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91. 发明授权

US08735399B2 Selective subtype alpha 2 adrenergic agents and methods for use thereof 有权
标题翻译：选择性亚型α2肾上腺素能药物及其使用方法
公开(公告)号：US08735399B2
公开(公告)日：2014-05-27
申请号：US12863386
申请日：2009-01-14
申请人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
发明人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
IPC分类号： A61K31/422 , A61K31/497 , C07D241/12 , C07D263/12 , C07D413/12 , C07D213/18
CPC分类号： C07D401/12 , A61K31/422 , A61K31/497 , C07D213/18 , C07D241/12 , C07D263/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides oxazolidine and thiazolidine derivatives that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译：本发明提供可用作亚型选择性α2肾上腺素能激动剂的恶唑烷和噻唑烷衍生物。因此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节相关的多种病症。

92. 发明申请

US20130172307A1 5a-ANDROSTANE (ALKYL)-3b, 5, 6b-TRIOL INJECTION AND PREPARATION METHOD THEREFOR 有权
标题翻译： 5-ANDROSTANE（ALKYL）-3b，5，6b-TRIOL注射及其制备方法
公开(公告)号：US20130172307A1
公开(公告)日：2013-07-04
申请号：US13821849
申请日：2011-07-08
申请人： Guangmei Yan , Halyan Hu , Jingxia Zhang , Pengxin Qiu , Ling Li , Ning Tian
发明人： Guangmei Yan , Halyan Hu , Jingxia Zhang , Pengxin Qiu , Ling Li , Ning Tian
IPC分类号： A61K47/40 , A61K31/568
CPC分类号： A61K47/40 , A61K9/0019 , A61K31/565 , A61K31/568 , A61K47/6951 , B82Y5/00
摘要： A 5α-androstane-3β,5,6β-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-β-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-β-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-β-cyclodextrin solution, 5α-androstane-3β,5,6β-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection, Drying the filtrate yields a solid for injection.
摘要翻译：公开了5α-雄甾烷-3β，5,6β-三醇注射剂及其制备方法。注射剂使用羟丙基-β-环糊精作为增溶剂，活性成分以1-20:40-500的重量比与羟丙基-β-环糊精存在。注射剂还可以包含1-100份至少一种等渗调节剂，0-200份至少一种冷冻干燥填料和0-2000份至少一种溶剂。制备方法包括将羟丙基-β-环糊精溶液，5α-雄甾烷-3Beta，5,6-三醇和至少一种额外的可溶性赋形剂按顺序溶解在水中以获得原始注射溶液，并将原始注射溶液脱色，去热原，过滤和灭菌获得注射，干燥滤液得到固体用于注射。

93. 发明申请

US20130065860A1 3-(4-(5-PHENYL-1 ,2,4-OXADIAZOL-3-YL)PHENOXY)PROPAN-2-OL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS 有权
标题翻译： 3-（4-（5-苯基-1,2,4-氧杂唑-3-基）苯氧基）丙-2-醇衍生物作为SPHINGOSINE-1磷酸酯受体调节剂
公开(公告)号：US20130065860A1
公开(公告)日：2013-03-14
申请号：US13604152
申请日：2012-09-05
申请人： Janet A. Takeuchi , Ling Li , Ken Chow
发明人： Janet A. Takeuchi , Ling Li , Ken Chow
IPC分类号： C07F9/653 , A61K31/4245 , A61K31/675 , A61P37/00 , A61P19/02 , A61P9/10 , A61P17/06 , A61P17/00 , A61P25/00 , A61P37/06 , A61P27/04 , A61P1/00 , C07D271/06 , A61P37/08
CPC分类号： A61K31/4245 , C07D271/06 , C07F9/65318
摘要： The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译：本发明涉及新的恶二唑衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。

94. 发明申请

US20120302606A1 3-(4-((1H-IMIDAZOL-1-YL)METHYL)PHENYL)-5-ARYL-1,2,4-OXADIAZOLE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS 有权
标题翻译： 3-（4 - （（1H-咪唑-1-基）甲基）苯基）-5-亚芳基-1,2,4-氧杂噻唑衍生物作为SPHINGOSINE-1磷酸酯受体调节剂
公开(公告)号：US20120302606A1
公开(公告)日：2012-11-29
申请号：US13567654
申请日：2012-08-06
申请人： Janet A. Takeuchi , Ken Chow , Ling Li
发明人： Janet A. Takeuchi , Ken Chow , Ling Li
IPC分类号： A61K31/4245 , A61P37/00 , A61K31/454 , C07D413/10 , C07D413/14
CPC分类号： C07D413/10
摘要： Substituted 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-phenyl-1,2,4-oxadiazole derivatives which are useful as sphingosine-1-phosphate modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译：取代的3-（4 - （（1H-咪唑-1-基）甲基）苯基）-5-苯基-1,2,4-恶二唑衍生物，其可用作鞘氨醇-1-磷酸调节剂并且可用于治疗多种的与调节鞘氨醇-1-磷酸受体相关的疾病。

95. 发明申请

US20120264730A1 SUBSTITUTED BICYCLIC METHYL AZETIDINES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS 失效
标题翻译：作为SPHINGOSINE-1磷酸酯受体调节剂的取代的双环亚甲基
公开(公告)号：US20120264730A1
公开(公告)日：2012-10-18
申请号：US13442023
申请日：2012-04-09
申请人： Janet A. Takeuchi , Ling Li , Wha Bin Im
发明人： Janet A. Takeuchi , Ling Li , Wha Bin Im
IPC分类号： A61K31/4709 , A61P27/02 , A61P27/06 , A61P29/00 , A61P9/00 , A61P11/00 , A61P7/00 , A61P35/04 , A61P9/10 , A61P37/06 , A61P1/00 , A61P25/00 , A61P17/06 , A61P13/12 , A61P17/00 , A61P37/08 , A61P11/06 , A61P19/10 , A61P25/28 , C07D401/10
CPC分类号： C07D401/06 , A61K31/4709 , A61K45/06 , C07D215/14
摘要： The present invention relates to novel substituted bicyclic methyl azetidine derivatives which are useful as sphingosine-1-phosphate receptors modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译：本发明涉及可用作鞘氨醇-1-磷酸受体调节剂并可用于治疗与调节鞘氨醇-1-磷酸受体相关的多种病症的新型取代的双环甲基氮杂环丁烷衍生物。

96. 发明申请

US20110270858A1 FILE TYPE RECOGNITION ANALYSIS METHOD AND SYSTEM 有权
标题翻译：文件类型识别分析方法和系统
公开(公告)号：US20110270858A1
公开(公告)日：2011-11-03
申请号：US13142923
申请日：2009-08-10
申请人： Xiao Zhuang , Su LV , Ling Li , Xiaozhou Hu , Zhenglin Li , Yaoyao Zhu
发明人： Xiao Zhuang , Su LV , Ling Li , Xiaozhou Hu , Zhenglin Li , Yaoyao Zhu
IPC分类号： G06F17/30
CPC分类号： G06F17/30067
摘要： The invention provides a method and system for file type identifying and analyzing, which is high in processing efficiency and accuracy, simple in parameter configuring and speedy in analyzing. The method for file type identifying and analyzing is a method for identifying file type read from a database and making an analysis, characterized by comprising the following step: a loading step for loading file categories and file format parameters into a memory; a file reading step for reading files from the memory; a file type identifying step for determining whether the read files are of the file type that can be identified by the memory; a file analyzing step for analyzing files and generating an analysis report in the event that the file type can be identified. With the invention, the time required for file analysis can be effectively shortened and the accuracy of file identifying and analyzing can be ensured.
摘要翻译：本发明提供了一种文件类型识别和分析的方法和系统，其处理效率和准确度高，参数配置简单，分析速度快。用于文件类型识别和分析的方法是用于识别从数据库读取的文件类型并进行分析的方法，其特征在于包括以下步骤：用于将文件类别和文件格式参数加载到存储器中的加载步骤; 用于从存储器读取文件的文件读取步骤; 文件类型识别步骤，用于确定所述读取文件是否是可由所述存储器识别的文件类型; 文件分析步骤，用于在可以识别文件类型的情况下分析文件并生成分析报告。利用本发明，可以有效地缩短文件分析所需的时间，并且可以确保文件识别和分析的准确性。

97. 发明申请

US20110034517A1 SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF 失效
标题翻译：选择性亚型ALPHA 2 ADRENERGIC AGENTS及其使用方法
公开(公告)号：US20110034517A1
公开(公告)日：2011-02-10
申请号：US12811773
申请日：2009-01-14
申请人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
发明人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
IPC分类号： A61K31/4439 , C07D413/12 , C07D417/12 , C07D401/12 , A61P25/28 , A61P1/00 , A61P25/00 , A61P3/10 , A61P25/18
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译：本发明提供了明确定义的杂环化合物，其可用作亚型选择性α2肾上腺素能激动剂。因此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节相关的多种病症。

98. 发明授权

US07858539B2 Processes for generating halamine compounds on textile substrates to produce antimicrobial finish 失效
标题翻译：在纺织品基材上产生卤胺化合物以产生抗微生物剂的方法
公开(公告)号：US07858539B2
公开(公告)日：2010-12-28
申请号：US11784711
申请日：2007-04-09
申请人： Ling Li , Shulong Li , Jeffrey S. Lane
发明人： Ling Li , Shulong Li , Jeffrey S. Lane
IPC分类号： B32B27/04
CPC分类号： D06M13/33 , A01N25/10 , A01N25/34 , A01N59/00 , D06M13/325 , D06M13/35 , D06M13/352 , D06M13/355 , D06M15/3562 , D06M15/61 , D06M16/00 , Y10T442/2525 , A01N2300/00
摘要： Provided herein are processes for topically applying an antimicrobial finish to a textile substrate, such as a yarn, a fabric, a composite, or an assembled article (for example, a garment). Specifically, the antimicrobial finish is based on hindered amine compounds that are applied in an aqueous bath (such as a commercial or home laundry setting), using the factors of pH and compound solubility to promote the formation of a durable antimicrobial halamine finish. Advantageously, the antimicrobial finish, which may be applied to fabrics made of any of a variety of fiber types and combinations of fiber types, has been found to be durable to repeated launderings.
摘要翻译：本文提供了将抗微生物整理剂局部施加到织物基底如纱线，织物，复合材料或组装制品（例如衣服）上的方法。具体地说，抗微生物整理剂是以使用pH和化合物溶解度的因素促进形成持久的抗微生物胺盐酸盐处理剂为基础的受水胺化合物，其应用于水浴（例如商业或家庭洗衣设备）中。有利地，已经发现可以应用于由各种纤维类型和纤维类型的组合制成的织物的抗微生物整理剂对于重复的洗涤是耐用的。

99. 发明申请

US20100319074A1 MULTI-TARGETED RNAI THERAPEUTICS FOR SCARLESS WOUND HEALING OF SKIN 有权
标题翻译：多用途无脊椎动物皮肤愈合治疗RNAI治疗
公开(公告)号：US20100319074A1
公开(公告)日：2010-12-16
申请号：US12741645
申请日：2008-11-06
申请人： Patrick Y. Lu , Ling Li , Vera Simonenko
发明人： Patrick Y. Lu , Ling Li , Vera Simonenko
IPC分类号： A61K31/713 , C07H21/04 , A61P17/02 , A61K49/00
CPC分类号： A61K31/7105 , C12N15/1136 , C12N15/1138 , C12N2310/14
摘要： The present invention provides small interfering RNA (siRNA) molecules, compositions containing them, and methods of using them for improvement of skin scarless wound healing and other skin conditions, such as psoriasis and lupus-caused cutaneous lesions. The invention includes siRNA molecules and compositions containing them that inhibit the expression of one or more genes that promote pathological or undesired processes in wound healing and methods of using them.
摘要翻译：本发明提供小干扰RNA（siRNA）分子，含有它们的组合物，以及使用它们用于改善皮肤无伤口伤口愈合和其它皮肤状况的方法，例如牛皮癣和狼疮引起的皮肤损伤。本发明包括siRNA分子和含有它们的组合物，其抑制一种或多种促进伤口愈合中病理或不期望过程的基因的表达以及使用它们的方法。

100. 发明授权

US07638648B2 Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效
标题翻译：具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法
公开(公告)号：US07638648B2
公开(公告)日：2009-12-29
申请号：US11728313
申请日：2007-03-23
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： C07D265/06 , C07D263/02 , C07D277/02 , C07D213/02 , C07D333/04 , C07D307/34 , C07C229/34
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译：本说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。

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