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91. 发明授权

US07990532B2 Method and apparatus for multimodal detection 有权
标题翻译：多模态检测方法和装置
公开(公告)号：US07990532B2
公开(公告)日：2011-08-02
申请号：US12718362
申请日：2010-03-05
申请人： Jason Neiss , Patrick Treado , Robert C. Schweitzer
发明人： Jason Neiss , Patrick Treado , Robert C. Schweitzer
IPC分类号： G01J3/44
CPC分类号： G01J3/28
摘要： System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the entities is assessed wherein the first feature is characteristic of the unknown substance. A region of interest is selected wherein the region of interest comprises at least one entity exhibiting the first feature. A spatially accurate wavelength resolved Raman image is obtained wherein each pixel in the image is the Raman spectrum of the sample at the corresponding location. The spatially accurate wavelength resolved image is assessed to thereby identify the unknown substance.
摘要翻译：用于评估包含多个实体的样品中未知物质的发生的系统和方法。提供了包括代表至少一种已知物质的多个参考数据集的参考文库。评估实体的第一特征，其中第一特征是未知物质的特征。选择感兴趣区域，其中感兴趣区域包括展示第一特征的至少一个实体。获得空间精确的波长分辨拉曼图像，其中图像中的每个像素是相应位置处样品的拉曼光谱。评估空间上准确的波长分辨图像，从而识别未知物质。

92. 发明申请

US20080088844A1 Method and apparatus for a microscope image selector 有权
公开(公告)号：US20080088844A1
公开(公告)日：2008-04-17
申请号：US11902874
申请日：2007-09-26
申请人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
发明人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
IPC分类号： G01N21/25
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

93. 发明申请

US20060146315A1 Method and apparatus for compact dispersive imaging spectrometer 有权
标题翻译：紧凑型分散成像光谱仪的方法和装置
公开(公告)号：US20060146315A1
公开(公告)日：2006-07-06
申请号：US11364180
申请日：2006-03-01
申请人： Patrick Treado
发明人： Patrick Treado
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for compact dispersive imaging spectrometer. More specifically, one embodiment of the disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension. The portable system can include a photon emission source for sequentially illuminating a plurality of portions of said sample with a plurality of photons to produce photons scattered by the sample. The photon emission source can illuminate the sample along the first spatial dimension for each of plural predetermined positions of the second spatial dimension. The system may also include an optical lens for collecting the scattered photons to produce therefrom filtered photons, a dispersive spectrometer for determining a wavelength of ones of the filtered photons, a photon detector for receiving the filtered photons and obtaining therefrom plural spectra of said sample, and a processor for producing a two dimensional image of said sample from the plural spectra.
摘要翻译：本发明一般涉及紧凑型分散成像光谱仪的方法和装置。更具体地，本公开的一个实施例涉及用于获得具有第一和第二空间维度的样本的空间上准确的波长分辨图像的便携式系统。便携式系统可以包括光子发射源，用于用多个光子顺序照射所述样品的多个部分，以产生由样品散射的光子。光子发射源可以沿着第一空间维度对第二空间维度的多个预定位置中的每一个照射样本。该系统还可以包括用于收集散射光子以产生滤光光子的光学透镜，用于确定滤光光子中波长的波长的色散光谱仪，用于接收经滤光的光子并由此获得所述样品的多个光谱的光子检测器，以及用于从所述多个光谱产生所述样本的二维图像的处理器。

94. 发明授权

US11145411B2 System and method for serum based cancer detection 有权
公开(公告)号：US11145411B2
公开(公告)日：2021-10-12
申请号：US14440987
申请日：2013-11-06
申请人： CHEMIMAGE CORPORATION , Patrick Treado , Shona Stewart , Heather Kirschner , Ryan Priore , Alan Wilson
发明人： Patrick Treado , Shona Stewart , Heather Kirschner , Ryan Priore , Alan Wilson
IPC分类号： G01N21/65 , G01N33/49 , G16H50/20 , G16B40/00 , G01N33/574 , G01J3/44 , G01J3/18
摘要： A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

95. 发明申请

US20120134582A1 System and Method for Multimodal Detection of Unknown Substances Including Explosives 审中-公开
标题翻译：包括爆炸物在内的未知物质的多模态检测系统和方法
公开(公告)号：US20120134582A1
公开(公告)日：2012-05-31
申请号：US13193860
申请日：2011-07-29
申请人： Patrick Treado , Robert Schewitzer , Jason Neiss
发明人： Patrick Treado , Robert Schewitzer , Jason Neiss
IPC分类号： G06K9/00
CPC分类号： G01J3/28
摘要： A system and method for identifying an unknown substance in a sample comprising multiple entities. A method may comprise generating a RGB image representative of a sample and assessing said RGB image to identify at least one region of interest. This region of interest may he assessed to generate a spatially accurate wavelength resolved image, which may be a hyperspectral image. This spatially accurate wavelength resolved image may comprise a fluorescence, Raman, near infrared, short wave infrared, mid wave infrared and/or long wave infrared image. This spatially accurate wavelength resolved image may be assessed to identify said unknown substance. A system may comprise: a reference database, a first detector for generating an RGB image, a second detector for generating a spatially accurate wavelength resolved image, and a means for assessing said RGB image and said spatially accurate wavelength resolved image.
摘要翻译：一种用于识别包含多个实体的样品中的未知物质的系统和方法。方法可以包括生成代表样本的RGB图像并评估所述RGB图像以识别至少一个感兴趣的区域。他可以评估该感兴趣的区域以产生空间准确的波长分辨图像，其可以是高光谱图像。该空间准确的波长分辨图像可以包括荧光，拉曼，近红外，短波红外，中波红外和/或长波红外图像。可以评估该空间上准确的波长分辨图像以识别所述未知物质。系统可以包括：参考数据库，用于产生RGB图像的第一检测器，用于产生空间上精确的波长分辨图像的第二检测器，以及用于评估所述RGB图像和所述空间上精确的波长分辨图像的装置。

96. 发明申请

US20050030545A1 Method and apparatus for compact Fabry-Perot imaging spectrometer 有权
标题翻译：紧凑法布里 - 珀罗成像光谱仪的方法和装置
公开(公告)号：US20050030545A1
公开(公告)日：2005-02-10
申请号：US10893230
申请日：2004-07-19
申请人： David Tuschel , Patrick Treado , Chenhui Wang
发明人： David Tuschel , Patrick Treado , Chenhui Wang
IPC分类号： G01B9/02 , G01J20060101 , G01J3/02 , G01J3/10 , G01J3/28 , G01J3/30 , G01J3/44 , G01N21/64 , G01N21/65 , G02F1/1333 , G02F1/1335 , G02F1/1347
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for compact Fabry-Perot imaging spectrometer. More specifically, in one embodiment, the disclosure concerns a tunable Fabry-Perot optical filter for providing a spatially accurate wavelength-resolved image of a sample having two spatial dimensions. The optical filter may include plural filter elements having an initial predetermined spacing between adjacent filter elements; and a micro electromechanical system (“MEMS”) actuator. One of the plural filter elements may be attached to the MEMS actuator so that the actuator is capable of moving said one filter element relative to another of said plural filter elements to thereby tune said Fabry-Perot optical filter.
摘要翻译：本发明一般涉及用于紧凑型法布里 - 珀罗成像光谱仪的方法和装置。更具体地说，在一个实施例中，本发明涉及一种可调谐法布里 - 珀罗滤光器，用于提供具有两个空间维度的样品的空间上准确的波长分辨图像。滤光器可以包括在相邻滤光元件之间具有初始预定间隔的多个滤光元件; 和微机电系统（“MEMS”）致动器。多个滤波器元件中的一个可以附接到MEMS致动器，使得致动器能够相对于所述多个滤波器元件中的另一个移动所述一个滤波器元件，从而调谐所述法布里 - 珀罗滤光器。

97. 发明申请

US20070008525A1 Method for Raman imaging of semiconductor materials 审中-公开
标题翻译：半导体材料拉曼成像方法
公开(公告)号：US20070008525A1
公开(公告)日：2007-01-11
申请号：US11520348
申请日：2006-09-13
申请人： David Tuschel , Patrick Treado , Joseph Demuth
发明人： David Tuschel , Patrick Treado , Joseph Demuth
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/28 , G01N21/274 , G01N21/6489 , G01N21/65
摘要： An ion implanted semiconductor surface is illuminated with a flood illumination of monochromatic radiation, and an image of the surface is taken using light which has been Raman scattered. The illumination and imaging system are calibrated by flood illuminating a uniformly Raman scattering surface.
摘要翻译：用单色辐射的泛光照射照射离子注入的半导体表面，并且使用已经被拉曼散射的光进行表面的图像。照明和成像系统通过泛光照射均匀的拉曼散射表面来校准。

98. 发明申请

US20050030533A1 Method and apparatus for compact dispersive imaging spectrometer 有权
标题翻译：紧凑型分散成像光谱仪的方法和装置
公开(公告)号：US20050030533A1
公开(公告)日：2005-02-10
申请号：US10893339
申请日：2004-07-19
申请人： Patrick Treado
发明人： Patrick Treado
IPC分类号： G01B9/02 , G01J20060101 , G01J3/02 , G01J3/10 , G01J3/28 , G01J3/30 , G01J3/44 , G01N21/64 , G01N21/65 , G02F1/1333 , G02F1/1335 , G02F1/1347
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for compact dispersive imaging spectrometer. More specifically, one embodiment of the disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension. The portable system can include a photon emission source for sequentially illuminating a plurality of portions of said sample with a plurality of photons to produce photons scattered by the sample. The photon emission source can illuminate the sample along the first spatial dimension for each of plural predetermined positions of the second spatial dimension. The system may also include an optical lens for collecting the scattered photons to produce therefrom filtered photons, a dispersive spectrometer for determining a wavelength of ones of the filtered photons, a photon detector for receiving the filtered photons and obtaining therefrom plural spectra of said sample, and a processor for producing a two dimensional image of said sample from the plural spectra.
摘要翻译：本发明一般涉及紧凑型分散成像光谱仪的方法和装置。更具体地，本公开的一个实施例涉及用于获得具有第一和第二空间维度的样本的空间上准确的波长分辨图像的便携式系统。便携式系统可以包括光子发射源，用于用多个光子顺序照射所述样品的多个部分，以产生由样品散射的光子。光子发射源可以沿着第一空间维度对第二空间维度的多个预定位置中的每一个照射样本。该系统还可以包括用于收集散射光子以产生滤光光子的光学透镜，用于确定滤光光子中波长的波长的色散光谱仪，用于接收经滤光的光子并由此获得所述样品的多个光谱的光子检测器，以及用于从所述多个光谱产生所述样本的二维图像的处理器。

99. 发明授权

US6002476A Chemical imaging system 失效
标题翻译：化学成像系统
公开(公告)号：US6002476A
公开(公告)日：1999-12-14
申请号：US64347
申请日：1998-04-22
申请人： Patrick Treado
发明人： Patrick Treado
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： A Raman chemical imaging system uses a laser illumination source for illuminating an area of a sample. The spectrum of scattered light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. An Evans Split-Element type liquid crystal tunable filter (LCTF) selects a Raman image of the collimated beam. A detector collects the filtered Raman images which are subsequently processed to determine the constituent materials. The Evans Split-Element-type LCTF suitable for high-definition Raman chemical imaging is incorporated into an efficient Raman imaging system that provides significant performance advantages relative to any previous approach to Raman microscopy. The LCTF and associated optical path is physically compact, which accommodates integration of the LCTF within an infinity-corrected optical microscope. The LCTF simultaneously provides diffraction-limited spatial resolution and 9 cm.sup.-1 spectral bandpass across the full free spectral range of the imaging spectrometer. The LCTF Raman microscope successfully integrates the utility of optical imaging and the analytical capabilities of Raman spectroscopy which has practical significance in materials analysis, including the diagnosis of cancer.
摘要翻译：拉曼化学成像系统使用激光照射源来照射样品的区域。收集来自样品的照射区域的散射光的光谱，并从其中产生准直光束。 Evans分离元件型液晶可调滤波器（LCTF）选择准直光束的拉曼图像。检测器收集随后被处理以确定构成材料的经过滤的拉曼图像。适用于高清晰度拉曼化学成像的Evans Split-Element型LCTF被纳入一个有效的拉曼成像系统中，相对于任何以前的拉曼显微镜方法，其具有显着的性能优势。 LCTF和相关的光路物理紧凑，可以将LCTF集成在无穷远校正的光学显微镜内。 LCTF同时在成像光谱仪的完整自由光谱范围内提供衍射极限空间分辨率和9 cm -1光谱带通。 LCTF拉曼显微镜成功整合了光学成像的实用性和拉曼光谱分析能力，在材料分析，包括癌症诊断中具有现实意义。

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