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91. 发明授权

US08722634B2 Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity 有权
标题翻译：使用从苦瓜属提取的化合物在制备用于预防和治疗糖尿病和肥胖症的药物中的用途
公开(公告)号：US08722634B2
公开(公告)日：2014-05-13
申请号：US12865843
申请日：2009-01-14
申请人： Yang Ye , Minjia Tan , Changqiang Ke , Tong Chen , Xiqiang Li , Edward Kraegen , Jiming Ye , David James , Gregory Cooney
发明人： Yang Ye , Minjia Tan , Changqiang Ke , Tong Chen , Xiqiang Li , Edward Kraegen , Jiming Ye , David James , Gregory Cooney
IPC分类号： A61K31/70
CPC分类号： A61K31/575 , A61K31/704
摘要： The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
摘要翻译：本发明公开了葫芦科三萜类化合物的医学用途，其由葫芦科科的苦瓜属分离，用于制备预防和治疗糖尿病和肥胖症的药物。上述葫芦巴三萜类化合物可以作为葡萄糖吸收刺激剂，用于将葡萄糖转运蛋白4（GLUT4）转运至细胞膜的激动剂和腺苷一磷酸酯活化蛋白激酶（AMPK）的激活剂。他们可能有预防和治疗糖尿病和肥胖的潜力。

92. 发明授权

US08515937B1 Automated identification and assessment of keywords capable of driving traffic to particular sites 有权
标题翻译：自动识别和评估能够将特定网站流量的关键字
公开(公告)号：US08515937B1
公开(公告)日：2013-08-20
申请号：US12494143
申请日：2009-06-29
申请人： Qiang Sun , Paul Sauer , Niall O'Driscoll , David James , Kenji Matsuoka , Prathibha Deshikachar
发明人： Qiang Sun , Paul Sauer , Niall O'Driscoll , David James , Kenji Matsuoka , Prathibha Deshikachar
IPC分类号： G06F7/00 , G06F17/30 , G06F15/173 , G06F12/00
CPC分类号： G06Q30/02 , G06Q10/10
摘要： An analytics system and associated methods are disclosed. The analytics system may be used by site owners and others for various purposes, such as to identify and compare network sites that satisfy particular criteria, and to identify and compare keywords associated with these sites. The system may, among other services, include a service for analyzing keywords in terms of their potential to drive search engine to traffic to a particular site. The analysis may include an assessment of amounts of traffic these keywords are responsible for driving to sites having a shared audience with the particular site. The service may also generate associated keyword-related recommendations for increasing search engine traffic to the particular site.
摘要翻译：公开了分析系统和相关方法。分析系统可以由站点所有者和其他用户用于各种目的，例如识别和比较满足特定标准的网站，并且识别和比较与这些站点相关联的关键字。除了其他服务之外，该系统可以包括用于分析关键字的服务，从而可以将搜索引擎推送到特定站点。分析可能包括对这些关键字负责驾驶到具有特定站点的共享观众的站点的流量量的评估。该服务还可以生成与关键字相关的相关建议，用于增加到特定站点的搜索引擎流量。

93. 发明授权

US08464083B1 Exiting low-power state without requiring user authentication 有权
标题翻译：退出低功耗状态，无需用户认证
公开(公告)号：US08464083B1
公开(公告)日：2013-06-11
申请号：US12891462
申请日：2010-09-27
申请人： Sameer Nanda , David James
发明人： Sameer Nanda , David James
IPC分类号： G06F1/32 , G06F21/00 , G06F1/00 , G06F7/04 , G06F12/14
CPC分类号： G06F21/81 , G06F1/3203 , G06F21/31 , G06F2221/2137
摘要： According to an example embodiment, a method may include, in response to an idle time of a computing device meeting or exceeding a power-save time threshold value, placing the computing device into a low-power state; in response to receiving an input to the computing device after the computing device has been placed into the low-power state, exiting the low-power state; determining whether the idle time meets or exceeds a lockout threshold value that is greater than the power-save time threshold value; after having exited from the low-power state, if the idle time meets or exceeds the lockout threshold value, requiring a user to perform a successful predetermined authentication to the computing device before allowing the user to access applications in the computing device; and if the idle time does not meet or exceed the lockout threshold value, allowing the user to access applications in the computing device without requiring the user to perform the successful predetermined authentication to the computing device.
摘要翻译：根据示例实施例，一种方法可以响应于计算设备的空闲时间满足或超过节电时间阈值，将计算设备置于低功率状态; 响应于在计算设备已经被置于低功率状态之后接收到计算设备的输入，退出低功率状态; 确定所述空闲时间是否满足或超过大于所述节电时间阈值的锁定阈值; 在从低功率状态退出之后，如果空闲时间满足或超过锁定阈值，则要求用户在允许用户访问计算设备中的应用程序之前对计算设备执行成功的预定认证; 并且如果空闲时间不满足或超过锁定阈值，则允许用户访问计算设备中的应用，而不需要用户对计算设备执行成功的预定认证。

94. 发明申请

US20120266568A1 FLEXIBLE CELLULOSIC FIBER-BASED HONEYCOMB MATERIAL 有权
标题翻译：柔性纤维素纤维蜂窝材料
公开(公告)号：US20120266568A1
公开(公告)日：2012-10-25
申请号：US13518536
申请日：2010-12-22
申请人： Hugues Prud'homme , Diego De Paoli , Michael Kumar , Marc Brassard , David James
发明人： Hugues Prud'homme , Diego De Paoli , Michael Kumar , Marc Brassard , David James
IPC分类号： B32B3/12 , B65B11/00 , B32B37/14
CPC分类号： B32B3/12 , B32B21/02 , B32B23/02 , B32B29/00 , B32B29/005 , B32B37/12 , B32B37/146 , B32B2250/40 , B32B2305/024 , B32B2307/21 , B32B2307/546 , B32B2307/718 , B32B2317/10 , B32B2317/12 , B32B2317/125 , B32B2553/00 , B65B11/00 , B65B55/20 , Y10T156/10 , Y10T428/1303 , Y10T428/24149 , Y10T428/24165 , Y10T428/24942
摘要： A flexible cellulosic fiber-based material including: a core portion having a geometrically patterned structure defining two spaced-apart substantially planar faces and providing air space therebetween, the core portion including cellulosic fiber-based walls having a core grammage; and at least one cellulosic fiber-based liner bonded to a respective one of the planar faces of the core portion and having a liner grammage lower than the core grammage, the material being flexible along a plane defined by the at least one liner.
摘要翻译：一种柔性纤维素纤维基材料，包括：芯部分，其具有限定两个间隔开的基本上平坦的表面并在其间提供空气空间的几何图案化结构，所述芯部分包括具有芯部克重的纤维素纤维基壁; 以及至少一个纤维素纤维基衬里，其结合到所述芯部分的相应一个平面上并且具有低于所述纤芯克重的衬里克重，所述材料沿着由所述至少一个衬垫限定的平面是柔性的。

95. 发明申请

US20110105483A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US20110105483A1
公开(公告)日：2011-05-05
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa Przewloka
IPC分类号： A61K31/4196 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P37/00 , A61P31/10 , A61P7/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperprolif erative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的多药耐药性疾病如癌症的药物中的用途。

96. 发明申请

US20100311787A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 失效
标题翻译：用于炎症和免疫相关用途的化合物
公开(公告)号：US20100311787A1
公开(公告)日：2010-12-09
申请号：US12718366
申请日：2010-03-05
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
IPC分类号： A61K31/437 , A61K31/4184 , A61K31/4439 , A61K31/433 , A61P37/00 , A61P35/00 , A61P17/06 , A61P1/04 , A61P3/10 , A61P19/02 , A61P11/00 , A61P25/28 , C12N5/0783
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。

97. 发明申请

US20090100370A1 Graphical Representation of Tabular Data 有权
标题翻译：表格数据的图形表示
公开(公告)号：US20090100370A1
公开(公告)日：2009-04-16
申请号：US11869919
申请日：2007-10-10
申请人： Peter Francis Martone , David James , Jeff Liu , Ransom VanOrman , Jun Wang , Sobia Tariq
发明人： Peter Francis Martone , David James , Jeff Liu , Ransom VanOrman , Jun Wang , Sobia Tariq
IPC分类号： G06F3/048
CPC分类号： G06F17/246 , G06F17/245 , G06F17/30398 , G06F17/30572
摘要： An enterprise management system may present data in a user interface that contains tabular data and a graphical representation of the tabular data. The graphical representation may change based on portions of the tabular data that may be selected, and may show a graphical data summary if no rows are selected, or detailed graphical illustrations of the selected rows. In some cases, filters may be applied to the data, and a selection tool may enable a user to select from several different parameters in each row.
摘要翻译：企业管理系统可以在包含表格数据和表格数据的图形表示的用户界面中呈现数据。图形表示可以基于可以选择的表格数据的部分而改变，并且如果没有选择行，则可以显示图形数据摘要，或者所选行的详细图示。在一些情况下，可以将过滤器应用于数据，并且选择工具可以使得用户能够从每一行中的几个不同参数中进行选择。

98. 发明申请

US20080243782A1 Client collection membership evaluation 审中-公开
标题翻译：客户收集会员评估
公开(公告)号：US20080243782A1
公开(公告)日：2008-10-02
申请号：US11729018
申请日：2007-03-28
申请人： Dattatraya Rajpure , Eric Holtz , David James
发明人： Dattatraya Rajpure , Eric Holtz , David James
IPC分类号： G06F17/30
CPC分类号： H04L41/12 , H04L41/0893
摘要： Client collection membership evaluation techniques are described. In an implementation, attributed are identified that define membership in one or more collections. A plurality of clients is monitored for changes to computing resources that correspond to the identified attributes. Membership of clients having the changes is evaluated using one or more queries that include one or more of the identified attributes from respective collections.
摘要翻译：描述客户收集成员评估技术。在一个实现中，识别归属于一个或多个集合中的成员资格。监视多个客户端以对与所识别的属性相对应的计算资源的改变。具有更改的客户端的成员资格使用一个或多个包含来自相应集合的一个或多个所标识属性的查询进行评估。

99. 发明申请

US20080125587A1 Synthesis of triazole compounds that modulate HSP90 activity 审中-公开
标题翻译：合成调节HSP90活性的三唑化合物
公开(公告)号：US20080125587A1
公开(公告)日：2008-05-29
申请号：US11807333
申请日：2007-05-25
申请人： Dinesh U. Chimmanamada , Chi-Wan Lee , David James , Shijie Zhang , Weiwen Ying , Junghyun Chae , Teresa Przewloka
发明人： Dinesh U. Chimmanamada , Chi-Wan Lee , David James , Shijie Zhang , Weiwen Ying , Junghyun Chae , Teresa Przewloka
IPC分类号： C07D249/12 , C07D407/02 , C07D403/02 , C07D401/02 , C07D401/04 , C07D403/10 , C07D417/02 , C07D487/04 , C07D413/12 , C07D413/02
CPC分类号： C07D403/04 , C07D249/12 , C07D249/14 , C07D401/04 , C07D401/10 , C07D403/10 , C07D413/04 , C07D417/04
摘要： The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent.In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) with an oxidizing agent, thereby producing a compound of formula (IA).The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:
摘要翻译：本发明提供抑制Hsp90活性的三唑化合物的新方法。本发明的一个实施方案涉及制备由以下结构式表示的三唑化合物或互变异构体，药学上可接受的盐，溶剂化物或包合物或其前药的方法，其包括以下步骤：a）使酰胺由以下结构式表示：用硫化试剂形成硫代酰胺; b）使步骤a）的硫代酰胺与肼反应形成腙酰胺; c）使步骤b）的腙与羰基化或硫代羰基化试剂反应。在一个实施方案中，本发明是合成式（IA）化合物或互变异构体，其药学上可接受的盐，溶剂化物或包合物或其前药的方法，包括使式（IIA）化合物与氧化剂，从而制备式（IA）化合物。本发明还涉及制备由以下结构式表示的化合物或其互变异构体的方法：或其互变异构体，药学上可接受的盐，溶剂化物或包合物或其前药。该方法包括使由以下结构式表示的第一起始化合物在汞盐存在下与由以下结构式表示的第二起始化合物反应的步骤：

100. 发明申请

US20070286805A1 Methods of Validating Target for Modulating Insulin Action, Screening for Modulators of Insulin Action and Therapeutic Uses Thereof 审中-公开
标题翻译：验证调节胰岛素作用靶标的方法，筛选胰岛素作用调节剂及其治疗用途
公开(公告)号：US20070286805A1
公开(公告)日：2007-12-13
申请号：US10579125
申请日：2004-11-15
申请人： David James , Gregory Cooney , Juan Molero-Navajas
发明人： David James , Gregory Cooney , Juan Molero-Navajas
IPC分类号： C12Q1/54 , A61K45/00 , A61K49/00 , A61P3/04 , C12Q1/68 , G01N33/573 , A61P3/10 , A61P9/00 , C12Q1/48
CPC分类号： G01N33/5038 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0362 , C12N15/8509 , C12Q1/32 , G01N33/5008 , G01N33/5079 , G01N33/5088 , G01N33/74
摘要： The present invention provides several assay formats for determining the effect of compounds on one or more metabolism-associated phenotypes in a cell, tissue or animal. The assay formats are based upon the finding that Cbl (e.g., the protooncogene c-Cbl) is an upstream regulator of AMPK activity and ACC activity in muscle, and that this regulatory pathway modifies whole body energy expenditure and whole body insulin sensitivity.
摘要翻译：本发明提供了用于确定化合物对细胞，组织或动物中的一种或多种代谢相关表型的影响的几种测定形式。测定形式基于Cbl（例如原癌基因c-Cbl）是肌肉中AMPK活性和ACC活性的上游调节因子的发现，并且该调节途径修饰全身能量消耗和全身胰岛素敏感性。

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