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91. 发明授权

US07979117B2 Device and method for controlled delivery of active substance into the skin 失效
标题翻译：用于将活性物质控制递送到皮肤中的装置和方法
公开(公告)号：US07979117B2
公开(公告)日：2011-07-12
申请号：US10493386
申请日：2002-10-23
申请人： Daniela Mavor , Zvi Nitzan , Dov Tamarkin , Giora Arbel , Nurit Harel , Yossi Gross
发明人： Daniela Mavor , Zvi Nitzan , Dov Tamarkin , Giora Arbel , Nurit Harel , Yossi Gross
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044
摘要： An apparatus for dermal treatment of an active substance having certain physical properties having a flexible, wearable patch conformable to the contour of a skin surface and having: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode capable of closing an electrical circuit with the skin surface, a power source for providing a current and voltage connected through a conductive media to the first and second electrode, and an apparatus for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.
摘要翻译：一种用于对具有某些物理性质的活性物质进行真皮处理的装置，其具有柔软的，可穿戴的贴片，其符合皮肤表面的轮廓，并且具有：第一电极，其适于通过将电流施加到皮肤上而将活性物质传递到皮肤中皮肤表面，能够与皮肤表面封闭电路的第二电极，用于将通过导电介质连接的电流和电压提供给第一和第二电极的电源，以及用于基本上控制活性物质的穿透深度的装置通过从多个变量中选择至少一个变量。

92. 发明授权

US07647100B2 Method, apparatus, and kit for onychomycosis treatment 失效
标题翻译：用于甲真菌病治疗的方法，仪器和试剂盒
公开(公告)号：US07647100B2
公开(公告)日：2010-01-12
申请号：US10890297
申请日：2004-07-14
申请人： Zvika Nitzan , Dov Tamarkin , Daniela Mavor , Nurit Harel , Noam Emanuel
发明人： Zvika Nitzan , Dov Tamarkin , Daniela Mavor , Nurit Harel , Noam Emanuel
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user. Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.
摘要翻译：提出了用于甲真菌病治疗的方法，仪器和试剂盒。在一个实施方案中，用于治疗的试剂盒包括组合物中的抗真菌剂和电动贴剂。贴片的示例性实施例包括第一电极，具有第一和第二端子的电源，耦合到电源的第二端子的第二电极和支撑第一电极，第二电极和电源的基座部件。实施例包括将第一和第二电极和电源印刷在基底构件上的那些。抗真菌剂可以团聚，而组合物包含电离剂。可以实施家庭使用，因为实施例包括其中电源的电压或电流不能由用户调整的实施例。示例性方法包括选择需要治疗的指甲或患病区域，并如所述施用试剂盒。

93. 发明授权

US07643874B2 Dermal patch 失效
标题翻译：皮肤贴片
公开(公告)号：US07643874B2
公开(公告)日：2010-01-05
申请号：US10757414
申请日：2004-01-15
申请人： Zvi Nitzan , Yossi Gross , Daniela Mavor , Dov Tamarkin
发明人： Zvi Nitzan , Yossi Gross , Daniela Mavor , Dov Tamarkin
IPC分类号： A61M1/30
CPC分类号： A61N1/0448 , A61N1/042 , A61N1/0424 , A61N1/0436 , A61N1/044 , A61N1/325
摘要： The invention is generally directed to a kit and patch for transdermal or intradermal delivery of at least one substance into the skin. The kit includes a dermal patch having an electrochemical cell with two electrodes and a retainer for retaining a conductive fluid which further includes an active substance. The conductive fluid can be deposited on at least one of the two electrodes. Alternatively, the conductive fluid can be applied topically to the skin.
摘要翻译：本发明通常涉及用于将至少一种物质透皮或皮内递送至皮肤的试剂盒和贴剂。该试剂盒包括具有具有两个电极的电化学电池的皮肤贴片和用于保持进一步包含活性物质的导电流体的保持器。导电流体可以沉积在两个电极中的至少一个上。或者，导电流体可以局部施用于皮肤。

94. 发明申请

US20090041678A1 Metronidazole-based dermatological foams and emulsions for the preparation thereof 审中-公开
标题翻译：用于制备基于甲硝唑的皮肤病学泡沫体和乳剂
公开(公告)号：US20090041678A1
公开(公告)日：2009-02-12
申请号：US12076115
申请日：2008-03-13
申请人： Dov Tamarkin , Doron Friedman
发明人： Dov Tamarkin , Doron Friedman
IPC分类号： A61K9/12 , A61K31/4164
CPC分类号： A61K9/122 , A61K9/0014 , A61K9/107
摘要： Oil-in-water emulsions expandable into stable foams having diminished inhibitor of skin breathing and useful for the treatment of dermatological conditions/afflictions, e.g., rosacea, advantageously contain: (a) 72% to 76% of water; (b) 0.1 % to 5% of a gelling agent for the aqueous phase of the emulsion; (c) 0.75% to 2% of metronidazole; (d) 5% to 10% of mineral oil; (e) 0.5% to 10% of a surfactant; (f) 0.5% to 5% of a fatty acid; (g) 0% to 4% of a metronidazole absorption promoter (c); and (h) 0.1% to 5% of a preservative selected from the group consisting of methylparaben, propylparaben, phenoxyethanol and mixtures thereof.
摘要翻译：油包水乳液可扩展成具有减少的皮肤呼吸抑制剂并且可用于治疗皮肤病学条件（例如红斑痤疮）的稳定泡沫，有利地包含：（a）72％至76％的水; （b）0.1％至5％的乳液水相胶凝剂; （c）0.75％至2％的甲硝唑; （d）5％至10％的矿物油; （e）0.5〜10％的表面活性剂; （f）0.5〜5％的脂肪酸; （g）0％至4％的甲硝唑吸收促进剂（c）; 和（h）0.1％至5％的选自对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，苯氧基乙醇的防腐剂及其混合物。

95. 发明授权

US07340297B2 Kit, device and method for controlled delivery of oxidizing agent into the skin 失效
标题翻译：用于将氧化剂控制递送到皮肤中的试剂盒，装置和方法
公开(公告)号：US07340297B2
公开(公告)日：2008-03-04
申请号：US10858045
申请日：2004-06-02
申请人： Dov Tamarkin , Daniela Mavor , Zvi Nitzan , Giora Arbel , Nurit Harel , Shalom Luski , Yossi Gross
发明人： Dov Tamarkin , Daniela Mavor , Zvi Nitzan , Giora Arbel , Nurit Harel , Shalom Luski , Yossi Gross
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61K9/0009
摘要： A kit, device and method for delivering an oxidizing agent onto and/or into the body are disclosed. Moreover, a dermal patch device, which delivers an oxidizing agent using iontophoresis and or electroosmosis onto and/or into the body is disclosed. Furthermore, use of a dermal patch device for treatment of a body area with an oxidizing agent is disclosed. The device may be a thin and flexible dermal patch. A method of using such a device/kit for treatment of a disorder of a body area with an oxidizing agent is also disclosed.
摘要翻译：公开了用于将氧化剂递送到身体和/或进入身体的套件，装置和方法。此外，公开了一种使用离子电渗疗法和/或电沉积递送至身体的氧化剂的皮肤贴剂装置。此外，公开了使用用氧化剂处理身体区域的真皮贴剂装置。该装置可以是薄而柔软的皮肤贴剂。还公开了使用这种装置/试剂盒用于用氧化剂治疗身体区域紊乱的方法。

96. 发明授权

US08871184B2 Topical tetracycline compositions 有权
标题翻译：局部四环素组合物
公开(公告)号：US08871184B2
公开(公告)日：2014-10-28
申请号：US13499475
申请日：2010-10-01
申请人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Rita Keynan , Nukri Papiashvili
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K31/4164 , A61K47/10 , A61K8/34 , A61K31/593 , A61K31/57 , A61K9/00 , A61K8/36 , A61K31/573 , A61K9/12 , A61K47/12
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents; and the amount of viscosity modifying agents can optionally be reduced by at least an amount by weight that would have increased the viscosity of the carrier without the tetracycline antibiotic by at least 30%; wherein the tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down; wherein when packaged in an aerosol container to which is added a liquefied or compressed gas propellant the composition affords upon release from the container a breakable foam of at least good quality that breaks easily upon application of shear force.
摘要翻译：一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度; 并且粘度调节剂的量可以任选地减少至少一种使四环素类抗生素的载体的粘度增加至少30％的重量; 其中四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解; 其中当包装在添加了液化或压缩气体推进剂的气溶胶容器中时，组合物在从容器释放至少良好质量的可施加剪切力的容易破裂的泡沫时提供。

97. 发明申请

US20120087872A1 Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof 审中-公开
标题翻译：可泡沫车辆和包含非质子极性溶剂的药物组合物及其用途
公开(公告)号：US20120087872A1
公开(公告)日：2012-04-12
申请号：US13263201
申请日：2010-04-28
申请人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
发明人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号： A61K9/12 , A61P17/00 , A61P29/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/46 , A61K9/0014 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/38 , A61K2800/31 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
摘要翻译：本发明教导了包含非质子极性溶剂的可发泡药物和化妆品组合物; 泡沫组合物及其用途。

98. 发明申请

US20080152596A1 Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof 审中-公开
标题翻译：聚丙二醇可发泡载体及其药物组合物
公开(公告)号：US20080152596A1
公开(公告)日：2008-06-26
申请号：US11894767
申请日：2007-08-20
申请人： Doron Friedman , Dov Tamarkin , Naomi Feiman , David Schuz , Tal Berman
发明人： Doron Friedman , Dov Tamarkin , Naomi Feiman , David Schuz , Tal Berman
IPC分类号： A61K9/00
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/86 , A61K9/122 , A61Q5/006 , A61Q19/007 , A61Q19/008 , A61Q19/02 , A61Q19/06
摘要： The present invention teaches a foamable pharmaceutical carrier comprising polypropylene glycol (PPG) alkyl ether, a surface-active agent water and a liquefied hydrocarbon gas propellant; and pharmaceutical compositions thereof.The present invention further teaches a foamable pharmaceutical carrier comprising polypropylene glycol (PPG) alkyl ether, a surface-active agent, and a liquefied hydrocarbon gas propellant; and pharmaceutical compositions thereof.
摘要翻译：本发明教导了包含聚丙二醇（PPG）烷基醚，表面活性剂水和液化烃气体推进剂的可发泡药物载体; 及其药物组合物。本发明进一步教导了包含聚丙二醇（PPG）烷基醚，表面活性剂和液化烃气体推进剂的可发泡药物载体; 及其药物组合物。

99. 发明授权

US09265725B2 Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof 有权
标题翻译：二羧酸可发泡载体及其药物组合物
公开(公告)号：US09265725B2
公开(公告)日：2016-02-23
申请号：US11825406
申请日：2007-07-05
申请人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
发明人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号： A61K9/12 , A61K8/362 , A61K8/37 , A61K8/49 , A61K8/86 , A61K9/00 , A61Q19/00 , A01N25/16 , A61K8/04
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/362 , A61K8/37 , A61K8/4993 , A61K8/86 , A61K9/0014 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
摘要翻译：本发明教导了一种可发泡药物载体，其包含选自二羧酸和二羧酸酯的有益剂; 选自由至少一种表面活性剂组成的组的稳定剂; 至少一种聚合物及其混合物; 选自水，亲水溶剂，疏水溶剂，有效溶剂，极性溶剂，硅氧烷，软化剂及其混合物的溶剂，其中选择有益剂，稳定剂和溶剂以提供组合物其基本上耐老化和相分离，或基本上稳定其它活性成分。本发明还涉及另外含有液化烃气体推进剂的可发泡组合物。

100. 发明授权

US09167813B2 Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses 有权
标题翻译：非表面活性剂水醇发泡组合物，易碎泡沫及其用途
公开(公告)号：US09167813B2
公开(公告)日：2015-10-27
申请号：US13359709
申请日：2012-01-27
申请人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
IPC分类号： A61K9/12 , A61P17/00 , A01N25/16 , A61K9/00
CPC分类号： A61K31/7056 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/196 , A61K31/327 , A61K31/573 , A61K31/58 , A61K47/10 , A61K47/38
摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.
摘要翻译：一种基本上无表面活性剂的可发泡组合物，其包括短链醇，水，聚合物，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。一种基本上无表面活性剂的可发泡组合物，其包括水，聚合物，脂肪醇或脂肪酸和推进剂。一种使用基本上无表面活性剂的可发泡组合物的处理方法。

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