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91. 发明授权

US07805308B2 Hidden trajectory modeling with differential cepstra for speech recognition 有权
标题翻译：用差分cepstra进行隐藏轨迹建模，用于语音识别
公开(公告)号：US07805308B2
公开(公告)日：2010-09-28
申请号：US11655704
申请日：2007-01-19
申请人： Li Deng , Dong Yu
发明人： Li Deng , Dong Yu
IPC分类号： G10L13/02
CPC分类号： G10L15/02 , G10L25/24
摘要： A novel system for speech recognition uses differential cepstra over time frames as acoustic features, together with the traditional static cepstral features, for hidden trajectory modeling, and provides greater accuracy and performance in automatic speech recognition. According to one illustrative embodiment, an automatic speech recognition method includes receiving a speech input, generating an interpretation of the speech, and providing an output based at least in part on the interpretation of the speech input. The interpretation of the speech uses hidden trajectory modeling with observation vectors that are based on cepstra and on differential cepstra derived from the cepstra. A method is developed that can automatically train the hidden trajectory model's parameters that are corresponding to the components of the differential cepstra in the full acoustic feature vectors.
摘要翻译：一种用于语音识别的新型系统使用差分cepstra作为声学特征，以及传统的静态倒频谱特征，用于隐藏轨迹建模，并在自动语音识别中提供更高的精度和性能。根据一个说明性实施例，自动语音识别方法包括接收语音输入，产生语音的解释，以及至少部分地基于语音输入的解释来提供输出。语言的解释使用基于cepstra和来自cepstra的差异cepstra的观察向量的隐藏轨迹建模。开发了一种能够自动训练隐藏轨迹模型参数的方法，该参数对应于全声学特征向量中差分cepstra的分量。

92. 发明申请

US20080177546A1 Hidden trajectory modeling with differential cepstra for speech recognition 有权
标题翻译：用差分cepstra进行隐藏轨迹建模，用于语音识别
公开(公告)号：US20080177546A1
公开(公告)日：2008-07-24
申请号：US11655704
申请日：2007-01-19
申请人： Li Deng , Dong Yu
发明人： Li Deng , Dong Yu
IPC分类号： G10L15/28
CPC分类号： G10L15/02 , G10L25/24
摘要： A novel system for speech recognition uses differential cepstra over time frames as acoustic features, together with the traditional static cepstral features, for hidden trajectory modeling, and provides greater accuracy and performance in automatic speech recognition. According to one illustrative embodiment, an automatic speech recognition method includes receiving a speech input, generating an interpretation of the speech, and providing an output based at least in part on the interpretation of the speech input. The interpretation of the speech uses hidden trajectory modeling with observation vectors that are based on cepstra and on differential cepstra derived from the cepstra. A method is developed that can automatically train the hidden trajectory model's parameters that are corresponding to the components of the differential cepstra in the full acoustic feature vectors.
摘要翻译：一种用于语音识别的新型系统使用差分cepstra作为声学特征，以及传统的静态倒频谱特征，用于隐藏轨迹建模，并在自动语音识别中提供更高的精度和性能。根据一个说明性实施例，自动语音识别方法包括接收语音输入，产生语音的解释，以及至少部分地基于语音输入的解释来提供输出。语言的解释使用基于cepstra和来自cepstra的差异cepstra的观察向量的隐藏轨迹建模。开发了一种能够自动训练隐藏轨迹模型参数的方法，该参数对应于全声学特征向量中差分cepstra的分量。

93. 发明申请

US20080052075A1 Incrementally regulated discriminative margins in MCE training for speech recognition 有权
标题翻译：增加对语音识别的MCE训练中的歧视性空白
公开(公告)号：US20080052075A1
公开(公告)日：2008-02-28
申请号：US11509980
申请日：2006-08-25
申请人： Xiaodong He , Alex Acero , Dong Yu , Li Deng
发明人： Xiaodong He , Alex Acero , Dong Yu , Li Deng
IPC分类号： G10L15/14
CPC分类号： G10L15/063 , G10L15/144
摘要： A method and apparatus for training an acoustic model are disclosed. A training corpus is accessed and converted into an initial acoustic model. Scores are calculated for a correct class and competitive classes, respectively, for each token given the acoustic model. From this score a misclassification measure is calculated and then a loss function is calculated from the misclassification measure. The loss function also includes a margin value that varies over each iteration in the training. Based on the calculated loss function the acoustic model is updated, where the loss function with the margin value is minimized. This process repeats until such time as an empirical convergence is met.
摘要翻译：公开了一种用于训练声学模型的方法和装置。训练语料库被访问并转换成初始声学模型。对于给定声学模型的每个令牌，分数是针对正确的班级和竞赛班分别计算的。从该分数计算错误分类度量，然后根据误分类度量计算损失函数。损失函数还包括在训练中每次迭代变化的保证金值。基于计算的损耗函数，声学模型被更新，其中具有边际值的损失函数被最小化。该过程重复，直到满足经验收敛的时间为止。

94. 发明授权

US08946175B1 Stabilized immunomodulatory oligonucleotides 有权
标题翻译：稳定免疫调节寡核苷酸
公开(公告)号：US08946175B1
公开(公告)日：2015-02-03
申请号：US13210903
申请日：2011-08-16
申请人： Ekambar R. Kandimalla , Lakshmi Bhagat , Rajendra K. Pandey , Dong Yu , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Lakshmi Bhagat , Rajendra K. Pandey , Dong Yu , Sudhir Agrawal
IPC分类号： A61K48/00 , A61K45/00 , A61K47/00 , A61K39/00 , A61K39/38
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/3183 , C12N2310/321 , C12N2310/336 , C12N2310/53 , C12N2320/51 , C12N2310/3521
摘要： The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5′- or 3′-end. These oligonucleotides have either reduced or improved immunostimulatory properties. The invention establishes that 5′-terminal secondary structures affect immunostimulatory activity significantly more than those at the 3′-end. The invention also provides methods for increasing or decreasing the immunostimulatory activity of a CpG-containing nucleic acid.
摘要翻译：本发明提供了在5'-或3'-末端具有至少一个CpG二核苷酸和二级结构的免疫刺激性寡核苷酸。这些寡核苷酸具有降低的或改善的免疫刺激性质。本发明确定5'-末端二级结构比3'-末端显着地影响免疫刺激活性。本发明还提供了增加或降低含CpG的核酸的免疫刺激活性的方法。

95. 发明授权

US08809678B2 Coated nanoparticles and quantum dots for solution-based fabrication of photovoltaic cells 有权
标题翻译：用于光伏电池基于溶液的制造的涂层纳米颗粒和量子点
公开(公告)号：US08809678B2
公开(公告)日：2014-08-19
申请号：US13465084
申请日：2012-05-07
申请人： Brian M. Sager , Dong Yu , Matthew R. Robinson
发明人： Brian M. Sager , Dong Yu , Matthew R. Robinson
IPC分类号： H01L31/04 , B05D5/12 , H01B1/02 , B41F31/00
CPC分类号： H01L31/0322 , B22F1/0018 , B22F1/025 , B22F2999/00 , B82Y20/00 , B82Y30/00 , C23C16/45544 , C23C18/1216 , C23C18/52 , H01L31/035281 , H01L31/0384 , H01L31/0749 , H01L51/0026 , H01L51/0037 , H01L51/426 , Y02E10/541 , Y02E10/549 , Y10S977/773 , Y10S977/857 , Y10S977/89 , Y10S977/892 , Y10T428/12181 , Y10T428/2991 , B22F1/02 , B22F2202/15 , B22F2202/01
摘要： CIGS absorber layers fabricated using coated semiconducting nanoparticles and/or quantum dots are disclosed. Core nanoparticles and/or quantum dots containing one or more elements from group 13 and/or IIIA and/or VIA may be coated with one or more layers containing elements group IB, IIIA or VIA. Using nanoparticles with a defined surface area, a layer thickness could be tuned to give the proper stoichiometric ratio, and/or crystal phase, and/or size, and/or shape. The coated nanoparticles could then be placed in a dispersant for use as an ink, paste, or paint. By appropriate coating of the core nanoparticles, the resulting coated nanoparticles can have the desired elements intermixed within the size scale of the nanoparticle, while the phase can be controlled by tuning the stoichiometry, and the stoichiometry of the coated nanoparticle may be tuned by controlling the thickness of the coating(s).
摘要翻译：公开了使用涂覆的半导体纳米颗粒和/或量子点制造的CIGS吸收层。含有来自组13和/或IIIA和/或VIA的一种或多种元素的核心纳米颗粒和/或量子点可以涂覆有含有IB，IIIA或VIA族元素的一层或多层。使用具有限定表面积的纳米颗粒，可以调节层厚度以获得适当的化学计量比和/或晶体相，和/或尺寸和/或形状。然后将涂覆的纳米颗粒置于分散剂中用作油墨，糊剂或油漆。通过适当地涂覆核心纳米颗粒，所得到的涂覆的纳米颗粒可以在纳米颗粒的尺寸尺度内混合所需要的元素，而可以通过调整化学计量来控制相位，并且涂覆的纳米颗粒的化学计量可以通过控制涂层厚度。

96. 发明申请

US20120201807A1 MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS BY UTILIZING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES 审中-公开
标题翻译：通过利用改性免疫球蛋白对寡核苷酸的化合物的免疫调节性质的调节
公开(公告)号：US20120201807A1
公开(公告)日：2012-08-09
申请号：US13404309
申请日：2012-02-24
申请人： Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar R. Kandimalla
发明人： Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar R. Kandimalla
IPC分类号： A61K39/00 , A61P37/04 , A61K39/35 , C07H21/04 , A61K39/395
CPC分类号： C12N15/117 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N2310/17 , C12N2310/33 , C12N2310/3519 , C12N2310/51
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5′ end.
摘要翻译：本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。更具体地，本发明提供用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫和免疫刺激性寡核苷酸。本发明的免疫和免疫刺激寡核苷酸优选包含新的嘌呤。根据本发明的免疫反应物还包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核酸连接体，至少一个寡核苷酸是免疫调节性寡核苷酸并具有可接近的5'末端。

97. 发明申请

US20120185252A1 CONFIDENCE MEASURE GENERATION FOR SPEECH RELATED SEARCHING 有权
标题翻译：用于语音相关搜索的信心度量产生
公开(公告)号：US20120185252A1
公开(公告)日：2012-07-19
申请号：US13428917
申请日：2012-03-23
申请人： Ye-Yi Wang , Yun-Cheng Ju , Dong Yu
发明人： Ye-Yi Wang , Yun-Cheng Ju , Dong Yu
IPC分类号： G10L15/04
CPC分类号： G10L15/1822
摘要： A method of generating a confidence measure generator is provided for use in a voice search system, the voice search system including voice search components comprising a speech recognition system, a dialog manager and a search system. The method includes selecting voice search features, from a plurality of the voice search components, to be considered by the confidence measure generator in generating a voice search confidence measure. The method includes training a model, using a computer processor, to generate the voice search confidence measure based on selected voice search features.
摘要翻译：提供了一种产生置信度量产生器的方法，用于语音搜索系统中，该语音搜索系统包括包括语音识别系统，对话管理器和搜索系统的语音搜索组件。该方法包括从多个语音搜索组件中选择语音搜索特征，以由置信度量产生器在生成语音搜索置信度量时考虑。该方法包括使用计算机处理器来训练模型，以基于所选择的语音搜索特征生成语音搜索置信度度量。

98. 发明申请

US20120107303A1 SYNERGISTIC TREATMENT OF CANCER USING IMMUNOMERS IN CONJUNCTION WITH CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：使用免疫调节剂联合化疗药物治疗癌症的协同治疗
公开(公告)号：US20120107303A1
公开(公告)日：2012-05-03
申请号：US13006860
申请日：2011-01-14
申请人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshml Bhagat , Dong Yu
发明人： Ekambar R. Kandimalla , Sudhir Agrawal , Daqing Wang , Lakshml Bhagat , Dong Yu
IPC分类号： A61K39/395 , A61P35/00 , A61K39/385 , A61K31/7088 , A61K39/00
CPC分类号： A61K39/0011 , A61K39/39558 , A61K2039/55561 , C07K16/2887 , C07K16/32 , C07K2317/24 , A61K2300/00
摘要： The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers in combination with chemotherapeutic agents to provide a synergistic therapeutic effect.
摘要翻译：本发明涉及免疫刺激性寡核苷酸和/或免疫组合物与化学治疗剂组合以提供协同治疗效果的治疗用途。

99. 发明授权

US08153777B2 Modulation of toll-like receptor 5 expression by antisense oligonucleotides 失效
标题翻译：通过反义寡核苷酸调节toll样受体5的表达
公开(公告)号：US08153777B2
公开(公告)日：2012-04-10
申请号：US12612413
申请日：2009-11-04
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00 , A61K39/395 , C12N15/63
CPC分类号： A61K39/39 , A61K2039/55561 , C07H21/04 , C12N15/1138 , C12N2310/11 , Y02A50/401 , Y02A50/412 , Y02A50/414
摘要： Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR5. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR5 expression and for prevention or treatment of diseases wherein modulation of TLR5 expression would be beneficial are provided.
摘要翻译：提供反义寡核苷酸化合物，组合物和方法用于下调TLR5的表达。组合物包含靶向编码TLR5的核酸的反义寡核苷酸。组合物还可以包含靶向编码TLR5的核酸与其它治疗和/或预防化合物和/或组合物组合的反义寡核苷酸。提供这些化合物和组合物用于下调TLR5表达和预防或治疗TLR5表达调节将是有益的疾病的方法。

100. 发明授权

US08088309B2 Solution-based fabrication of photovoltaic cell 有权
标题翻译：光伏电池基于解决方案的制造
公开(公告)号：US08088309B2
公开(公告)日：2012-01-03
申请号：US11933400
申请日：2007-10-31
申请人： Dong Yu , Jacqueline Fidanza , Brian M. Sager
发明人： Dong Yu , Jacqueline Fidanza , Brian M. Sager
IPC分类号： H01B1/22 , B05D5/12
CPC分类号： H01L31/06 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C23C18/1204 , C23C18/1266 , C23C18/1295 , H01L31/0322 , H01L31/0749 , H01L31/18 , Y02E10/541 , Y02P70/521
摘要： An ink for forming CIGS photovoltaic cell active layers is disclosed along with methods for making the ink, methods for making the active layers and a solar cell made with the active layer. The ink contains a mixture of nanoparticles of elements of groups IB, IIIA and (optionally) VIA. The particles are in a desired particle size range of between about 1 nm and about 500 nm in diameter, where a majority of the mass of the particles comprises particles ranging in size from no more than about 40% above or below an average particle size or, if the average particle size is less than about 5 nanometers, from no more than about 2 nanometers above or below the average particle size. The use of such ink avoids the need to expose the material to an H2Se gas during the construction of a photovoltaic cell and allows more uniform melting during film annealing, more uniform intermixing of nanoparticles, and allows higher quality absorber films to be formed.
摘要翻译：公开了一种用于形成CIGS光伏电池有源层的墨水以及用于制备墨水的方法，制备活性层的方法和由活性层制成的太阳能电池。油墨含有IB，IIIA和（任选地）VIA组分的纳米颗粒的混合物。颗粒的直径在约1nm至约500nm之间的所需粒度范围，其中大部分颗粒的质量包括尺寸不超过平均粒度的约40％或以下的颗粒，或如果平均粒度小于约5纳米，高于或低于平均粒度的不超过约2纳米。使用这种墨水避免了在构建光伏电池期间将材料暴露于H 2 Se气体的需要，并且允许在膜退火期间更均匀的熔融，更均匀的纳米颗粒的混合，并且允许形成更高质量的吸收膜。

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