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91. 发明授权

US07049583B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07049583B2
公开(公告)日：2006-05-23
申请号：US10636753
申请日：2003-08-08
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J49/04
CPC分类号： H01J49/0418 , H01J49/424
摘要： A mass spectrometer is disclosed comprising an ion trap ion source wherein a microtitre sample or target plate forms part of one end-cap electrode.
摘要翻译：公开了一种质谱仪，其包括离子阱离子源，其中微量滴定样品或靶板形成一个端帽电极的一部分。

92. 发明授权

US06906318B2 Ion detector 有权
标题翻译：离子检测器
公开(公告)号：US06906318B2
公开(公告)日：2005-06-14
申请号：US10777574
申请日：2004-02-12
申请人： Robert Harold Bateman , Jeff Brown , Martin Green
发明人： Robert Harold Bateman , Jeff Brown , Martin Green
IPC分类号： B01D59/44 , G01K1/08 , H01J37/244 , H01J49/00 , H01J49/40
CPC分类号： H01J43/246
摘要： An ion detector 7 for a mass spectrometer is disclosed comprising a microchannel plate 8 which receives ions 12 at an input surface and releases secondary electrons 16 from an output surface. A detecting device 9 having a detecting surface is arranged to receive at least some of the electrons 16 emitted by the microchannel plate 8. The area of the detecting surface is substantially greater than the area of the output surface of the microchannel plate 8.
摘要翻译：公开了一种用于质谱仪的离子检测器7，其包括微通道板8，微通道板8在输入表面处接收离子12并从输出表面释放二次电子16。具有检测表面的检测装置9布置成接收由微通道板8发射的至少一些电子16。检测表面的面积显着大于微通道板8的输出表面的面积。

93. 发明授权

US06875980B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06875980B2
公开(公告)日：2005-04-05
申请号：US10636767
申请日：2003-08-08
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J49/34 , H01J49/40 , H01J49/42
CPC分类号： H01J49/004 , H01J49/42
摘要： A mass spectrometer is disclosed wherein a relatively energetic pulse of ions having a relatively narrow spread of mass to charge ratios are ejected from a quadrupole ion trap and received in an ion trap upstream of a Time of Flight mass analyser. The ions are collisionally cooled within the ion trap and are pulsed out of the ion trap and into an extraction region of the Time of Flight mass analyser without substantially exciting the ions. This enables improved operation with the Time of Flight mass analyser. According to another embodiment, parent ions are fragmented and the resulting fragment ions are stored in two ion traps having different low mass cut-offs. The trapping system enables MS/MS experiments to be performed with a very high duty cycle.
摘要翻译：公开了一种质谱仪，其中具有相对较窄的质荷比扩散的相对高能的离子脉冲从四极离子阱排出并被接收在飞行时间质量分析器上游的离子阱中。离子在离子阱内被碰撞冷却，并从离子阱中脉冲出并进入飞行时间质量分析仪的提取区域，而基本上不激励离子。这可以通过“飞行时间”质量分析仪进行改进的操作。根据另一个实施方案，母体离子是碎片化的，所得到的碎片离子存储在具有不同低质量截止值的两个离子阱中。捕获系统能够以非常高的占空比执行MS / MS实验。

94. 发明授权

US06872939B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06872939B2
公开(公告)日：2005-03-29
申请号：US10439225
申请日：2003-05-16
申请人： Robert Harold Bateman , John Brian Hoyes , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , Jason Lee Wildgoose
IPC分类号： H01J49/04 , H01J49/40 , H01J49/42 , H01J49/00 , B01D59/44
CPC分类号： H01J49/421 , H01J49/0081
摘要： A mass spectrometer includes an ion detector positioned upstream of a quadrupole mass filter/analyser. Ions are passed through the quadrupole mass filter/analyser, stored in an ion trap and then passed back through the same mass filter/analyser before being detected by the upstream ion detector. With this arrangement, MS/MS experiments can be performed using an apparatus having only a single mass filter/analyser.
摘要翻译：质谱仪包括位于四极质量过滤器/分析器上游的离子检测器。离子通过四极质量过滤器/分析仪，储存在离子阱中，然后通过相同的质量过滤器/分析仪通过上游离子检测器检测。利用这种布置，可以使用仅具有单个质量过滤器/分析器的装置来执行MS / MS实验。

95. 发明授权

US06835928B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06835928B2
公开(公告)日：2004-12-28
申请号：US10654483
申请日：2003-09-04
申请人： Robert Harold Bateman
发明人： Robert Harold Bateman
IPC分类号： H01J442
CPC分类号： H01J49/004
摘要： A mass spectrometer is disclosed comprising a multi-mode quadrupole rod set. In a first mode of operation, the quadrupole rod set is operated as a mass filter to selectively transmit ions having desired mass to charge ratios to an ion detector. In a second mode of operation, the quadrupole rod set operates as a drift or time of flight region in which ions which have been pulsed into the drift or time of flight region become temporally separated according to their mass to charge ratios. In the second mode of operation, the ion detector determines the time of flight of ions passing through the quadrupole rod set.
摘要翻译：公开了一种包括多模四极杆组的质谱仪。在第一操作模式中，四极杆组作为质量过滤器运行，以选择性地将具有所需质荷比的离子传输到离子检测器。在第二种操作模式中，四极杆组作为飞行区域的漂移或时间运行，其中脉冲进入漂移区域或飞行时间区域的离子根据其质荷比暂时分离。在第二种操作模式中，离子检测器确定通过四极杆组的离子的飞行时间。

96. 发明授权

US06794641B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06794641B2
公开(公告)日：2004-09-21
申请号：US10448059
申请日：2003-05-30
申请人： Robert Harold Bateman , Kevin Giles , Steve Pringle
发明人： Robert Harold Bateman , Kevin Giles , Steve Pringle
IPC分类号： H01J4940
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed wherein ions from a pulsed ion source are dispersed in a drift region so that the ions become separated according to their mass to charge ratios. The ions are then received by an ion guide in which multiple trapping regions are created and wherein the multiple trapping regions are translated along the length of the ion guide. The ion guide receives the ions so that all the ions trapped in a particular trapping region have substantially the same or similar mass to charge ratios. The ions are released from the exit of the ion guide and the pusher/puller electrode of an orthogonal acceleration Time of Flight mass analyzer is arranged to be energised in synchronization with the ions emerging from the ion guide. The trapping regions may be translated along the ion guide with a velocity which becomes progressively slower and the delay time of the pusher/puller electrode may be progressively increased.
摘要翻译：公开了一种质谱仪，其中来自脉冲离子源的离子分散在漂移区域中，使得离子根据其质荷比分离。然后由离子导向器接收离子，其中产生多个俘获区域，并且其中多个俘获区域沿离子导向件的长度平移。离子导向器接收离子，使得捕获在特定捕获区域中的所有离子具有基本上相同或相似的质荷比。离子从离子导向器的出口释放，并且正交加速时间飞行质量分析器的推动器/牵引电极被布置成与从离子导向器出射的离子同步地通电。俘获区域可以沿着离子导向器平移，速度逐渐变慢，并且推动器/拉电极的延迟时间可以逐渐增加。

97. 发明授权

US06794640B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06794640B2
公开(公告)日：2004-09-21
申请号：US10301710
申请日：2002-11-22
申请人： Robert Harold Bateman , Jeff Brown , Anthony James Gilbert
发明人： Robert Harold Bateman , Jeff Brown , Anthony James Gilbert
IPC分类号： H01J4900
CPC分类号： H01J49/004 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap such as a 3D quadrupole field ion trap upstream of a pusher electrode of an orthogonal acceleration Time of Flight mass analyzer. According to a first embodiment bunches of ions are released from the ion trap and the pusher electrode is energised after a delay time which is progressively varied. According to a second embodiment ions are released from the ion trap in reverse order of mass to charge ratio with the ions having the largest mass to charge ratio being released first. By appropriate release of the ions from the ion trap it is possible to ensure that substantially all of the ions arrive at the pusher electrode at substantially the same time. According to both embodiments it is possible to achieve a duty cycle approaching 100% across a large range of mass to charge ratios.
摘要翻译：公开了一种质谱仪，其包括质量选择性离子阱，例如正交加速时间飞行质量分析仪的推进器电极上游的3D四极场离子阱。根据第一实施例，一束离子从离子阱中释放出来，并且推进器电极在逐渐变化的延迟时间之后通电。根据第二实施方案，离子从离子阱以与质荷比最大的离子的质荷比相反的顺序被释放。通过从离子阱适当释放离子，可以确保基本上所有的离子基本上同时到达推动器电极。根据两个实施例，可以实现在大范围的质荷比之间接近100％的占空比。

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