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91. 发明授权

US06214022B1 Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis 失效
标题翻译：用于在分离吻合期间维持血管中的血液流动的灌注装置
公开(公告)号：US06214022B1
公开(公告)日：2001-04-10
申请号：US09301019
申请日：1999-04-28
申请人： Charles S. Taylor , Alfredo R. Cantu , Son M. Gia , Jeff A. Krolic , Robert G. Matheny , Amr Salahieh , Ivan Sepetka
发明人： Charles S. Taylor , Alfredo R. Cantu , Son M. Gia , Jeff A. Krolic , Robert G. Matheny , Amr Salahieh , Ivan Sepetka
IPC分类号： A61B1708
CPC分类号： A61B17/11 , A61B17/0469 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/1219 , A61B2017/1135 , A61B2017/12127
摘要： A plurality of embodiments of a distal perfusion device are disclosed, which device facilitates anastomosis constructions by maintaining a dry anastomosis site while simultaneously maintaining blood flow distally in the blood vessel to prevent ischemia and reduce overall patient trauma. The perfusion device is configured for installation into a blood vessel such as a left anterior descending coronary artery through an incision therein, to which is to be grafted a distal end of a blood vessel such as an internal mammary artery. The device includes a central member of selected configuration and material, terminating at either end thereof in respective selectively tapered end members. A lumen extending through the central member and end members, and selected perforations in the end members, maintain blood flow through the perfusion device. A selected portion or portions of the device's outer circumference fit snugly within the artery in the regions beyond and/or at the anastomosis site, to maintain the latter free of blood. Several methods for deploying and removing respective embodiments of the device also are illustrated.
摘要翻译：公开了一种远端灌注装置的多个实施例，该装置通过维持干吻合部位来促进吻合结构，同时在血管中保持血液向远端流动以防止局部缺血并减少总的患者创伤。灌注装置被构造成通过其中的切口安装到诸如左前降支冠状动脉的血管中，其将被移植到诸如内部乳腺动脉的血管的远端。该装置包括选定构型和材料的中心构件，其终端位于相应的选择性锥形端构件的任一端。延伸穿过中心构件和端构件的内腔以及端构件中选择的穿孔保持血流通过灌注装置。装置的外周的选定部分或部分适合紧贴在吻合部位之外和/或处于吻合部位的区域内的动脉内，以保持后者无血液。还示出了用于部署和移除设备的各个实施例的几种方法。

92. 发明授权

US6113616A Surgical instruments for making precise incisions in a cardiac vessel 失效
标题翻译：用于在心脏血管中进行精确切口的手术器械
公开(公告)号：US6113616A
公开(公告)日：2000-09-05
申请号：US27611
申请日：1998-02-23
申请人： Charles S. Taylor , John J. Frantzen , Ivan Sepetka
发明人： Charles S. Taylor , John J. Frantzen , Ivan Sepetka
IPC分类号： A61B17/00 , A61B17/28 , A61B17/32
CPC分类号： A61B17/32 , A61B17/320016 , A61B2017/00243 , A61B2017/00703 , A61B2017/00778 , A61B2017/2925 , A61B2017/320052
摘要： Surgical instruments and methods for making substantially linear incisions, especially through walls of vessels, such arteries, specifically designed for coronary artery bypass graft procedures (CABG) on the beating heart. The invention is particularly useful to create the incision in the artery to which a bypass graft is sewn, typically the left anterior descending artery (LAD). The instruments allow incisions to be rapidly made, precisely measured and cleanly formed so that a bypass graft can be rapidly sewn in place, without undue trauma to surrounding tissue and excessive loss of blood. In one embodiment, a hand-held instrument has a cutting edge formed on the interior edge of a curved blade fixed near the end of the instrument. The tip of the blade has a point for penetrating the vessel wall which may have several alternate shapes to facilitate penetration of the vessel wall while minimizing to the surrounding tissue. In another embodiment the hand-held instrument includes a moveable member which creates an incision by engaging a cutting blade against a stop, cutting tissue therebetween, the stop including a pointed including a pointed tip similar to the previous embodiment. In another embodiment, the instrument features a motion-canceling member which compensates for the movement of the target surface to be incised. This embodiment has a cutting blade which is manipulated from a handle which is isolated from the movement of the tissue containing or proximate to the target of the incision.
摘要翻译：手术器械和方法，用于进行基本上线性的切口，特别是通过血管壁，这种动脉，专门设计用于搏动心脏上的冠状动脉旁路移植手术（CABG）。本发明特别有用于在缝合旁路移植物的动脉中产生切口，通常为左前降支动脉（LAD）。这些仪器允许快速地进行切割，精确测量和清洁地形成，使得旁路移植物可以快速缝合就位，而不会对周围组织造成过度的创伤和过度的血液损失。在一个实施例中，手持式仪器具有形成在靠近仪器端部的弯曲刀片的内边缘上的切割刃。叶片的尖端具有用于穿透血管壁的点，该点可以具有若干替代形状，以促进血管壁的穿透，同时使周围组织最小化。在另一个实施例中，手持式器械包括可移动构件，其通过将切割刀片接合止挡件而形成切口，在其间切割组织，止动件包括类似于前述实施例的尖端，包括尖端。在另一个实施例中，仪器具有补偿待切割的目标表面的移动的运动消除构件。该实施例具有从手柄操纵的切割刀片，该手柄与包含或接近切口目标的组织的运动隔离。

93. 发明授权

US6083220A Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 失效
公开(公告)号：US6083220A
公开(公告)日：2000-07-04
申请号：US647114
申请日：1996-05-09
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61M25/00 , A61B18/08
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

94. 发明授权

US5947962A Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries veins aneurysms vascular malformations and arteriovenous fistulas 失效
标题翻译：用于动脉血栓形成的血管内电解可分离线和尖端静脉瘤动脉瘤血管畸形和动静脉瘘
公开(公告)号：US5947962A
公开(公告)日：1999-09-07
申请号：US944583
申请日：1997-10-06
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61M25/00 , A61B17/38
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.
摘要翻译：动脉，静脉，动脉瘤，血管畸形或动脉瘘通过血管内插入铂丝和/或尖端进入血管腔而通过血管内阻塞闭塞。血管腔填充有尖端以阻止血液流动或进入腔中的血液，使得腔中的血块凝块和形成闭塞。尖端可以是细长的和柔性的，使得其通过在其自身上折叠多次来包装空腔，或者可以通过尖端的丝状或模糊结构来包装空腔。然后将尖端机械地从线分离，或者通过电极将电极与线分离。之后取出线和微导管，留下尖端嵌入形成在血管腔内的血栓。通过在微导管上提供不透射线的近端标记物和线上的相应指示标记，更容易跟踪导线在微导管中的移动。通过将接地电极放置在微导管的远端并在微导管电极和尖端之间流动电流来促进血栓形成。

95. 发明授权

US5928226A Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 失效
公开(公告)号：US5928226A
公开(公告)日：1999-07-27
申请号：US944581
申请日：1997-10-06
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61M25/00 , A61B17/38
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/0042 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

96. 发明授权

US5895385A Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 失效
标题翻译：动脉，静脉，动脉瘤，血管畸形和动静脉瘘中血栓形成的血管内电解可分离线和尖端
公开(公告)号：US5895385A
公开(公告)日：1999-04-20
申请号：US944827
申请日：1997-11-06
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61M25/00 , A61B17/38
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/0042 , A61M2025/09175
摘要： An artery, vein, aneurysms vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.
摘要翻译：动脉，静脉，动脉瘤血管畸形或动脉瘘通过血管内插入铂丝和/或尖端进入血管腔而通过血管内闭塞而闭塞。血管腔填充有尖端以阻止血液流动或进入腔中的血液，使得腔中的血块凝块和形成闭塞。尖端可以是细长的和柔性的，使得其通过在其自身上折叠多次来包装空腔，或者可以通过尖端的丝状或模糊结构来包装空腔。然后将尖端机械地从线分离，或者通过电极将电极与线分离。之后取出线和微导管，留下尖端嵌入形成在血管腔内的血栓。通过在微导管上提供不透射线的近端标记物和线上的相应指示标记，更容易跟踪导线在微导管中的移动。通过将接地电极放置在微导管的远端并在微导管电极和尖端之间流动电流来促进血栓形成。

97. 发明授权

US5624449A Electrolytically severable joint for endovascular embolic devices 失效
标题翻译：用于血管内栓塞装置的电解分离接头
公开(公告)号：US5624449A
公开(公告)日：1997-04-29
申请号：US431827
申请日：1995-04-28
申请人： Pete P. Pham , Hong Doan , Ivan Sepetka , Joseph Eder , Edward Snyder
发明人： Pete P. Pham , Hong Doan , Ivan Sepetka , Joseph Eder , Edward Snyder
IPC分类号： A61B17/00 , A61B17/12 , A61F2/82 , A61F2/84 , A61M25/01
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00004 , A61B2017/12063
摘要： This invention is an apparatus for endovascular occlusion through the formation of thrombi in arteries, veins, aneurysms, vascular malformations, and arteriovenous fistulas. In particular, it deals with an improved sacrificial link between an endovascular device which is introduced to and is intended to remain at the desired thrombus formation site and the device used to introduce the device. The invention further includes a method for introduction of the device and its electrolytic separation.
摘要翻译：本发明是通过在动脉，静脉，动脉瘤，血管畸形和动静脉瘘中形成血栓的血管内闭塞的装置。特别地，它涉及在引入到并期望保留在期望的血栓形成部位的血管内装置和用于引入装置的装置之间的改进的牺牲连接。本发明还包括引入该装置及其电解分离的方法。

98. 发明授权

US5540680A Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 失效
公开(公告)号：US5540680A
公开(公告)日：1996-07-30
申请号：US311508
申请日：1994-09-23
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61F2/82 , A61M25/00 , A61M37/00 , A61B17/38
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

99. 发明授权

US5122136A Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 失效
标题翻译：血管内皮细胞，血管，血管，血管造影和异常细胞膜电图的电内分离电位指示
公开(公告)号：US5122136A
公开(公告)日：1992-06-16
申请号：US492717
申请日：1990-03-13
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61M25/00
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/0042 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular electrothrombosis by the endovascular insertion of a platinum guidewire tip into the vascular cavity followed by application of a positive current. The guidewire tip is then separated from the guidewire by electrolytic separation of the tip from the guidewire. A portion of the guidewire connected between the tip and the body of the guidewire is comprised of stainless steel and exposed to the bloodstream so that upon continued application of a positive current to the exposed portion, the exposed portion is corroded away at least at one location and the tip is separated from the body of the guidewire. The guidewire and the microcatheter are thereafter removed leaving the guidewire tip embedded in the thrombus formed within the vascular cavity.
摘要翻译：动脉，静脉，动脉瘤，血管畸形或动脉瘘通过血管内血栓形成栓塞，通过血管内插入铂导丝尖端进入血管腔，然后施加正电流。然后通过尖端与导丝的电解分离，将导丝尖端与导丝分离。连接在引导线的尖端和主体之间的导丝的一部分由不锈钢构成并暴露于血流，使得在持续向暴露部分施加正电流时，暴露部分至少在一个位置被腐蚀并且尖端与导丝的主体分离。之后取出导线和微导管，留下引导线尖端嵌入血管腔内形成的血栓。

100. 发明授权

US08771294B2 Aneurysm treatment devices and methods 失效
标题翻译：动脉瘤治疗装置及方法
公开(公告)号：US08771294B2
公开(公告)日：2014-07-08
申请号：US11111487
申请日：2005-04-21
申请人： Ivan Sepetka , Maria Aboytes , Maybelle Jordan , Craig Friedman , Arindam Datta
发明人： Ivan Sepetka , Maria Aboytes , Maybelle Jordan , Craig Friedman , Arindam Datta
IPC分类号： A61B17/04
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12172 , A61B17/12181 , A61B90/39 , A61B2017/00862 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054 , A61B2017/12095
摘要： An aneurysm treatment device for in situ treatment of aneurysms comprises a collapsible member having a first shape wherein the first shape is an expanded geometric configuration, and a second shape, wherein the second shape is a collapsed configuration that is loadable into a catheter. The aneurysm treatment device is capable or returning to the first shape in the sac of an aneurysm upon deployment, where it occludes the aneurysm. In another embodiment an occlusion device comprises a flexible, longitudinally extending elastomeric matrix member that assumes a non-linear shape to conformally fill a targeted vascular site.
摘要翻译：用于动态瘤的原位治疗的动脉瘤治疗装置包括具有第一形状的可折叠构件，其中第一形状是扩张几何形状，以及第二形状，其中第二形状是可装载到导管中的收缩构型。动脉瘤治疗装置在部署时能够或返回到动脉瘤囊中的第一形状，其中阻塞动脉瘤。在另一个实施例中，闭塞装置包括柔性的纵向延伸的弹性体基体构件，其构成保形填充目标血管部位的非线性形状。

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