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91. 发明授权

US07575543B1 Bit-storing apparatus 有权
标题翻译：位存储装置
公开(公告)号：US07575543B1
公开(公告)日：2009-08-18
申请号：US12284374
申请日：2008-09-22
申请人： Ying Sun , Chi Sun
发明人： Ying Sun , Chi Sun
IPC分类号： B23Q3/157
CPC分类号： B23Q3/15526 , B23Q3/15746 , Y10T483/1836 , Y10T483/1891
摘要： A chain-type bit-storing apparatus is provided for a CNC machine tool. The chain-type bit-storing apparatus includes a chain engaged with sprockets rotationally provided thereon. The chain includes links each includes a frame, a rotator rotationally connected to the frame, a pin for pivotally connecting the frame thereof to the rotator of another link and a socket connected to the frame and used to receive a bit. There is a pivoting unit for pivoting a selected one of the bits by pivoting a related one of the links.
摘要翻译：为数控机床提供链式钻头存储装置。链式钻头存储装置包括与其上旋转地设置的链轮接合的链条。链条包括链接，每个链接包括框架，旋转地连接到框架的旋转体，用于将其框架枢转地连接到另一个链节的旋转体的销和连接到框架并用于接收位的插座。存在枢转单元，用于通过枢转相关的一个链接来枢转所选择的一个位。

92. 发明申请

US20090142299A1 MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS 有权
标题翻译：大肠杆菌四氢叶酸C丝氨酸蛋白酶抑制剂
公开(公告)号：US20090142299A1
公开(公告)日：2009-06-04
申请号：US12270963
申请日：2008-11-14
申请人： Ying Sun , Dong Liu , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Dong Liu , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/21 , C07K5/12 , A61K38/06 , A61P31/12
CPC分类号： C07K5/0808 , A61K38/212 , A61K38/215 , C07K5/0812 , A61K2300/00
摘要： The present invention relates to compounds of Formula I, II, III or IV, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
摘要翻译：本发明涉及式I，II，III或IV化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

93. 发明授权

US07486989B2 Device for delivery of oxidizing agents to barrier membranes 有权
标题翻译：用于将氧化剂输送到阻隔膜的装置
公开(公告)号：US07486989B2
公开(公告)日：2009-02-03
申请号：US10609849
申请日：2003-06-30
申请人： Ying Sun , Jue-Chen Liu , Jeffrey M. Wu
发明人： Ying Sun , Jue-Chen Liu , Jeffrey M. Wu
IPC分类号： A61N1/30 , A61M31/00
CPC分类号： A61N1/30
摘要： The present invention features a method of treating infection in a barrier membrane by applying to the membrane a device having a barrier membrane contacting surface that administers an oxidizing agent to the barrier membrane, wherein the device contains: a power source; a first conductive electrode, wherein the first conductive electrode is an inert anode; a second conductive electrode, wherein the second conductive electrode is a cathode; and a carrier containing water; wherein the power source is in electric communication with the first conductive electrode and the second conductive electrode, wherein the first conductive electrode is in ionic communication with the carrier, wherein the oxidizing agent is generated by electric current passing from the first conductive electrode through the carrier, and wherein the carrier is in communication with the barrier membrane contacting surface.
摘要翻译：本发明的特征在于一种通过向隔膜施加具有向隔离膜施用氧化剂的阻挡膜接触表面的装置来处理隔离膜中的感染的方法，其中所述装置包含：电源; 第一导电电极，其中所述第一导电电极是惰性阳极; 第二导电电极，其中所述第二导电电极是阴极; 和含水的载体; 其中所述电源与所述第一导电电极和所述第二导电电极电连通，其中所述第一导电电极与所述载体离子连通，其中所述氧化剂通过从所述第一导电电极通过所述载体的电流产生，并且其中所述载体与所述阻隔膜接触表面连通。

94. 发明申请

US20090005659A1 Tissue Ablation by Shear Force for Sampling Biological Fluids and Delivering Active Agents 审中-公开
标题翻译：通过剪切力抽取生物流体和提供活性剂的组织消融
公开(公告)号：US20090005659A1
公开(公告)日：2009-01-01
申请号：US12181192
申请日：2008-07-28
申请人： Nikiforos Kollias , Ying Sun , Coston Anthony F.
发明人： Nikiforos Kollias , Ying Sun , Coston Anthony F.
IPC分类号： A61B5/00 , A61N1/30
CPC分类号： A61N1/303
摘要： A shear device for use in transporting a molecule through a mammal's mammalian barrier membrane of at least one layer of cells includes a sheet containing an opening(s) and a shear member(s). The sheet is configured for contacting the mammalian barrier membrane (e.g., human skin) and the shear member is configured for ablating a portion of the mammalian barrier membrane forced through the opening(s). This ablating is accomplished by movement of the shear member(s) over the sheet and the opening(s). The ablation of the portion of the mammalian barrier membrane is such that a driving force can be employed to transport the molecule therethrough.
摘要翻译：用于通过哺乳动物的至少一层细胞的哺乳动物屏障膜输送分子的剪切装置包括含有开口和剪切构件的片材。该片被配置用于接触哺乳动物屏障膜（例如，人皮肤），并且剪切构件被配置用于烧蚀被迫穿过开口的哺乳动物屏障膜的一部分。这种消融是通过剪切构件在片材和开口上的移动来实现的。哺乳动物屏障膜部分的消融使得可以采用驱动力来输送分子。

95. 发明授权

US07419962B2 3,6-bicyclolides 有权
标题翻译： 3,6-双环氯化物
公开(公告)号：US07419962B2
公开(公告)日：2008-09-02
申请号：US11295736
申请日：2005-12-06
申请人： Yat Sun Or , Datong Tang , Ying Sun , Yonghua Gai , Guoyou Xu , Zhe Wang
发明人： Yat Sun Or , Datong Tang , Ying Sun , Yonghua Gai , Guoyou Xu , Zhe Wang
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了具有抗菌性质的式（I）化合物或其药学上可接受的盐，酯或前药。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

96. 发明申请

US20080125444A1 ACYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS 失效
标题翻译： ACYCLIC OXIMYL HEPATITIS C蛋白酶抑制剂
公开(公告)号：US20080125444A1
公开(公告)日：2008-05-29
申请号：US11758901
申请日：2007-06-06
申请人： Ying Sun , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Yat Sun Or , Zhe Wang
IPC分类号： A61K31/497 , A61K31/4015 , A61K31/4025 , C07D207/12 , C07D403/12 , C12N7/06 , C07D405/12 , C07D401/14 , A61P31/12 , A61K31/4375
CPC分类号： C07D207/12 , A61K38/00 , C07D207/16 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07K5/0812
摘要： The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

97. 发明申请

US20070281884A1 Macrocyclic oximyl hepatitis C protease inhibitors 审中-公开
标题翻译：大环肟基丙型肝炎蛋白酶抑制剂
公开(公告)号：US20070281884A1
公开(公告)日：2007-12-06
申请号：US11502740
申请日：2006-08-11
申请人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/12 , A61K31/395 , C07K5/12
CPC分类号： A61K38/212 , A61K38/12 , A61K38/215 , C07K5/0804 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

98. 发明授权

US07273851B2 Tri-peptide hepatitis C serine protease inhibitors 有权
标题翻译：三肽丙型肝炎丝氨酸蛋白酶抑制剂
公开(公告)号：US07273851B2
公开(公告)日：2007-09-25
申请号：US10849107
申请日：2004-05-19
申请人： Zhenwei Miao , Ying Sun , Suanne Nakajima , Datong Tang , Zhe Wang , Yat S. Or
发明人： Zhenwei Miao , Ying Sun , Suanne Nakajima , Datong Tang , Zhe Wang , Yat S. Or
IPC分类号： A61K38/00
CPC分类号： C07K5/0808 , A61K38/00
摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐，酯或前药。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

99. 发明申请

US20070142384A1 Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权
标题翻译：用于治疗代谢紊乱的化合物，药物组合物和方法
公开(公告)号：US20070142384A1
公开(公告)日：2007-06-21
申请号：US10591214
申请日：2005-02-24
申请人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jinqian Liu , Jiwen Liu , Jian Luo , Zhihua Ma , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： A61K31/522 , A61K31/4965 , A61K31/52 , A61K31/4709 , A61K31/498 , A61K31/4439 , A61K31/415
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译：本发明提供了可用于例如用于调节受试者中胰岛素水平的化合物，并且具有通式QL 1 -PL 2 -MXL 3 SUP> -A，其中变量Q，L 1，P，L 2，M，X，L 3和A的定义是本文提供。本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

100. 发明授权

US07229972B2 3,6-Bicyclolides 有权
标题翻译： 3,6-双环化合物
公开(公告)号：US07229972B2
公开(公告)日：2007-06-12
申请号：US11008581
申请日：2004-12-07
申请人： Yat Sun Or , Datong Tang , Yonghua Gai , Ying Sun , Guoyou Xu , Zhe Wang
发明人： Yat Sun Or , Datong Tang , Yonghua Gai , Ying Sun , Guoyou Xu , Zhe Wang
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了具有抗菌性质的式（I）化合物或其药学上可接受的盐，酯或前药。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

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