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91. 发明授权

US07938823B2 Surgical clamp having transmurality assessment capabilities 有权
标题翻译：手术夹具具有透视性评估能力
公开(公告)号：US07938823B2
公开(公告)日：2011-05-10
申请号：US11708887
申请日：2007-02-21
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/1465
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融机构连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

92. 发明授权

US07905879B2 Cryoablation catheter handle 有权
标题翻译：冷冻消融导管手柄
公开(公告)号：US07905879B2
公开(公告)日：2011-03-15
申请号：US11499213
申请日：2006-08-04
申请人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
发明人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61M39/1011
摘要： A cryocatheter system includes a first handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; a second handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; and a catheter having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path. The distal end of the first handle portion is matable with the proximal end of the second handle portion to place the respective first and second fluid flow paths of each handle portion in fluid communication; and the distal end of the second handle portion is matable with the proximal end of the catheter to place the respective first and second fluid flow paths of the second handle portion and the catheter in fluid communication.
摘要翻译：一种低温切管系统包括具有近端，远端，第一流体流动路径和第二流体流路的第一手柄部分; 具有近端，远端，第一流体流动路径和第二流体流路的第二手柄部分; 以及具有近端，远端，第一流体流动路径和第二流体流动路径的导管。第一手柄部分的远端可与第二手柄部分的近端配合，以使每个手柄部分的相应的第一和第二流体流动路径流体连通; 并且第二手柄部分的远端可与导管的近端配合，以使第二手柄部分和导管的相应的第一和第二流体流动路径流体连通。

93. 发明授权

US07625369B2 Method and device for epicardial ablation 失效
标题翻译：心外膜消融的方法和装置
公开(公告)号：US07625369B2
公开(公告)日：2009-12-01
申请号：US11526494
申请日：2006-09-25
申请人： Marwan Abboud , Dan Wittenberger , Daniel Nahon , Steven G. Arless
发明人： Marwan Abboud , Dan Wittenberger , Daniel Nahon , Steven G. Arless
IPC分类号： A61B18/02
CPC分类号： A61B18/02
摘要： A method is disclosed for treating heart and vascular tissue with cryotreatment. A medical instrument, such as a catheter is positioned to contact a target region of cardiac tissue such as the epicardial tissue. The instrument or catheter provided includes a cryotreatment element that has thermally-transmissive properties. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of heart or vascular tissue to be treated, usually by piercing the epicardium sac via an opening in the patient's body. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the targeted heart or vascular tissue, inducing hypothermia and forming iceballs proximate the tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue.
摘要翻译：公开了一种用冷冻治疗来治疗心脏和血管组织的方法。诸如导管的医疗器械定位成接触诸如心外膜组织的心脏组织的靶区域。提供的仪器或导管包括具有热传递特性的冷冻处理元件。冷冻处理元件可以是用于封闭其中的流体制冷剂的流动的冷冻箱。冷冻治疗元件设置在待治疗的心脏或血管组织的位置，通常通过穿过患者体内的开口刺穿心外膜。冷冻箱内的制冷剂流动相对于目标心脏或血管组织产生吸热冷却，诱导低体温并在组织附近形成冰球。冷却可以是可逆的和非永久性的，或者可能是永久性的导致细胞死亡，坏死，凋亡和/或手术切除或消融组织。

94. 发明授权

US07465300B2 Catheter with cryogenic and electrical heating ablation 有权
标题翻译：导管用低温和电加热消融
公开(公告)号：US07465300B2
公开(公告)日：2008-12-16
申请号：US11219061
申请日：2005-09-02
申请人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
发明人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles. In one embodiment a microwave energy source operates at a frequency to extend beyond the thermal conduction depth, or to penetrate the cryogenic ice ball and be absorbed in tissue beyond an ice boundary, thus extending the depth and/or width of a single treatment locus. In another embodiment, the cooling and the application of RF energy are both controlled to position the ablation region away from the surface contacted by the electrode, for example to leave surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth. The driver or RF energy source may supply microwave energy at a frequency effective to penetrate the ice ball which develops on a cryocatheter, and different frequencies may be selected for preferential absorption in a layer of defined thickness at depth in the nearby tissue. The catheter may operate between 70 and minus 70 degrees Celsius for different tissue applications, such as angioplasty, cardiac ablation and tissue remodeling, and may preset the temperature of the tip or adjacent tissue, and otherwise overlay or delay the two different profiles to tailor the shape or position where ablation occurs or to speed up a treatment cycle.
摘要翻译：导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。 RF电极可以被操作以加热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织，从而允许操作的更大的通用性和增强病变大小，速度或放置多病变治疗或单次病变再治疗周期。在一个实施例中，微波能量源的频率以超出热传导深度的频率运行，或者穿透低温冰球并被吸收在超过冰界的组织中，从而延长单个处理轨迹的深度和/或宽度。在另一个实施例中，RF能量的冷却和应用都被控制以将消融区域远离与电极接触的表面，例如在深度消融时留下表面组织而不受伤害，或者提供具有更大均匀性的消融带，增加深度。驱动器或RF能源可以以有效穿透在低温导管上形成的冰球的频率提供微波能量，并且可以选择不同的频率用于在附近组织的深度处的限定厚度的层中的优先吸收。对于不同的组织应用（例如血管成形术，心脏消融和组织重建），导管可以在70摄氏度和零下70度之间运行，并且可以预设尖端或相邻组织的温度，否则叠加或延迟两个不同的轮廓以定制消融发生的形状或位置或加速治疗周期。

95. 发明申请

US20080243111A1 Surgical method and apparatus for treating atrial fibrillation 有权
标题翻译：用于治疗房颤的手术方法和装置
公开(公告)号：US20080243111A1
公开(公告)日：2008-10-02
申请号：US11184045
申请日：2006-01-06
申请人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
发明人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
IPC分类号： A61B17/32 , A61B18/02
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括导管主体，近端和远端; 第一个管腔第二个管腔以及可从第一直径扩展到第二直径的消融元件，所述消融元件具有与心脏组织的不平坦表面形貌一致的表面部分。消融元件可以包括一个或多个可变形的球囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用该装置消除左心房中的组织，由此通过冷冻组织产生消融。

96. 发明授权

US07404816B2 Leak detection system 有权
标题翻译：泄漏检测系统
公开(公告)号：US07404816B2
公开(公告)日：2008-07-29
申请号：US10889620
申请日：2004-07-12
申请人： Marwan Abboud , Johnny Al Asmar , John W. Lehmann
发明人： Marwan Abboud , Johnny Al Asmar , John W. Lehmann
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00119 , A61B2018/0212 , A61B2018/0262 , A61F7/12
摘要： A surgical device includes a device body defining a sealed fluid path having a first end and a second end, a refrigerant supply in communication with the first end of the sealed fluid path, and a vacuum source in communication with the second end of the sealed fluid path. Leak detection apparatus can be provided in communication with the sealed fluid path.
摘要翻译：手术装置包括限定具有第一端和第二端的密封流体路径的装置主体，与密封流体路径的第一端连通的制冷剂供应源和与密封流体的第二端连通的真空源路径。泄漏检测装置可以与密封流体通道连通。

97. 发明申请

US20080114345A1 CATHETER WITH CRYOGENIC AND ELECTRICAL HEATING ABLATION 有权
标题翻译：具有低温和电加热的导管
公开(公告)号：US20080114345A1
公开(公告)日：2008-05-15
申请号：US11971582
申请日：2008-01-09
申请人： Steven Arless , Fredric Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
发明人： Steven Arless , Fredric Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion retreatment cycles. In one embodiment a microwave energy source operates at a frequency to extend beyond the thermal conduction depth, or to penetrate the cryogenic ice ball and be absorbed in tissue beyond an ice boundary, thus extending the depth and/or width of a single treatment locus. In another embodiment, the cooling and the application of RF energy are both controlled to position the ablation region away from the surface contacted by the electrode, for example to leave surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth. The driver or RF energy source may supply microwave energy at a frequency effective to penetrate the ice ball which develops on a cryocatheter, and different frequencies may be selected for preferential absorption in a layer of defined thickness at depth in the nearby tissue. The catheter may operate between 70 and minus 70 degrees Celsius for different tissue applications, such as angioplasty, cardiac ablation and tissue remodeling, and may preset the temperature of the tip or adjacent tissue, and otherwise overlay or delay the two different profiles to tailor the shape or position where ablation occurs or to speed up a treatment cycle.
摘要翻译：导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。 RF电极可以被操作以加热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织，从而允许操作的更大的通用性和增强病变大小，速度或放置多病变治疗或单次病变治疗周期。在一个实施例中，微波能量源的频率以超出热传导深度的频率运行，或者穿透低温冰球并被吸收在超过冰界的组织中，从而延长单个处理轨迹的深度和/或宽度。在另一个实施例中，RF能量的冷却和应用都被控制以将消融区域远离与电极接触的表面，例如在深度消融时留下表面组织而不受伤害，或者提供具有更大均匀性的消融带，增加深度。驱动器或RF能源可以以有效穿透在低温导管上形成的冰球的频率提供微波能量，并且可以选择不同的频率用于在附近组织的深度处的限定厚度的层中的优先吸收。对于不同的组织应用（例如血管成形术，心脏消融和组织重建），导管可以在70摄氏度和零下70度之间运行，并且可以预设尖端或相邻组织的温度，否则叠加或延迟两个不同的轮廓以定制消融发生的形状或位置或加速治疗周期。

98. 发明申请

US20080009851A1 Variable geometry cooling chamber 有权
标题翻译：可变几何冷却室
公开(公告)号：US20080009851A1
公开(公告)日：2008-01-10
申请号：US11476928
申请日：2006-06-28
申请人： Dan Wittenberger , Marwan Abboud , Ioana Deac
发明人： Dan Wittenberger , Marwan Abboud , Ioana Deac
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00256 , A61B2017/00867 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M29/02 , A61M2025/1093 , A61M2029/025
摘要： The present invention provides a medical device that may include a catheter body having proximal and distal portions, a fluid injection lumen disposed within elongate body, and a guidewire lumen disposed within the elongate body. A tip portion defining a cavity in fluid communication with the fluid injection lumen may be coupled to the distal end of the guidewire lumen, and an expandable element may be coupled to the distal portion of the catheter body and to the tip portion, such that the expandable element is in fluid communication with the fluid injection lumen. A shaping element may at least partially surround the expandable element, where the shaping element is configurable in a first geometric configuration and a second geometric configuration.
摘要翻译：本发明提供一种医疗装置，其可以包括具有近端部分和远端部分的导管主体，设置在细长主体内的流体注射内腔和设置在细长主体内的导丝管腔。限定与流体注射腔流体连通的空腔的尖端部分可以联接到导丝管腔的远端，并且可扩张元件可以联接到导管主体的远端部分和尖端部分，使得可膨胀元件与流体注射内腔流体连通。成形元件可以至少部分地围绕可膨胀元件，其中成形元件可配置为第一几何配置和第二几何配置。

99. 发明申请

US20070149961A1 Surgical clamp having trasmurality assessment capabilities 有权
标题翻译：手术夹具具有纹理评估能力
公开(公告)号：US20070149961A1
公开(公告)日：2007-06-28
申请号：US11709040
申请日：2007-02-21
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Real Ste-Marie , Sean Carroll , Allan Skanes , Alan Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Real Ste-Marie , Sean Carroll , Allan Skanes , Alan Menkis
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/1465
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are-movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以抓住其间的组织。消融机构连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

100. 发明申请

US20070021741A1 Method and device for epicardial ablation 失效
标题翻译：心外膜消融的方法和装置
公开(公告)号：US20070021741A1
公开(公告)日：2007-01-25
申请号：US11526494
申请日：2006-09-25
申请人： Marwan Abboud , Dan Wittenberger , Daniel Nahon , Steven Arless
发明人： Marwan Abboud , Dan Wittenberger , Daniel Nahon , Steven Arless
IPC分类号： A61B18/02
CPC分类号： A61B18/02
摘要： A method is disclosed for treating heart and vascular tissue with cryotreatment. A medical instrument, such as a catheter is positioned to contact a target region of cardiac tissue such as the epicardial tissue. The instrument or catheter provided includes a cryotreatment element that has thermally-transmissive properties. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of heart or vascular tissue to be treated, usually by piercing the epicardium sac via an opening in the patient's body. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the targeted heart or vascular tissue, inducing hypothermia and forming iceballs proximate the tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue.
摘要翻译：公开了一种用冷冻治疗来治疗心脏和血管组织的方法。诸如导管的医疗器械定位成接触诸如心外膜组织的心脏组织的靶区域。提供的仪器或导管包括具有热传递特性的冷冻处理元件。冷冻处理元件可以是用于封闭其中的流体制冷剂的流动的冷冻箱。冷冻治疗元件设置在待治疗的心脏或血管组织的位置，通常通过穿过患者体内的开口刺穿心外膜。冷冻箱内的制冷剂流动相对于目标心脏或血管组织产生吸热冷却，诱导低体温并在组织附近形成冰球。冷却可以是可逆的和非永久性的，或者可能是永久性的导致细胞死亡，坏死，凋亡和/或手术切除或消融组织。

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