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91. 发明授权

US07737155B2 Nitrogen-containing heterocyclic compounds and methods of use thereof 有权
标题翻译：含氮杂环化合物及其使用方法
公开(公告)号：US07737155B2
公开(公告)日：2010-06-15
申请号：US11771538
申请日：2007-06-29
申请人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian
发明人： Anandan Palani , Dong Xiao , Xianhai Huang , Ashwin U. Rao , Xiao Chen , Jun Qin , Ying R. Huang , Robert G. Aslanian
IPC分类号： C07D491/052 , A61K31/519 , A61P9/00 , A61P25/00 , A61P33/00 , A61P29/00 , A61P1/00 , A61P3/10
CPC分类号： C07D491/04 , C07D471/04
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译：本发明提供式（I）的化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：和L选自：药物组合物，其包含一种或多种更多的式（I）化合物和使用式（I）化合物的方法。

92. 发明授权

US07482468B2 Imidazole and benzimidazole derivatives useful as histamine H3 antagonists 失效
标题翻译：可用作组胺H3拮抗剂的咪唑和苯并咪唑衍生物
公开(公告)号：US07482468B2
公开(公告)日：2009-01-27
申请号：US11334932
申请日：2006-01-19
申请人： Robert G. Aslanian , Wing C. Tom , Xiaohong Zhu
发明人： Robert G. Aslanian , Wing C. Tom , Xiaohong Zhu
IPC分类号： C07D403/10 , C07D403/14 , C07D221/04
CPC分类号： C07D491/10 , C07D233/84 , C07D235/26 , C07D235/28 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14
摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: n is 2-5; R is R3-aryl, R3-heteroaryl, R3-cycloalkyl, R3-heterocycloalkyl, alkyl, haloalkyl, —OR4, —SR4 or —S(O)1-2R5; R1 and R2 are H or optionally substituted phenyl or optionally substituted and X is —O— or —S—; or R1 and R2, together with the carbon atoms to which they are attached form optionally substituted and X is —O—, —S— or —NR7—; Z is and the remaining variables are as defined in the specification; also disclosed are pharmaceutical compositions comprising the compounds of formula I; also disclosed are methods of treating allergy, allergy-induced airway responses, congestion, obesity and metabolic syndrome using the compounds of Formula I, as well as combinations with other drugs useful for treating those diseases.
摘要翻译：公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中：n为2-5; R是R 3 - 芳基，R 3 - 杂芳基，R 3 - 环烷基，R 3 - 杂环烷基，烷基，卤代烷基，-OR 4，-SR 4或-S（O）1-2R 5; R1和R2是H或任选取代的苯基或任选取代的，X是-O-或-S-; 或R 1和R 2与它们所连接的碳原子一起形成任选被取代，X是-O - ， - S-或-NR 7 - ; Z是，其余变量如规范中所定义; 还公开了包含式I化合物的药物组合物; 还公开了使用式I化合物治疗过敏，过敏诱发的气道反应，充血，肥胖和代谢综合征的方法，以及与用于治疗这些疾病的其它药物的组合。

93. 发明申请

US20070173495A1 Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia 失效
标题翻译：杂环作为治疗血脂异常的烟酸受体激动剂
公开(公告)号：US20070173495A1
公开(公告)日：2007-07-26
申请号：US11654137
申请日：2007-01-17
申请人： Anandan Palani , Jun Qin , Dong Xiao , Ying R. Huang , Xiao Chen , Zhidan Liu , Sylvia J. Degrado , Robert G. Aslanian , Xianhai Huang
发明人： Anandan Palani , Jun Qin , Dong Xiao , Ying R. Huang , Xiao Chen , Zhidan Liu , Sylvia J. Degrado , Robert G. Aslanian , Xianhai Huang
IPC分类号： A61K31/551 , A61K31/519 , C07D491/02
CPC分类号： C07D491/04
摘要： A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome and dyslipidemia.
摘要翻译：具有式（I）的一般结构的化合物或其药学上可接受的盐，溶剂合物，酯或互变异构体可用于治疗疾病，病症或病症如代谢综合征和血脂异常。

94. 发明授权

US06906081B2 Use of dual H3/M2 antagonists in the treatment of cognition deficit disorders 失效
标题翻译：使用双重H3 / M2拮抗剂治疗认知缺陷障碍
公开(公告)号：US06906081B2
公开(公告)日：2005-06-14
申请号：US10072340
申请日：2002-02-06
申请人： John A. Hey , Robert G. Aslanian
发明人： John A. Hey , Robert G. Aslanian
IPC分类号： C07D211/26 , A61K31/404 , A61K31/417 , A61K31/4178 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/551 , A61K45/00 , A61K45/06 , A61P25/00 , A61P25/28 , A61P43/00 , C07D211/14 , C07D211/58 , C07D405/14 , A61K31/44
CPC分类号： A61K31/4545 , A61K31/445
摘要： This invention relates to a method of treating cognition deficit disorders comprising administering to a mammal in need of such treatment an effective amount of a dual histamine H3 receptor antagonist/m2 muscarinic antagonist, or a combination of a histamine H3 receptor antagonist and a m2 muscarinic antagonist.
摘要翻译：本发明涉及一种治疗认知缺陷障碍的方法，包括对需要这种治疗的哺乳动物施用有效量的双重组胺H 3受体拮抗剂/ m 2毒蕈碱拮抗剂，或组胺H 3受体拮抗剂和am2S毒蕈碱拮抗剂的组合。

95. 发明授权

US06518287B2 Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists 失效
公开(公告)号：US06518287B2
公开(公告)日：2003-02-11
申请号：US09955380
申请日：2001-09-18
申请人： Robert G. Aslanian , Stuart Rosenblum , Mwangi Wa Mutahi , Neng-Yang Shih , John J. Piwinski
发明人： Robert G. Aslanian , Stuart Rosenblum , Mwangi Wa Mutahi , Neng-Yang Shih , John J. Piwinski
IPC分类号： A61K314439
CPC分类号： C07D233/64 , C07D401/12 , C07D401/14
摘要： The present invention discloses novel substituted imidazole compounds which have either or dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, inflammatory and CNS-related diseases and others.

96. 发明授权

US6100279A Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom 失效
标题翻译：被含有一个氮原子的五，六或七元杂环取代的咪唑烷基
公开(公告)号：US6100279A
公开(公告)日：2000-08-08
申请号：US185973
申请日：1998-11-05
申请人： Wayne D. Vaccaro , Ronald L. Wolin , Daniel M. Solomon , Robert G. Aslanian , John J. Piwinski , Stuart B. Rosenblum
发明人： Wayne D. Vaccaro , Ronald L. Wolin , Daniel M. Solomon , Robert G. Aslanian , John J. Piwinski , Stuart B. Rosenblum
IPC分类号： A61K31/415 , A61K31/445 , A61K31/495 , A61K45/06 , C07D401/06 , C07D403/06
CPC分类号： C07D401/06 , A61K31/415 , A61K31/445 , A61K31/495 , A61K45/06 , C07D403/06
摘要： Disclosed are compounds of Formula I ##STR1## or pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula I. Further disclosed is a method of treating allergy (for example asthma), inflammation, hypotension, raised intraocular pressure (such as glaucoma)--i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimer's, schizophrenia, obesity and migraine) comprising administering an effective amount of a compound of Formula I to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula I in combination or admixture with a histamine H, receptor antagonist.
摘要翻译：公开了式I的化合物或其药学上可接受的盐或溶剂化物。还公开了包含药学上可接受的载体和有效量的式I化合物的药物组合物。还公开了治疗过敏（例如哮喘），炎症，低血压，升高的眼内压（如青光眼）的方法，降低眼内压，睡眠障碍，超低运动状态和胃肠道酸性分泌的方法，中枢神经系统的低血压和多动症（例如，激动和抑郁）和其他CNS疾病（例如阿兹海默氏症，精神分裂症，肥胖症和偏头痛）包括向需要这种治疗的患者施用有效量的式I化合物。还公开了治疗上呼吸道过敏反应的方法，包括与组胺H受体拮抗剂组合或混合施用式I化合物或其盐或溶剂合物。

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