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91. 发明授权

US5856329A Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury 失效
标题翻译：使用（2-咪唑啉-2-基氨基）喹喔啉处理眼神经损伤的方法
公开(公告)号：US5856329A
公开(公告)日：1999-01-05
申请号：US496262
申请日：1995-06-28
申请人： Larry A. Wheeler , Elizabeth Woldemussie , Ronald K. Lai
发明人： Larry A. Wheeler , Elizabeth Woldemussie , Ronald K. Lai
IPC分类号： C07D403/12 , A61K31/495 , A61K31/498 , A61P27/02
CPC分类号： A61K31/498 , A61K31/495 , Y10S514/912
摘要： A method according to which neuroprotection is conferred upon ocular nerve cells by administration of a drug of formula I to the optic nerve and/or retina of a mammal within a period prior to or following an insult to ocular nerve cells but prior to cell death ##STR1## wherein the 2-imidazolin-2-ylamino group may be in either the 5- or 6-position of the quinoxaline nucleus; x, y and z may be in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and R is an optional substitutent in either the 2- or 3-position of the quinoxaline nucleus and may be hydrogen, lower alkyl or lower alkoxy is disclosed.
摘要翻译：根据该方法，通过在对眼神经细胞的侮辱之前或之后但在细胞死亡之前的一段时间内将式I的药物施用于哺乳动物的视神经和/或视网膜而赋予眼神经细胞。 IMAGE>式I，其中2-咪唑啉-2-基氨基可以在喹喔啉核的5-或6-位; x，y和z可以在剩余的5-，6-，7-或8-位中的任一个中，并且选自氢，卤素，低级烷基，低级烷氧基或三氟甲基; 并且R是喹喔啉核的2-或3-位任选的取代基，并且可以是氢，低级烷基或低级烷氧基。

92. 发明授权

US5773440A Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives 失效
标题翻译：使用（2-咪唑啉-2-基氨基）喹喔啉衍生物的方法
公开(公告)号：US5773440A
公开(公告)日：1998-06-30
申请号：US880473
申请日：1997-06-23
申请人： James A. Burke , Michael E. Garst , Larry A. Wheeler
发明人： James A. Burke , Michael E. Garst , Larry A. Wheeler
IPC分类号： C07D401/12 , A61K31/495 , A61K31/498 , A61P1/12 , A61P1/14 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/02 , A61P13/02 , A61P13/12 , A61P15/00 , A61P23/00 , A61P23/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P27/16 , A61P29/00 , C07D403/12
CPC分类号： A61K31/498 , A61K31/495
摘要： A method of treating a mammal is disclosed comprises administering to a mammal an effective amount to provide a desired therapeutic effect in the mammal of a compound selected from the group consisting of those having the formula: ##STR1## , and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R.sub.1 and R.sub.2 each is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms, the 2-imidazolin-2-ylamino group may be in any of the 5-, 6-, 7- or 8-positions of the quinoxaline nucleus, and R.sub.3, R.sub.4 and R.sub.5 each is located in one of the remaining 5-, 6-, 7- or 8-positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals containing 1 to 3 carbon atoms wherein said desired therapeutic effect is a reduction of at least one effect of an inflammatory disorder.
摘要翻译：公开了治疗哺乳动物的方法包括向哺乳动物施用有效量以在哺乳动物中提供期望的治疗效果，所述化合物选自下列化合物：具有下式的那些化合物及其药学上可接受的酸加成盐和其混合物，其中R 1和R 2各自选自含有1至4个碳原子的烷基和含有1至4个碳原子的烷氧基，2-咪唑啉-2-基氨基可以是5 喹喔啉核的6-，7-或8-位，并且R3，R4和R5各自位于喹喔啉核的剩余的5-，6-，7-或8-位之一中，并且独立选择来自由Cl，Br，H组成的组和含有1至3个碳原子的烷基，其中所述期望的治疗效果是减少至少一种炎性病症的作用。

93. 发明授权

US5326763A Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives 失效
标题翻译：使用（2-咪唑啉-2-基氨基）喹喔啉衍生物的方法
公开(公告)号：US5326763A
公开(公告)日：1994-07-05
申请号：US10954
申请日：1993-01-29
申请人： Charles Gluchowski , Michael E. Garst , James A. Burke , Larry A. Wheeler
发明人： Charles Gluchowski , Michael E. Garst , James A. Burke , Larry A. Wheeler
IPC分类号： A61K31/495 , C07D403/12 , A61K31/50
CPC分类号： C07D403/12 , A61K31/495 , Y10S514/816 , Y10S514/854 , Y10S514/93
摘要： A method of treating a mammal comprises administering to a mammal an effective amount to provide a reduction inflammation in the mammal of a compound selected from the group consisting of those having the formula: ##STR1## pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R.sub.1 and R.sub.4 are independently selected from the group consisting of H and alkyl radicals having 1 to 4 carbon atoms; the R.sub.2 s are independently selected from H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo; the R.sub.3 s are independently selected from H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo; the 2-imidazolin-2-ylamino group may be in any of the 5-, 6, 7- or 8- positions of the quinoxaline nucleus; and R.sub.5, R.sub.6 and R.sub.7 each is located in one of the remaining 5-, 6-, 7- or 8- positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals having 1 to 3 carbon atoms.
摘要翻译：治疗哺乳动物的方法包括向哺乳动物施用有效量以在哺乳动物中提供选自下列化合物的化合物的还原性炎症：具有下式的那些化合物：其药学上可接受的酸加成盐及其混合物，其中 R 1和R 4独立地选自H和具有1至4个碳原子的烷基; R 2独立地选自H或具有1至4个碳原子的烷基，或者一起是氧代; R 3独立地选自H或具有1至4个碳原子的烷基，或者一起是氧代; 2-咪唑啉-2-基氨基可以在喹喔啉核的5-,6,7或8-位中的任一个中; 并且R5，R6和R7各自位于喹喔啉核的剩余的5-，6-，7-或8-位中的一个中，并且独立地选自Cl，Br，H和具有1至 3个碳原子。

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