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    • 91. 发明授权
    • Compounds and methods for kinase modulation, and indications therefor
    • 用于激酶调节的化合物和方法及其适应症
    • US08901118B2
    • 2014-12-02
    • US13090969
    • 2011-04-20
    • Jiazhong ZhangPrabha N. IbrahimWayne SpevakJianming TsaiTodd EwingYing ZhangChao Zhang
    • Jiazhong ZhangPrabha N. IbrahimWayne SpevakJianming TsaiTodd EwingYing ZhangChao Zhang
    • C07D487/04A61K31/519C07D471/04A61P19/02A61P19/10A61P25/28A61P29/00A61K31/437
    • C07D487/04C07D471/04
    • Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described, wherein the compounds have formula I: In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, global ischemia, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors.
    • 描述了其化合物和盐,其制剂,其缀合物,其衍生物,其形式及其用途,其中所述化合物具有式I:在某些方面和实施方案中,所述的化合物或其盐,其制剂,其缀合物,其衍生物 其形式在Fms,Kit,Flt3,TrkA,TrkB和TrkC激酶蛋白中的一种或多种上是有活性的。 还描述了其用于治疗疾病和病症的方法,包括与Fms,Kit,Flt3,TrkA,TrkB和TrkC中的一种或多种的活性相关的疾病和病症,包括类风湿性关节炎,骨关节炎,骨质疏松症,假体周围骨质溶解, 系统性硬化症,脱髓鞘疾病,多发性硬化症,Charcot玛丽牙综合征,肌萎缩性侧索硬化症,阿尔茨海默氏病,帕金森病,全球缺血,溃疡性结肠炎,克罗恩病,免疫性血小板减少性紫癜,动脉粥样硬化,系统性红斑狼疮,自体移植骨髓移植,移植排斥 肾小球肾炎,间质性肾炎,狼疮性肾炎,肾小管坏死,糖尿病性肾病,肾肥大,I型糖尿病,急性疼痛,炎性疼痛,神经性疼痛,急性骨髓性白血病,黑素瘤,多发性骨髓瘤,乳腺癌,前列腺癌,胰腺癌,肺癌 癌症,卵巢癌,神经胶质瘤,成胶质细胞瘤,神经 纤维瘤病,溶骨性骨转移,脑转移,胃肠道间质瘤和巨细胞瘤。
    • 95. 发明申请
    • SURFACE NANOREPLICATION USING POLYMER NANOMASKS
    • 使用聚合物纳米颗粒的表面纳米粒子
    • US20140205766A1
    • 2014-07-24
    • US13748827
    • 2013-01-24
    • Jennifer Lynn LyonJianguo WangRuchirej YongsunthonYing Zhang
    • Jennifer Lynn LyonJianguo WangRuchirej YongsunthonYing Zhang
    • B05D5/00
    • B05D5/00B82Y10/00B82Y40/00G03F7/0002
    • Methods for replicating a nanopillared surface include applying a nanopillar-forming material to a surface of a replica substrate to form a precursor layer on the replica-substrate surface. A template surface of a nanomask may be contacted to the precursor layer. The nanomask may include a self-assembled polymer layer on a nanomask-substrate surface, the template surface being defined in the self-assembled polymer layer. The self-assembled polymer layer may have nano-sized pores with openings at the template surface. The precursor layer may be cured while the template surface remains in contact with the precursor layer. The nanomask is removed to expose a nanopillared surface having a plurality of nanopillars on the replica-substrate surface. The nanopillars on the replica-substrate surface may correspond to the pores in the template surface. Nanopillared surfaces may be replicated on one side of the replica substrate or on two opposing sides of the replica substrate.
    • 用于复制纳米孔径表面的方法包括将纳米柱形成材料施加到复制基底的表面以在复制基底表面上形成前体层。 纳米掩模的模板表面可以与前体层接触。 纳米掩模可以包括在纳米掩模 - 衬底表面上的自组装聚合物层,模板表面限定在自组装聚合物层中。 自组装聚合物层可以具有在模板表面处具有开口的纳米尺寸的孔。 当模板表面保持与前体层接触时,前体层可以被固化。 去除纳米掩模以暴露在复制衬底表面上具有多个纳米柱的纳米圆柱形表面。 复制衬底表面上的纳米柱可以对应于模板表面中的孔。 纳米球形表面可以在复制基底的一侧或复制基底的两个相对侧上复制。
    • 100. 发明申请
    • Elastic Enforcement Layer for Cloud Security Using SDN
    • 使用SDN进行云安全的弹性执行层
    • US20130332983A1
    • 2013-12-12
    • US13494637
    • 2012-06-12
    • Tommy KoorevaarMakan PourzandiYing Zhang
    • Tommy KoorevaarMakan PourzandiYing Zhang
    • G06F21/00G06F9/455
    • G06F9/45558G06F2009/4557G06F2009/45595H04L45/306H04L63/20
    • An efficient elastic enforcement layer (EEL) for realizing security policies is deployed in a cloud computing environment based on a split architecture framework. The split architecture network includes a controller coupled to switches. When the controller receives a packet originating from a source VM, it extracts an application identifier from the received packet that identifies an application running on the source VM. Based on the application identifier, the controller determines a chain of middlebox types. The controller further determines middlebox instances based on current availability of resources. The controller then adds a set of rules to the switches to cause the switches to forward the packet toward the destination VM via the middlebox instances.
    • 基于分割架构框架,在云计算环境中部署了实现安全策略的高效弹性执行层(EEL)。 分离架构网络包括耦合到交换机的控制器。 当控制器接收到源VM的数据包时,它会从接收到的数据包中提取一个应用程序标识符,该数据包标识在源虚拟机上运行的应用程序。 基于应用程序标识符,控制器确定一系列中间件类型。 控制器还根据资源的当前可用性进一步确定中间件实例。 然后,控制器向交换机添加一组规则,以使交换机通过中间箱实例将数据包转发到目标VM。