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91. 发明授权

US08206901B2 Method for the synthesis of a bifunctional complex 有权
标题翻译：双功能复合物的合成方法
公开(公告)号：US08206901B2
公开(公告)日：2012-06-26
申请号：US10525817
申请日：2003-10-30
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
IPC分类号： C12Q1/68 , C12P19/34 , C40B50/10 , C40B50/16
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译：公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。

92. 发明授权

US07915201B2 Ligational encoding of small molecules 有权
标题翻译：小分子的编码编码
公开(公告)号：US07915201B2
公开(公告)日：2011-03-29
申请号：US10549619
申请日：2004-03-22
申请人： Thomas Franch , Soeren Nyboe Jacobsen , Torben Ravn Rasmussen , Soeren Neve , Henrik Pedersen , Alex Haahr Gouliaev
发明人： Thomas Franch , Soeren Nyboe Jacobsen , Torben Ravn Rasmussen , Soeren Neve , Henrik Pedersen , Alex Haahr Gouliaev
IPC分类号： C40B50/00 , C40B30/00
CPC分类号： C07H21/04 , C12N15/1068 , C12P21/02 , C40B40/06 , C40B50/04
摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of i) providing a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and ii) hybridising the anti-codon of one or more of the provided building blocks to the template, iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule, iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities, v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and wherein said at least two chemical entities are provided by separate building blocks.
摘要翻译：本发明涉及一种合成双功能复合物的方法，所述双功能复合物包含编码分子和识别已经参与编码分子合成的化学实体的标识多核苷酸，所述方法包括以下步骤：i）提供a）至少一个包含一个或更多能够与抗密码子杂交的密码子，其中所述模板任选地与一个或多个化学实体相关联，以及b）多个结构单元，每个结构单元包含与一个或多个化学实体相关的抗密码子，以及ii）将一个或多个所提供的构建块的抗密码子与模板杂交，iii）共价连接所述抗密码子和/或将至少一个模板与至少一个构建块的抗密码子连接，由此产生能够识别已经参与编码分子的合成的化学实体的标识符多核苷酸，iv）将模板从一个或多个分离出来更多的与其杂交的抗密码子，从而产生与多个化学实体相关联的至少部分单链标识多核苷酸，v）产生包含编码分子的双功能复合物和识别参与合成的化学实体的标识符多核苷酸的编码分子，其中所述编码的分子通过使与所述标识多核苷酸相关联的所述多个化学实体中的至少两个反应而产生，并且其中所述至少两个化学实体由单独的构建块提供。

93. 发明申请

US20100226854A1 MHC Peptide Complexes and Uses Thereof in Infectious Diseases 有权
标题翻译： MHC肽复合物及其在传染病中的应用
公开(公告)号：US20100226854A1
公开(公告)日：2010-09-09
申请号：US12619039
申请日：2009-11-16
申请人： Jørgen Schøller , Henrik Pedersen , Liselotte Brix
发明人： Jørgen Schøller , Henrik Pedersen , Liselotte Brix
IPC分类号： A61K39/00 , C07K14/74 , A61P31/12 , C12N9/96 , C07K16/00 , C12N5/07 , A61K51/08 , A61K39/395 , C12Q1/02 , C12N5/0783
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K49/1896 , G01N33/56905 , G01N33/56911 , G01N33/56972 , G01N33/56977 , G01N33/574 , G01N2333/70539 , G01N2800/24 , Y02A50/401 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.
摘要翻译：公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如，在治疗和诊断领域。本发明一般涉及治疗领域，包括治疗方法和治疗组合物。本发明还包括MHC复合物和MHC多聚体的样品安装用途。

94. 发明申请

US20100086640A1 PROTEIN 有权
标题翻译：蛋白
公开(公告)号：US20100086640A1
公开(公告)日：2010-04-08
申请号：US12552572
申请日：2009-09-02
申请人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
发明人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
IPC分类号： A21D13/06 , A21D8/04
CPC分类号： A21D8/042 , A23C19/0328 , A23D7/02 , A23K20/189 , A23K50/75 , A23L7/107 , A23L7/109 , A23L7/111 , A23L27/60 , A23L29/06 , C11B3/003 , C12N9/18 , C12P7/62 , C12P19/44 , C12Y301/01
摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.
摘要翻译：与甘油三酯相比，极性脂质活性比例更高的真菌野生型脂肪分解酶，其中所述酶优选具有至少为4的磷脂：甘油三酯活性比。优选地，根据本发明的脂肪分解酶具有糖脂：甘油三酯水解活性比至少为1.5。在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID NO：1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列，与其具有至少90％的同一性。本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ ID No.5所示核苷酸的核酸第7号（b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

95. 发明申请

US20100016177A1 TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES 有权
标题翻译：使用这种分子的模板分子和方法
公开(公告)号：US20100016177A1
公开(公告)日：2010-01-21
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
IPC分类号： C40B40/08 , C07H1/00 , C12P19/34 , C40B50/06
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译：本发明涉及一种合成模板分子的方法。在本发明的一个方面，模板分子连接到模板，其模板化其合成。该内容允许生成可以被筛选的文库。治疗活动。

96. 发明授权

US07622290B2 Fungal lipolytic enzymes, nucleic acids encoding, and uses thereof 有权
标题翻译：真菌脂肪分解酶，编码的核酸及其用途
公开(公告)号：US07622290B2
公开(公告)日：2009-11-24
申请号：US11519734
申请日：2006-09-12
申请人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
发明人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
IPC分类号： C12P1/00 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A21D8/042 , A23C19/0328 , A23D7/02 , A23K20/189 , A23K50/75 , A23L7/107 , A23L7/109 , A23L7/111 , A23L27/60 , A23L29/06 , C11B3/003 , C12N9/18 , C12P7/62 , C12P19/44 , C12Y301/01
摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.
摘要翻译：与甘油三酯相比，极性脂质活性比例更高的真菌野生型脂肪分解酶，其中所述酶优选具有至少为4的磷脂：甘油三酯活性比。优选地，根据本发明的脂肪分解酶具有糖脂：甘油三酯水解活性比至少为1.5。在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID NO：1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列，与其具有至少90％的同一性。本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ ID No.5所示核苷酸的核酸第7号（b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

97. 发明申请

US20090143232A1 METHOD FOR SYNTHESISING TEMPLATED MOLECULES 有权
标题翻译：用于合成模板分子的方法
公开(公告)号：US20090143232A1
公开(公告)日：2009-06-04
申请号：US12179323
申请日：2008-07-24
申请人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
发明人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
IPC分类号： C40B10/00 , C07H1/00 , C40B40/08 , C40B30/04 , C40B50/14
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译：本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。该方法可以用于产生可以选择用于生物活性的模板分子的文库。

98. 发明申请

US20090098592A1 METHOD 审中-公开
标题翻译：方法
公开(公告)号：US20090098592A1
公开(公告)日：2009-04-16
申请号：US12243364
申请日：2008-10-01
申请人： Claus Lindvald JOHANSEN , Soren Kjaerulff , Susan Mampusta Madrid , Henrik Pedersen , Charlotte Horsmans Poulsen , Masoud Rajabi Zargahi
发明人： Claus Lindvald JOHANSEN , Soren Kjaerulff , Susan Mampusta Madrid , Henrik Pedersen , Charlotte Horsmans Poulsen , Masoud Rajabi Zargahi
IPC分类号： C12Q1/26 , C07K1/00 , C12P21/04 , C12Q1/02 , C12N9/88 , C12N9/02
CPC分类号： C07K14/39 , C12N15/81 , C12P21/02
摘要： A method is described for releasing a soluble or membrane associated intracellular protein of interest (POI) comprising the steps of: providing a cell comprising a soluble or membrane associated intracellular POI; contacting the cell with a membrane extracting composition; and causing the POI to be released from the cell under conditions sufficient for the specific release of the POI and in a soluble form.
摘要翻译：描述了一种用于释放可溶性或膜相关胞内细胞内蛋白质（POI）的方法，包括以下步骤：提供包含可溶性或膜结合的细胞内POI的细胞; 使细胞与膜提取组合物接触; 并且使得POI在足以特异性释放POI并且以可溶形式的条件下从细胞释放。

99. 发明申请

US20080213843A1 Glucoamylase Variants 失效
标题翻译：葡糖淀粉酶变体
公开(公告)号：US20080213843A1
公开(公告)日：2008-09-04
申请号：US12034906
申请日：2008-02-21
申请人： Bjarne Ronfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
发明人： Bjarne Ronfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
IPC分类号： C12P19/20 , C12N9/34 , C07H21/04 , C12N15/00 , C12N1/20 , C12N1/14
CPC分类号： C12N9/2428 , C12P19/20 , Y02E50/17
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
摘要翻译：本发明涉及亲本真菌葡糖淀粉酶的变体，其具有改变的性质，特别是改进的热稳定性和/或增加的比活性。

100. 发明授权

US07421269B2 Functional cover for use with a wireless terminal 有权
标题翻译：与无线终端一起使用的功能封面
公开(公告)号：US07421269B2
公开(公告)日：2008-09-02
申请号：US10085010
申请日：2002-03-01
申请人： Pekka Kostiainen , Kenn Berend Pedersen , Henrik Pedersen
发明人： Pekka Kostiainen , Kenn Berend Pedersen , Henrik Pedersen
IPC分类号： H04M3/00
CPC分类号： H04M1/72575
摘要： A wireless communication terminal has a user exchangeable cover part. The wireless communication terminal and user exchangeable cover part are electrically interconnected by means of an electrical connector. The user exchangeable cover part comprises identification means. The user exchangeable cover part has electrical circuitry for supporting a user interface of the wireless terminal. The wireless terminal identifies the user exchangeable cover part by detecting the identification means. The wireless terminal operates the electrical circuitry of the user exchangeable cover part in dependence of the identification of user exchangeable cover part.
摘要翻译：无线通信终端具有用户可更换盖部分。无线通信终端和用户可更换盖部分通过电连接器电互连。用户可更换盖部分包括识别装置。用户可更换盖部分具有用于支持无线终端的用户接口的电路。无线终端通过检测识别装置识别用户可交换盖部分。无线终端根据用户可更换盖部分的识别操作用户可更换盖部分的电路。

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