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91. 发明授权

US07319006B2 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US07319006B2
公开(公告)日：2008-01-15
申请号：US10856109
申请日：2004-05-28
申请人： Daniel E. Afar , Rene S. Hubert , Arthur B. Raitano , Douglas Saffran , Steven Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Arthur B. Raitano , Douglas Saffran , Steven Chappell Mitchell
IPC分类号： C12Q1/68
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K14/82 , C07K16/3038 , C07K16/3069 , C07K2317/34 , C07K2319/00 , C07K2319/30 , C12N2799/027 , G01N33/57434 , Y10S435/975
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAP's are described and characterized herein. The human STEAP's exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（ Six 上皮 Prostate的抗原。本文描述和表征了四种特定的人STEAP。人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

92. 发明授权

US07223542B2 36P6D5: secreted tumor antigen 失效
标题翻译： 36P6D5：分泌肿瘤抗原
公开(公告)号：US07223542B2
公开(公告)日：2007-05-29
申请号：US10365254
申请日：2003-02-11
申请人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
发明人： Arthur B. Raitano , Aya Jakobovits , Mary Faris , Daniel E. H. Afar , Rene S. Hubert , Steve Chappell Mitchell
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K16/18 , C07K16/3069 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/57484 , Y02A50/466
摘要： Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary and pancreas.
摘要翻译：描述了一种基因及其编码的分泌型肿瘤抗原，称为36P6D5，以及用于治疗表达36P6D5的各种癌症的诊断和治疗方法和组合物，特别包括膀胱，肾脏，前列腺，乳腺，结肠，卵巢和胰腺。

93. 发明授权

US07220823B2 Transmembrane protein expressed in prostate and other cancers 有权
标题翻译：在前列腺和其他癌症中表达的跨膜蛋白
公开(公告)号：US07220823B2
公开(公告)日：2007-05-22
申请号：US10285045
申请日：2002-10-30
申请人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran
发明人： Daniel E. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas C. Saffran
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K7/00 , C07K14/00
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/1709 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers.
摘要翻译：描述了一种新型前列腺肿瘤相关基因（称为24P4C12）及其编码的蛋白质。 24P4C12在前列腺组织异种移植物中高度表达，提供证据表明它在至少一些前列腺癌中被开启。 24P4C12提供了前列腺癌和其他癌症的诊断和/或治疗靶点。

94. 发明授权

US07208280B2 Nucleic acid and corresponding protein entitled 101P3A41 useful in treatment and detection of cancer 失效
标题翻译：核酸和相应的标题为101P3A41的蛋白质可用于治疗和检测癌症
公开(公告)号：US07208280B2
公开(公告)日：2007-04-24
申请号：US10001469
申请日：2001-10-31
申请人： Aya Jakobovits , Arthur B. Raitano , Daniel E. H. Afar , Douglas Saffran , Rene S. Hubert , Mary Faris , Pia M. Challita-Eid
发明人： Aya Jakobovits , Arthur B. Raitano , Daniel E. H. Afar , Douglas Saffran , Rene S. Hubert , Mary Faris , Pia M. Challita-Eid
IPC分类号： G01M33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/705 , C07K16/28 , C07K2317/34
摘要： A novel gene (designated 101P3A11 and also referred to as PHOR-1) and its encoded protein are described. While 101P3A11 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in prostate, colon and kidney cancers. Thus, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译：描述了一种新型基因（命名为101P3A11，也称为PHOR-1）及其编码的蛋白质。虽然101P3A11在正常成人组织中表现出组织特异性表达，但在前列腺，结肠和肾癌中异常表达。因此，101P3A11为癌症提供了诊断，预后，预防和/或治疗靶点。 101P3A11基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

95. 发明授权

US07067130B2 Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer 有权
公开(公告)号：US07067130B2
公开(公告)日：2006-06-27
申请号：US10062109
申请日：2002-01-31
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： A61K39/395 , C12N15/00 , C12N15/63
CPC分类号： C07K14/47 , A61K39/00 , C07K16/40 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , Y02A50/466
摘要： A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit a humoral or cellular immune response.

96. 发明授权

US06652859B1 PTANS: testis specific proteins expressed in prostate cancer 失效
标题翻译： PTANS：前列腺癌中表达的睾丸特异性蛋白
公开(公告)号：US06652859B1
公开(公告)日：2003-11-25
申请号：US09409938
申请日：1999-09-30
申请人： Daniel E. Afar , Rene S. Hubert , Arthur B. Raitano , Stephen Chappell Mitchell
发明人： Daniel E. Afar , Rene S. Hubert , Arthur B. Raitano , Stephen Chappell Mitchell
IPC分类号： A61K3900
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , Y10S977/927
摘要： Novel testis-specific genes and encoded proteins (PTANs) are described. PTANs are over-expressed in prostate cancer. The nucleotide and amino acid sequences of three distinct PTAN isoforms, designated PTAN-1, PTAN-2 and PTAN-3 are provided. The PTANs show no homology to any known gene. The testis-specific expression profile of PTAN in normal adult tissues, combined with the over-expression observed in prostate tumor xenografts, suggests that PTAN may be aberrancy over-expressed in at least some prostate cancers, and thus may be a useful diagnostic and/or therapeutic target for prostate cancers.
摘要翻译：描述了新型睾丸特异性基因和编码蛋白（PTAN）。 PTAN在前列腺癌中过度表达。提供了三种不同PTAN同种型（称为PTAN-1，PTAN-2和PTAN-3）的核苷酸和氨基酸序列。 PTAN与任何已知基因不显示同源性。 PTAN在正常成人组织中的睾丸特异性表达谱与前列腺肿瘤异种移植物中观察到的过表达相结合，表明PTAN可能在至少一些前列腺癌中过度表达，因此可能是有用的诊断和/ 或前列腺癌的治疗靶标。

97. 发明授权

US08497351B2 Nucleic acid and corresponding protein entitled 162P1E6 useful in treatment and detection of cancer 失效
标题翻译：核酸和相应的蛋白质162P1E6可用于治疗和检测癌症
公开(公告)号：US08497351B2
公开(公告)日：2013-07-30
申请号：US13043221
申请日：2011-03-08
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07K5/00
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 162P1E6) and its encoded protein, and variants thereof, are described wherein 162P1E6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 162P1E6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 162P1E6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 162P1E6 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（命名为162P1E6）及其编码的蛋白质及其变体，其中162P1E6在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，162P1E6提供诊断，预后，癌症的预防和/或治疗靶标。 162P1E6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与162P1E6反应的抗体或T细胞可用于主动或被动免疫。

98. 发明授权

US08101372B2 Diagnosis and therapy of cancer using SGP28-related molecules 失效
标题翻译：使用SGP28相关分子诊断和治疗癌症
公开(公告)号：US08101372B2
公开(公告)日：2012-01-24
申请号：US12343170
申请日：2008-12-23
申请人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
发明人： Rene S. Hubert , Arthur B. Raitano , Daniel E. H. Afar , Steve Chappell Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , A01K2217/05 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/3069 , C07K2319/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.
摘要翻译：本发明涉及用于诊断和治疗前列腺癌的方法和组合物，其利用对应于人SGP28基因的分离的多核苷酸，由SGP28基因及其片段编码的蛋白质，以及能够特异性识别和结合SGP28蛋白质的抗体。

99. 发明授权

US07982004B2 Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer 失效
标题翻译：核酸和相应的标题为161P5C5的蛋白质可用于治疗和检测癌症
公开(公告)号：US07982004B2
公开(公告)日：2011-07-19
申请号：US12646863
申请日：2009-12-23
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07K1/00
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P5C5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P5C5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P5C5 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为161P5C5）及其编码的蛋白及其变体，其中161P5C5在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P5C5提供诊断，预后，癌症的预防和/或治疗靶标。 161P5C5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P5C5反应的抗体或T细胞可用于主动或被动免疫。

100. 发明申请

US20110123539A1 NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 151P3D4 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开
标题翻译：核酸和相关蛋白151P3D4用于治疗和检测癌症
公开(公告)号：US20110123539A1
公开(公告)日：2011-05-26
申请号：US13016639
申请日：2011-01-28
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/395 , C07K16/18 , C12N5/071 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 151P3D4) and its encoded protein, and variants thereof, are described wherein 151P3D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 151P3D4 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 151P3D4 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 151P3D4 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为151P3D4）及其编码的蛋白及其变体，其中151P3D4在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，151P3D4提供诊断，预后，癌症的预防和/或治疗靶标。 151P3D4基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与151P3D4反应的抗体或T细胞可用于主动或被动免疫。

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