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91. 发明授权

US4235888A Pseudotrissaccharides, a process for their production and their use as medicaments 失效
标题翻译：伪三糖，其生产过程及其作为药物的用途
公开(公告)号：US4235888A
公开(公告)日：1980-11-25
申请号：US52871
申请日：1979-06-28
申请人： Peter Stadler , Karl-Georg Metzger , Eckart Voss , Uwe Petersen , Hans-Joachim Zeiler , Hans-Joachim Kabbe
发明人： Peter Stadler , Karl-Georg Metzger , Eckart Voss , Uwe Petersen , Hans-Joachim Zeiler , Hans-Joachim Kabbe
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07D317/72 , C07H15/236 , C07H17/08
CPC分类号： C07D317/72 , C07H15/236
摘要： Pseudotrisaccharides of the sisomycin type are provided which are effective an antibacterial agents, particularly against gram-negative microorganisms. The invention also includes methods for the manufacture of the pseudotrisaccharides, compositions containing said pseudotrisaccharides and methods for the treatment of warm-blooded animals using said compounds and compositions.
摘要翻译：提供了具有抗菌剂，特别是抗革兰氏阴性微生物的抗生素，具有抗生素的类型。本发明还包括制备假三糖的方法，含有所述假三糖的组合物和使用所述化合物和组合物治疗温血动物的方法。

92. 发明授权

US5648493A Preparation of 7-(3-amino- and 3-amino-methyl-1-pyrrolidinyl)-3-quinolonecarboxylic acids and -naphthyridonecarboxylic acids 失效
标题翻译： 7-（3-氨基 - 和3-氨基 - 甲基-1-吡咯烷基）-3-喹诺酮羧酸和萘啶酮羧酸的制备
公开(公告)号：US5648493A
公开(公告)日：1997-07-15
申请号：US717748
申请日：1991-06-19
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D227/04 , A61K31/397 , A61K31/435 , A61K31/47 , A61P31/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D227/10 , C07D401/04 , C07D405/12 , C07D471/04 , C07D498/06 , C07D513/06 , C07D215/233
CPC分类号： C07D401/04 , C07D207/14 , C07D471/04 , Y02P20/55
摘要： Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##
摘要翻译：用于制备式（I）的抗菌化合物的方法包括将式IMA的（V）的氧代化合物与式VI的氨基化合物缩合以产生式（III）使式（III）的化合物与式（II）的化合物反应，得到式（IV）化合物，然后除去氨基保护基

93. 发明授权

US5969141A Intermediates for 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarbox ylic acid antibacterial agents 失效
标题翻译： 7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧代-3-喹啉羧酸抗菌剂的中间体
公开(公告)号：US5969141A
公开(公告)日：1999-10-19
申请号：US701273
申请日：1996-08-22
申请人： Uwe Petersen , Klaus Grohe , Hans-Joachim Zeiler , Karl Georg Metzger
发明人： Uwe Petersen , Klaus Grohe , Hans-Joachim Zeiler , Karl Georg Metzger
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P31/04 , C07D215/56 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
CPC分类号： C07D215/56 , C07D401/04 , C07D409/12 , C07D413/04
摘要： The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.
摘要翻译：本发明涉及式（I）的7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧代-3-喹啉 - 汽车壳酸，其中X1，X2，R1和 R2具有以下说明书中指出的含义。此外，本发明涉及制备式（I）化合物的方法和含有它们的抗菌剂。

94. 发明授权

US5723627A Preparation of 7-(3-amino- and 3-amino-methyl-1-pyrrolidinyl)-3-quinolonecarboxylic acids and -naphthridonecarboxylic acids 失效
标题翻译： 7-（3-氨基 - 和3-氨基 - 甲基-1-吡咯烷基）-3-喹诺酮羧酸和萘啶酮羧酸的制备
公开(公告)号：US5723627A
公开(公告)日：1998-03-03
申请号：US803479
申请日：1997-02-20
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Michael Schriewer , Ingo Haller , Karl Georg Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D227/04 , A61K31/397 , A61K31/435 , A61K31/47 , A61P31/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D227/10 , C07D401/04 , C07D405/12 , C07D471/04 , C07D498/06 , C07D513/06 , C07D211/56
CPC分类号： C07D401/04 , C07D207/14 , C07D471/04 , Y02P20/55
摘要： Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##
摘要翻译：用于制备式（I）的抗菌化合物的方法包括将式IMA的（V）的氧代化合物与式VI的氨基化合物缩合以产生式（III）使式（III）的化合物与式（II）的化合物反应，得到式（IV）的化合物，然后除去氨基保护基

95. 发明授权

US5371090A Naphthyridonecarboxylic acid derivatives 失效
标题翻译：萘啶酮酸衍生物
公开(公告)号：US5371090A
公开(公告)日：1994-12-06
申请号：US199371
申请日：1994-02-18
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
IPC分类号： A61K31/435 , A61K31/44 , A61K31/47 , A61K31/535 , A61P31/04 , C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D471/02
CPC分类号： C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04
摘要： The invention relates to naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.
摘要翻译：本发明涉及通过任选的部分氢化的氮杂吲哚啉基环在7-位上被取代的萘啶酮羧酸衍生物，其制备方法以及含有它们的抗菌剂和饲料添加剂。

96. 发明授权

US5312823A 7-azaisoindolinyl-quinolone-carboxylic acid derivatives 失效
标题翻译： 7-氮杂吲哚啉基 - 喹诺酮 - 羧酸衍生物
公开(公告)号：US5312823A
公开(公告)日：1994-05-17
申请号：US901056
申请日：1992-06-19
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Hans-Joachim Zeiler
IPC分类号： A61K31/435 , A61K31/44 , A61K31/47 , A61K31/535 , A61P31/04 , C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/55
CPC分类号： C07D239/26 , C07D241/12 , C07D471/04 , C07D487/04
摘要： The invention relates to new quinolonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.
摘要翻译：本发明涉及通过任选的部分氢化的氮杂吲哚啉基环在7-位上被取代的新的喹诺酮羧酸衍生物，其制备方法以及含有它们的抗菌剂和饲料添加剂。

97. 发明授权

US5464796A 7-isoindolinyl-quinolone-carboxylic acid derivatives 失效
标题翻译： 7-异吲哚啉基 - 喹诺酮 - 羧酸衍生物
公开(公告)号：US5464796A
公开(公告)日：1995-11-07
申请号：US896955
申请日：1992-06-11
申请人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Franz Kunisch , Thomas Philipps , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Ingo Haller , Hans-Joachim Zeiler
发明人： Uwe Petersen , Andreas Krebs , Thomas Schenke , Franz Kunisch , Thomas Philipps , Klaus Grohe , Klaus-Dieter Bremm , Rainer Endermann , Karl-Georg Metzger , Ingo Haller , Hans-Joachim Zeiler
IPC分类号： A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/535 , A61P31/00 , A61P31/04 , C07D209/44 , C07D215/56 , C07D401/04 , C07D405/14 , C07D471/04 , C07D471/06 , C07D498/04 , C07D498/06 , C07D513/06 , C07D215/38
CPC分类号： C07D215/56 , C07D209/44 , C07D401/04 , C07D471/04
摘要： The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a partly hydrogenated isoindolinyl ring, processes for their preparation and antibacterial agents and feed additives containing these compounds.
摘要翻译：本发明涉及通过部分氢化的异吲哚啉环在7位上被取代的新的喹诺酮和萘啶酮羧酸衍生物，其制备方法以及含有这些化合物的抗菌剂和饲料添加剂。

98. 发明授权

US4895803A Method for decontamination of mycoplasma-infected cell cultures 失效
标题翻译：支原体感染细胞培养物去污方法
公开(公告)号：US4895803A
公开(公告)日：1990-01-23
申请号：US921995
申请日：1986-10-22
申请人： Gunter E. Hubner , Helmut Brunner , Hans-Joachim Zeiler
发明人： Gunter E. Hubner , Helmut Brunner , Hans-Joachim Zeiler
IPC分类号： C12N5/06 , A61L2/00 , C07D215/56 , C07D401/04 , C12N1/38 , C12N5/00 , C12R1/91
CPC分类号： A61L2/0088 , C12N1/38
摘要： A method for decontaminating cell cultures comprising contacting cell cultures with quinolone- and 1,8-naphthyridonecarboxylic acids of the formula (I) ##STR1## in which R.sup.1 represents methyl, ethyl, propyl, isopropyl, cyclopropyl, vinyl, 2-hydroxyethyl, 2-fluorethyl, methoxy, amino, methylamino, dimethylamino, ethylamino, phenyl, 4-fluorophenyl or 2,4-difluorophenyl,R.sup.2 represents hydrogen, alkyl having 1 to 4 carbon atoms, or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,R.sup.3 represents methyl or a cyclic amino group such as ##STR2## in which R.sup.4 represents hydrogen, alkyl having 1 to 4 carbon atoms, 2-hydroxyethyl, allyl, propargyl, 2-oxopropyl, 3-oxobutyl, phenacyl, formyl, CFCl.sub.2 --S--, CFCl.sub.2 --SO.sub.2 --, CH.sub.3 O--CO--S--, benzyl, 4-aminobenzyl or ##STR3## R.sup.5 represents hydrogen or methyl, R.sup.6 represents hydrogen, alkyl having 1 to 4 carbon atoms, phenyl or benzyloxomethyl,R.sup.7 represents hydrogen, amino, methylamino, ethylamino, aminomethyl, methylaminomethyl, ethylaminomethyl, dimethylaminomethyl, hydroxyl, or hydroxymethyl,R.sup.8 represents hydrogen, methyl, ethyl or chlorineX represents fluorine, chlorine or nitro andA represents N or C-R.sup.9, in whichR.sup.9 represents hydrogen, halogen such as fluorine or chlorine, methyl or nitro, or can also, together with R.sup.1, form a bridge of the structure --O--CH.sub.2 --CH--CH.sub.3, --S--CH.sub.2 --CH--CH.sub.3 or --CH.sub.2 --CH.sub.2 --CH--CH.sub.3.
摘要翻译：一种净化细胞培养物的方法，包括使细胞培养物与式（I）的化合物和其中R1代表甲基，乙基，丙基，异丙基，环丙基，乙烯基，2-羟基乙基，2- - 甲氧基，氨基，甲基氨基，二甲基氨基，乙基氨基，苯基，4-氟苯基或2,4-二氟苯基，R 2表示氢，具有1至4个碳原子的烷基，或（5-甲基-2-氧代-1,3 R 3表示氢，具有1至4个碳原子的烷基，2-甲基苯基，2-甲氧基丙基，羟乙基，烯丙基，炔丙基，2-氧代丙基，3-氧代丁基，苯甲酰甲基，甲酰基，CFCl 2 -S-，CFCl 2 -SO 2 - ，CH 3 O-CO-S-，苄基，4-氨基苄基或R 5表示氢或甲基， R6表示氢，具有1至4个碳原子的烷基，苯基或苄氧基甲基，R7表示氢，氨基，甲基氨基，乙基氨基，氨基甲基，甲基氨基甲基，乙基氨基甲基，一分子羟基或羟甲基，R 8表示氢，甲基，乙基或氯，X表示氟，氯或硝基，A表示N或C-R 9，其中R 9表示氢，卤素如氟或氯，甲基或硝基，或也可以与R1一起形成结构-O-CH 2 -CH-CH 3，-S-CH 2 -CH-CH 3或-CH 2 -CH 2 -CH-CH 3的桥。

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