucleic acid molecules to identify the presence of a nucleic acid molecule encoding a Bax inhibitor protein in a sample or to increase or decrease the level of expression of a Bax inhibitor protein in a cell. In addition, the invention provides substantially purified BI-1 (SEQ ID NO: 3) and BI-2 (SEQ ID NO: 6) polypeptides, portions of such polypeptides, and antibodies specific for BI-1 or BI-2. The invention also provides methods of using a BI-1 or BI-2 polypeptide, or a peptide portion thereof, to identify the presence of a member of the Bcl-2 family of proteins in a sample. The invention further provides methods of identifying agents that can modulate the binding of BI-1 or BI-2 to a Bcl-2 family protein, or that can modulate the function of BI-1 or BI-2, irrespective of its ability to bind a Bcl-2 family protein.

98. 发明授权

US5702897A Interaction of proteins involved in a cell death pathway 失效
标题翻译：参与细胞死亡途径的蛋白质的相互作用
公开(公告)号：US5702897A
公开(公告)日：1997-12-30
申请号：US607269
申请日：1996-02-20
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： G01N33/502 , C07K14/4747 , C12Q1/6897 , G01N33/5008 , G01N33/68 , G01N2510/00
摘要： The present invention provides methods for detecting an interaction among proteins involved in regulating cell death. The invention also provides a drug screening assay useful for identifying agents that alter an interaction among proteins involved in controlling cell death. The invention further provides a method for identifying novel proteins that are involved in a cell death pathway.
摘要翻译：本发明提供了检测涉及调节细胞死亡的蛋白质之间相互作用的方法。本发明还提供了用于鉴定改变参与控制细胞死亡的蛋白质之间的相互作用的试剂的药物筛选测定法。本发明还提供了鉴定参与细胞死亡途径的新蛋白质的方法。

99. 发明授权

US5484710A Method of down-regulating a gene linked to a P-53 responsive element 失效
标题翻译：降低与P-53反应元件连锁的基因的方法
公开(公告)号：US5484710A
公开(公告)日：1996-01-16
申请号：US182619
申请日：1994-01-14
申请人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
发明人： John C. Reed , Toshiyuki Miyashita , Masayoshi Harigai , Motoi Hanada
IPC分类号： C07K14/47 , C07K14/82 , C12Q1/68 , C12P21/00 , C12N15/09
CPC分类号： C12Q1/6897 , C07K14/4746 , C07K14/4747 , C07K14/82
摘要： The present invention provides regulatory elements that are linked to genes involved in cell death and are regulated by p53 tumor suppressor protein. Examples of such p53 responsive elements (p53-RE) include p53-RE.sup.D, which is involved in p53-mediated down-regulation of the Bcl-2 gene, and p53-RE.sup.U, which is involved in p53-mediated up-regulation of the Bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death and contains a p53-RE.
摘要翻译：本发明提供与参与细胞死亡的基因相关的调节元件，并且由p53肿瘤抑制蛋白调节。这种p53反应元件（p53-RE）的实例包括p53-RED，其参与p53介导的Bcl-2基因的下调和p53-REU，其参与p53介导的上调调节 Bax基因。本发明还提供用于鉴定试剂的筛选试验，例如有效调节参与细胞死亡并含有p53-RE的基因的表达的药物。

100. 发明授权

US4533917A Multiple frequency side lobe interference rejector 失效
标题翻译：多频旁瓣干扰放电器
公开(公告)号：US4533917A
公开(公告)日：1985-08-06
申请号：US593151
申请日：1984-03-26
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： G01S13/76 , G01S3/16 , G01S3/28
CPC分类号： G01S13/762
摘要： A transceiver, such as a radar transponder, for receiving signals, converting the frequency of the input signals to a digital address and storing a signal representative of the amplitude of the input signal in a bin determined by the address. If the current amplitude exceeds a predetermined relationship with the stored amplitude a response is transmitted and if the current amplitude exceeds the stored amplitude the current amplitude is stored.
摘要翻译：用于接收信号的收发器，例如雷达应答器，将输入信号的频率转换为数字地址，并将表示输入信号的幅度的信号存储在由地址确定的存储区中。如果当前振幅超过与所存储的振幅的预定关系，则响应被发送，并且如果电流幅度超过存储的振幅，则存储电流幅度。

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