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91. 发明授权

US5814480A DNA encoding human metallothioein 失效
标题翻译：编码人金属硫蛋白的DNA
公开(公告)号：US5814480A
公开(公告)日：1998-09-29
申请号：US785530
申请日：1997-01-17
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P37/00 , A61P39/02 , C07K14/825 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/825 , A61K38/00
摘要： The present invention provides a human metallothionein (HMBP-I) and polynucleotides which identify and encode HMBP-I. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HMBP-I and a method for producing HMBP-I. The invention also provides for agonists, antibodies, or antagonists specifically binding HMBP-I, and their use, in the prevention and treatment of diseases associated with expression of HMBP-I. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HMBP-I for the treatment of diseases associated with the expression of HMBP-I. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HMBP-I.
摘要翻译：本发明提供人金属硫蛋白（HMBP-1）和识别和编码HMBP-1的多核苷酸。本发明还提供了包含编码HMBP-1的核酸序列和生产HMBP-1的方法的遗传工程表达载体和宿主细胞。本发明还提供了特异性结合HMBP-1的激动剂，抗体或拮抗剂及其用于预防和治疗与HMBP-1表达有关的疾病的用途。此外，本发明提供了反义分子用于编码HMBP-1的多核苷酸用于治疗与HMBP-1表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HMBP-1的抗体的诊断测定法。

92. 发明授权

US5756299A Human carbonyl reductase 失效
标题翻译：人羰基还原酶
公开(公告)号：US5756299A
公开(公告)日：1998-05-26
申请号：US762129
申请日：1996-12-09
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/04 , C12N15/53 , C12Q1/68
CPC分类号： C12N9/0006 , A61K38/00
摘要： The present invention provides a human carbonyl reductase (HCRD) and polynucleotides which identify and encode HCRD. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCRD and a method for producing HCRD. The invention also provides for agonists, antibodies, or antagonists specifically binding HCRD, and their use, in the prevention and treatment of diseases associated with expression of HCRD. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCRD for the treatment of diseases associated with the expression of HCRD. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCRD.
摘要翻译：本发明提供了人羰基还原酶（HCRD）和识别和编码HCRD的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HCRD的核酸序列和生产HCRD的方法。本发明还提供了特异性结合HCRD的激动剂，抗体或拮抗剂及其在预防和治疗与HCRD表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码HCRD的多核苷酸用于治疗与HCRD表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HCRD的抗体的诊断测定法。

93. 发明授权

US06503733B1 Human anion channel 失效
标题翻译：人阴离子通道
公开(公告)号：US06503733B1
公开(公告)日：2003-01-07
申请号：US09690196
申请日：2000-10-16
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C12P2106
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human anion channel (NANCH) and polynucleotides which identify and encode NANCH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NANCH and a method for producing NANCH. The invention also provides for agonists, antibodies, or antagonists specifically binding NANCH, and their use, in the prevention and treatment of diseases associated with expression of NANCH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NANCH for the treatment of diseases associated with the expression of NANCH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NANCH.
摘要翻译：本发明提供新型人阴离子通道（NANCH）和识别和编码NANCH的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NANCH的核酸序列和生产NANCH的方法。本发明还提供了特异性结合NANCH的激动剂，抗体或拮抗剂及其在预防和治疗与NANCH表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NANCH的多核苷酸用于治疗与NANCH表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NANCH的抗体的诊断测定法。

94. 发明授权

US06485933B1 B cell receptor associated proteins 失效
标题翻译： B细胞受体相关蛋白
公开(公告)号：US06485933B1
公开(公告)日：2002-11-26
申请号：US08851971
申请日：1997-05-07
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli , Sherry A. Capitant
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli , Sherry A. Capitant
IPC分类号： C07H2102
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides B cell receptor associated proteins (BCRP) and polynucleotides which identify and encode BCRP. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of BCRP.
摘要翻译：本发明提供鉴定和编码BCRP的B细胞受体相关蛋白（BCRP）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与BCRP表达相关的疾病的方法。

95. 发明授权

US06228616B1 Human anion channel 失效
标题翻译：人阴离子通道
公开(公告)号：US06228616B1
公开(公告)日：2001-05-08
申请号：US09443948
申请日：1999-11-19
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C12P2106
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human anion channel (NANCH) and polynucleotides which identify and encode NANCH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NANCH and a method for producing NANCH. The invention also provides for agonists, antibodies, or antagonists specifically binding NANCH, and their use, in the prevention and treatment of diseases associated with expression of NANCH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NANCH for the treatment of diseases associated with the expression of NANCH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NANCH.
摘要翻译：本发明提供新型人阴离子通道（NANCH）和识别和编码NANCH的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NANCH的核酸序列和生产NANCH的方法。本发明还提供了特异性结合NANCH的激动剂，抗体或拮抗剂及其在预防和治疗与NANCH表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NANCH的多核苷酸用于治疗与NANCH表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NANCH的抗体的诊断测定法。

96. 发明授权

US6103477A Rho protein 失效
公开(公告)号：US6103477A
公开(公告)日：2000-08-15
申请号：US416489
申请日：1999-10-12
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12N15/10 , C12N15/09
CPC分类号： C07K14/4722 , A61K38/00
摘要： The present invention provides a human Rho protein (HRHO) and polynucleotides which identify and encode HRHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HRHO and for treating or preventing disorders associated with expression of HRHO.

97. 发明授权

US6087333A Disease associated acidic protein 失效
标题翻译：疾病相关酸性蛋白
公开(公告)号：US6087333A
公开(公告)日：2000-07-11
申请号：US382080
申请日：1999-08-24
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a human disease associated acidic protein and polynucleotides which identify and encode DAAP. The invention also provides expression vectors, host cells. agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of DAAP.
摘要翻译：本发明提供了一种人类疾病相关的酸性蛋白质和鉴定和编码DAAP的多核苷酸。本发明还提供表达载体宿主细胞。激动剂，抗体和拮抗剂。本发明还提供了治疗与DAAP表达相关的疾病的方法。

98. 发明授权

US6074843A Polynucleotides encoding human TSC-22 protein homologs 失效
标题翻译：编码人TSC-22蛋白同源物的多核苷酸
公开(公告)号：US6074843A
公开(公告)日：2000-06-13
申请号：US851190
申请日：1997-05-05
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12P21/06 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human TSC-22-like protein (HT22L) and polynucleotides which encode HT22L. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HT22L.
摘要翻译：本发明提供人TSC-22样蛋白（HT22L）和编码HT22L的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了治疗与HT22L表达相关的疾病的方法。

99. 发明授权

US6063594A DNA encoding a novel human anion channel 失效
标题翻译：编码新型人阴离子通道的DNA
公开(公告)号：US6063594A
公开(公告)日：2000-05-16
申请号：US792014
申请日：1997-01-31
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C07K14/435
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel anion channel (NANCH) and polynucleotides which identify and encode NANCH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NANCH and a method for producing NANCH. The invention also provides for agonists, antibodies, or antagonists specifically binding NANCH, and their use, in the prevention and treatment of diseases associated with expression of NANCH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NANCH for the treatment of diseases associated with the expression of NANCH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NANCH.
摘要翻译：本发明提供了一种新型的阴离子通道（NANCH）和识别和编码NANCH的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NANCH的核酸序列和生产NANCH的方法。本发明还提供了特异性结合NANCH的激动剂，抗体或拮抗剂及其在预防和治疗与NANCH表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NANCH的多核苷酸用于治疗与NANCH表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NANCH的抗体的诊断测定法。

100. 发明授权

US6063377A Rho protein 失效
公开(公告)号：US6063377A
公开(公告)日：2000-05-16
申请号：US213397
申请日：1998-12-15
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12N9/16 , A61K38/46
CPC分类号： C07K14/4722 , A61K38/00
摘要： The present invention provides a human Rho protein (HRHO) and polynucleotides which identify and encode HRHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HRHO and for treating or preventing disorders associated with expression of HRHO.

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