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92. 发明授权

US6166072A Amino acid derivatives 失效
标题翻译：氨基酸衍生物
公开(公告)号：US6166072A
公开(公告)日：2000-12-26
申请号：US342492
申请日：1999-06-29
申请人： Stanley Charles Bell , Michael De Vivo , Allen Hopper , Methvin Isaac , Anne O'Brien , Vassil Ilya Ognyanov , Richard Schumacher
发明人： Stanley Charles Bell , Michael De Vivo , Allen Hopper , Methvin Isaac , Anne O'Brien , Vassil Ilya Ognyanov , Richard Schumacher
IPC分类号： C07C323/60 , A61K31/21
CPC分类号： C07C323/60
摘要： Described herein are compounds having the general formula: ##STR1## wherein: Ar.sup.1 and Ar.sup.2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO.sub.2, Ph, CF.sub.3, CN, OH, methylenedioxy, ethylenedioxy, SO.sub.2 NRR', NRR', CO.sub.2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above;wherein any cycloalkyl or aryl substituent is linked to Ar.sup.1 or Ar.sup.2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH.sub.2).sub.n -- group, a --(CH.sub.2).sub.n --Z-- group, or a --Z--(CH.sub.2).sub.n --Z-- group, where Z represents an O atom, a S atom, an NH group or an N-alkyl group, and n is an integer from 1 to 4;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;R.sup.3 is selected from the group consisting of H and aryl, which may be substituted as for Ar.sup.1 ;R.sup.4 and R.sup.5 are independently selected from the group consisting of H, alkyl, alkanoyl, benzoyl and benzyl.
摘要翻译：本文描述的是具有以下通式的化合物：其中：Ar 1和Ar 2是独立选择的芳基，任选地被选自烷基，环烷基，烷氧基，烷酰基，芳烷基，芳烷氧基，卤素，NO 2，Ph，CF 3， CN，OH，亚甲二氧基，亚乙二氧基，SO 2 NRR'，NRR'，CO 2 R（其中R和R'独立地选自H和烷基）和可如上所述被取代的第二芳基; 其中任何环烷基或芳基取代基通过可以是单键的桥连元件连接到Ar 1或Ar 2上，亚乙烯基，亚乙炔基，Z基，-Z-（CH 2）n - 基， - （CH 2））nZ-基或-Z-（CH2）nZ-基，其中Z表示O原子，S原子，NH基或N-烷基，n是1至4的整数; 其中Ar1和Ar2可以通过单键连接到它们连接的中心原子上，亚烷基，亚烯基或亚炔基; 其中Ar1和Ar2可以通过单键连接到它们连接的中心原子上，亚烷基，亚烯基或亚炔基; R 3选自H和芳基，其可以被取代为Ar 1; R 4和R 5独立地选自H，烷基，烷酰基，苯甲酰基和苄基。

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