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91. 发明申请

US20220072197A1 METHOD FOR PRODUCING A FIBRIN-BASED BIOARTIFICIAL, PRIMARILY ACELLULAR CONSTRUCT, AND THE CONSTRUCT ITSELF 有权
公开(公告)号：US20220072197A1
公开(公告)日：2022-03-10
申请号：US17346872
申请日：2021-06-14
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Thomas APER , Mathias WILHELMI , Axel HAVERICH
IPC分类号： A61L27/26 , A61L31/04 , A61L27/22 , A61L27/50 , A61L27/54 , A61L33/00 , A61L33/08
摘要： The invention relates to a method for producing a bioartificial and primarily acellular fibrin-based construct, wherein a mixture of cell-free compositions containing fibrinogen and thrombin is applied to a surface and subsequently pressurised. An additional aspect of the invention is directed to such fibrin-based bioartificial acellular constructs obtained according to the invention, with improved biomechanical properties, as well as to the use of same in the field of implantology, cartilage replacement or tissue replacement.

92. 发明申请

US20220017919A1 RECOMBINANT VECTORS SUITABLE FOR THE TREATMENT OF IPEX SYNDROME 有权
公开(公告)号：US20220017919A1
公开(公告)日：2022-01-20
申请号：US17295093
申请日：2019-11-19
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Paris , Assistance Publique-Hôpitaux de Paris (APHP) , Fondation Imagine , Université d'Evry-Val-d'Essonne , Ecole Pratique des Hautes Etudes , Medizinische Hochschule Hannover
发明人： Isabelle ANDRE , Emmanuelle SIX , Florence BELLIER , Marianne DELVILLE , Marina CAVAZZANA , Mario AMENDOLA , Axel SCHAMBACH
IPC分类号： C12N15/86 , C07K14/705 , C07K14/47 , C12N5/0783 , A61K35/17
摘要： IPEX (Immune dysregulation Polyendocrinopathy X linked) syndrome is a primary immunodeficiency caused by mutations in the gene encoding the transcription factor forkhead box P3 (FOXP3), which leads to the loss of function of thymus-derived CD4+CD25+ regulatory T (tTreg) cells. Preclinical and clinical studies suggest that T cell gene therapy approaches designed to selectively restore the repertoire of Treg cells by transfer of wild type FOXP3 gene is a promising potential cure for IPEX. However, there is still a need for a vector that can be used efficiently for the preparation of said Treg cells. The inventors thus compared 6 different lentiviral constructs according to 4 criteria (vector titers, level of transduction of human CD4+ T cells, level of expression of FOXP3 and ΔLNGFR genes, degree of correlation between both expression) and selected one construct comprising a bidirectional PGK-EF1a promoter that showed remarkable efficiency.

93. 发明申请

US20210353733A1 VACCINE AND ANTIBODY AGAINST CLOSTRIDIOIDES DIFFICILE TOXIN 有权
公开(公告)号：US20210353733A1
公开(公告)日：2021-11-18
申请号：US17277572
申请日：2018-09-19
申请人： Technische Universität Braunschweig , Max-Planck-Gesellschaft Zur Förderung Der Wissenschaft E.V. , Medizinische Hochschule Hannover
发明人： Viola Fühner , Michael Hust , Stefan Dübel , Felix Löffler , Ralf Gerhard
IPC分类号： A61K39/08 , C07K16/12
摘要： The invention provides an antigenic peptide comprising an epitope for use in the prevention and/or treatment of an infection by C. difficile, e.g. for use as a vaccine in the prevention and/or treatment of an infection by C. difficile, and protective antibodies directed against the epitope.

94. 发明申请

US20210301038A1 POLYSIALIC ACID AND DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITION AND METHOD OF PRODUCING POLYSIALIC ACID 有权
公开(公告)号：US20210301038A1
公开(公告)日：2021-09-30
申请号：US17263595
申请日：2019-07-31
申请人： Medizinische Hochschule Hannover (MHH) , Deutsches Zentrum für Neurodegenerative Erkrankungen E.V. (DZNE)
发明人： Alexander Dityatev , Hristo Varbanov , Shaobo Jia , Rita Gerardy-Schahn , Evgeni Ponimaskin , Hauke Thiesler , Herbert Hildebrandt , Timm Fiebig
IPC分类号： C08B37/00 , A61K9/00 , A61P25/28
摘要： The present invention relates to a polysialic acid according to the general formula (1) as given as follows and derivatives thereof: (α(2→8)Neu5Ac)n, with n being an integer in the range from 6 to 13, for use in the prevention or treatment of neurological and neuropsychiatric disorders. The present invention also relates to a pharmaceutical composition comprising as an active ingredient said polysialic acid and/or derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to a method of producing said polysialic acid and/or pharmaceutically acceptable salts thereof.

95. 发明申请

US20210180054A1 Improved Compound for Treatment of Heart Failure 有权
公开(公告)号：US20210180054A1
公开(公告)日：2021-06-17
申请号：US16769873
申请日：2018-12-14
申请人： Medizinische Hochschule Hannover
发明人： Thomas Thum , Sandor Batkai , Ariana Foinquinos
IPC分类号： C12N15/11 , C07H21/04 , A61P9/04 , A61P19/04 , A61K45/06
摘要： The present invention refers to an oligonucleotide which is an effective inhibitor of microRNA miR-132 and its use in medicine, particularly in the prevention or treatment of cardiac and/or fibrotic disorders.

96. 发明申请

US20210155902A1 STEM-CELL DERIVED MYELOID CELLS, GENERATION AND USE THEREOF 有权
公开(公告)号：US20210155902A1
公开(公告)日：2021-05-27
申请号：US16610624
申请日：2018-05-04
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Nico LACHMANN , Mania ACKERMANN , Henning KEMPF , Robert ZWEIGERDT , Thomas MORITZ
IPC分类号： C12N5/0786 , C12N5/0787 , C12N5/078 , A61K35/15 , A61K35/18 , A61K35/19 , A61P31/04 , C12P21/00
摘要： The present invention relates to stem-cell derived hematopoietic cells, in particular, myeloid cells, preferably, macrophages, their generation and use. In particular, the invention relates to a method of producing hematopoietic, preferably, myeloid cells, comprising cultivating embryoid bodies, which are, e.g., derivable from pluripotent stem cells such as induced pluripotent stem cells (iPSC), in suspension culture, to produce myeloid cell forming complexes, which are further cultivated in suspension culture to produce myeloid cells such as macrophages. This allows for a scalable and continuous production, e.g., in industry-compatible stirred tank bioreactors. Macrophages, e.g., macrophages produced with this method that have unique characteristics, can be used in pharmaceutical compositions for treatment of patients, e.g., for treatment of infection such as bacterial infection. The invention further provides application systems suitable for spraying, comprising myeloid cells such as macrophages, which can have a reduced size, for use in treatment of patients for treatment of infection, e.g., bacterial infection or wound healing.

97. 发明授权

US10851359B2 Anti-tumor medicament based on adenovirus 有权
公开(公告)号：US10851359B2
公开(公告)日：2020-12-01
申请号：US15560076
申请日：2016-03-24
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Rita Gerardy-Schahn , Florian Kuehnel , Nikolas Martin , David Schwarzer
IPC分类号： C12N9/24 , C07K14/005 , A61K35/761 , A61K38/16 , A61P35/00 , C12N15/86
摘要： The invention provides manipulated adenovirus, i.e. a viral particle based on a manipulated adenovirus, for use as a medicament, especially for use in the treatment of tumours. The viral particle of the invention has the advantage of having a preference or specificity for tumour cells, yielding a preferred infection of tumour cells. The viral particle is based on adenovirus, especially type C, preferably serotype 2 (Ad2), more preferably serotype 5 (Ad5), in which the native entire fiber protein, and its coding sequence, respectively, is deleted and replaced by a fusion protein providing specificity for cell surface bound polysialic acid.

98. 发明授权

US10668272B2 Cochlear implant 审中-公开
公开(公告)号：US10668272B2
公开(公告)日：2020-06-02
申请号：US15744186
申请日：2016-07-27
申请人： Medizinische Hochschule Hannover , Gottfried Wilhelm Leibniz Universitaet Hannover
发明人： Holger Blume , Wolfgang Ertmer , Thomas Lenarz , Andrej Kral
IPC分类号： A61N1/00 , A61N1/05 , A61N1/36 , H02J50/05 , H02J50/10
摘要： A cochlear implant of a cochlear implant system is described. The cochlear implant comprises electrodes which are mechanically connected to one another and can be inserted in a row in the form of a spiral into a cochlea in order for auditory nerve receptors to be stimulated, a control circuit that can specifically apply electric pulses to the individual electrodes, and an energy source. The control circuit allows the electrodes to be fed in a pulsed manner with electric signals generated by a processor from the acoustic signals, and auditory nerve receptors adjacent to the electrodes to be stimulated. The electrodes are components of modules, each of which comprises its own decoder-and-control circuit for decoding module addresses and stimulation signals and generating electric pulses for the electrodes. Encoded module addresses and stimulation signals generated from acoustic signals are applied to inputs of the decoder-and-control circuit.

99. 发明申请

US20190336571A1 NEUROTOXIN FOR USE IN THE TREATMENT OF PERSONALITY DISORDERS 审中-公开
公开(公告)号：US20190336571A1
公开(公告)日：2019-11-07
申请号：US15746889
申请日：2016-07-13
申请人： Michelle Magid , MEDIZINISCHE HOCHSCHULE HANNOVER , ASKLEPIOS KLINIKEN HAMBURG GMBH
发明人： Michelle Magid , Tillmann Krueger , Alex Wollmer
IPC分类号： A61K38/16 , A61K9/00 , A61P25/18
摘要： The present invention relates to the use of a neurotoxin, especially botulinum toxin, for use as a medicament in the treatment of a personality disorder and/or a habit and impulse disorder and/or a conduct disorder, as well as to a method for the treatment of a personality disorder and/or of a habit and impulse disorder and/or of a behavioural and emotional disorder with onset usually occurring in childhood and adolescence by administration of the neurotoxin to a patient diagnosed with this disorder. Preferably, the neurotoxin is for use as a medicament in the treatment of an emotionally unstable personality disorder and/or of another personality disorder and/or of a habit and impulse control and/or behavioural and emotional disorders with onset usually occurring in childhood and adolescence, in which the disorder is preferably characterised by emotional instability and impulsivity.

100. 发明授权

US10441377B2 Surgical guidance device and method for its preparation 有权
公开(公告)号：US10441377B2
公开(公告)日：2019-10-15
申请号：US15546146
申请日：2016-02-09
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Thomas Stephen Rau , Omid Majdani , Thomas Lenarz , Luder Alexander Kahrs
IPC分类号： A61B17/17 , A61B17/34 , A61B90/11 , A61B17/56 , A61B34/10 , A61B17/00
摘要： The invention is related to a surgical device for patient-specific guidance of at least one tool used during a surgical intervention, comprising at least the following features: a) at least one carrier system which is arranged for fixation on a bone structure of a patient, b) at least one guiding system connectable to the carrier system, the at least one guiding system comprising at least one base module and at least one guiding part for precisely defined guidance of at least one tool used during the surgical intervention, c) at least one connecting means for establishing a mechanical connection between the at least one guiding part and the at least one base module, wherein the connecting means comprises at least a non-fixed operating state and a fixed operating state, wherein in the non-fixed operating state the at least one guiding part can be adjusted relative to the base module in a patient-specific adjustment and in the fixed operating state the at least one guiding part is mechanically fixated relative to the at least one base module in the patient-specific adjustment, d) at least one mechanical interface for connecting the carrier system to the guiding system, comprising first interface means of the carrier system and second interface means of the guiding system, wherein the first interface means can be connected via form fit with the second interface means, thereby ensuring a defined adjustment of the guiding system relative to the carrier system by means of form fit. The invention is further related to a method for preparation of such a surgical guidance device.

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