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91. 发明申请

US20190015505A1 Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II 审中-公开
公开(公告)号：US20190015505A1
公开(公告)日：2019-01-17
申请号：US16032482
申请日：2018-07-11
申请人： UNIVERSITY OF MACAU
发明人： Hang Fai KWOK
IPC分类号： A61K39/395 , C07K16/40 , A61P9/12 , A61K45/06
摘要： Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence suggests the mechanisms by which angiotensin II (AngII) elevates blood pressure and enhances cardiovascular remodeling and damage may be distinct. However, the signal transduction cascade by which AngII specifically initiates cardiovascular remodeling such as hypertrophy and fibrosis remains insufficiently understood. In vascular smooth muscle cells, a metalloproteinase ADAM17 mediates epidermal growth factor receptor (EGFR) transactivation, which may be responsible for cardiovascular remodeling but not hypertension induced by AngII. Thus, the objective of this study was to test the hypothesis that activation of vascular ADAM1.7 is indispensable for vascular remodeling but not for hypertension induced by AngII. Vascular ADAM17 deficient mice and control mice were infused with AngII for 2 weeks. Control mice infused with Angti showed cardiac hypertrophy, vascular medial hypertrophy and perivascular fibrosis. These phenotypes were prevented in vascular ADAM17 deficient mice independent of blood pressure alteration. AngII infusion enhanced ADAM17 expression, EGFR activation and ER stress in the vasculature, which were diminished in ADAM17 deficient mice. Treatment with a human cross-reactive ADAM17 inhibitory antibody also prevented cardiovascular remodeling and ER stress but not hypertension in C57B1/6 mice infused with AngII. In vitro data further supported these findings. In conclusion, vascular ADAM17 mediates AngThinduced cardiovascular remodeling via EGFR activation independent of blood pressure regulation. ADAM17 seems to be a unique therapeutic target for the prevention of hypertensive complications.

92. 发明授权

US10016759B2 Cooperative-electrode driving technique for droplet-velocity improvement of digital microfluidic systems 有权
公开(公告)号：US10016759B2
公开(公告)日：2018-07-10
申请号：US14683316
申请日：2015-04-10
申请人： University of Macau
发明人： Cheng Dong , Tianlan Chen , Jie Gao , Yanwei Jia , Pui-In Mak , Mang-I Vai , Rui Paulo da Silva Martins
IPC分类号： B01L3/00 , G01N27/447
CPC分类号： B01L3/502784 , B01L2200/143 , B01L2300/025 , B01L2300/0887 , B01L2400/0427
摘要： According to one aspect of the present disclosure, a control-engaged electrode-driving method for droplet actuation is provided. The method includes, a first pulse is provided to a first electrode for kicking off a droplet till a centroid of the droplet reaching a centroid of the first electrode. A second pulse is provided to a second electrode when a leading edge of the droplet reaching the second electrode.

93. 发明授权

US09673781B2 Radio-frequency-to-baseband function-reuse receiver with shared amplifiers for common-mode and differential-mode amplification 有权
公开(公告)号：US09673781B2
公开(公告)日：2017-06-06
申请号：US14884860
申请日：2015-10-16
申请人： University of Macau
发明人： Pui-In Mak , Zhicheng Lin , Rui Paulo da Silva Martins
IPC分类号： H04B1/00 , H04J11/00 , H03H11/04 , H03H19/00 , H03H11/12 , H03F1/02 , H03F3/19 , H03F3/45 , H04B1/16 , H03B5/12
CPC分类号： H03H11/0472 , H03B5/1237 , H03B5/1246 , H03B2202/06 , H03F1/0205 , H03F3/19 , H03F3/45076 , H03F2200/294 , H03F2200/451 , H03H11/1291 , H03H19/002 , H03H19/004 , H03H2011/0483 , H03H2210/025 , H04B1/16 , H04B1/1638
摘要： According to another aspect of the present disclosure, a radio-frequency-to-baseband-function-reuse receiver with shared amplifiers for common-mode and differential-mode amplification is provided. The receiver includes two set networks connected in parallel. The set networks includes a first and a second input capacitors, a first and a second output capacitors, a first transconductance amplifier having an input terminal, a second transconductance amplifier having an input terminal, a first switch, and a second switch. The first and the second input capacitors connect to a first node. The first and the second output capacitors connect to a second node. The first transconductance amplifier connects between the first input capacitor and the first output capacitor. The second transconductance amplifier connects between the second input capacitor and the second output capacitor. The first switch connects between the input terminal of the first transconductance amplifier and the second node. The second switch connects between the input terminal of the second transconductance amplifier and the second node.

94. 发明申请

US20170145472A1 METHOD OF DETECTING HELICASE ACTIVITY 审中-公开
公开(公告)号：US20170145472A1
公开(公告)日：2017-05-25
申请号：US14950538
申请日：2015-11-24
申请人： University of Macau , Hong Kong Baptist University
发明人： Dik-Lung Ma , Chung-Hang Leung , Hai-Jing Zhong , Bingyong He
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/68 , C12Y306/04012 , G01N33/533 , G01N33/68 , G01N33/6875 , G01N2333/914 , G01N2333/922
摘要： The present invention provides a method of detecting helicase activity in a test solution, providing a substrate solution containing a double-stranded DNA, wherein said double-stranded DNA is a substrate for a helicase to be detected; (b) introducing the substrate solution to the test solution to form a reaction solution; (c) applying a luminescent probe into the reaction solution to form a mixture; and (d) measuring a luminescent response of the luminescent probe in the mixture, wherein the luminescent response corresponds to the helicase activity in the test solution. The present invention also refers to a method of screening a potent luminescent probe for detecting helicase activity, and a series of luminescent Ir (III) complexes. Said luminescent Ir (III) complex comprises an iridium-containing dimer and a nitrogen-containing ligand

95. 发明申请

US20160347779A1 METHOD FOR ANTAGONIZING STAT3 DIMERIZATION AND COMPOUNDS FOR USE THEREIN 有权
标题翻译：用于拮抗STAT3二聚化的方法和用于其的化合物
公开(公告)号：US20160347779A1
公开(公告)日：2016-12-01
申请号：US15168556
申请日：2016-05-31
申请人： University of Macau , Hong Kong Baptist University , Kaohsiung Medical University
发明人： Chung-Hang Leung , Dik-Lung Ma , Hui-Min Wang
IPC分类号： C07F15/00
CPC分类号： C07F15/0073
摘要： A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.
摘要翻译：另外，在有需要的患者中拮抗STAT3二聚化的方法，其通过向该患者施用治疗上可接受的剂量的式I化合物。此外，通过给予有需要的癌症患者的治疗有效剂量的式I的化合物。

96. 发明申请

US20160233908A1 RADIO-FREQUENCY-TO-BASEBAND FUNCTION-REUSE RECEIVER WITH SHARED AMPLIFIERS FOR COMMON-MODE AND DIFFERENTIAL-MODE AMPLIFICATION 有权
标题翻译：具有共模放大器和差分放大倍数的共享放大器的无线电频率到基带功能 - 重用接收器
公开(公告)号：US20160233908A1
公开(公告)日：2016-08-11
申请号：US14884860
申请日：2015-10-16
申请人： University of Macau
发明人： Pui-In MAK , Zhicheng LIN , Rui Paulo da Silva MARTINS
IPC分类号： H04B1/16 , H03F3/19 , H03F3/45 , H03F1/02
CPC分类号： H03H11/0472 , H03B5/1237 , H03B5/1246 , H03B2202/06 , H03F1/0205 , H03F3/19 , H03F3/45076 , H03F2200/294 , H03F2200/451 , H03H11/1291 , H03H19/002 , H03H19/004 , H03H2011/0483 , H03H2210/025 , H04B1/16 , H04B1/1638
摘要： According to another aspect of the present disclosure, a radio-frequency-to-baseband-function-reuse receiver with shared amplifiers for common-mode and differential-mode amplification is provided. The receiver includes two set networks connected in parallel. The set networks includes a first and a second input capacitors, a first and a second output capacitors, a first transconductance amplifier having an input terminal, a second transconductance amplifier having an input terminal, a first switch, and a second switch. The first and the second input capacitors connect to a first node. The first and the second output capacitors connect to a second node. The first transconductance amplifier connects between the first input capacitor and the first output capacitor. The second transconductance amplifier connects between the second input capacitor and the second output capacitor. The first switch connects between the input terminal of the first transconductance amplifier and the second node. The second switch connects between the input terminal of the second transconductance amplifier and the second node.
摘要翻译：根据本公开的另一方面，提供了一种具有用于共模和差模放大的共享放大器的射频到基带功能重用接收机。接收机包括并联连接的两组网络。集网络包括第一和第二输入电容器，第一和第二输出电容器，具有输入端的第一跨导放大器，具有输入端的第二跨导放大器，第一开关和第二开关。第一和第二输入电容器连接到第一节点。第一和第二输出电容器连接到第二节点。第一跨导放大器连接在第一输入电容器和第一输出电容器之间。第二跨导放大器连接在第二输入电容器和第二输出电容器之间。第一开关连接在第一跨导放大器的输入端和第二节点之间。第二开关连接在第二跨导放大器的输入端和第二节点之间。

97. 发明申请

US20160233906A1 GAIN-BOOSTED N-PATH PASSIVE-MIXER-FIRST RECEIVER WITH A SINGLE MIXING STEP 有权
标题翻译：具有单一混合步长的增强型N路PASS-MIXER-FIRST接收器
公开(公告)号：US20160233906A1
公开(公告)日：2016-08-11
申请号：US14862392
申请日：2015-09-23
申请人： University of Macau
发明人： Pui-In MAK , Zhicheng LIN , Rui Paulo da Silva MARTINS
IPC分类号： H04B1/16
CPC分类号： H03H11/0472 , H03B5/1237 , H03B5/1246 , H03B2202/06 , H03F1/0205 , H03F3/19 , H03F3/45076 , H03F2200/294 , H03F2200/451 , H03H11/1291 , H03H19/002 , H03H19/004 , H03H2011/0483 , H03H2210/025 , H04B1/16 , H04B1/1638
摘要： The present invention discloses a gain-boosted n-path passive-mixer-first receiver. According to another aspect of the present disclosure, a gain-boosted n-path passive-mixer-first receiver is provided. The receiver includes a number n of switch-capacitor (sc) sets, a resistor, and a transconductance amplifier. The sc sets connect in parallel, and the sc sets have a first node and a second node. The resistor connects to the first node. The transconductance amplifier connects to the resistor and the second node.
摘要翻译：本发明公开了一种增益升压的n路无源混频器接收机。根据本公开的另一方面，提供增益升高的n路无源混频器优先接收机。接收器包括数量为n的开关电容器（sc）组，电阻器和跨导放大器。 sc集并行连接，sc集合具有第一节点和第二节点。电阻器连接到第一个节点。跨导放大器连接到电阻和第二个节点。

98. 发明授权

US09374063B1 Gain-boosted N-path bandpass filter 有权
标题翻译：增益N路径带通滤波器
公开(公告)号：US09374063B1
公开(公告)日：2016-06-21
申请号：US14726881
申请日：2015-06-01
申请人： University of Macau
发明人： Pui-In Mak , Zhicheng Lin , Rui Paulo da Silva Martins
IPC分类号： H03H19/00 , H03H11/04 , H03H11/12
CPC分类号： H03H11/0472 , H03B5/1237 , H03B5/1246 , H03B2202/06 , H03F1/0205 , H03F3/19 , H03F3/45076 , H03F2200/294 , H03F2200/451 , H03H11/1291 , H03H19/002 , H03H19/004 , H03H2011/0483 , H03H2210/025 , H04B1/16 , H04B1/1638
摘要： The present invention discloses a gain-boosted N-path SC bandpass filter (GB-BPF) with a number of sought features. It is based on a transconductance amplifier (Gm) with an N-path SC branch as its feedback network, offering 1) double RF filtering at the input and output of the Gm in one step; 2) customized passband gain and bandwidth with input-impedance match, and 3) reduced physical capacitance thanks to the loop gain offered by Gm. All have been examined using a RLC model of the SC branch before applying the linear periodically time-variant (LPTV) analysis to derive the R, L and C expressions and analytically study the harmonic selectivity, harmonic folding and noise. The latter reveals that: 1) the noise due to the switches is notched at the output, allowing smaller switches to save the LO power; and 2) the noises due to the source resistance and Gm are narrowband at the output, reducing the folded noise during harmonic mixing.
摘要翻译：本发明公开了一种具有多个寻求特征的增益增强的N路径SC带通滤波器（GB-BPF）。它基于具有N路径SC分支作为其反馈网络的跨导放大器（Gm），在一步中在Gm的输入和输出处提供1）双RF滤波; 2）通过输入阻抗匹配定制通带增益和带宽，3）由于Gm提供的环路增益，3）降低了物理电容。在应用线性周期时变（LPTV）分析之前，已经使用SC分支的RLC模型来检验所有的R，L和C表达式，并分析研究谐波选择性，谐波折叠和噪声。后者显示：1）由于开关引起的噪声在输出端被切口，允许较小的开关节省LO功率; 和2）由于源电阻而产生的噪声，Gm在输出处是窄带，减少了谐波混合期间的折叠噪声。

99. 发明申请

US20160101419A1 MICROFLUIDICS SEPARATION METHOD AND SYSTEM THEREOF 有权
标题翻译：微流化分离方法及其系统
公开(公告)号：US20160101419A1
公开(公告)日：2016-04-14
申请号：US14512466
申请日：2014-10-13
申请人： University of Macau
发明人： Cheuk-Wing LI , Ming Yuen LEE , Guodong YU , Jingyun JIANG
IPC分类号： B01L3/00 , B01D11/04
CPC分类号： B01L3/502753 , B01D11/0496 , B01L3/502776 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874
摘要： A microfluidic system for separating an analyte from a sample fluid including a series of fluidic channels including at least one first region and at least one second region. The first region includes a plurality of L-nodes, which connects to each other in series. The second region includes a plurality of R-nodes, which connects to each other in series. The first region is configured to trigger at least about one lamination process cycle for both the sample fluid and the buffer fluid and the second region is configured to trigger at least about one reverse lamination process cycle for both the sample fluid and the buffer fluid, whereby the lamination process cycle and the reverse lamination process cycle causes the analyte to diffuse to the buffer fluid from the sample fluid. A method for separating the analyte is also disclosed.
摘要翻译：一种微流体系统，用于从包括至少一个第一区域和至少一个第二区域的一系列流体通道的样品流体中分离分析物。第一区域包括多个串联连接的L个节点。第二区域包括多个串联连接的R节点。第一区域被配置为针对样品流体和缓冲流体触发至少约一个层压处理循环，并且第二区域被配置为触发样品流体和缓冲流体的至少约一个反向层压处理循环，由此层压处理循环和反向层叠处理循环使得分析物从样品流体扩散到缓冲流体。还公开了分离分析物的方法。

100. 发明申请

US20150123738A1 POLY-PHASE LOCAL OSCILLATOR 有权
标题翻译：多相本地振荡器
公开(公告)号：US20150123738A1
公开(公告)日：2015-05-07
申请号：US14073060
申请日：2013-11-06
申请人： University of Macau
发明人： Ka-Fai UN , Pui-In MAK , Rui Paulo da Silva MARTINS
IPC分类号： H03B5/12
CPC分类号： H03B5/1228 , H03B27/00 , H03K23/68 , H03L7/087 , H03L7/18 , H03L7/23 , H03L7/24
摘要： One embodiment of the present invention features a poly-phase local oscillator generator combining frequency dividers and direct-injection-locked phase correctors. The poly-phase local oscillator generator comprises a plurality of phase correctors configured to relax frequency and tuning range of a reference local oscillator (LO), and a plurality of frequency dividers, coupled to the phase correctors, configured to offer different frequency segments. The phase correctors are expandable, so that phase accuracy can be optimized by cascading more of themselves.
摘要翻译：本发明的一个实施例的特征在于组合分频器和直接注入锁相相位校正器的多相本地振荡器发生器。多相本地振荡器发生器包括多个相位校正器，其被配置为松弛参考本地振荡器（LO）的频率和调谐范围，以及耦合到相位校正器的多个分频器，被配置为提供不同的频率段。相位校正器是可扩展的，因此可以通过级联更多的自身来优化相位精度。

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