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91. 发明申请

US20050171363A1 Process for producing trifluoromethyl- substituted 2- alkoxyacetophenone derivatives 有权
标题翻译：制备三氟甲基取代的2-烷氧基苯乙酮衍生物的方法
公开(公告)号：US20050171363A1
公开(公告)日：2005-08-04
申请号：US10473399
申请日：2003-08-08
申请人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
发明人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
IPC分类号： C07C43/315 , C07C45/57 , C07C45/59 , C07C45/60 , C07C49/84 , C07D317/16 , C07D317/22 , C07D323/02
CPC分类号： C07D317/22 , C07C43/315 , C07C45/57 , C07C45/59 , C07C45/60 , C07C49/84 , C07D317/16 , C07C49/80
摘要： A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether.
摘要翻译：制备溴化缩醛的方法（由式3表示）包括（a）在亚烷基二醇的存在下用Br 2 H 3溴化三氟甲基取代的苯乙酮。（b）使溴化缩醛与金属醇盐反应，从而将溴化缩醛转化成醚，任选地制备三氟甲基取代的2-烷氧基苯乙酮衍生物（由式9表示）和（c）在酸催化剂的存在下水解醚，以从乙醚中除去缩醛基，从而制备2-烷氧基苯乙酮衍生物。或者，2-烷氧基苯乙酮可以通过以下方法制备：（a）使三氟甲基取代的苯甲酰甲基卤化物与缩醛化剂反应，从而将苯甲酰甲酰卤转化成缩醛; （b）使缩醛与金属醇盐反应，从而将缩醛转化成醚; 和（c）在酸催化剂存在下水解该醚，以从乙醚中除去缩醛基。

92. 发明授权

US06833468B2 Process for producing 4,4,4-trifluoro-3-hydroxybutyric acid derivatives 失效
标题翻译：制备4,4,4-三氟-3-羟基丁酸衍生物的方法
公开(公告)号：US06833468B2
公开(公告)日：2004-12-21
申请号：US10202833
申请日：2002-07-26
申请人： Akihiro Ishii , Masatomi Kanai , Takashi Hayami , Katsuyoshi Shibata , Masaki Matsui , Kazumasa Funabiki , Yokusu Kuriyama , Manabu Yasumoto
发明人： Akihiro Ishii , Masatomi Kanai , Takashi Hayami , Katsuyoshi Shibata , Masaki Matsui , Kazumasa Funabiki , Yokusu Kuriyama , Manabu Yasumoto
IPC分类号： C07C6900
CPC分类号： C07C69/675 , C07B2200/07 , C07C29/143 , C07C45/516 , C07C45/78 , C07C45/81 , C07C49/82 , C07C49/84 , C07C31/42
摘要： A first process for producing an optically active perfluoroalklylcarbinol derivative includes (a) reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfluoroalkylaldehyde to obtain a condensate; and (b) hydrolyzing the condensate under an acid condition. A second process for increasing optical purity of an optically active 4,4,4-trifluoro-3-hydroxy-1-aryl-1-butanone derivative includes (a) precipitating a racemic crystal of the derivative, from the derivative; and (b) removing the racemic crystal from the derivative. A third process for increasing optical purity of the butanone derivative includes recrystallizing the derivative. Novel compounds are optically active and inactive 4,4,4-trifluoro-3-hydroxybotanoic aryl ester derivatives. A fourth or fifth process for producing an optically active and inactive 4,4,4-trifluoro-3-hydroxybutyric acid aryl ester derivative includes oxidizing an optically active or optically inactive 4,4,4-trifluoro-3-hydroxy-1-aryl-1-butanone derivative. A sixth process for increasing optical purity of the optically active aryl ester derivative includes recrystallizing the derivative. A seventh process for producing an optically active 4,4,4-trifluoro-3-butanediol includes reducing the optically active aryl ester derivative by a hydride. An eighth or ninth process for producing an optically active or inactive 4,4,4-trifluoro-3-hydroxybutyric acid alkyl ester derivative includes reacting under an acid condition the optically active or optically inactive aryl ester derivative with a lower alcohol. It is possible to suitably combine at least two of the first to ninth processes.
摘要翻译：制备光学活性全氟烷基甲醇基衍生物的第一种方法包括（a）使光学活性亚胺与全氟烷基醛的半缩醛化合物或全氟烷基醛的水合物反应得到缩合物; 和（b）在酸性条件下水解冷凝物。提高光学活性4,4,4-三氟-3-羟基-1-芳基-1-丁酮衍生物的光学纯度的第二种方法包括（a）衍生物沉淀衍生物的外消旋晶体; 和（b）从衍生物中除去外消旋晶体。提高丁酮衍生物的光学纯度的第三种方法包括使衍生物重结晶。新型化合物是光学活性和无活性的4,4,4-三氟-3-羟基伯烷基酯衍生物。用于制备光学活性和无活性的4,4,4-三氟-3-羟基丁酸芳基酯衍生物的第四或第五种方法包括将光学活性或光学活性的4,4,4-三氟-3-羟基-1-芳基 -1-丁酮衍生物。提高光学活性芳基酯衍生物的光学纯度的第六种方法包括使衍生物重结晶。制备光学活性4,4,4-三氟-3-丁二醇的第七种方法包括用氢化物还原光学活性芳基酯衍生物。用于制备光学活性或无活性的4,4,4-三氟-3-羟基丁酸烷基酯衍生物的第八或第九方法包括在酸性条件下使光学活性或光学惰性的芳基酯衍生物与低级醇反应。可以适当地组合第一至第九工艺中的至少两个。

93. 发明授权

US06642409B2 Process for producing 4,4,4-trifluoro-3-hydroxybutyric acid derivatives 失效
标题翻译：制备4,4,4-三氟-3-羟基丁酸衍生物的方法
公开(公告)号：US06642409B2
公开(公告)日：2003-11-04
申请号：US09770671
申请日：2001-01-29
申请人： Akihiro Ishii , Masatomi Kanai , Takashi Hayami , Katsuyoshi Shibata , Masaki Matsui , Kazumasa Funabiki , Yokusu Kuriyama , Manabu Yasumoto
发明人： Akihiro Ishii , Masatomi Kanai , Takashi Hayami , Katsuyoshi Shibata , Masaki Matsui , Kazumasa Funabiki , Yokusu Kuriyama , Manabu Yasumoto
IPC分类号： C07C6993
CPC分类号： C07C69/675 , C07B2200/07 , C07C29/143 , C07C45/516 , C07C45/78 , C07C45/81 , C07C49/82 , C07C49/84 , C07C31/42
摘要： A first process for producing an optically active perfluoroalklylcarbinol derivative includes (a) reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfinoroalkylaldehyde to obtain a condensate; and (b) hydrolyzing the condensate under an acid condition. A second process for increasing optical purity of an optically active 4,4,4-trifluoro-3-hydroxy-1-aryl-1-butanone derivative includes (a) precipitating a racemic crystal of the derivative, from the derivative; and (b) removing the racemic crystal from the derivative. A third process for increasing optical purity of the butanone derivative (includes recrystallizing the derivative. Novel compounds are optically active and inactive 4,4,4-trifluoro-3-hydroxybotanoic aryl ester derivatives. A fourth or fifth process for producing an optically active and inactive 4,4,4-trifloro-3-hydroxybutyric acid aryl ester derivative includes oxidizing an optically active or optically inactive 4,4,4-trifluoro-3-hydroxy-1-aryl-1-butanone derivative. A sixth process for increasing optical purity of the optically active aryl ester derivative includes recrystallizing the derivative. A seventh process for producing an optically active 4,4,4-trifluoro-3-butanediol includes reducing the optically active aryl ester derivative by a hydride. An eighth or ninth process for producing an optically active or inactive 4,4,4-trifluoro-3-hydroxybutyric acid alkyl ester derivative includes reacting under an acid condition the optically active or optically inactive aryl ester derivative with a lower alcohol. It is possible to suitably combine at least two of the first to ninth processes.
摘要翻译：制备光学活性全氟烷基甲醇基衍生物的第一种方法包括（a）使光学活性亚胺与全氟烷基醛的半缩醛化合物或全氟烷基醛的水合物反应得到一种缩合物; 和（b）在酸性条件下水解冷凝物。提高光学活性4,4,4-三氟-3-羟基-1-芳基-1-丁酮衍生物的光学纯度的第二种方法包括（a）衍生物沉淀衍生物的外消旋晶体; 和（b）从衍生物中除去外消旋晶体。提供丁酮衍生物的光学纯度的第三种方法（包括重结晶衍生物）新型化合物是光学活性和无活性的4,4,4-三氟-3-羟基己酸芳基酯衍生物。第四或第五种光学活性和不活泼的4,4,4-三氟-3-羟基丁酸芳酯衍生物包括氧化光学活性或光学活性的4,4,4-三氟-3-羟基-1-芳基-1-丁酮衍生物。第六种增加方法光学活性芳基酯衍生物的光学纯度包括使该衍生物重结晶。第四种制备光学活性4,4,4-三氟-3-丁二醇的方法包括用氢化物还原光学活性芳基酯衍生物，第八或第九种方法用于制备光学活性或无活性的4,4,4-三氟-3-羟基丁酸烷基酯衍生物包括在酸性条件下使光学活性或光学惰性的芳基酯衍生物 e与低级酒精。可以适当地组合第一至第九工艺中的至少两个。

94. 发明授权

US06424127B1 Alternator controller 有权
标题翻译：发电机控制器
公开(公告)号：US06424127B1
公开(公告)日：2002-07-23
申请号：US09732707
申请日：2000-12-11
申请人： Akihiro Ishii
发明人： Akihiro Ishii
IPC分类号： H02P908
CPC分类号： H02P9/08
摘要： Power generation by an alternator is controlled by switching a target charging voltage by a signal from an engine control unit so that engine-starting characteristics when the engine starts are prevented from deterioration due to the load of the alternator. The circuit initiates the generation by the alternator according to a gradual excitation control signal when the engine starts and makes the alternator generate according to a prohibit-power-generation signal after the completion of the starting.
摘要翻译：通过由发动机控制单元的信号切换目标充电电压来控制交流发电机的发电，从而防止发动机起动时的发动机起动特性由于交流发电机的负载而劣化。当发动机起动时，电路根据逐渐的励磁控制信号，通过交流发电机起动发电，并且在启动完成之后根据禁止发电信号使交流发电机产生。

95. 发明授权

US06399806B1 Process for producing binaphthol bistriflate 失效
标题翻译：双酚双酚A的生产工艺
公开(公告)号：US06399806B1
公开(公告)日：2002-06-04
申请号：US09697683
申请日：2000-10-27
申请人： Akihiro Ishii , Mikio Ujiie , Yokusu Kuriyama , Mitsuru Tanuma
发明人： Akihiro Ishii , Mikio Ujiie , Yokusu Kuriyama , Mitsuru Tanuma
IPC分类号： C07C30300
CPC分类号： C07C303/28 , C07C309/65
摘要： A process for producing a binaphthol bistriflate, 2,2′-bis(trifluoromethanesulfonyloxy)-1,1′-binaphthyl, includes reacting 1,1′-bi-2-naphthol with trifluoromethanesulfonyl fluoride, in a polar solvent, in the presence of an organic base. The reaction proceeds quickly at a low temperature by using a polar solvent as the reaction solvent, while the reaction pressure does not become high. The polar solvent is preferably at least one selected from N,N-dimethylformamide, N,N-dimethylacetoamide, 1-methyl-2-pyrrolidinone, and acetonitrile.
摘要翻译： 2,2-双（三氟甲磺酰氧基）-1,1'-联萘双酚双酚A的制备方法包括在极性溶剂中，在1,1'-双（三氟甲磺酰氧基）-1,1'-联萘存在下使1,1'-双-2-萘酚与三氟甲磺酰氟反应，有机基地。通过使用极性溶剂作为反应溶剂，反应在低温下快速进行，反应压力不高。极性溶剂优选为选自N，N-二甲基甲酰胺，N，N-二甲基乙酰胺，1-甲基-2-吡咯烷酮和乙腈中的至少一种。

96. 发明授权

US5440047A Method of preparing 2-chloro-pyridinemethanol 失效
标题翻译： 2-氯 - 吡啶甲醇的制备方法
公开(公告)号：US5440047A
公开(公告)日：1995-08-08
申请号：US252484
申请日：1994-06-01
申请人： Yasunobu Nishimura , Akihiro Ishii , Yuzuru Morino , Yoshiyuki Kikuchi
发明人： Yasunobu Nishimura , Akihiro Ishii , Yuzuru Morino , Yoshiyuki Kikuchi
IPC分类号： B01J31/02 , C07B61/00 , C07D213/61 , C07D213/68 , C07D213/30
CPC分类号： C07D213/61
摘要： The invention relates to a method of preparing 2-chloro-pyridinemethanol represented by the following formula (1). The method includes the steps of: (a) reacting 2-chloro-monochloromethylpyridine with an alkali metal salt of a carboxylic acid and/or a hydrate of the alkali metal salt so as to form an ester derivative; and (b) hydrolyzing the ester derivative so as to form the 2-chloro-pyridinemethanol. ##STR1##
摘要翻译：本发明涉及一种由下式（1）表示的2-氯 - 吡啶甲醇的制备方法。该方法包括以下步骤：（a）使2-氯 - 一氯甲基吡啶与羧酸的碱金属盐和/或碱金属盐的水合物反应，形成酯衍生物; 和（b）水解酯衍生物以形成2-氯 - 吡啶甲醇。（1）

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