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91. 发明授权

US08603536B2 Microparticle coated medical device 失效
公开(公告)号：US08603536B2
公开(公告)日：2013-12-10
申请号：US10663568
申请日：2003-09-15
申请人： Steven Z. Wu , Syed F. A. Hossainy , Sameer Harish , Deborra Sanders-Millare , Daryush Mirzaee
发明人： Steven Z. Wu , Syed F. A. Hossainy , Sameer Harish , Deborra Sanders-Millare , Daryush Mirzaee
IPC分类号： A61K9/16
CPC分类号： A61L31/16 , A61K9/1635 , A61K9/1652 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2300/622 , C08L29/04
摘要： A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a medical device, such as a stent, is disclosed. The drug-loaded microparticle is formulated by combining a drug with various chemical solutions. Specified sizes of the microparticles and amounts of drug(s) contained within the microparticles may be varied by altering the proportions of the chemicals/solutions. In addition to various drugs, therapeutic substances and radioactive isotopes may also be loaded into the microparticles. The drug-loaded microparticle are suspended in a polymer solution forming a polymer matrix. The polymer matrix may be applied to the entire surface or only selected portions of the medical device via dipping, spraying or combinations thereof.

92. 发明授权

US08568764B2 Methods of forming coating layers for medical devices utilizing flash vaporization 有权
标题翻译：利用闪蒸法形成用于医疗器械的涂层的方法
公开(公告)号：US08568764B2
公开(公告)日：2013-10-29
申请号：US11445041
申请日：2006-05-31
申请人： Florian N. Ludwig , Syed F. A. Hossainy , Srinivasan Sridharan , Carol Lee
发明人： Florian N. Ludwig , Syed F. A. Hossainy , Srinivasan Sridharan , Carol Lee
IPC分类号： A61F2/00 , A61M31/00
CPC分类号： A61L31/10 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61M31/002
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.
摘要翻译：公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。所述方法包括在从涂料组合物中除去溶剂之前固定活性剂的形态或相分布。涂层可用于控制活性剂或活性剂的组合的递送。

93. 发明授权

US08246973B2 Freeze-thaw method for modifying stent coating 有权
标题翻译：用于修改支架涂层的冻融方法
公开(公告)号：US08246973B2
公开(公告)日：2012-08-21
申请号：US11472760
申请日：2006-06-21
申请人： Syed F. A. Hossainy , Gordon Stewart , Benjamyn Serna , Lothar W. Kleiner
发明人： Syed F. A. Hossainy , Gordon Stewart , Benjamyn Serna , Lothar W. Kleiner
IPC分类号： A61F13/00 , A61L33/00 , B05D3/02
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/608 , A61L2420/02
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
摘要翻译：公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。所述方法包括将湿或干涂层暴露于冻融循环。涂层可用于控制递送活性剂或活性剂的组合。

94. 发明授权

US08191501B2 Apparatus for selectively coating a medical article 有权
标题翻译：用于选择性地涂敷医疗用品的装置
公开(公告)号：US08191501B2
公开(公告)日：2012-06-05
申请号：US12616651
申请日：2009-11-11
申请人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： B05B5/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译：用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。

95. 发明授权

US08123799B1 Modified implantable device surface and a method of making the same 有权
标题翻译：改进的可植入装置表面及其制造方法
公开(公告)号：US08123799B1
公开(公告)日：2012-02-28
申请号：US09997449
申请日：2001-11-30
申请人： Shamim M. Malik , Charles D. Claude , Syed F. A. Hossainy
发明人： Shamim M. Malik , Charles D. Claude , Syed F. A. Hossainy
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/82 , A61L31/022 , A61L2400/18 , B05D1/62 , B05D2502/00 , C23C16/26 , H01J37/32082 , C08L33/08
摘要： A medical device, such as a stent, is disclosed having a modified surface. A method of making the modification is also disclosed. The modification includes depositing a substance within the surface of the device and forming a film layer on the surface of the device. The substance can include carbon and the film layer can be a polymeric layer, such as a plasma polymerized organic film layer.
摘要翻译：公开了一种诸如支架的医疗装置，具有改进的表面。还公开了进行修饰的方法。该修改包括将物质沉积在器件的表面内并在器件的表面上形成膜层。该物质可以包括碳，并且膜层可以是聚合物层，例如等离子体聚合的有机膜层。

96. 发明授权

US08042487B2 System for coating stents 有权
标题翻译：涂层支架系统
公开(公告)号：US08042487B2
公开(公告)日：2011-10-25
申请号：US12014017
申请日：2008-01-14
申请人： Syed F. A. Hossainy
发明人： Syed F. A. Hossainy
IPC分类号： B05C13/02 , B05B7/06
CPC分类号： B05D1/34 , B05B13/0228 , B05D1/002 , B05D1/02
摘要： A system for coating implantable medical devices, such as stents, and a method of coating stents using the system is also disclosed. The system includes a barrier or barriers for isolating an area of the stent on which a composition for coating a stent is applied. Two coating compositions can be applied simultaneously to a stent by separate nozzles on different sides of a barrier. Cross-contamination of the compositions is prevented by the barrier.
摘要翻译：还公开了一种用于涂覆诸如支架的可植入医疗装置的系统，以及使用该系统涂覆支架的方法。该系统包括用于隔离其上应用用于涂覆支架的组合物的支架的区域的屏障或障碍物。两个涂层组合物可以通过在屏障的不同侧面上的分开的喷嘴同时施用于支架。通过屏障防止组合物的交叉污染。

97. 发明授权

US08025916B2 Methods for forming a composite stent with regioselective material 有权
标题翻译：用区域选择材料形成复合支架的方法
公开(公告)号：US08025916B2
公开(公告)日：2011-09-27
申请号：US11641236
申请日：2006-12-18
申请人： Syed F. A. Hossainy , Orlando Padilla , Daryush Mirzaee , Fuh-Wei Tang
发明人： Syed F. A. Hossainy , Orlando Padilla , Daryush Mirzaee , Fuh-Wei Tang
IPC分类号： A61L33/00
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2230/0076 , A61F2250/0018 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10S623/916
摘要： A composite stent and a method for making the same are provided.
摘要翻译：提供复合支架及其制造方法。

98. 发明授权

US08007856B2 Mounting assembly for a stent and a method of using the same to coat a stent 有权
标题翻译：用于支架的安装组件及其使用方法来涂覆支架
公开(公告)号：US08007856B2
公开(公告)日：2011-08-30
申请号：US12606161
申请日：2009-10-26
申请人： Syed F. A. Hossainy , Charles Snyder , Anh Tran , Arthur J. Wen
发明人： Syed F. A. Hossainy , Charles Snyder , Anh Tran , Arthur J. Wen
IPC分类号： B05D1/00 , B05D1/36 , B05C13/00
CPC分类号： B05B13/0442 , B05D1/002 , B05D1/02
摘要： A mounting assembly for a stent and a method of coating a stent using the assembly are provided.
摘要翻译：提供了用于支架的安装组件和使用该组件涂覆支架的方法。

99. 发明授权

US07967998B2 Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 有权
标题翻译：抛光可植入医疗器械降低血栓形成并增加机械稳定性的方法
公开(公告)号：US07967998B2
公开(公告)日：2011-06-28
申请号：US11969181
申请日：2008-01-03
申请人： David C. Gale , Syed F. A. Hossainy
发明人： David C. Gale , Syed F. A. Hossainy
IPC分类号： C03C15/00
CPC分类号： A61L31/10 , A61F2/91 , A61F2210/0004 , Y10S623/901
摘要： The present invention relates to a method of polishing an implantable medical device. The method may include positioning an implantable medical device on a support. At least a portion of a surface of the implantable medical device may include a polymer. A fluid may be contacted with at least a portion of the surface of the positioned implantable medical device. In an embodiment, the fluid may be capable of dissolving at least a portion of the polymer at or near the surface of the implantable medical device. The method may further include allowing the fluid to modify at least a portion of the surface of the positioned medical device. A majority of the contacted fluid may be removed from the surface of the implantable medical device. In certain embodiments, the modified portion of the surface may be substantially less thrombogenetic and substantially more mechanically stable than an unmodified surface.
摘要翻译：本发明涉及一种抛光可植入医疗器械的方法。该方法可以包括将可植入医疗装置定位在支撑件上。可植入医疗装置的表面的至少一部分可以包括聚合物。流体可以与定位的可植入医疗装置的表面的至少一部分接触。在一个实施方案中，流体可能能够将聚合物的至少一部分溶解在可植入医疗装置的表面处或附近。该方法还可以包括允许流体修改定位的医疗装置的表面的至少一部分。接触流体的大部分可以从可植入医疗装置的表面移除。在某些实施方案中，表面的改性部分可以比未修饰的表面基本上更少的血栓形成和基本上更机械稳定的。

100. 发明授权

US07955381B1 Polymer-bioceramic composite implantable medical device with different types of bioceramic particles 有权
标题翻译：具有不同类型生物陶瓷颗粒的聚合物 - 生物陶瓷复合植入式医疗装置
公开(公告)号：US07955381B1
公开(公告)日：2011-06-07
申请号：US11823931
申请日：2007-06-29
申请人： Yunbing Wang , David C. Gale , Syed F. A. Hossainy
发明人： Yunbing Wang , David C. Gale , Syed F. A. Hossainy
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61L31/128 , A61L31/14 , C08L67/04
摘要： Implantable medical devices fabricated from polymer/bioceramic composites with different types of bioceramic particles are disclosed. The plurality of bioceramic particles can include acidic particles and basic particles, the acidic particles and basic particles having different particle size distributions. The degradation of a selected type of particle can be reduced or prevented during a selected time frame by encapsulating some or all of the selected type of particles with a bioabsorbable polymer.
摘要翻译：公开了由具有不同类型的生物陶瓷颗粒的聚合物/生物陶瓷复合材料制成的植入式医疗装置。多个生物陶瓷颗粒可以包括酸性颗粒和碱性颗粒，酸性颗粒和碱性颗粒具有不同的粒度分布。通过用生物可吸收的聚合物包封一些或所有选定类型的颗粒，可以在选定的时间范围内减少或预防选定类型的颗粒的降解。

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