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91. 发明申请

US20100173797A1 CLINICALLY INTELLIGENT DIAGNOSTIC DEVICES AND METHODS 失效
标题翻译：临床智能诊断装置及方法
公开(公告)号：US20100173797A1
公开(公告)日：2010-07-08
申请号：US12614895
申请日：2009-11-09
申请人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
发明人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
IPC分类号： C40B30/04
CPC分类号： B01F13/0088 , B01F13/08 , B01F13/0809 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00481 , B01J2219/00497 , B01J2219/00509 , B01J2219/00511 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00664 , B01J2219/00677 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074 , B01J2219/00745 , B01L3/5027 , B01L3/5085 , B01L3/50857 , B01L2300/021 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B01L2300/0864 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/54366 , G01N33/6803 , G01N33/6845
摘要： The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
摘要翻译：本发明涉及诊断装置（例如微阵列）的临床智能设计以及制造和使用这些装置在特定临床症状或症状组的鉴别诊断中的方法。在一个方面，所述装置包括用于执行多个分析物的并行筛选的各种探针。基于与特定疾病和病症相关的症状的已知临床表现，将探针聚集在装置上。

92. 发明申请

US20100056503A1 Compounds for modulating integrin CD11b/CD18 有权
标题翻译：用于调节整合蛋白CD11b / CD18的化合物
公开(公告)号：US20100056503A1
公开(公告)日：2010-03-04
申请号：US12456692
申请日：2009-06-19
申请人： Vineet Gupta , M. Amin Arnaout
发明人： Vineet Gupta , M. Amin Arnaout
IPC分类号： A61K31/54 , C07D415/00 , C07D277/20 , C07D263/30 , C07D279/18 , C07D265/34 , C07D491/04 , A61K31/535 , A61K31/495 , A61K31/426 , A61K31/427 , A61K31/421
CPC分类号： G01N33/5032 , C07C233/81 , C07C251/20 , C07C311/39 , C07C2601/14 , C07D213/85 , C07D239/48 , C07D249/10 , C07D263/46 , C07D265/34 , C07D277/14 , C07D277/36 , C07D277/42 , C07D277/54 , C07D277/72 , C07D311/16 , C07D333/22 , C07D333/68 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/06 , C07D498/04 , C07D513/18
摘要： The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.
摘要翻译：该应用描述了用于鉴定整合素CD11b / CD18的小分子调节剂和能够调节该受体活性的小分子的测定法。这些化合物可用于某些实施方案中用于治疗选自炎症，免疫相关疾病，癌症，缺血再灌注损伤，中风，与血管损伤相关的新内膜增厚，大疱性类天疱疮，新生儿梗阻性肾病和心血管疾病的疾病或病症，或在其它实施方案中用于治疗选自免疫缺陷，获得性免疫缺陷综合征（AIDS），髓过氧化物酶缺乏症，威斯科特 - 奥德里奇综合征，慢性肉芽肿病，超IgM综合征，白细胞粘附缺陷，Chediak-Higashi综合征，和严重的联合免疫缺陷。

93. 发明授权

US07622250B2 Clinically intelligent diagnostic devices and methods 失效
标题翻译：临床智能诊断装置及方法
公开(公告)号：US07622250B2
公开(公告)日：2009-11-24
申请号：US11102498
申请日：2005-04-08
申请人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
发明人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： B01F13/0088 , B01F13/08 , B01F13/0809 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00481 , B01J2219/00497 , B01J2219/00509 , B01J2219/00511 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00664 , B01J2219/00677 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074 , B01J2219/00745 , B01L3/5027 , B01L3/5085 , B01L3/50857 , B01L2300/021 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B01L2300/0864 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/54366 , G01N33/6803 , G01N33/6845
摘要： The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
摘要翻译：本发明涉及诊断装置（例如微阵列）的临床智能设计以及制造和使用这些装置在特定临床症状或症状组的鉴别诊断中的方法。在一个方面，所述装置包括用于执行多个分析物的并行筛选的各种探针。基于与特定疾病和病症相关的症状的已知临床表现，将探针聚集在装置上。

94. 发明申请

US20080049949A1 Lightweight audio system for automotive applications and method 有权
标题翻译：汽车应用轻便音响系统及方法
公开(公告)号：US20080049949A1
公开(公告)日：2008-02-28
申请号：US11893357
申请日：2007-08-15
申请人： Chris Snider , Vineet Gupta , Joseph Huntzinger , Michael Coady , Curtis Stapert , Kevin Meyer , Timothy Garner , Jeffrey Bell , Robert Vadas , Donald Moeschberger , Allen Oberlin , Paul Burton , Dan Carman , Gary Stahl , John Matly , Rick Hatcher , Edgar Hassler , Quan Nguyen , William Reed , Kip Piel , Jerry Wendling , Tim Kenworthy , Paul Uglum , Michael Fye , Philip Scott
发明人： Chris Snider , Vineet Gupta , Joseph Huntzinger , Michael Coady , Curtis Stapert , Kevin Meyer , Timothy Garner , Jeffrey Bell , Robert Vadas , Donald Moeschberger , Allen Oberlin , Paul Burton , Dan Carman , Gary Stahl , John Matly , Rick Hatcher , Edgar Hassler , Quan Nguyen , William Reed , Kip Piel , Jerry Wendling , Tim Kenworthy , Paul Uglum , Michael Fye , Philip Scott
IPC分类号： H04B1/00
CPC分类号： H05K9/0007 , B29C59/16 , B60R11/02 , G06F11/00 , H04B1/082 , H04R1/02 , H05K1/0215 , H05K1/141 , H05K5/0217 , H05K5/0221 , H05K5/0226 , H05K7/20409 , H05K7/20418 , H05K7/20436 , H05K9/0047 , H05K9/0079 , H05K9/0081 , H05K13/00 , H05K2201/09081 , H05K2201/10386 , H05K2201/10446 , Y10T16/547 , Y10T16/5476 , Y10T29/49002 , Y10T29/49124 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49169 , Y10T29/49172 , Y10T29/4957 , Y10T29/49826 , Y10T29/49861 , Y10T29/5313 , Y10T74/20396 , Y10T403/70 , Y10T403/77 , Y10T428/24289
摘要： A lightweight radio/CD player for vehicular application is virtually “fastenerless” and includes a case and frontal interface formed of polymer based material that is molded to provide details to accept audio devices such as playback mechanisms (if desired) and radio receivers, as well as the circuit boards required for electrical control and display. The case and frontal interface are of composite structure, including an insert molded electrically conductive wire mesh screen that has been pre-formed to contour with the molding operation. The wire mesh provides EMC, RFI, BCI and ESD shielding and grounding of the circuit boards via exposed wire mesh pads and adjacent ground clips. The PCB architecture is bifurcated into a first board carrying common circuit components in a surface mount configuration suitable for high volume production, and a second board carrying application specific circuit components in a wave soldered stick mount configuration. The major components and subassemblies are self-fixturing during the final assembly process, eliminating the need for dedicated tools, fixtures and assembly equipment. The major components and subassemblies self-interconnect by integral guide and connection features effecting “slide lock” and “snap lock” self-interconnection. The radio architecture includes improved push buttons employing 4-bar living hinge linkage and front loaded decorative trim buttons.
摘要翻译：用于车辆应用的轻量级无线电/ CD播放器实际上是“无紧固件”，并且包括由聚合物基材料形成的壳体和正面接口，其被模制以提供细节以接收音频设备，如回放机构（如果需要）和无线电接收器，以及作为电气控制和显示所需的电路板。外壳和正面接口为复合结构，包括已经通过模制操作预先形成轮廓的镶嵌模制导电丝网。金属丝网通过暴露的金属丝网垫和相邻的接地夹提供EMC，RFI，BCI和ESD屏蔽和电路板的接地。 PCB结构分为第一板，其承载具有适合于大批量生产的表面安装配置中的公共电路部件，以及第二板，其以波焊焊棒安装配置的方式承载特定于应用的电路部件。主要组件和组件在最终组装过程中是自固定的，无需专用工具，夹具和组装设备。主要部件和组件通过整体引导和连接功能自我互连，实现“滑动锁定”和“卡锁”自动互连。无线电架构包括改进的按钮，采用4杆活动铰链和前装饰装饰钮扣。

95. 发明授权

US07223538B2 Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays 失效
标题翻译：核酸的后合成标记，使用合成后标记的核酸，单核苷酸多态性检测以及相关化合物和微阵列进行测定
公开(公告)号：US07223538B2
公开(公告)日：2007-05-29
申请号：US10022014
申请日：2001-12-14
申请人： Charles K. Brush , Vineet Gupta
发明人： Charles K. Brush , Vineet Gupta
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6816 , C12Q1/6837 , C12Q2525/113 , C12Q2521/101
摘要： An assay is provided for nucleic acids that can be post-synthetically labeled, wherein modified nucleoside triphosphates are used that are more efficiently and specifically incorporated during nucleic acid synthesis than labeled nucleoside triphosphates. In a preferred embodiment, nucleoside α-thiotriphosphates are utilized. Maleimide or iodoacetamide conjugating moieties can be attached post-synthetically. The conjugating moieties may include a reporter group. Also disclosed are new methods for detecting single nucleotide polymorphism.
摘要翻译：提供了可以进行后合成标记的核酸的测定法，其中使用在核酸合成中比标记的核苷三磷酸更有效和特异性并入的修饰的核苷三磷酸。在优选的实施方案中，使用核苷α-硫代三磷酸酯。马来酰亚胺或碘乙酰胺共轭部分可以在合成后连接。缀合部分可以包括报告基团。还公开了用于检测单核苷酸多态性的新方法。

96. 发明申请

US20050191694A1 Clinically intelligent diagnostic devices and methods 失效
公开(公告)号：US20050191694A1
公开(公告)日：2005-09-01
申请号：US11102498
申请日：2005-04-08
申请人： Alice Jacobs , Vineet Gupta , Boris Nikolic
发明人： Alice Jacobs , Vineet Gupta , Boris Nikolic
IPC分类号： B01F13/00 , B01F13/08 , B01J19/00 , B01L3/00 , B81B1/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： B01F13/0088 , B01F13/08 , B01F13/0809 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00481 , B01J2219/00497 , B01J2219/00509 , B01J2219/00511 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00664 , B01J2219/00677 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074 , B01J2219/00745 , B01L3/5027 , B01L3/5085 , B01L3/50857 , B01L2300/021 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B01L2300/0864 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/54366 , G01N33/6803 , G01N33/6845
摘要： The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.

97. 发明授权

US06905816B2 Clinically intelligent diagnostic devices and methods 失效
标题翻译：临床智能诊断装置及方法
公开(公告)号：US06905816B2
公开(公告)日：2005-06-14
申请号：US09996056
申请日：2001-11-27
申请人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
发明人： Alice A. Jacobs , Vineet Gupta , Boris Nikolic
IPC分类号： B01F13/00 , B01F13/08 , B01J19/00 , B01L3/00 , B81B1/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/68 , C12Q1/70
CPC分类号： B01F13/0088 , B01F13/08 , B01F13/0809 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00481 , B01J2219/00497 , B01J2219/00509 , B01J2219/00511 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00664 , B01J2219/00677 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/0074 , B01J2219/00745 , B01L3/5027 , B01L3/5085 , B01L3/50857 , B01L2300/021 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B01L2300/0864 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B60/14 , C40B70/00 , G01N33/53 , G01N33/543 , G01N33/54366 , G01N33/6803 , G01N33/6845
摘要： The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
摘要翻译：本发明涉及诊断装置（例如微阵列）的临床智能设计以及制造和使用这些装置在特定临床症状或症状组的鉴别诊断中的方法。在一个方面，所述装置包括用于执行多个分析物的并行筛选的各种探针。基于与特定疾病和病症相关的症状的已知临床表现，将探针聚集在装置上。

98. 发明授权

US06362976B1 Dual silicone keypad actuation 失效
标题翻译：双硅胶键盘驱动
公开(公告)号：US06362976B1
公开(公告)日：2002-03-26
申请号：US09649781
申请日：2000-08-29
申请人： Philip D. Winters , Vineet Gupta
发明人： Philip D. Winters , Vineet Gupta
IPC分类号： H04B103
CPC分类号： H04B1/082
摘要： A radio having a detachable pod assembly and a pair of silicone keypads. The first silicone keypad is located within the detachable pod assembly, while the second silicone keypad is closely coupled with a printed circuit board that is electrically coupled with a microprocessor based controller. When the pod assembly is snapped into the radio faceplate, there is preferably a 0.2 mm interference fit between the two silicone keypads. When the user depresses the first silicone keypad, the actuation forces depress the second silicone keypad in series. As the second silicone keypad is depressed, a carbon contact “pill” on the second silicone keypad contacts the printed circuit board and signals the circuit board's microprocessor that a button has been depressed. The microprocessor then directs the radio to respond accordingly.
摘要翻译：具有可拆卸荚组件和一对硅胶键盘的收音机。第一硅胶键盘位于可拆卸的盒组件内，而第二硅胶键盘与与基于微处理器的控制器电耦合的印刷电路板紧密耦合。当吊舱组件卡入无线电面板时，两个硅胶键盘之间最好有0.2毫米的过盈配合。当用户按下第一硅胶键盘时，致动力将第二硅胶键盘串联。当第二硅胶键盘被压下时，第二硅胶键盘上的碳触点“药丸”接触印刷电路板，并向电路板的微处理器发出按钮被按下的信号。然后微处理器指示收音机作出相应响应。

99. 发明授权

US06194179B1 Method for preparing polynucleotide sequences and uses thereof 失效
标题翻译：多核苷酸序列的制备方法及用途
公开(公告)号：US06194179B1
公开(公告)日：2001-02-27
申请号：US09357541
申请日：1999-07-20
申请人： Milton H. Werner , Vineet Gupta
发明人： Milton H. Werner , Vineet Gupta
IPC分类号： C12D1934
CPC分类号： C12P19/34 , C12N15/10 , C12N15/66 , C12Q1/6853 , Y10T436/143333 , C12Q2525/131
摘要： Methods are described for the preparation of quantities of preselected polynucleotide sequences in purified form. The method is independent of length or sequence, and can be used to prepare multi-milligram quantities of, for example, single length, isotope-enriched duplex DNA following a single-step chromatographic purification of the desired product. The method of the present invention allows for preparative scale synthesis of DNA yielding a single product length. The application of the method to NMR spectroscopy of DNA provides the opportunity to identify biologically relevant interactions between polynucleotide sequences and other macromolecules, and assist in the identification and development of agents having therapeutic utility as a consequence of the promotion or antagonism of these interactions.
摘要翻译：描述了用于制备纯化形式的预选多核苷酸序列的量的方法。该方法与长度或序列无关，并且可以用于在所需产物的单步色谱纯化后制备多毫克量的例如单长度同位素富集的双链体DNA。本发明的方法允许制备尺度合成产生单一产物长度的DNA。该方法对DNA的NMR光谱的应用提供了鉴定多核苷酸序列与其他大分子之间的生物相关相互作用的机会，并且有助于鉴定和开发具有治疗效用的作为促进或拮抗这些相互作用的结果的试剂。

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